Authentic Biochemistry
By Dr Daniel J. Guerra
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Episodes: 726
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You have wisely landed upon Authentic Biochemistry, with Dr. Daniel J Guerra, where published biochemical, physiological, genetic and immunological research along with biomedical and pharmaceutical science are interrogated.
Support this podcast: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/support
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Immune Cell Biochemistry I. T cell Membrane Biochemistry.CODA 1.Authentic biochemistry Podcast.Dr. Daniel J. Guerra
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May 04, 2024 |
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Immune Cell Biochemistry I. T Lymphocyte Membrane.C.15. Authentic Biochemistry Podcast.Dr Daniel J. Guerra.01May2024.
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May 02, 2024 |
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Immune Cell Biochemistry I. T Lymphocyte Membrane.C.14 Authentic Biochemistry Podcast. Dr Daniel J. Guerra. 30.4.24 .
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May 01, 2024 |
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Immune Cell Biochemistry I. T Lymphocyte Membrane c.13. Authentic Biochemistry Podcast. Dr .Daniel J. Guerra.28.4.24 .
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Apr 29, 2024 |
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Immune Cell Biochemistry I. T Lymphocyte Membrane Biochemistry c.12. Omega -3 fatty acids and mdiminished macrophage inflammatory gene expression. Dr. Daniel J. Guerra Authentic Biochemistry 26..4.24
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Apr 27, 2024 |
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A brief introduction to an epistemological dialectic directed toward research science. Dr. Daniel J. Guerra. 25.4.2924. Authentic Biochemistry Podcast
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Apr 26, 2024 |
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Immune Cell Biochemistry I. T Lymphocyte Membrane Biochemistry c.11. Dr. Daniel J. Guerra. Authentic Biochemistry. 24.4.24
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Apr 25, 2024 |
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Immune Cell Biochemistry I. T Lymphocyte Membrane Biochemistry c.10. Immune cell membrane glycosphingolipids. Dr. Daniel J. Guerra Authentic Biochemistry 23.4.24.
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Apr 24, 2024 |
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Immune Cell Biochemistry I. T lymphocyte Membrane Biochemistry. c.9. The involved CH2O sequence event ontology. DJGPhD.22.4.24
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Apr 23, 2024 |
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Immune Cell Biochemistry I. T lymphocyte Membrane Biochemistry c.8. 20April 2024.Authentic Biochemistry Podcast. Dr. Daniel J. Guerra.
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Apr 21, 2024 |
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Immune Cell Biochemistry I. T lymphocyte Membrane Biochemistry. c.7. .18April 2024.Authentic Biochemistry Podcast. Dr. Daniel J. Guerra
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Apr 19, 2024 |
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Immune Cell Biochemistry I. T lymphocyte Membrane Biochemistry c.6. 17April 2024.Authentic Biochemistry Podcast.Dr. Daniel J. Guerra.
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Apr 17, 2024 |
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T lymphocyte Membrane Biochemistry I. Immune Cell Biochemistry I c.5 Authentic Biochemistry 16April2024 Dr Daniel J. Guerra
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Apr 17, 2024 |
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Immune Cell Biochemistry I. T lymphocyte Membrane Biochemistry c.4. 15April 2024. Chemokine gradients and the membrane lipid raft. Authentic Biochemistry Podcast Dr. Daniel J. Guerra
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Apr 16, 2024 |
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Immune Cell Biochemistry I. T lymphocyte Membrane Biochemistry c.3. 14 April 2024 .Authentic Biochemistry Podcast.Dr. Daniel J. Guerra
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Apr 15, 2024 |
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Immune Cell Biochemistry I.T lymphocyte Membrane Biochemistry c.2 Lipid mespmorph and radius assymetry direct Tcell membrane sterol and protein interdigitation that is altered by pressure via PV=nRT.
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Apr 13, 2024 |
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Immune Cell Biochemistry I.T lymphocyte Membrane Biochemistry c.1. DJGPhD.11April24.Authentic Biochemistry Podcast
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Apr 12, 2024 |
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Biochemical Mosaic III. Coda. DJGPhD .09April24.Authentic Biochemistry Podcast
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Apr 10, 2024 |
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Biochemical Mosaic III. c.14. From physical chemistry to the mechanisms of sphingomyelinase mediated inflammation: abrief dialectical accounting of research involving abiotic vs biological phenomena.
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Apr 08, 2024 |
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Biochemical Mosaic III.c.13. A priori intralocution of inflammasome genomic loci with stress phenomena immunoepigenetically resolves defensive inflammation. DJGPhD.6April24. Authentic Biochemistry.
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Apr 07, 2024 |
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Biochemical Mosaic III. c12. A prolegomena to any future biochemical Instanence. Dr Daniel J. Guerra. 4April2024. Authentic Biochemistry Podcast
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Apr 05, 2024 |
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Biochemical Mosaic III. Inflamasomes c.11 A Dialectical Event Ontological conciliantus contrarion perspective.DJGPhD.3April24.Authentic Biochemistry Podcast.
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Apr 04, 2024 |
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Biochemical Mosaic III.c.10 Atherogenesis and neointma formation are associated with sphingomyelinase membrane raft NOX aggregation during inflammasome activation.DJGPhD.2April24
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Apr 03, 2024 |
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Biochemical Mosaic III.c.9 Clinical associations of inflammasome mediated pathophysiology linked to epigenetic methylation patterning and DNA repair. DJGPhD.1April24.
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Apr 02, 2024 |
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Biochemical Mosaic III.c.8. S. aureus clearance via dual pyroptosis and necroptosis salientsand the control over the hyperinflammatory axis of clinical disease. DJGPhD.31.3.24
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Apr 01, 2024 |
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Biochemical Mosaic III.c.7 Convergence of Inflammasome molecular patterning obtains PRR-like sequalae that are hypo-modified epigenetically in multple Human pathophysiologies
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Mar 28, 2024 |
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Biochemical Mosaic III. c.6. S auereus induced inflammasome activating pyroptosis circumvents immune clearance and ARDS pulmonary chronic activation share similar hyperinflammatory presentation.DJGPhD
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Mar 27, 2024 |
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Biochemical Mosaic III. c.5. Gal3 and NRLP3 inflammasome coordinate inflammation via IL-1Beta convertase activation that is associated with NAFLD and NASH and inhibition of ABCA1 cholesterol efflux.
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Mar 25, 2024 |
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Biochemical MosaicIII. C.4. My oppositional dialectic and episteme- metaphysical discourse on method+ Gal3 as proinflammatory lectin may not uniformly correlate with pathobiochemical events. DJGPhD.
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Mar 23, 2024 |
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Biochemical Mosaic III c.3. Bacterial glycosphingolipid mediated inflammasome activation and the Galectin:NLRP3 interaction pathophenocopy oxy-mtDNA TLR induction.DJGPhD.21.3.24
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Mar 22, 2024 |
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Biochemical Mosaic III. C.2 A Non-canonical autophagic inhibition of NLRP3 inflammasome mediated inflammation in UVB-treated human keratinocytes.DJGPhD. 20.3.24.
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Mar 21, 2024 |
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Biochemical Mosaic III. C.1. Inflammasomes. DJGPhD.19.3.24 Authentic Biochemistry Podcast
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Mar 20, 2024 |
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Biochemical MosaicII.Book2.C.13.Dialectical event ontologies involving CNS plasmalogen and sphingolipid interlocution and the universality of Mozart and the Beatles. DJGPhD.17.3.24.Authentic Biochem.
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Mar 18, 2024 |
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Biochemical Mosaic II.Book 2. c.12 Adduced mTORC mediated glycerol-sphingolipid enzyme mRNA transcriptome association with Plasmalogen apodiction of myelination.DJGPhD.16.3.24
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Mar 17, 2024 |
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MosaicII,Bk.2.c.11 Squalene monooxygenase (SM) stabilization due to plasmalogen pathway fatty acid reductase deficiency promotes SM epoxidase alternate activity thus lowering24OHCHOL-LXR-myelination.
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Mar 14, 2024 |
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Biochemical Mosaic II. Book2. c.10.Plasmalogen mediated oxy vs epoxy sterol synthesis may control cns inflammation and myelination given acid-catalyzed transacetalization sequalae.DJGPhD.12March24
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Mar 13, 2024 |
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Biochemical Mosaic II. Book2. c.9. Plasmalogen regulation of composite ruling over prescriptive organization of cellular-biochemical phenomena includes florid mediation of the CNS.DJGPhD.11MARCH2024.
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Mar 12, 2024 |
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Biochemical Mosaic II.c.8 Cell death and CE-circ RNA vs.miRNA in Hepatocellular carcinoma: the spectre of AGPS et al. DJGPhD. 10March24.Authentic Biochemistry.
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Mar 11, 2024 |
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Biochemical Mosaic II.c.7. Fatty acid desaturation and mole% PC/PE/PL/CER are elevated via circRNA in Medublastoma while AGPS increased circRNA's in thyroid cancer.DJGPhD.7Mar24. Authentic Biochem.
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Mar 08, 2024 |
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Biochemical Mosaic II.c.6 Meduloblastoma is linked to plasmalogen and circ RNA phenomena that are pathophenocopied in other cancers. DJGPhD.5.Mar24.Authentic Biochemistry
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Mar 06, 2024 |
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Biochemical Mosaic II. c.5 Peroxisomal plasmalogen biosynthesis may regulate transcriptomic and proteomic sequalae to plasmamembrane mediated signal transduction. DJGPhD.4March24.
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Mar 04, 2024 |
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Biochemical Mosaic II. c.4. Peroxisomal biogenesis and AGPS-mediated plasmalogen synthesis involve circular RNA species that alter microRNA and mRNA expression in human cancers. DJGPhD.3MAR24.
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Mar 04, 2024 |
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Saturday Night Authentic Biochemistry The Agentic operator as metaphysical metaphor in metabolic regulation. DJGPhD.2March 2024.
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Mar 03, 2024 |
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Biochemical Mosaic II. c.3 Plasmalogen metabolism is coherently associated with peroxisomal integrity and replication. DJGPhD.01March 2024 Authentic Biochemistry.
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Mar 02, 2024 |
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Biochemical Mosaic II. C.2. Plasmalogen and PAF biosynthesis in relation to glycerol lipid and intermediary subcellular metabolism.DJGPhD.27.2.24
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Feb 28, 2024 |
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Biochemical Mosaic II. Plasmalogens & other ether lipids. c.1 DJGPhD.26.2.24. Authentic Biochemistry Podcast
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Feb 26, 2024 |
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A Dialectical Interlocution with Mozart. DJGPhD.24.2.24 Authentic Biochemistry Podcast
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Feb 25, 2024 |
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Biochemical Mosaic I. CODA. Membrane lipids function as biosensors for pKa's of phosphonoester anionic charge density with polybasic protein domains to mediate communication including transcription.
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Feb 24, 2024 |
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Biochemical MosaicI.c.13 Phosphatidic acid as key lipid intermediary of membrane secretion signalling and cellular intracommunication via kinase cascade and transcriptional regulation.DJGPhD.22.2.24
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Feb 23, 2024 |
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Biochemical Mosaic I. c.12. The porosomal secretory system requires anioic lipids including phosphatidic acid. DJGPhD.21.2.24
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Feb 22, 2024 |
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Biochemical Mosaic I.c.11. Glycerolipid metabolism coupled to mTORC1 enzyme phosphorylation necessarily involves a complete analysis of membrane lipid molecular species distribution.DJGPhD.20.2.24
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Feb 20, 2024 |
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Biochemical Mosaic I c.10. Is PE depletion reversed by mTORC1 phosphorylation of LIPIN1 or is DAG authentically activating CCT via membrane association thus obtaining robust PL synthesis? DJGPhD.
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Feb 19, 2024 |
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Biochemical Mosaic I. c.9 Increased inner mitochondrial membrane PE from PS decarboxylase decreases protease mediated degradation of phospholipid transfer proteins thus maintaining fusion potency.
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Feb 19, 2024 |
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Biochemical Mosaic I PA-phosphatase c.8. Membrane fusion and the dynamics of mitochondrial reduction vs. proliferation; the PA phosphatase in lipid metabolism. DJGPhD. 16.2.24 Authentic Biochemistry
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Feb 17, 2024 |
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Biochemical Mosaic I. Phosphatidic acid Phosphatase. c.7. Mutational reversal of IDH1 leads to NADPH depletion concomitant with potent anti-PHD enantiomeric 2-hydroxyglutarate obtaining pseudohypoxia.
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Feb 16, 2024 |
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Biochemical Mosaic I. The PA phosphatase c.6. Alteration of the TCA pathway intermediates and hypoxia/nutrient deficiency control HIF1α stability indirectly regulating IMM protein and lipid turnover.
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Feb 13, 2024 |
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The Biochemical Mosaic I. Phosphatidic Acid Phosphatase c.5. Tumor cells adapt bioenergetic fuel economy toward cell immortalization via re-crafting of mitochondrial IM lipid speciation.DJGPhD.12Feb24
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Feb 12, 2024 |
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Biochemical Mosaic I. Phosphatidic Acid Phosphatase c.4 GLN utilization and an IMM protease regulate mitochondrial involvement in cancer growth. DJGPhD. Authentic Biochemistry 10Feb24
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Feb 11, 2024 |
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Biochemical Mosaic Event Ontologies I. Phosphatidic Acid Phosphatase. c.3 Indirect consequences of mitochondrial proteomic variation potentially obtains GLN-linked Warburg glycolysis preventing ROS.
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Feb 09, 2024 |
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Biochemical Mosaic Event Ontologies I. Phosphatidic Acid Phosphatase. Autophagy commitment is linked to mTORC1 v. AMPK oppostional kinase networks maintaining proteostasis and lipid homeostasis.DJGPhD
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Feb 09, 2024 |
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Biochemical Mosaic Event Ontologies I. Phosphatidic Acid Phosphatase. Prologomena c.1.
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Feb 07, 2024 |
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BioMedical Portrait VIII. C.22 CODA. Microglial Leukotrienes in neurodegeneration.DJGPhD.04Feb2024. Authentic Biochemistry Podcast.
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Feb 04, 2024 |
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BioMedical Portrait VIII. c.21 Lysopholpids like sphingolipids hydrogen bond to cholesterol mediating lipid membrane raft mobility. DJGPhD. 2Feb2024. Authentic Biochemistry Podcast
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Feb 03, 2024 |
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BioMedical Portrait VIII C.20. Heterologous lipid sequence membrane domains rearrange according to LysoPL polarity after PLA2 mediated 20:4 removal and acetosalicylic acid alters fatty acid ordering.
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Feb 01, 2024 |
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BioMed PortraitVIII.c.19. Membrane thermotropic phase transition enthalpic responses to Leukotriene synthesis in relation to cholesterol and lysophospholipid fluid dynamics.DJGPhD.31.1.24.Authentic BC
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Jan 31, 2024 |
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BioMed Portrait VIII.c.18Aspirin PGS (COX) inhibited membrane topological and integrated molecular dynamics: leukotriene –cytokine mediated asthmatic inflammation.DJGPhD.29.1.24. Authentic Biochem.
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Jan 29, 2024 |
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Sententia non Fengo, concluding remarks. BioMedical PortraitVIII. (C.17). LTC4 and LTD4 interact with IL-33 inducing cytokine generation in lung ILC2s.DJGPhD.28.1.24
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Jan 29, 2024 |
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Sententia non Fengo: A minor prolegomenon to the purpose of Authentic Biochemistry. DJGPhD.28.1.24
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Jan 28, 2024 |
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BioMed Portrait VIII. c.16. Coordinated complimentarity of cell cycle MEK kinase cascade with the IL33-ST2 and CysLT1R mediatedILC2 activation to promote type 2 immunopathology. DJGPhD.25.1.24
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Jan 26, 2024 |
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BioMedical Portrait VIII.c.15. ILC associated hippocampal RNA-BP's exacerbate GLU neurotoxicity and regulate CysLT1R in lung ILC2's. DJGPhD. 23.1.24.
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Jan 23, 2024 |
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BioMedical Portrait VIII.c.14 The dialectical events between immune responses and leukotriene signaling are modulated by tissue-resident and circulating cell patterns via RNA binding proteins.DJGPhD.
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Jan 22, 2024 |
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BioMedical PortraitVIII.c.13 Leukotriene metabolism and reception is linked to innate like lymphocytes involved in airway inflammation and hyper-responsiveness-associated asthma.DJGPhD.19.1.24.AB.
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Jan 20, 2024 |
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BioMedical Portrait VIII.c.12. 5-LOX associates with FLAP and PLA2 at the nuclear envelope to trigger and control ILC2 mediation of the allergic asthma AHR pathology. DJGPhD 17.1.24. Authentic Bioch.
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Jan 18, 2024 |
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BioMedical Portrait VIII. C.11 Peptidyl leukotrieneR- mediated transcription of PTGS2and LOX15B with IL4/IL13 and IL33 in asthmatic lung airway constrictionin MDM's LM's and ILC2's DJGPhD.16.1.24
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Jan 17, 2024 |
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BioMedical Portrait VIII. c.10. The LOX5 and LOX12/15 pathways for 20:4, 20:5 and 22:6produce over 50 unique molecular species of oxylipins and lipoxins with unique biological sequalae.DJGPhD.14.1.24.
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Jan 15, 2024 |
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BioMedical Portrait VIII. c.9. Initial detail of the LOX vs.COX isoform utilization of essential and other dietary PUFA's in complex leukotriene biosynthesis. DJGPhD.11Jan24.Authentic Biochemistry.
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Jan 12, 2024 |
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BioMedical Portrait vIII. Leukotrienes. c.8 Leukotriene regulated Heterodimer Nuclear Receptor transcription factors organize around complex multi-ligand binding and sojourner molecular modifiers
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Jan 10, 2024 |
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BioMedical Portrait VIII.c.7. Differential control over fatty acid oxygenation and PPAR/RXR heterodimer pairing in mammalian uterine cell estrus physiology.DJGPhD.8Jan2024
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Jan 09, 2024 |
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EtOH Membrane Intoxication c.3. Epiphantei: ethanol-induced membrane degeneration results in altered porosity/tortuosity dynamics and microglia-failed tissue surveilance/repair in the CNS.DJGPhD.
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Jan 06, 2024 |
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EtOH c.2 Mean diffusivity and tortuosity metrics in ethanol induced white matter lesions.
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Jan 06, 2024 |
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BioMedical Portrait VIII.c.6 Precursor 20:4 5,8,11,14 derived prostaglandins and leukotriene roles in PPAR and RXR transcription factor expression in mammalian reproductive tissues. DJGPhD. 04JAN24.AB
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Jan 04, 2024 |
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Post Holiday EtOH Lectures. Volume One. Dr. Daniel J. Guerra. 01Jan2024. Authentic Biochemistry
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Jan 02, 2024 |
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BioMedical Portrait VIII.c.5 Leukotrienes. Lipoxygenase isoform mediated control over resident tissue macrophage speciation.Dr Daniel J. Guerra. 01Jan2024. Authentic Biochemistry Podcast
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Jan 01, 2024 |
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BioMedical Portrait VIII. c.4 A deft-handed apprehension of chirality to facillitate reasoned appreciation of leukotriene molecular heterogeneity.DJGPhD. 30.12.23. Authentic Biochemistry.
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Dec 31, 2023 |
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BioMedical Portrait VIII.c.3. Leukotriene molecular speciation involves subcellular re-distribution of modifying enzymes and adaptor proteins associating with ER and Nuclear membranes.DJGPhD.28.12.23
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Dec 29, 2023 |
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BioMedical Portrait VIII.c.2 Leukotrienes: regio-associated oxygenation patterns of lipoxins and peptido-LTC's distrubute among pro-inflammatory states . DJGPhD. 27.12.23. Authentic Biochemistry
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Dec 28, 2023 |
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BioMedical Portrait VIII. c.1 Leukotrienes: an Introduction. Dr Daniel J. Guerra. 26.12.23 Authentic Biochemistry Podcast.
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Dec 27, 2023 |
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Christmas Eve Special:Research science relies on the means by which it is apprehended thus continuously challenged and improved with the goal of finding truths about nature in perpetuity.DJGPhD
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Dec 25, 2023 |
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Dyslipidaemia Coda IV. Antinomies and paralogisms in discerning apoplipoprotein contribution to HTG vs.CAD. DJGPhD.21.12.23.Authentic Biochemistry.
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Dec 21, 2023 |
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Dyslipiaemia Coda III. The proposed use of apolipoprotein serum concentration and hyperTAG may require a deeper analysis at the transcriptomic and proteomic levels. DJGPhD.20.12.23 Authentic Biochem.
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Dec 21, 2023 |
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DYSLIPIDAEMIA CODA II. Hypertriacylglycerolaemia is linked to mutations in LPL and various apolipoproteins linking CAD to TAG. 18.12.23. DJGPhD.Authentic Biochemistry
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Dec 18, 2023 |
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BioMedical Portrait VII. C.7. Lipoprotein biosynthesis and apolipoprotein structure. DJGPhD. 16.12/23. Authentic Biochemistry
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Dec 16, 2023 |
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BioMedical Portrait VII.c.6 Lipoprotein Lipase regulation performs a critical role in lipid homeostasis as evidenced by chylomicron clearance resistance in obese dyslipidaemic adolescents and adults.
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Dec 14, 2023 |
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BPVII.c.5 Diminished circ.LPL and adiponectin in obese adolescents correlates with higher dyslipidaemic T2D, MetSynD, and insulin resistance via inflammation-triggering lipoprotein non-clearance.
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Dec 12, 2023 |
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BioMedical Portrait VII. C.4 Chylomicron associated endothelial luminal LPL differential interaction with ANGTPL isoforms reults in unique TRL disposition. DJGPhD.10Dec23
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Dec 11, 2023 |
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BioMedical Portarit VII. c.3. Introduction to chylomicron apoB48 and the angiopoietin-like LPL inhibitor contributions to circulating TAG. DJGPhD.9DEC23. authentic Biochemistry
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Dec 09, 2023 |
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BioMed Portrait VII. c.2 Lipoprotein lipase mediated TAG delivery and adolescent obesity. DJGPhD.6Dec23. Authentic Biochemistry
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Dec 07, 2023 |
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BioMedical Portrait VII. Lipoprotein Lipase Pathobiochemistry. Prolegomena. DJGPhD. 5Dec23 Authentic Biochemistry
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Dec 06, 2023 |
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Bio Med Portrait. c.16. NK cells promote the inflammatory court in NAFLD via mutations in lipid metabolism and excessive GK mediated glycolysis and lipogenesis in hepatocytes DJGPhD.3Dec23b
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Dec 04, 2023 |
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BioMed Portrait VI.C.15 Characterization of four lipid and glucose metabolic polypeptides linked to obesity/T2D and NASH-->HCC.DJGPhD.3Dec23.Authentic Biochemistry Podcast
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Dec 03, 2023 |
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BioMedical PortraitVI.C.14.Liver NK cell chemokine recruitment and the significant role of obesity in possible immunotoxicity in HCC ontogeny.DJGPhD.30.11.23
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Dec 01, 2023 |
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BioMedical PortraitVI.c.13. Senescense and the aging of cells within systems apprehends the event ontologies of the stress phenomena-immune surveillance axis.DJGPhD.29.11.23. Authentic Biochemistry.
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Nov 30, 2023 |
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BioMedical Portrait VI. c.12. Obesity and viral infection-associated NK malfunction may lead to NASH and subsequent HCC. DJGPhD.28.11.23. Authentic Biochemistry
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Nov 29, 2023 |
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BioMedical Portrait VI. c.11 NK cell involvement in HepatoCellular Carcinoma. DJGPhD. 26.11.23. Authentic Biochemistry
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Nov 27, 2023 |
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"The Universe by Negation" DJGPhD.23.11.23
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Nov 24, 2023 |
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BioMedical Portrait VI.c.10.Alterations in the cytotoxic immune response can be dissociated from inflammation via intermediary metabolic mutation.DJGPhD.22.11.23. Authentic Biochemistry Pootdcast.
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Nov 23, 2023 |
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BioMedical PortraitVI.c.9 HLH mutations obtain complex NKvs.CD8+ T cell alterations in cytototoxicity and proliferation.DJGPhD.21.11.23 Authentic Biochemistry.
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Nov 22, 2023 |
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BioMedical Portrait VI.c.8.The cytotoxicity of the NK cell Is a function of its bioenergetics. Glycolysis/OXPHOS vs. FAO/OXPHOS during activation/proliferation
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Nov 21, 2023 |
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BioMedical PortraitVI.C.7 IEI/IEM pathobiochemistry involves bioenergetics, transcriptional , translational, and post-translational modification sequalae.DJGPhD.19.11.23 Authentic Biochemistry.
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Nov 19, 2023 |
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BioMedical Portrait VI c.6.Hemophagocytic lymphohistiocytosis ACAD9/Rab27A/+/- FBase1 mutations linked to NK and CTL immunodeficiences.DJGPhD. 16/11/23. Authentic Biochemistry.
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Nov 17, 2023 |
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BioMed Portrait VIc.5. NK cell Inborn Error Of Immunity links to failed fatty acyl CoA dehydrogenase-obtained immunodeficiency.DJGPhD. 15.11.23. Authentic Biochemistry
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Nov 16, 2023 |
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BioMedical Portrait VI.c4. Tumor and DC antigen VAX directed melanoma therapy reveals CD8+CTL and NK cell surface population dynamics.DJGPhG.14.11.23. Authentic Biochemistry.
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Nov 15, 2023 |
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BioMedical PortraitVIc.3. NK cell phenotypic variation is tighly regulated to facillitate unique immune sequalae including tumor ablation, pathogen elimination and autoimmunity.13.11.23.DJGPhD
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Nov 14, 2023 |
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BioMedical ortrait VI. Development of a dendritic cell antigen presenting melanoma kinase derived vax targeting NK cells to ablate malignancy.DJGPhD.11NOV23
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Nov 12, 2023 |
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BioMedical Potrait VI. Natural Killer Cells: opening remarks. DJGPhD.9NOV23. Authentic Biochemistry
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Nov 09, 2023 |
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BioMedical Portrait V. Coda c.13 Small molecule pyrazolo-oxazepine derivitive mediated PFK-1 activation depletes NADPH dependent neutrophil oxidative burst. DJGPhD.07NOV23. Authentic Biochemistry
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Nov 08, 2023 |
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BioMedical Portrait V.c.12. Is there a compositional-sequential event ontology linking "moonlighting"c-Fos with NOX2 PX domain PIP3 binding?DJGPhD. 6NOV23
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Nov 06, 2023 |
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BioMedical Portrait V.c.11 The Phosphoglycerolipid metabolome that orchestrates membrane topology and surface chemistry that supports necessary protein association for neutrophil immunoresponses.
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Nov 05, 2023 |
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BioMedical Portrait V.c.10. Phosphphatidyl inositols and phagosmal genesis in activated neutrophils upon pathogen infection.
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Nov 05, 2023 |
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BioMedical PortraitV.c9. Both glycolytic and OPP regulation combine complex allosteric and amphibolic sequalae that may converge on an immune- hyperinflammatory state. DJGPhD.2NOV23.
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Nov 02, 2023 |
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BioMedical Portrait V.c8. NOX2 subunitorganization, oxygen availability and phase I discussion of glycolytic allosteric control.DJGPhD.01Nov23
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Nov 01, 2023 |
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BioMedical Portrait V C.5 Periodontitis-linked CVD. DJGPhD. 30.10.31
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Nov 01, 2023 |
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BioMedical Portrait V. c7. NETs and the combined activities of elastase,NOX2,MPO and IP3 PTEN phosphatase potentiate inflammation-linked pathologies of lung and pancreas. DJGPhD.31.10.23 and
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Nov 01, 2023 |
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BioMedical Portrait V C.6 P. gingivalis Two Component System assembly and activation mediate infection court involvement in subsequent host vector pathology.DJGPhD. 30.10.23b.
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Oct 30, 2023 |
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BioMedical Portrait Vc4 Two component signal system pathogenic bacterial responses to host immunity and the gigipain cysteine protease opposing serum secretory IgA mediated phagocyte activation.DJGPhD
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Oct 29, 2023 |
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BioMedical Portrait V.c3. The categorical analysis of Neutrophil involvement in multiple pathophysiologies requires cellular signaling to derivatize pleiotropic disease ontologies. DJGPhD.26.10.23
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Oct 27, 2023 |
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BioMedical Portrait V. The neutrohil oxidative burst and the roles of Phox generating superoxide and peptide arginine deiminase in phagocyte defense against pathogens and contrarion disease promotion.
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Oct 26, 2023 |
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BioMedical Portrait V. Introductory alethic unfolding of neutrophil glycolysis associated hyperinflammatory restraint.
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Oct 24, 2023 |
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Continuing dialectical event ontology of epistemological requirements for validation of biochemical research. DJGPhD.23.10.23. Authentic Biochemistry Podcast
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Oct 23, 2023 |
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All reciprocity in not disinterested so phenomena must be in equilibrium. But phenomena at equilibrium are invisible so reciprocity must be uncertain. DJGPhD.22.10.23. Authentic Biochemistry
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Oct 23, 2023 |
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BioMedical Portrait IV. Postcript DJGPhD. 21 October 2023. Authentic Biochemistry Podcast
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Oct 22, 2023 |
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BioMedical Portrait IV. 13b. Magnetic Resonance Imaging as a non-invasive tool in Neurodegenerative Diseases. DJGPhD.19.10.23 Authentic Biochemistry.
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Oct 19, 2023 |
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BioMedical Portrait IV. CODAIII. c13. Microglial and astrocytic CNS local neuronal environment temporality may apprehend FTD stages in the human CNS.DJGPhD.18.10.23. Authentic Biochemistry Podcast
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Oct 18, 2023 |
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BioMedica; Portrait IV Coda II.c12. Biochemical Concatenations-the spatiotemporal sequences of molecular-cellular events of FTD's from proteinopathies to signalling and antigen recognition. DJGPhD.
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Oct 17, 2023 |
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BioMedical Portrait IV c11. FTLD-tau is correlated with microglial and astrocytic inflammation and subsequent neural degeneration. DJGPhD. 16.10.23 Authentic Biochemistry.
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Oct 17, 2023 |
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BioMedical PortraitIV The Frontal Temporal Dementias. Tau and TDP43 proteinopathies as an introduction to the extended pathobiochemical event ontologies. DJGPhD.16.10.23.Authentic Biochemistry Podcast
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Oct 16, 2023 |
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BioMedical Portrait IV. TDP43 is involved in numerous pathologies that connect to the major cellular mechanisms governing DNA RRR, RNA metabolism and protein mediated cell fate. DJGPhD.14.10.23
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Oct 14, 2023 |
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BioMedical Portrait IV c8. Proteolytic processing of cytosolic RNA-bp ,TDP43, associates with CNS neuropathologies while native nuclear translocation is linked to exon shuffling. DJGPhD.12Oct23.
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Oct 12, 2023 |
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BioMedical Portrait IV c7.Progranulin associated frontotemporal lobar degeneration and AD, PD, and LBD, share a TDP-43 proteinopathy linked to mRNA translation. DJGPhD.11OCT23. Authentic Biochemistry
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Oct 12, 2023 |
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BioMedical Portrait IV. c6. Proteinopathies in neurodegeneration may be the result of insufficient temporal control over microglial phagocytic and pro-inflammatory molecular event ontologies.DJGPhD
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Oct 10, 2023 |
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BioMedical Portrait IV.c5. Microglial removal of lipoprotein and proteinopathic molecular events must include lysosomal degradation and antigen presentation while supporting signaling and inflammation
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Oct 10, 2023 |
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BioMedical PortraitIVc4. Microglial Rho GTPases equipped with GGylation, palmitoylation and/or phosphorylation obtain a spectrum of biochemical functions in neuropathologies.DJGPhD.8Oct23b. Authentic.
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Oct 08, 2023 |
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BioMedical Portrait IV. c3. Two down-regulated microglial polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy distinct LDL binding proteins typically cargo oxy cholesterol.
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Oct 08, 2023 |
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BioMedical PortraitIV.NHD patient fibroblasts used to generate iPSC's differentiated into Induced microglia like cells (iMGLs) pathophenocopied TREM2 mutations and lysosomal malfunctions.DJGPhD.
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Oct 05, 2023 |
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BioMedical Portrait IV. HLA disease including neuropatholgies. The Nasu-Hakola, a.k.a. polycystic lipomembranous osteodysplasia associated TREM2 disease. DJGPhD.04Oct2023.Authentic Biochemistry.
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Oct 05, 2023 |
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BioMedical PortraitIIIC13c. Leucocyte and lymphocyte mediated SASP involve a corruption in robust novel immune responses while enhancing chronic autoimmune inflammation in the obese and elderly.DJGPhD
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Oct 02, 2023 |
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BioMedical PortraitIII. c13b.Immune cell metabolic dialectical usurpation of architechtonic control over inflammation and cell fate obtained from senescence and obesity.-linked dyslipidaemia.DJGPhD.
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Oct 01, 2023 |
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BioiMedical Portrait III. NLRP3 Inflammasome and senescence-associated heterochromatic foci in macrophages, Kuppfer Cells and Liver sinusoidal endothelial cells contibute to liver/adipose disease
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Sep 30, 2023 |
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BioMedical Portrait III.c12. Senescent cells from aging and obesity obtain chronic hyperinflammation of adipose associated leucocyte infiltrates potentiating alternating systemic proliferation or PCD.
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Sep 28, 2023 |
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BioMedical Portrait III. AMPK regulation of ACC2 blocks MalCoA inhibition of CPTI allowing for fatty acid beta oxidation thus alleviating adipose obesity-induced macrophage pro-inflammation.DJGPhD.
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Sep 26, 2023 |
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BioMedical Portrait III. c10. Ribosomal collision frequency is attenuated by ZAK and GCN2 via mutually exclusive signalling events, DJGPhD. 25.9.23. Authentic Biochemistry Podcast
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Sep 26, 2023 |
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BioMedical Portrait III. c9. Amino acid deprivation-linked fall of polypeptide synthetic fidelity triggers downstream ribosomal stress response phenomena including kinase mediated cell fate sequalae.
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Sep 23, 2023 |
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BioMedical Portrait III. c8. Unique mRNA upstream open reading frames direct both the integrated stress response and rare selective up-regulation of stress-correcting protein synthesis.DJGPhD.21.9.23
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Sep 21, 2023 |
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BioMedical Portrait III.c.7 Elementary polypeptide synthesis-translation. Lecture 1. DJGPhD.20.9.23.Authentic Biochemistry Podcast.
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Sep 20, 2023 |
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BioMedical Portrait III. c6. Adipokine and the succinate receptor systems in obese adipose inflammation as regulated by AMPK.DJGPhD.19.9.23. Authentic Biochemistry Podcast
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Sep 20, 2023 |
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BioMedical Portrait III.c.5. Adipokine mediated adipose inflamation is linked to the hypothalamic control over metabolism and systemic inflammation.DJGPhD.18.9.23.Authentic Biochemistry Podcast
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Sep 18, 2023 |
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BioMedical Portrait III. c.4. Adipose tissue macrophages express galectin binding proteins which alter immunosuppression and polarization;adipokines mediate the inflammatory response. DJGPhD.17.9.23
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Sep 17, 2023 |
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BioMedical Portrait III. Immunometabolic disease 3c.Reactive N and O interconversions in obese adipose exacerbate systemic inflammation. 17.9.23. DJGPhD. Authentic Biochemistry Podcast.
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Sep 17, 2023 |
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BioMedical Portrait III. Immunometabolic disease. The obesity-compromised adipose poise to hyperinflammation. DJGPhD. 15.9.23. Authentic Biochemistry.
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Sep 15, 2023 |
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BioMedical Portrait III. c1. Immuno-metabolic disease. Dr. Daniel J. Guerra. 14.9.23. Authentic Biochemistry Podcast.
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Sep 15, 2023 |
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Biochemical Energetics. Elementary Considerations chapter2. DJGPhD. 13.9.23 Authentic Biochemistry Podcast
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Sep 13, 2023 |
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Biochemical Energetics I Elementary Considerations. DJGPhD 12Sept23. Authentic Biochemistry Podcast.
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Sep 12, 2023 |
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BioMedical Portrait II. Hashimoto's Thyroiditis prevalence in women linked to mitochondrial electron transport chain activity, ATP/ADP translocation, and potent autoantibodies to thyroid peroxidase.
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Sep 10, 2023 |
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BioMedical Portrait II. c.14. Predominance of Hashimoto's Thyroiditis in Women: is there a link to the decreased expression of TLR7 and the AMPK-alpha/Id3 axis on CD8+TE and Treg activity?
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Sep 10, 2023 |
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BioMedical PortraitII. c13. Female prevalent autoimmune RA-macrophage STAT3(TF) and NaMPT(NAD+ salvage pathway) promote rheumatoid arthritis & primer on thyroiditis
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Sep 09, 2023 |
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BioMedical Portrait II. C12. Lupus is far more common in women than men due to TLR7 enhancement and Rheumatoid Arthritis is more common in women due to macrophage bioeneregtic phenomenaDJGPhD.7Sept23
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Sep 08, 2023 |
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BioMedical Portrait II.c11. Autoimmune diseases like lupus are far more prevalent in women due to the lack of X chromosomal allelic inactivationof TLR7's. DJGPhD.7Sept23.Authentic Biochemistry.
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Sep 07, 2023 |
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Biomedical Portrait!!,c.10 Older women have more reactive oxygen and fewer functional mitochondria and DNA content than older men or younger women.DJGPhD.5Dept2023. Authentic Biochemistry Podcast.
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Sep 05, 2023 |
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BioMedical Portrait II. c9. Autoimmune diseases are more common in women than men: immune response triggering and the possible role of bioenergetics.DJGPhD.3sept23.Authentic Biochemistry.
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Sep 03, 2023 |
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BioMedical Portrait II. C.8. Alterations in sphingosine metabolism linked to breast cancer staging in women and progression of NAFLD to NASH and HCC is much lower in women until menopause.DJGPhD.
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Sep 02, 2023 |
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Biomedical Portrait II. C.7. Serum sphingolipid molecular speciation in women differs from men but association with tissue endomembranous lipid components fail to be addressed.DJGPhD. 31.8.23
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Aug 31, 2023 |
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BioMedical Portrait II. Metabolic and Bioenergetic distinction between men and women includes lipid deposition and utilization mechanisms.DJGPhD.30.8.23.Authentic Biochemistry Podcast.
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Aug 30, 2023 |
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BioMedical Portrait II, c.5. Muscle fibre sexual dimorphism obtains networks of genetic, epigenetic, and biochemical events.DJGPhD.29.8.23 Authentic Biochemistry Podcast
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Aug 29, 2023 |
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Biomedical PortraitII.C.4 THe sexual dimorphism of bioenergetics: introduction to carbon utilization. Video lecture link
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Aug 28, 2023 |
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BioMedical Portrait II. Chapter 3. Mitochondrial gene expression, lipid metabolism and cell fate are at least partiatially mediated by Fragile X protein competency. DJGPhD.24.8.23
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Aug 24, 2023 |
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BioMedical Portrait II. The Fragile X Syndrome. Discovery and subsequent association with the FMR1 gene. Premature Ovary Failure I vs. heritable intellectual disabilities DJGPhD.22.8.23
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Aug 23, 2023 |
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BioMedical Portrait II.Diseases of Bioenergetics:Male vs. Female Variation
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Aug 21, 2023 |
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BioMedical Portrait I. 13b. 25 hydroxy cholesterol controling SREBP is linked toinflammation and the regulation of potentiating estrogen mediation over AD in post menapausal women.DJGPHD.18.8.23
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Aug 19, 2023 |
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Biomedical Portrait I, 13. Receptor boud 17Beta-estradiol may overturn the the failure to synthesize cholesterol in CNS caveolae thus blocking release of Beta-secretase to generate A-beta from APP.
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Aug 18, 2023 |
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BioMedical Portraits I. Chapter 12. Unique lipoprotein lipase mediated lipid alteration of endothelial cell function in the mammalian CNS may traffick in oxysterol binding protein linked PM-female AD
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Aug 17, 2023 |
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BioMedical Portraits I. [11]. Phospholipid and lipoprotein lipase activity may link to oxy-cholesterol/PL transport mechanisms to generate post-menopausal AD. DJGPhD.16.8.23. Authentic Biochemistry
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Aug 16, 2023 |
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BioMedical PortraitI-10. Sterol binding protein and oxysterols regulate membrane fusion and trafficking obtaining a complex landscape for post menopausal estrogen assoc. neurodegeneration.DJGPhD.
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Aug 14, 2023 |
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BioMedical PortraitsI.9. The 27-hydroxychol association with estrogen receptors and LXR provide contrarion associations with female AD and immune-controlled bacterial pathophysiology.DJGPhD.14.8.23
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Aug 14, 2023 |
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BioMedical Portrait I. Chapter 8. Female AD progression post-menopausal severity is a complex pathobiochemical event that may involve cholesterol and steroid metabolism in the CNS and periphery.DJGPhD
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Aug 13, 2023 |
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BioMedical Portraits I. Chapter 7. Hormone replacement and the general distinctions of cholesterol homeostasis, metabolic zonation, hydroxysterols and estrogen receptor heterogeneity in female AD.
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Aug 11, 2023 |
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BioMedical Portraits I. Chapter 6. Complications of female cerebrovascular trauma and obesity-linked Type2 Diabetes in post-menopausal estrogen therapeutics for prophylactic treatment of subsequent AD
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Aug 09, 2023 |
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Biomedical Portraits I. Part 5. 17-beta estradiol monotherapy in post-menopausal women has no irrefutable therapeutic benefit for treating cognitive decline in early AD dementia.DJGPhD.8AUG23.AB.
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Aug 08, 2023 |
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BioMedical Portraits I. Part 4 Loss of female gonadal E2 production plus CNS E2 Receptor expression post-menopause involves irreversible alterations in metabolism:implications for neuroprotection.
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Aug 07, 2023 |
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BioMedical Portraits I. part 3 Estrogen receptor heterogeneity in signaling and transcription and the distinctions between model-murine and human reproductive and CNS biochemistry.DJGPhD 05AUG23
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Aug 05, 2023 |
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BioMedical Portraits I. Part 2.Murine model Alzheimer's Disease is poorly linked to menopuase or Vascular contributions to Cognitive Impairment & Dementia (VCID).DJGPhD 05AUG23
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Aug 05, 2023 |
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BioMedical Portraits I. Alzheimers Disease in Ageing Females is linked to CNS-sphingomyelinase mediated ketogenesis and VCID.Lecture 1. DJGPhD.3AUG23.Authentic Biochemistry
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Aug 03, 2023 |
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From Intellections' pathway into the forest of metaphysics.II DJGPhD.30.July 2023b. Authentic Biochemistry Podcast
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Jul 31, 2023 |
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The Road to Intellection I. DJGPhD. 30.7.23. Authentic Biochemistry Podcast
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Jul 30, 2023 |
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ImmunoEpigenetics 100B. Fine. The apodictic recombination-dependent TCR and Ig receptor system is mediated by epigentic modifications.DJGPhD.29.7.23. Authentic Biochemistry
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Jul 30, 2023 |
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ImmunoEpigenetics100A. The Tcell repose and ILC differentiation via E vs ID chromatin remodeling antagonism. DJGPhD.28.7.23. Authentic Biochemistry Podcast.
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Jul 28, 2023 |
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ImmunoEpigenetics 99. Tregs can foster a massive tumor microenvironment inhibition of T-eff cell populations via neo-antigen activation from dying tumor cells leading to cancer progression. DJGPhD
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Jul 27, 2023 |
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ImmunoEpigenetics 98. TCR mediated protection from neonate infection is naturally suppressed. BCG VAX may be a treatment against Type 1 Diabetes by increasing Treg mediated autoimmune suppression.
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Jul 26, 2023 |
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ImmunoEpigenetics97.Bcell maturation involves a multilevel epigenetic mark-up of differentiating pathways to subsequently respond to T cell activation upon 2nd signal stimulation. DJGPhD.24.7.23
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Jul 24, 2023 |
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ImmunoEpigenetics96. APC-agMHCII and Bcell:Tcell synapse interactions yield subsequent plasma cell antibody production under the H3K4me3 epigenetic alteration of chromatin accessibility.DJGPhD.23.7.23
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Jul 23, 2023 |
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Mountain Pass Adventure I. The "five best" and an excursion into asymmetry. Dr. Daniel J. Guerra. 22.7.23. Authentic Biochemistry Podcast.
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Jul 23, 2023 |
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ImmunoEpigenetics 95. Does H3K4 trimethylation play a quantitative or qualitative role in nascent activation of neonatal naive T cells toward a specific polarity of gene expression?DJGPhD.20.7.23
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Jul 20, 2023 |
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ImmunoEpigenetics. 94. Neonate TCR stimulation and subsequent signaling circumventing TCR specificity differ from adult activation and cytokine expression. DJGPhD. 19.7.23. Authentic Biochemistry
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Jul 20, 2023 |
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ImmunoEpigenetics 93. tTREG's not only control Th differentiation and proliferation but in an HLA-antigen mediated specificity thus differentiating CD4+ vs CD8+ inflammation as directed by 6mA.
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Jul 19, 2023 |
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ImmunoEpigenetics 92. thymic Treg populations alter Th1 differentiation. Antigen presenting DC's coordinate TCR with associated membrane proteins to support activation via PM lipid sequence.DJGPhD.
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Jul 17, 2023 |
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ImmunoEpigenetics91. WTAP conditional deletion via LoxPCre controlled by FoxP3 obtains a Treg phenotype incapable of supressing murine spontaneous colitis. DJGPhD. 15.7.23. Authentic Biochemistry.
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Jul 15, 2023 |
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ImmunoEpigenetics90. Tcell receptor organization activation and adaptor protein ligand molecular signaling is regulated down stream by 6methyl mRNA speciation.DJGPhD.7July2023.Authentic Biochemistry
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Jul 11, 2023 |
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Enzyme Kinetics sensu strictu. The Michaelis Menten equations and precison of the kcat. DJGPhD.9July23b. Authentic Biochemistry Podcast.
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Jul 10, 2023 |
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Primer on enzyme kinetics in clinical biochemical research. DR. Daniel J. Guerra. 09July2023. Authentic Biochemistry Podcast Productions
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Jul 09, 2023 |
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PhotosynthesisV. Photorespiration and synthesis of this holiday arc: fait accompli. DJGPhD.08July23b. Authentic BiochemistryPodcast.
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Jul 09, 2023 |
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Photosynthesis 4. Chlorophyll and carotene biosynthesis and some further detail on the mechanism of the Mn-H20 splitting complex of p680 PSII and diatomic molecular oxygen (O2) evolution.DJGPhD. 7July
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Jul 08, 2023 |
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Photosynthesis 3. Dr Daniel J Guerra. 07July2023 Authentic Biochemistry Podcast productions
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Jul 06, 2023 |
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Unique Lecture Post holidayIV. Photosynthesis 2. DJGPhD.05July23b Authentic Biochemistry Podcast production.
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Jul 05, 2023 |
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Unique Lecture Series Post holiday. III Higher plant photosynthesis 1. DJGPhD. 05July2023. Authentic Biochemistry Podcast.
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Jul 05, 2023 |
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Unique Lecture Series Holiday Time 4th of July2023.Non-arbitrary C-C bond formation chemistry: Aldol and Claisen condensation with Stork enamine synthesis (i.e. Michael reactions)
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Jul 04, 2023 |
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Unique Lecture Series . Holiday Time. 4th of July 2023! Hydrocarbons.
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Jul 01, 2023 |
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ImmunoEpigenetics 89. Final synthesis of statin drug mediated alteration of metabolism in T lymphocytes. DJGPhD.6.30.23. Authentic Biochemistry Podcast.
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Jun 30, 2023 |
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ImmunoEpigenetics 88. Statin treatment of early progenitor T cell acute lymphoblastic leukemia could pose biochemical impositions on healthy lymphocyte populations. DJGPhD.29.6.23.Authentic Biochem.
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Jun 30, 2023 |
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ImmunoEpigenetics87. Competitive inhibition of HMGCoA-R may enhance apoptosis while blocking cholesterologenesis and GGPP covalent modification of signaling kinases to thwart ETP-All in cell culture.
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Jun 28, 2023 |
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ImmunoEpigenetics86. Could regimented titrating statin pharmacotherapy be useful in controlling early T lymphoid progenitor cell ETP-ALL via an epigenetic mechansim? DJGPhD.27.6.23. Authentic Biochem
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Jun 28, 2023 |
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ImmunoEpigenetics85.Epigenetic plasticity-induced chromatin retailoring involving the mevalonic acid -prenyl lipid pathway promotes Early T-cell Precursor Acute Lymphoblastic Leukemia. DJGPhD.24.6.23
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Jun 25, 2023 |
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ImmunoEpigenetics84. T cell and ILC transcription factor and cytokine signaling coordination to accelerate a combined innate/acquired immune response requires discrete epigenetic programming. DJGPhD.
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Jun 24, 2023 |
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ImmunoEpigenetics 83. Epistemic and metaphysical considerations of immune cell epigenetic reprogramming obtaining biochemical event ontologies. DJGPhD.23.6.23. Authentic Biochemistry Podcast
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Jun 23, 2023 |
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ImmunoEpigenetics82.Innate lymphoid progenitor antibody-directed single cell DNAse hypersenitive site analysis of transcription factor specific histone methylation and acetylation modifications.DJGPhD
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Jun 23, 2023 |
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ImmunoEpigenetics 81.Innate lymphoid cells lack antigen receptors and are differentiated into multiple linneages via epigenetic priming of nucleosomal regions proximal to cell-specific TF's.DJGPhD.
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Jun 22, 2023 |
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ImmunoEpigenetics80.T lymphocyte biochemical communications are triggered epigentically and via membrane lipid molecular species recombination: A dialectical event ontological view. DJGPhD.17.6.23
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Jun 18, 2023 |
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ImmunoEpigenetics79. T lymphocyte DPPA induced HSP27 deoligomerization-activating DGK-a associated anergy is linked to cancer cell proliferation phenotypes. DJGPhD.16.6.23b Authentic Biochemistry
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Jun 17, 2023 |
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ImmunoEpigenetics 78. Classical ergodic forward deterministics do not explain biological systems; biochemical phenomena are tuned for uncertain events. DJGPhD.16.6.23. Authentic Biochemistry Podcast
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Jun 16, 2023 |
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ImmunoEpigenetics77. T cell membrane phospholipase D mediated PA deprotonation as a biosensor for an electrostatic/hydrogen-bond signal transductionDJGPhD.15.6.23. Authentic Biochemistry Podcast.
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Jun 16, 2023 |
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Interum lecture VI. Entropic forces and the ergodic hierarchy of GPCR-linked phsopholipase phase space postioning temporality. DJGPhD.13.6.23
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Jun 14, 2023 |
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Interum Lecture V. Semi-closure on free energy and enthalpic involvement in leptin/AMPK mediated orexigenic states . DJGPhD.12June23.Authentic Biochemistry Podcast
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Jun 12, 2023 |
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Interum Lecture IV. MBD:DNAMolecular Dynamics video lecture!
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Jun 12, 2023 |
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Interum Lecture III. Protein methylation binding domain association with substrate CpG alters equilibrium torsion angle (epsilon-zeta) conformational states via enthalpic-free energy conservation.
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Jun 11, 2023 |
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Interum Lecture II. Rates of reactions in living systems.DJGPhD.8June2023 Authentic Biochemistry Podcast
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Jun 09, 2023 |
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Interrum lecture I. Obesity unsuccessfully violates the first law of thermodynamics.
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Jun 07, 2023 |
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ImmunoEpigenetics 76. Sphingolipid metabolism and S1P receptor expression linked to multiple potentiating immunoinflammatory obese associated pathophysiologies. DJGPhD.6June23B AuthenticBiochemistry
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Jun 07, 2023 |
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ImmunoEpigenetics 75. Sphingolipid receptor molecular discernment from exosome cargo mediated control involves M1 to M2 polarization shift post myocardial infarction induced fibrosis. DJGPhD.6June23
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Jun 06, 2023 |
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ImmunoEpigenetics74.The methylation-specific epigenetic control over adipose tissue macrophage polarity is axially supported by leptin induced CNS control over satiety and pancreatic insulin secretion
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Jun 05, 2023 |
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ImmunoEpigenetics 73. The dialectical synthesis of adipose PPAR-gamma mediated fatty acid binding protein4 expression in foam cell formation and subsequent adipokine contribution to insulin secretion
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Jun 05, 2023 |
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ImmunoEpigenetics72. Chemistry of reactive oxygen/nitrogen radical species as adipose pathobiochemical sequalae to obesity via M1 macrophage polarity involving adipose and vasculature pathophysiology.
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Jun 03, 2023 |
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ImmunoEpigenetics 71. Insulin receptor corruption is mediated by high circulating fatty acids, in situ DAG-PKCepsilon induced phosphorylation and membrane protein aggregation in obese diabetics.DJGPhD
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Jun 02, 2023 |
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ImmunoEpigenetics 70.Obesity-linked adipose resident macrophage (M1)polarization meta-inflammation leads to Insulin Resistance via fatty acid oxygenation in situ. DJGPhD.01June2023.Authentic Biochem.
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Jun 02, 2023 |
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Intermediary Metabolism Lecture. Covalent modification of enzymes and transcription factors alter bioenergetics and the pro-inflammatory response in obese vs. healthy patients.31.5.23 DJGPhD
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May 31, 2023 |
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See the youtube video in the show notes
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May 26, 2023 |
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ImmunoEpigenetics 69. Lipoprotein and cargo cholesterol in the epigenetic regulation of the tumor microenvironment secreted pleckstrin convertase corrupting CD8+ Tcell cholesterol uptake and potency.
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May 25, 2023 |
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Graduate Biochemistry Lecture III. Dietary lipid control over neuroendocrine system involves multiple organ systems in contact with immune surveilance. DJGPhD. 24.5.23B Authentic Biochemistry
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May 24, 2023 |
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Graduate Biochemistry Lecture.II. Lipid digestion and enterocyte localized neuroendocrine secretion proximal to chylomicron assembly.Dr Daniel J. Guerra. Authentic Biochemistry Podcast 19.5.23.
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May 24, 2023 |
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Special Graduate Biochemistry Lecture! Lipoproteins I. Dr Daniel J. Guerra. Authentic Biochemistry Podcast 19.5.23.
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May 20, 2023 |
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ImmunoEpigenetics 68. Closure on atherosclerosis and CVD linking transcription factors and membrane receptors to oxidation of PUFA's and oxysterol resulting in methylation of ABCG and SREB promoters
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May 18, 2023 |
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ImmunoEpigenetics 67. Pathobiochemical alteration of cholesterol oxides mediated via cytochrome P450 and dehydro -reductases link atherosclerosis and the CTX/SLO motor neuron diseases. DJGPhD
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May 16, 2023 |
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ImmunoEpigenetics 66. The NOX/PHOX/DUOX enzymes in atherosclerosis, thyroid hormonogenesis and thyroid tumorigenesis. An epigenetic telos from oxidized lipid to altered transcription patterns.DJGPhD.
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May 16, 2023 |
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ImmunoEpigenetics65. 7-keto-cholesterol-induced miR-144 transcription inhibits IDH2 translation lowering NADPH required for NO synthesis to maintain endothelial function leading to atherosclerosis.
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May 14, 2023 |
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ImmunoEpigenetics64. IDH1/2 ad Malic enzymes 1/2/3 may generate NADPH thus driving removal of ROS while simultaneously promoting atherosclerosis and tumorigenesis via epigenetic and bioenergetic means
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May 12, 2023 |
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ImmunoEpigenetics63. Amino acid metabolism is linked to DNA methylation via glycolytic intermediates and redox poise to expose neomorphic /antimorphic IDH1/2 transformation generating oncometabolites
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May 10, 2023 |
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ImmunoEpigenetics62.Macrophage "training" and T cell activation are epigentically controlled by moonlighting glycolytic and amino acid metabolic enzymes generating enantiomers of 2-OH glutarate.DJGPhD
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May 10, 2023 |
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ImmunoEpigenetics61. The role of leucocyte and lymphocyte aerobic glycolysis and bioenergetic trafficking between cytosol and the mitochondria mediating nuclear epigenetic substrate availability.
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May 09, 2023 |
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Immunoepigenetics 60. LOH of PHLDA3 confers wt allelic methylation and loss of activity in pancreatic neuroendocrine tumorigenesis. DJGPhD.7May23 Authentic Biochemistry Podcast
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May 07, 2023 |
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ImmunoEpigenetics59. The P53/AKT/PHLDA3 axis over tumorigenicity is controlled by endomembraneous targeting via glycerol lipid PhosphatidylInositol bis-phosphate (PIP2) phosphorylation to PIP3.5.12.23
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May 06, 2023 |
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ImmunoEpigenetics 58. Epigenetic mechanisms role in Loss of Heterozygosity (LOH) in TSG's advancing targeting of solid tumors via pharmacotherapeutic CAR-T cells. DJGPhD 27.4.23. Authentic Biochem.
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Apr 28, 2023 |
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ImmunoEpigenetics 57. Plasmacytoid dendritic cell neoplasias and the CAR-T cell tumor microenvironment exposure altering epigenetic TF regulation leading to diverse differentiation. DJGPhD.20.4.23
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Apr 21, 2023 |
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ImmunoEpigenetics 56. Dendritic cell immunobiochemistry introductions. DJGPhD. Authentic Biochemistry 15.4.23
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Apr 15, 2023 |
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ImmunoEpigenetics55. ILC and Treg differentiation is mediated by acetylation and methylation epigenegtic authorship at discrete TF binding site domains.DJGPhD.14.4.23. Authentic Biochemistry
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Apr 14, 2023 |
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Immunoepigenetics 54. Macrophages, T lymphocytes and neutrophils each comply with epigenetic alterations to mediate the inflammatory response. DJGPhD.12April.2023.Authentic Biochemistry
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Apr 13, 2023 |
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ImmunoEpigenetics 53.The metaphysics of biochemical control within epigenetic alteration of gene expression as obtained in macrophage mediated immune activation. DJGPhD.7April23'Authentic Biochem
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Apr 07, 2023 |
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ImmunoEpigenetics 52. Integration of intermediary metabolism with epigenetic modification of immune cell activation and proliferation.DJGPhD. 5April23. Authentic Biochemistry Podcast.
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Apr 05, 2023 |
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ImmunoEpigenetics 51. The Glutamine contribution to tumor bioenergetics and lipogenesis and the role of storage TAG in macrophage pro-inflammation. DJGPhD. 29.3.23
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Mar 30, 2023 |
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ImmunoEpigenetics 50. Malic Enzyme serves as a cytosolic circuit to generate pyruvate from glutamine to drive cancer cell division by altering TCA flux and indirectly, cell cycle progression.DJGPhD
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Mar 25, 2023 |
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ImmunoEpigenetics49.SiRNA knockdown of ME1 increases Haeme Oxygenase activity in both glucose supplemented and deprived cancer cells. The Pseudoparadox of epigenetic control over metabolism. DJGPhD
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Mar 23, 2023 |
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ImmunoEpigenetics48. Importance of malic enzyme isoform subcellular distribution using 13CNMR -U13C C6 glucose isotopomer detection of pathway intermediates:GSIS vs. cancer.DJGPhD.21.3.23
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Mar 21, 2023 |
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Immunoepigenetics 47. Intermediary metabolism re-enters the discussion on tumor corruption of cell division via diversion of glucose to NADPH production.DJGPhD
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Mar 18, 2023 |
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ImmunoEpigenetics 46.The Keap1/Nrf2/MAF axis in colorectal cancer: Methylation specific promoter mediated expression of anti-oxidant genes unveiling a complex role in tumorigenesis.DJGPhD.15.3.23
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Mar 16, 2023 |
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ImmunoEpigenetics 45. Innate immune cell nSMASE generates ceramide mediated TLR signalling epigenetic alterations resulting in COX-2 electrophile PG- Michael adduct removal of KEAP/Nrf2 association.
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Mar 12, 2023 |
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ImmunoEpigenetics 44. Ceramide and NRF2 mediate oxygen stress and the pro-inflammatory cytokine respose via association with chromatin epigenetic retailoring. DJGPhD.8March23. Authentic Biochemistry.
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Mar 09, 2023 |
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ImmunoEpigenetics XXXXIII. In silico analysis of Rheumatoid Arthritis methylation patterns fails to obtain a general rule for epigenetic regulation of gene expression.DJGPhD07March23. ABPe
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Mar 08, 2023 |
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ImmunoEpigenetics XXXXII. T-ALL Homeobox A gene alteration of MEF2C expressional variation linked to T-cell differentiation blockade as regulated by CaMK and HDAC4/HDAC5. DJGPhD. 05March23.
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Mar 06, 2023 |
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ImmunoEpigenetics XXXXI. From Programmed Cell Death to Homeobox gene clusters, T-ALL leukaemias involve epigenetic events. DJGPhD.05March23. Authentic Biochemistry Podcast
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Mar 05, 2023 |
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ImmunoEpigenetics XXXX. Transcription factor complex permutaions combine with histone acetylomic and methylomic covalent mofications in T -ALL disease. DJGPhD. 04 March 2023. Authentic Biochemistry.
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Mar 04, 2023 |
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ImmunoEpigenetics XXXIX. T cell acute lymphoblastic leukaemia genetics and epigenetics: the role of chromatin retailoring via histone LYS acetylation/deacetylation event ontology. DJGPhD.3March23
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Mar 04, 2023 |
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ImmunoEpigenetics XXXVIII. Tcell receptor activation and the PIP3/AKT/mTORCI/mTORCII control over cytokine expression:a primer. DJGPhD.2March2023.Authentic Biochemistry Podcast.
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Mar 03, 2023 |
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ImmunoEpigenetics XXXVII. Differential substrates for the Adenylate Cyclase-PKA phosphorylation cascade distributes assymetric inflammatory, hormonal and metabolic sequalae. DJGPhD.01March23.
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Mar 02, 2023 |
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ImmunoEpigeneticsXXXVI. Tumor-specific methylation respondent transcription of Adenylate Cyclase 2 may be linked to differential cytokine expression controlling T cell activation. DJGPhD.01March23.
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Mar 01, 2023 |
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Immunoepigenetics XXXIV. Methylation signatures in neoplasias1. DJGPhD. Authentic Biochemistry Podcast Productions. 26.2.23
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Feb 26, 2023 |
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ImmunoEpigenetics XXXIII. Crisper CAS , small molecule,and LOXP-CRE targeting of SDH/ComplexII decrease Th1 cytokine production: Standard Oxidation Potentials and TCA anapleurotic involvement.DJGPhD.
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Feb 24, 2023 |
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ImmunoEpigeneticsXXXII. Apriori synthesis of the glycolytic/TCA/ETC axis mediating target and endogenous apoptotic control with Th and NK cell activation/proliferation and effector function. DJGPhD.
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Feb 22, 2023 |
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ImmunoEpigenetics XXXI. The role of SDH on Complex II electron flow to ubiquinone subsequent to cardiac arrest is associated neuronal PCD similar to Tcell bioenergetic switching during activation.
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Feb 19, 2023 |
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Immunoepigenetics XXX.NK lymphoyctes programed tumor cell death by titrating anti-apoptotic BCL proteins with BH3 pro-apoptotic events. DJGPhD. 17.2.23. Authentic Biochemistry Podcast
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Feb 18, 2023 |
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ImmunoEpigenetics XXIX. Apoptosis unthwarted:preventing phosphorylation of RNAPOLII tanks histone acetylation near Mcl enhancer region thus epigenetically inhibiting expression in glioblastoma cells.
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Feb 16, 2023 |
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A Dialectic on Research Scientific Method I. How research questions may be apprehended through the hypothetico-deductive-experimental paradigm. DJGPhD. 14.2.23
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Feb 14, 2023 |
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ImmunoEpigenetics XXVIII, Synthesis of epigenetically controlled ferroptosis with Cyto-Toxic T Lymphocyte APC/MHC activated IFN-Gamma induced tumor fatty acyl CoA synthase- lipid peroxide mechanism.
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Feb 14, 2023 |
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Immunoepigenetics XXVII. PKM2 as an epigenetic and metabolic author of cell proliferation leading to tumorigenesis. DJGPhD. 12 Feb 2023. Authentic Biochemistry Podcast
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Feb 13, 2023 |
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ImmunoEpigenetics XXVI.The repressive deubiquitinase (PR-DUB) inhibits ubiquitinated histone 2A occupancy on SLC7A11 promoter causing cystine starvation and GSH depletion promoting ferroptosis. DJGPhD
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Feb 11, 2023 |
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ImmunoEpigenetics XXV. Lymphocyte Specific Helicase inhibits ferroptosis while promoting tumorigenesis via fatty acid desaturase gene transcription and subsequent oleic acid formation via CoQ10.DJGPhD
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Feb 09, 2023 |
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A Biochemical Partita 7th Movement. The articulation of obesity as arbiter of pathophysiology. DJGPhD. 04Feb23. Authentic Biochemistry.
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Feb 05, 2023 |
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A Biochemical Partita 6th Movement. Human bioenergetics and hormonal regulation involving FA beta-oxidation and gluconeogenesis "discourage" glyoxylate cycle molecular evolution a priori. DJGPhD.
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Feb 04, 2023 |
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A Biochemical Partita 5th Movement. The hepatic Malate Apartate Shuttle combined with the 2-oxoglutarate carrier facilitate reducing power and the OAA carbon source for cytosolic gluconeogenesis.
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Feb 04, 2023 |
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A Biochemical Partita 4th Movement.Regulation of gluconeogenesis vs. glycolysis and the fatty acyl CoA beta-oxidation pathway provide REDOX and allosteric control over bioenergetics. DJGPhD.01FEB23.
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Feb 02, 2023 |
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ImmunoepigeneticsXXIV. The Cathelicidin anitmicrobial peptide cysteine protease domain may contibute to innate immune defense against cancer via epigenetically regulated ferroptosis.DJGPhD.1Feb23
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Feb 01, 2023 |
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A Biochemical Partita 3rd movement. Principle of Sufficient Reason and the refutation of biological reductionism. DJGPhD.31.1.23. Authentic Biochemistry Podcast Productions
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Feb 01, 2023 |
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A Biochemical Partita. 2nd movement. DJGPhD. 29.1.23 Authentic Biochemistry Podcast Production
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Jan 30, 2023 |
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A Biochemical Partita. Ist movement. DJGPhD. 28.1.23 Authentic Biochemistry Podcast Production
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Jan 28, 2023 |
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ImmunoepigeneticsXXIII. Vitamin D hydroxylation mediated alteration of VDR chromatin retailoring and alteration of promoter methylation generate a dialectically ontological pathophysiology.DJGPhD.
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Jan 28, 2023 |
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Immunoepigenetics XXII. The role of circulating vitaminD in the regulation of innate immune antimicrobial peptide generation. DJGPhD. 25.1.23 Authentic Biochemistry
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Jan 26, 2023 |
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ImmunoepigeneticsXXI. Methylation patterns of CpG vs histone modification of specific loci must be sequenced to verify pathophysiological events. DJGPhD. 22.1.23 Authentic Biochemistry.
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Jan 22, 2023 |
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A Special Message for Authentic Biochemists. A direct way to contact your host and a little more. DJGPhD.21.1.23 Authentic Biochemistry Productions.
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Jan 21, 2023 |
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Immunoepigenetics XX. Inflammatory cytokines and associated transcription factors are controlled by epigenetically regulated microRNA. DJGPhD.20.1.23. Authentic Biochemistry.
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Jan 21, 2023 |
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ImmunoEpigeneticsXIX. Diet-induced and db/db mouse model Type 2 diabetes is dissimilar to the human pathophysiology but shares epigenetic mechanisms controlling pro-inflammatory PLA2/COX2/PGE2.
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Jan 20, 2023 |
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ImmunoepigeneticsXVIII. Variable DNA and histone methylation in cooperation with micro RNA mediate macrophage plasticity,inflammation and wound repair in T2D patients. DJGPhD.18.1.23.AuthenticBiochem.
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Jan 19, 2023 |
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Epistemological integration into realized metaphysicsV. Energy and mass like space and time are estimations of uncertain certainties yet are used as universals in physico-chemical event ontologies
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Jan 16, 2023 |
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Immunoepigenetics XVII.TGF beta involvement in disease pathology and normal developmental physiology demonstrates the complexity of categorical ontologies in biochemical events.DJGPhD.13.1.23.AB
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Jan 14, 2023 |
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ImmunoepigeneticsXVI. TGFbeta 1 and subfamily member Activin A diferentially alter the categorical valence and modality of Th17 cells in multiple sclerosis via receptor kinase modulatory specificity.
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Jan 13, 2023 |
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ImmunoepigeneticsXV. In utero fetal exposure to high concentration of maternal cortisol can induce histone code hypomethylation proximal to the TGF B-1 receptor resulting in adult OA.DJGPhD.12Jan23
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Jan 13, 2023 |
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ImmunoepigeneticsXIV. Epithelial cell metabolism and the potential transition to mesenchyma is regulated by TGF-Beta and linked to ALK-1 receptor associated OA. DJGPhD.11Jan23.Authentic Biochemistry.
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Jan 11, 2023 |
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Biochemical Consequences of Sensorial Phenomenology V. The possibility of Necessary biological modality . DJGPhD. 09Jan23. Authentic Biochemistry.
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Jan 10, 2023 |
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ImmunoepigeneticsXIII. The interplay of NFKappB and articular cartilage glycosaminoglycan metabolism in regulating pro-inflammatory cytokine expression in OA. DJGPhD.Authentic Biochemistry. 08Jan2023
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Jan 08, 2023 |
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ImmunoepigeneticsXII. Osteo-Arthritis 1. Clinical manifestation and the role of TGF-Beta. DR. Daniel J. Guerra. 06Jan2023. Authentic Biochemistry Podcast Productions
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Jan 07, 2023 |
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Cytoepigenetics XI. The Treg essential linneage specific transcription factor FOXp3 promoter is regionally variably demethylated and acetylated to control Th immunosuppression.DJGPhD.04.Jan.23.
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Jan 04, 2023 |
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Epistemological integration into realized metaphysics III. Mensam de phaenomenus and the concept of evidentiary existentialism in research science. DJGPhD.01Jan23.Authentic Biochemistry.
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Jan 02, 2023 |
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ImmunoEpigenetics X(A). Inhibtion of histone trimethyl-Lys demethylases as arbiter of controlling human Acute Myeloid Leukaemia (AML). Dr Daniel J. Guerra. 30.12.22. Authentic Biochemistry
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Dec 31, 2022 |
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Diabetes XXV. Obesity linked disruption of adipose mediated endocrine hormone control over fatty acid turnover from TAG leads to T2D in humans. Dr. Daniel J. Guerra. 3April22.Authentic Biochemistry
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Dec 30, 2022 |
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Holiday Ethanol Abuse Lecture I. EtoH ingestion, while intoxicating redox metabolism is also a membrane lipid -protein interacting agent that corrupts inwardly rectifying K voltage gated channels.
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Dec 30, 2022 |
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ImmunoEpigeneticsIX. Promoter/Enhancer proximal and distal epigenetic signatures and transcription factor protein heterogeneity compose gene expression event ontology.DJGPhD.29.12.22.AuthenticBiochem
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Dec 29, 2022 |
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More "mere" epistemology opening a door to metaphysics II. Non-canonical epi-rational and epi-empirical retailoring of understanding and imagination via research scientific endojectification.DJGPhD.
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Dec 25, 2022 |
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ImmunoepigeneticsVIII. Protective immunotolerant neonate Th1 inactivity involves IL-12 p35subunit promoter methylation. DJGPhD.23.12.22. Authentic Biochemistry Podcast
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Dec 24, 2022 |
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Holiday Ethanol Use VIII. EtOH induced cAMP /CREB associated PKA kinase driven phosphorylation cascade co-opts the TLR4-mediated neuroinflammatory/neurotoxic CNS-microglial axis.DJGPhD.22.12.22.AB.
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Dec 23, 2022 |
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Holiday Ethanol Use VII. EtOH exposure precipitates chromatin methylation associated MCH and chemokine involvement linking arousal, reward and inflammation. DJGPhD.21.12.22 Authentic Biochem.
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Dec 21, 2022 |
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Mere Epistemology Knocking on Metaphysics for a late December Evening. I. DJGPhD.21 December 2022 Authentic Biochemistry Podcast
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Dec 21, 2022 |
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Holiday Ethanol Use VI. EtOH associated DNA methylation of neurotransmitter systems opens the door to neurotoxicity and cognitive deficits. DJGPhD.18.12.22b. Authentic Biochemistry Podcast
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Dec 18, 2022 |
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Holiday Ethanol Use V. EtOH mediated WNT signaling and PLC mediated IP3/DAG induction of protein kinase and Ca2+ mobilization contribute to aberrant transcription and translation corrupting health.
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Dec 18, 2022 |
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Holiday Ethanol Use IV. MDH and LDH play essential roles in EtOH mediated corruption of bioenergetics, development, and gene expression during fetal development.DJGPhD.16.12.22 b.Authentic Biochem.
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Dec 17, 2022 |
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Holiday Ethanol Use III. In utero fetal cardiac muscle development is corrupted by maternal EtOH exposure via metabolic, bioenergetic and epigenetic means involving fatty acid and folate redox poise.
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Dec 16, 2022 |
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Holiday EtOH Lecture II. Ethanol ingestion permanantly corrupts myelin lipid composition while altering MET and Folate metabolism leading to epigenetic syntactic and semantic chromatin errors.DJGPhD.
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Dec 14, 2022 |
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Immunoepigenetics VII. MicroRNA mediated feedback control over signalling response toward inflammation.DJGPhD. 10Dec22. Authentic Biochemistry
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Dec 11, 2022 |
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ImmunoepigeneticsV!. TLR's and TCR's use membrane lipid raft signal transduction to obtain transcription factor mediated cell fate via epigenetic modification. DJGPhD.09 Dec.22
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Dec 09, 2022 |
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ImmunoepigeneticsV. TCR activation and the integration of cell senescence with epigenetic authorship and reading-mediated tumorigenesis. DJGPhD.07Dec22. Authentic Biochemistry
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Dec 07, 2022 |
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ImmunoEpigeneticsIV. Membrane lipid raft components dynamically mediate Tcell reception, hippocampal pyrimidal neuron endocytosis, and lung cancer cell mesenchymal to endothelial transition.DJGPhD.
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Dec 05, 2022 |
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Immunoepigenetics 3. EtOH abuse interrupts membrane lipid raft -mediated TCR signaling by decreasing the TF NFAT nuclear translocation and IL-2 transcription.DJGPhD.04.DEC.22.Authentic Biochemistry.
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Dec 04, 2022 |
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Immunoepigenetics 2. Treg and ILC differentiation and the evolution of lymphocytic response specificity incl. B cell class switch recombination and somatic hypermutation deamination.DJGPhD.2.12.22
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Dec 02, 2022 |
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Membrane Biochemistry 86/Immunoepigentics1. The complex divergent roles of Inhibitor of DNA (Id) binding proteins in terminal differentiation and disease states. DJGPhD.01.12.22.Authentic Biochemistry
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Dec 02, 2022 |
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Membrane Biochemistry 85. EBV latent membrane protein induction of haemopoietic proliferative disease and Id repressor protein transcriptionally mediated terminal differentiation.DJGPhD.30.11.22.
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Nov 30, 2022 |
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Membrane Biochemistry 84. Isolation of membrane protein using non-ionic detergents exposes the prescence of cellular lipid raft domains. DJGPhD. 29.11.22. Authentic Biochemistry.
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Nov 30, 2022 |
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Membrane Biochemistry 83. Countercurrent distribution theory of membrane lipid raft mediated endomebranous sequence ontology. DJGPhD.26.11.22
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Nov 26, 2022 |
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Membarne Biochemistry 82. Coda in absentia. Redux of the epistemological lens and the membrane lipid raft resurfaces. Dr. Daniel J. Guerra. 23.11.22. Authentic Biochemistry Podcast
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Nov 23, 2022 |
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Membrane Biochemistry 81. Synopsis. Logical judgment and square of opposition applied to lipids as transcription factors and membrane sequence derivatives respectively. DJGPhD19.11.22.Authentic Bioch
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Nov 19, 2022 |
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Membrane Biochemisty.Steroidogenic endo-nuclear sphingolipid metabolism involving ganglioiside turnover mediates transcription factor de-repression via DAG kinase.DJGPhD.18.11.22.
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Nov 19, 2022 |
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Membrane Biochemistry 79. Sphingolipids and cyclic phosphatidic acid control PPAR isoform-mediated gene transcription over lipid metabolism and inflammation. DJGPhD.16.11.22. Authentic Biochemistry
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Nov 16, 2022 |
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Membrane Biochemistry 78. Nuclear sphingolipid metabolism controlling cAMP response element-mediated transcription promoting proinflammation and anti-inflammation temporally and spatially.DJGPhD.
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Nov 15, 2022 |
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Membrane Biochemistry 77. Membrane lipid mediated IGF-I in contextual expression within discrete organ systems controls an inflammatory valence DJGPhD. 9 November 2022 Authentic Biochemistry
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Nov 10, 2022 |
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Membrane Biochemistry 76. Introduction to SubCellular-Distribution Mechanisms and Function of Nuclear-Localized Lipids. DJGPhD.06Nov22b.Authentic Biochemistry Podcast
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Nov 06, 2022 |
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Membrane Biochemistry75. Rational judgment as the epistimological prolegomena to research science:isoprenoid lipid biosynthesis guided event ontologies.DJGPhD.6NOV22.Authentic Biochemistry.
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Nov 06, 2022 |
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Membrane Biochemistry 74. ER-Phosphatidylcholine biosynthesis regulates neuritigenesis and the use of logical judgment in research science. DJGPhD. 03Nov22. Authentic Biochemistry
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Nov 03, 2022 |
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Membrane Biochemistry 73. Pathogenic membrane associated phosphatidylcholine and sphingomyelin metabolism is linked to skeletal and CNS pathology. DJGPhD.02NOV22. Authentic Biochemistry
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Nov 02, 2022 |
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Membrane Biochemistry72. DHEA and the steroidogenic pathways as biochemical prolegomena to logical judgments. Dr. Daniel J. Guerra.29.10.22b.Authentic Biochemistry
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Oct 29, 2022 |
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Membrane Biochemistry 71. Intracellular-endomembranous cholesterol trafficking and estrogen biosynthesis is under epigenetic control. DJGPhD.29.10.22.Authentic Biochemistry.
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Oct 29, 2022 |
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Membrane Biochemistry 70. Ketogenesis and cholesterologenesis are mediated by mitochondrial bioenergetics and the ER+Peroxisomal metabolism of VLCPUFA's via membrane domain event ontology.DJGPhD
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Oct 27, 2022 |
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Membrane Biochemistry 69. Distilled electrochemical potential mediated Inner mitochondrial membrane redox and the introduction to sterol involvement.DJGPhD.27.10.22. Authentic Biochemistry
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Oct 27, 2022 |
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Membrane Biochemistry 68. Elevatum Hypostasis. Dr Daniel J. Guerra. 22.10.22b Authentic Biochemistry
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Oct 22, 2022 |
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Membrane Biochemistry 67. VDAC oligimerization inhibition can block mitochondria-mediated apoptosis and NLRP3 inflammasome activation. DJGPhD.22.10.22.Authentic Biochemistry.
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Oct 22, 2022 |
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Membrane Biochemistry 66. Staph aureus infection, autoimmune disease, biliary cholangitis, and neurodegeneration involve NLRP3 Inflammasome activation with core bioenergetic involvement. DJGPhD.
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Oct 21, 2022 |
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Membrane Biochemistry 65. The integration of pro-inflammatory signaling from a plenum of molecular membranous events: The NRLP3 Inflammsome. DJGPhD. 19.10.22. Authentic Biochemistry.
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Oct 20, 2022 |
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Membrane Biochemistry 64. Prelude to Biochemical Metaphysics and the Mitochondrial Membrane Damage Response I. Dr. Daniel J. Guerra.18.10.22.Authentic Biochemistry Podcast
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Oct 18, 2022 |
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Membrane Biochemistry 63. The TCR:APC Chemokine receptor Trigger for Cytokine Stimulation. DJGPhD. 16 Oct 2022 Authentic Biochemistry Podcast
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Oct 17, 2022 |
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Membrane Biochemistry 62. The T cell receptor mechanism II. Dr. Daniel J. Guerra. 14.10.22 Authentic Biochemistry
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Oct 15, 2022 |
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Membrane Biochemistry 61. The Tcell membrane :APC synapse I. Dr Daniel J. Guerra 13.10.22 Authentic Biochemistry
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Oct 13, 2022 |
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Membrane Biochemistry 60. Human neocortical membrane lipid evolution and the links to cognition,fasting, and neurodegeneration. Dr Daniel J. Guerra. 03Oct2022.Authentic Biochemistry.
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Oct 04, 2022 |
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Membrane Biochemistry 59. Back to the Basics.Dr Daniel J. Guerra 30 September 2022.Authentic Biochemistry
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Oct 01, 2022 |
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Membrane Biochemistry 58. Cardiolipin biosynthesis involves a PC-linoleic acid requiring maturase and a unique phosphatidylglycerol phosphate phosphatase. DJGPhD.25.9.22.Authentic Biochemistry
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Sep 26, 2022 |
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Membrane Biochemistry 57. c-Fos osteoclastogenesis and control over acetyl ceramide mediated apoptosis.Dr Daniel J.Guerra.22.9.22 Authentic Biochemistry
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Sep 22, 2022 |
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Membrane Biochemistry 56. Membrane Associated Cholesterol hydroxylation leads to bile acid conjugate- promoting human breast cancer stem cell proliferation. DJGPhD.19.9.22 Authentic Biochemistry.
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Sep 20, 2022 |
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Membrane Biochemistry 55. A phosphoglycerolipid primer. Dr Daniel J. Guerra. Authentic Biochemistry Podcast. 16 Sept. 2022.
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Sep 17, 2022 |
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Membrane Biochemistry 54. De-phospho TYR cFos doubles the VMax of specific glycolipid and phospholipid biosynthetic enzymes via ER stabilization.Dr Daniel J. Guerra. Authentic Biochemistry.14.9.22
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Sep 14, 2022 |
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Membrane Biochemistry 53. cFos correlates with light-induced retinal membrane retailoring without de novo transcription. Dr Dan Guerra. 13.9.22.Authentic Biochemistry Podcast
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Sep 13, 2022 |
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Membrane Biochemistry 52. Epigenetic modifications in pathophysiology and the synthesis of nascent membrane lipid in cell cycle progression. DJGPhD.12Sept22. AUthentic Biochemistry
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Sep 12, 2022 |
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Membrane Biochemistry 51. The BRD4 epigenetic reader control over cardiac mitochondrial function via bioenergetic gene expression may be corrupted in oncogenic pharmacotherapy driven BETi. DJGPhD.
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Sep 08, 2022 |
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Membrane Biochemistry L (50). SCFA's work via membrane free fatty acid receptors through transcription factor Nrf2 to reduce ROS with an epigenetic mark-up.DJGPhD.7Sept22.Authentic Biochemistry.
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Sep 07, 2022 |
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Membrane Biochemistry 49. linking membrane reception and endocrine steroid lipid signaling to disease and longevity.DJGPhD.06Sept22
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Sep 07, 2022 |
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Membrane Biochemistry 48.Coxsackievirus B enterovirus causes myocarditis in young men due to lack of estrogen-receptor-mediated control of mitochondrial fission/fusion & inflammation. DJGPhD.3Sept22
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Sep 04, 2022 |
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Membrane Biochemistry 47. AMPK is regulated by steroid hormone activating kinases and calcium. DJGPhD. 02September2022, Authentic Biochemistry Podcast
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Sep 02, 2022 |
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Membrane Biochemistry 46. Lung and endometrial cancer vs neurodegersative disease in steroid-sex-hormone NK cell biochemistry.DJGPhD.31.8.22. Authentic Biochemistry.
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Aug 31, 2022 |
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Membrane Biochemistry XXXXV. Female NK Cytotoxicity due to Membrane Surface Receptors may Obtain Reduced Pathogen Infection Rates and Cancer in Women v. Men.DJGPhD.30.8.22 Authentic Biochemistry.
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Aug 31, 2022 |
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Membrane Biochemistry 44. Synthesis of Lectures Video. Part One. Attached in show notes. Dr. Daniel J. Guerra. 29.8.22 Authentic biochemistry Podcast.
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Aug 29, 2022 |
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Membrane Biochemistry 43. Action potentials and the mechanisms of electrochemical communication in biological systems. DJGPhD.26.8.22. Authentic Biochemistry
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Aug 26, 2022 |
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Membrane Biochemistry XXXXII. Basic Electrobiochemistry of Biological Membranes. Dr Daniel J. Guerra. 24.8.22b Authentic Biochemistry Podcast Audio Lectures.
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Aug 24, 2022 |
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membrane Biochemistry XXXXI. A priori Synthesis of Sex-linked Biochemical Dimorphism and Canonical Membrane Event Ontology. Dr. Daniel J. Guerra. 24.8.22.Authentic Biochemistry Podcast.
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Aug 24, 2022 |
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Membrane Biochemistry XXXX. Immunological Response to Molecular Sex-linked Pattern Dimorphism Includes the Presentation of Differential Autoinflammatory Diseases. DJGPhD 22.8.22b.Authentic Biochem.
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Aug 22, 2022 |
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Membrane Biochemistry XXXIX. Maternal Inheritance of Mitochondrial DNA and the Heterozygous XY Chromosomal Contributions to Sexually Dimorphic Biochemical Processes.DJGPhD.22.8.22. Authentic Biochem.
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Aug 22, 2022 |
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Membrane Biochemistry XXXVIII. Sexual Biochemical Dimorphism Epigenetic Involvement in Early Infant CRF/HPA Axis and Subsequent Adult Neuropsychiatric Disease. DJGPhD.19.8.22. Authentic Biochemistry.
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Aug 19, 2022 |
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Membrane Biochemistry XXXVII. CRF Receptor Studies in Pre-Clinical Research as Bootstrapped to Human MDD, GAD, PTSD and Addiction.DJGPhD.19.8.22. Authentic Biochemistry
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Aug 19, 2022 |
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Membrane Biochemistry XXXVI. Sexual Differential CRF Signaling Accorded to Downstream Processing and Associated Neuropsychiatric and Phyiological Disorders.DJGPhD.17.8.22 Authentic Biochemistry.
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Aug 17, 2022 |
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Membrane Biochemistry XXXV. Lipocortin-1 induces cortisol thus suppressing phospholipase A2, blocking eicosanoid and leukocyte inflammatory events. DJGPhD.16.8.22. Authentic Biochemistry
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Aug 16, 2022 |
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Membrane Biochemistry XXXIV. Assymetric Glucocorticoid Pharmacotherapy in Rheumatoid Autoimmune Disease with T2Diabetes and the Fear Axis.DJGPhD.Authentic Biochemistry 15.8.22
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Aug 16, 2022 |
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Membrane Biochemistry XXXIII> Are Oxytocin and Corticotropin Releasing Factor Antiinflammatory, Analgesic and Anxiolytic? Dr Daniel J. Guerra. 14.8.22. Authentic Biochemistry
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Aug 15, 2022 |
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Membrane Biochemistry XXXII. The Subcortico-limbic network in Fear Conditioning as seen through the Dialectical Event Ontology lens. DJGPhD.10.AUG.22. Authentic Biochemistry
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Aug 11, 2022 |
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Membrane Biochemistry XXXI. Corticotropin Releasing Factor and "Fear" Neurobiochemical Correlates in the CNS. Dr Daniel J. Guerra. 9Aug2022. Authentic Biochemistry Podcast
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Aug 09, 2022 |
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Membrane Biochemistry XXX. Nociception as component of Subcortical-Limbic Involvement of the Conditioned Fear Response in Mammals. DJGPhD. 8Aug22. Authentic Biochemistry
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Aug 09, 2022 |
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Membrane Biochemistry XXIX. Final discussions on serum albumin and membrane disruption mediated inflammatory modulation. Dr. Daniel J. Guerra. 7bAug22.Authentic Biochemistry.
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Aug 07, 2022 |
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Membrane Biochemistry XXVIII. Serum Albumin as an arbiter of neuronal inflammation or peripheral removal of circulating endogenous Danger/Damage-Associated Molecular Patterns. 7Aug22. DJGPhD.
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Aug 07, 2022 |
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Membrane Biochemistry XXVII. Traumatic Brain Injury and Ischaemic Stroke associated neuroinflammation is mediated through membrane caveolae. Dr Daniel J. Guerra.3Aug22. Authentic Biochemistry.
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Aug 04, 2022 |
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Membrane Biochemistry XXVI. Lipid molecular structures and membrane morphology impacting biological activity. Dr Daniel J. Guerra. 01August2022. Authentic Biochemistry Podcast Productions.
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Aug 02, 2022 |
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Membrane Biochemistry XXV. From Plotinus through Kant to Membrane lipids: an a priori synthesis of research scientific event concepts. DJGPhD.Authentic Biochemistry.31.7.22
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Jul 31, 2022 |
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Membrane Biochemistry XXIV. Legionella- assocated TLR mediated LPS containing sialic acid interactions and the Caveolar Involvement in Pathobiochemistry.DJGPhD. 29.7.22.Authentic Biochemistry.
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Jul 30, 2022 |
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Membrane Biochemistry XXIII. DNA recombination and methylation associated autoimmune and cancer pathology via TLR4 and membrane lipid rafts. DJGPhD.28.7.22. Authentic Biochemistry
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Jul 28, 2022 |
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Membrane Biochemistry XXII*. The dialectical event ontology of caveolae-associated disease is florid with no absolute relational, quantitative, qualitative or modal conformity.DJGPhD.27.7.22
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Jul 28, 2022 |
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Membrane Biochemistry XX. Loss of CNS CA1-Caveolae Formation in Obese Type-2 Diabetics is Linked to insulin Resistance and Alzheimer's Disease. DJGPhD24.7.22. Authentic Biochemistry.
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Jul 24, 2022 |
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Membrane Biochemistry XIX. Oxysterols and LDLR in atherosclerosis: transcriptional mediation of membrane control over cholesterol homeostasis. 21.7.22. DJGPhD.Authentic Biochemistry
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Jul 21, 2022 |
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Membrane Biochemistry XVIII> Valproic acid and Platelt Activating Factor:Membrane lipids in Alzheimer's DiseaseDJGPhD 18.7.22 Authentic Biochemistry
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Jul 19, 2022 |
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Membrane Biochemistry XVII. Epoigenetic changes in protein controlled membrane lipid transport in human disease. DJGPhD.14.7.22
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Jul 15, 2022 |
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Membrane Biochemistry XVI. The Acid Sphingomyelinase Deficiencies. Dr Dan Guerra. 13.7.22 Authentic Biochemistry
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Jul 13, 2022 |
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Membrane Biochemistry XV. REST mediated gene repression and membrane function and plaque formation in atherosclerosis. DJGPhD. 11JUly22. Authentic Biochemistry
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Jul 12, 2022 |
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Membrane Biochemistry XIV. Apoptosis and Necroptosis review. Dr. Daniel J. Guerra. 8 July 2022. Authentic Biochemistry Podcast
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Jul 09, 2022 |
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Membrane Biochemistry XIII.Fatty acid induced membrane protein phosphorylation can shift pro-oncogenic to apoptotic cell fate in human breast cancer cell lines. DJGPhD. 5July 2022 Authentic Biochem.
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Jul 05, 2022 |
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Membrane Biochemistry XII. The specificity of membrane lipid raft molecular species and the dialectics of protein sorting. DJGPhD.3 July 2022 Authentic Biochemistry.
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Jul 04, 2022 |
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Membrane Biochemistry XI. Inflammasomes and omega three fatty acid involvement in various pathogenic and human disease states. DJGPhD.02.July 2022.
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Jul 02, 2022 |
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Membrane Biochemistry X. Dialectical Event Ontologies and the Complexity of Biological Systems. Dr. Daniel; J.Guerra 2 July 2022 Authentic Biochemistry
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Jul 02, 2022 |
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Membrane Biochemistry IX. Omega Three fatty acid utilization via oxygenation to control inflammation. DJGPhD. 30.6.22 Authentic Biochemistry Podcast production
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Jul 01, 2022 |
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Membrane Biochemistry VIII. The basics of lipid membranes. Part 1. Dr Daniel J. Guerra. Authentic Biochemistry Podacst Production. 28.6.22
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Jun 29, 2022 |
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Membrane Biochemistry VII. DNA methylation and histone acetylation may be at the core of memory and learning via LTP associated Integral Membrane Excitation. DJGPhD.24.6.22 Authentic Biochemistry.
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Jun 25, 2022 |
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Membrane Biochemistry VI. The involvement of membrane lipid omega 3 fatty acids in LTP and memory acquisition. Part 1. Dr Guerra. 23.6.22. Authentic Biochemistry
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Jun 24, 2022 |
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Membrane Biochemistry V. Epigenetic alteration of gene expression is predicated by free will induced synaptic plasticity as an event ontology. DJGPhD. 21.6.22 Authentic Biochemistry
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Jun 21, 2022 |
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Membrane Biochemistry IV. Synaptic Plasticity and Oncological Phenomena involving DNA Methylation. Dr. Daniel J. Guerra. 20.6.22 Authentic Biochemistry
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Jun 21, 2022 |
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CytoEpigenetics XIX. Some examples of epigenetic methylation and acetylation patterns in disease and the concept of maintenance methylation. Dr Daniel J. Guerra. 06June2022
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Jun 06, 2022 |
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CytoEpigenetics XVIII. Membrane lipid architectonics organized for cell cycle and both nuclear and mitochondrial biochemical mediation of gene expression. Dr. Dan Guerra. 05 June 2022
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Jun 05, 2022 |
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CytoEpigenetics XVII. The role of ceramide metabolism in epigenetic and bioenergetic cross talk among multiple subcellular compartments. Dr Dan Guerra. 03June2022 Authentic Biochemistry Podcast
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Jun 04, 2022 |
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CytoEpigenetics XVI. The Mt DNA replicase and helicase enzymes are epigenetically nuclear encoded and localize to the mitochondrial membrane into lipid rafts containing cholesterol. DJGPhD. 2June2022
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Jun 02, 2022 |
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CytoEpigenetics XV.An AMPK phosphorylation cascade promoting mTOR pro-translational induction of NFkappa-B SASP transcription is modulated by NAD+ Sirtuin and PARP during Chromatin retailoring.DJGPhD
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May 28, 2022 |
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CytoEpigenetics XIV. The details of AMPK mediated control over DNA methyl transferase thus coordinating bioenergetics with cell fate via the epitranscriptome. DJGPhD. 25.5.22
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May 26, 2022 |
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CytoEpigeneticsXIII. Epitranscriptomics of Fatty acid Utilization is a driver of Heart-Failure associated Cardiorenal disease. Dr daniel J. Guerra. Authentic Biochemistry.22.5.22
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May 22, 2022 |
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CytoEpigenetics XII. The central role of mitochondria in regulating cell fate and metabolic switching is necessary and universal in epigenetic modification of gene expression. DJGPhD.20.5.22
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May 21, 2022 |
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CytoEpigenetics XI. The interactive intermediary metabolic architectonic of methylation and acetylation in epigenetic mediation of gene expression between the mitochondria and nucleus. DJGPhD.17.5.22
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May 18, 2022 |
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CytoEpigenetics X. The IDH isofrom roles of mutant, hypoxic and constitutive activities mediate DNA, RNA and Histone3 Lys methylation patterns thus redirecting gene expression.DJGPhD.15.5.22
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May 16, 2022 |
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Cytoepigenetics IX. c-MYC controls transcription of two dehydrogenases that alter the ratio of 2-HG/alphaKG thus controling epigenetic signatures on DNA and RNA in a cancer mouse model.DJGPhD.11May22
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May 12, 2022 |
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CytoEpigenetics VIII. The epigenetic processors, TET and BRD4, mediate control over fatty acid oxidation, pyruvate metabolism, the electron tranport chain and OXPHOS. DJGPhD.8May22. Authentic Biochem
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May 09, 2022 |
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Cytoepigenetics VIIB. Warburg glycolysis explained from an epigenetic perspective plus some details of DNA methylation/demethylation. DJGPhD. Authentic Biochemistry Podcast 06May2022
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May 07, 2022 |
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Cytoepigenetics VIIa. Micro RNA control over the electron transport chain and oxidative phosphorylation via binding to nuclear and mitochondrial transcripts. DJGPhD03.may 2022. Authentic Biochemistry
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May 04, 2022 |
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CytoEpigenetics V!. The 'magmatic' alteration of nuclear and mitochondrial gene expression via microRNA processing and translocalization is under bioenergetic control. DJGPhD. 2 May 2022.
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May 03, 2022 |
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Cytoepigenetics V. Small interfering and micro RNA mediate mitochondrial and nuclear transcripts thus rendering cell fate, bioenergetics, and immunogenicity. DJGPhD.29.4.22. Authentic Biochemsitry
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Apr 29, 2022 |
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Cytoepigenetics IV. Using Raman and IR spectroscopy to analyze the physical chemistry of pyrimidine nucleotide methylation. Dr. Daniel J. Guerra. 26.4.22. Authentic Biochemistry Podcast Productions
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Apr 26, 2022 |
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Cytoepigenetics IIIB. The Geometrical constraints decribed by the valence shell electron pair repulsion in biochemical reactivity. DJGPhD.25.4.22
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Apr 25, 2022 |
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Cytoepigenetics IIIA. Dissection of the PPAR-gamma epigenetic retailoring. Dr Daniel J. Guerra. Authentic Biochemistry Podcast. 25.4.2022
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Apr 25, 2022 |
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Cytoepigenetics II. The First Principle of Biochemical Epigenetics and the dialectic of methylated promoter region PPAR-gamma and peroxisomal mitigation between rodent and human. DJGPhD.24.4.22
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Apr 25, 2022 |
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CytoEpigenetics I. Introduction. Dr. Daniel J. Guerra . 22.4.22. Authentic Biochemistry Podcast Productions
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Apr 23, 2022 |
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Authentic Biochemistry is moving to a remote geographical region but will do so seamlessly and with full dedication. Please SUBSCRIBE and take notice of the discussion I have recorded here. DJGPhD
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Apr 20, 2022 |
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Diabetes XXXVI. Coda. Final lecture in diabetic dyslipidaemia.
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Apr 20, 2022 |
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Diabetes XXXV. Rodent model adipose mitochondrial respiratory contribution to obesity control involves a selenium protein and UCP1 sulfenylation. Dr Daniel J. Guerra. Authentic Biochemistry.18.4.22
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Apr 19, 2022 |
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Diabetes XXXIV. White vs brown adipocytes and the role of transcription factors and metabolic enzyme expression to mediate bioenergetics vs.lipogenesis in store depot fat.DJGPhD.17.4.22. Authentic B.
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Apr 18, 2022 |
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Diabetes XXXIII. Synthesis of lecture arc Part 2. Dr Daniel J. Guerra. Authentic Biochemistry Podcast Studios. 16.4.22
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Apr 16, 2022 |
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Diabetes XXXII. Fatty acid oxygenation and use of eicosanoid molecular species to regulate T2D-linked inflammation via the agonization of the nuclear receptor transcription factor PPAR.DJGPhD 15.4.22
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Apr 15, 2022 |
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Diabetes XXXI. REDOX biochemistry mini-review and the roles of essential fatty acid elongation/desaturation metabolism and COX/LOX oxygenation as ligands for PPAR isoforms in T2D pharmacotherapy.
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Apr 14, 2022 |
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Diabetes XXX. The pleitropic roles of free fatty acids and PPAR's as mediating insulin sensitivity, intermediary metabolism and the inflammatory response in T2D.Dr Daniel J. Guerra 13.4.22. Authentic
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Apr 13, 2022 |
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DiabetesXXIX. THe CNS axis of Obesity-linked T2D via alterations in PPAR transcription factor mediated expression of ameliorative hippocampal AMPAR and LTP neural transmission in Alzheimer's Discsease
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Apr 12, 2022 |
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Diabetes XXVIII. Diabetic nephropathy is a consequence of non-esterified free fatty acid associated ceramide induction of the IRS-1 phosphorylation in glomerular podocytes inducing inflammation
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Apr 08, 2022 |
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Diabetes XXVII. Dyslipidaemia and the Insulin Resistance Axis. Dr. Daniel J. Guerra. Authentic Biochemistry Podcast 7April2022.
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Apr 07, 2022 |
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Diabetes XXVI. Adipogenic and hypertrophic adiposity differentially control dyslipidaemia and Insulin resistance in association with pro-inflammatory cytokine induced T2D and breast cancer.DJGPhD.
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Apr 05, 2022 |
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Diabetes XXIV. Sphingosine 1-phosphate targeting and the abalation of primary breast cancer metastasis: IL6 mediated tumorigenesis blockade? Dr Daniel J. Guerra 01April2022. Authentic Bbiochemistry
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Apr 02, 2022 |
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Diabetes XXIII. Obesity-associated IL6 and sphingosine 1-phosphate are linked to breast cancer.Dr. Daniel J. Guerra. 31 March 2022. Authentic Biochemstry
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Apr 01, 2022 |
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Diabetes XXII. Obesity and cancer are linked by inflammation and dyslipidaemia. Dr Daniel J. Guerra. 30.3.22 Authentic Biochemistry
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Mar 31, 2022 |
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Diabetes XXI. TAG accumulation in skeletal muscle of diabetics vs athletes and suggested role of Intramuscular TAG in Insulin Resistance due to subcelluar localization of lipid droplets. DJGPhD.27.3
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Mar 28, 2022 |
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Diabetes XX. Intermediary metabolic allosteric regulation in the Myocardial Infarcted heart reveals HF aetiology from obesity-linked Type 2 Diabetes. DJGPhD.25.3.22. Authentic Biochemistry Production
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Mar 25, 2022 |
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Diabetes XIX. THe ketogenesis bioenergetic system can be corrupted via DAG-kinase mediated pyroptosis in the obese/T2D CNS. Dr. Dan Guerra. 22.3.22. Authentic Biochemistry Podcast
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Mar 22, 2022 |
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Diabetes XVIII. Myokine mediated muscle mass signaling is corrupted by obesity linked Type 2 diabetes via massive inflammation and dyslipidaemia.DJGPhD. 21.3.22. Authentic Biochemistry
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Mar 21, 2022 |
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Diabetes XVII. Short and medium chain fatty acid derived ketones and skeletal muscle Myokines to improve cognitive and homeostatic well-being in humans. DJGPhD. 20.3.22 Authentic Biochemistry.
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Mar 21, 2022 |
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Diabetes XVI. Fornix white matter fascicular region of the hippocampus nuclei is spared from neurodegeneration by dietary medium chain saturated fatty acid. DJGPhD.Authentic Biochemistry19.3.22
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Mar 19, 2022 |
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Diabetes XIV. The Neuropsychiatric/Neurodegeneration axis from Sphingomyelin Degeneration to Increased Inflammation. Dr. Daniel J. Guerra. 17.3.22. Authentic Biochemistry Productions
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Mar 17, 2022 |
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Diabetes XII. Free fatty acid dyslipidaemia associated dysregulation of hepatic and skeletal muscle Insulin Receptor Substrate (IRS)1/2 axis. Dr. Daniel J. Guerra15.3.22. Authentic Biochemistry .
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Mar 16, 2022 |
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Diabetes XI. Biometrics in research interpretation. Dr Dan Guerra 14.3.22 Authentic Biochemistry.
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Mar 14, 2022 |
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Diabetes IX. The role of peroxisomes in ether-linked lipid biosynthesis. Dr.Daniel J. Guerra. 07March2022. Authentic Biochemistry Podcast production
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Mar 08, 2022 |
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DiabetesVIII. Subcellular organization and the role of lipid metabolism in mitochondria and peroxisomes. Dr Daniel J. Guerra. 05March22. Authentic Biochemistry
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Mar 05, 2022 |
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Diabetes VII. Cholangiocarcinomas and the corruption of the biliary system as sequalae of obesity and associated pancreatic exocrine insufficiency of diabetes. Dr Dan Guerra. 3.March.2022. A.B.
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Mar 04, 2022 |
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Diabetes V . PEI and Diabetic Dyslipidaemia with Primary Cholagiocarcinoma. Primer on lipid digestion and Lipoprotein Trafficking. Dr. Dan Guerra. Authentic Biochemistry 01.March.2022
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Mar 02, 2022 |
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Diabetes IV. Pancreatic Exocrine Insufficiency in Types I, II, and III Diabetes Mellitus. Dr DAniel J. Guerra. 28.2.22. Authentic Biochemistry
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Mar 01, 2022 |
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Diabetes III. Sphingosine 1-Phosphate in glioblastoma and prostagladin E2/EP4 in diabetic nephropathy-an axis of angiogenesis. Dr. Daniel J. Guerra. 25.2.22 Authentic Biochemistry
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Feb 26, 2022 |
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Diabetes II. The Insulin resistance factor and glucose intoxication associated dyslipidaemia and introduction to diabetic nephropathy. DJGPhD. 23.2.22. Authentic Biochemistry Podcast.
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Feb 24, 2022 |
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Type 2 Diabetes I. Initial lecture describing insulin resistance and dyslipidaemia. Dr Daniel J. Guerra 22.2.22 Authentic Biochemistry Podcast.
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Feb 23, 2022 |
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Fatty Acids IX. The Monounsaturated fatty acid inhibition of ferroptosis and apoptosis leads to cancer progression. Pharmacotherapeutic Considerations. Dr Daniel J. Guerra. 17.2.22 Authentic Biochem.
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Feb 18, 2022 |
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Fatty Acids VIII. The Potential for Ferroptosis enhancement via inhibition of Stearoyl CoA Desaturase as pharmacotherapy in Pancreatic Ductal Carcinoma.DJGPhD.16.2.22. Authentic Biochemistry.
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Feb 16, 2022 |
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Fatty Acids VII. Stearoyl CoA Desaturase biochemistry and assocation with immune and metabolic disease. Dr Dan Guerra
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Feb 12, 2022 |
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Fatty Acids VI. The Inflammasome paradigm and transcription factor-mediated cytokine production as result of high carbohydrate diet and obesity. Dr. Daniel J. Guerra. 10.Feb 2022. Authentic Bichem.
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Feb 11, 2022 |
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Fatty Acids V. Ketogenesis as a therapeutic to redistribute preserved Heart Failure cardiac ejection fraction via blockage of mitochondrial protein hyperactylation. DJGPhD.9FEB22. Authentic Biochem.
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Feb 10, 2022 |
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Fatty Acids IV. Adipocyte lipases and the Diacylglycerol PKC/PKD circuit of cellular degeneration leading to chronic inflammation-associated obesity. DJGPhD.07.Feb.22. Authentic Biochemistry
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Feb 08, 2022 |
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Fatty Acids III. The inflammatory diseases and the correlation to dyslipidaemia. Dr Dan Guerra. 05 February 2022. Authentic Biochemistry Studios.
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Feb 06, 2022 |
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Fatty Acids II. Obesity and lipotoxicity. Dr Daniel J. Guerra. Authentic Biochemistry 04. February 2022
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Feb 05, 2022 |
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Fatty Acids I. Dr. Daniel J. Guerra. 03.02.22. Authentic Biochemistry Podcast
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Feb 04, 2022 |
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Anabolism VII. The allosteric control of purine biosynthesis involves complementarity and recipricol maintenance of steady state ADP/GDP ratios. DJGPhD. 31.01.22. Authentic Biochemistry.
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Feb 01, 2022 |
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Anabolism VI. de novo Purine Nucleotide Biosynthesis. Dr. Dan Guerra. 30.01.22. Authentic Biochemistry
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Jan 30, 2022 |
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Anabolism V. The nucleic acids. Dr. Daniel J. Guerra. Authentic Biochemistry Podcast.28.01.22
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Jan 29, 2022 |
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Anabolism IV. Cholesterologenesis. Dr Daniel J. Guerra. 26 January 2022. Authentic Biochemistry Podcast
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Jan 27, 2022 |
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Anabolism III. Fatty acid synthesis de novo . Dr. Daniel J. Guerra. Authentic Biochemistry Podcast Productions. 25.01.22
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Jan 26, 2022 |
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Anabolism II. The role of Acetyl CoA Carboxylase isoform expression and discrete allosteric regulation in controlling hepatic fatty acid metabolism. Dr Dan Guerra. 23.01.22. Authentic Biochemistry.
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Jan 24, 2022 |
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Anabolism I. Dr Daniel J. Guerra Authentic Biochemistry Podcast Production 22.01.22
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Jan 23, 2022 |
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Membrane lipid provide the architectonic signatures for cellular interactions including avirulence and either systemic and systematic-inflammatory disease. DJGPhD. 17.1.22. AuthenticBiochemistry
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Jan 17, 2022 |
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Porphyria gingivalis derived dihydroceramides and serine dipeptide lipids secretion induce periodontitis and systemic hyperinflammation as associated with obesity and high sucrose diet. DJGPhD.16.1.22
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Jan 17, 2022 |
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Dihydroceramides as virulence factors in periodontal disease. Dr. Daniel J. Guerra Authentic Biochemistry. 15 January 2022
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Jan 16, 2022 |
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Pathogenesis and Virulence are Linked to Alterations in the Infection Court via Secretion of Bacteriocins in Dental Plaque-producing Caries and S. pneumoniae Migration to the Lower Respiratory Tract.
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Jan 14, 2022 |
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Acquired Molecular Evolution of Antibacterial Resistance Unintentionally Selected via Pharmacotherapy to Counteract Natural Avirulence. DJGPhD. Authentic Biochemistry. 12.Jan2022
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Jan 13, 2022 |
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Avirulence protein factor heterogeneity in multiple mammalian host/pathogen interactions. Dr. Dan Guerra. Authentic Biochemistry Production.11.Jan.2022
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Jan 12, 2022 |
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Avirulence in the Streptococci and the Two-Component System of Histidine Kinase and Response Regulator. II. DJGPhD. Authentic Biochemistry 09Jan2022
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Jan 10, 2022 |
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Avirulence and the mechanisms of pathobiochemistry I. Dr. Daniel J. Guerra. Authentic Biochemistry Podcast Production. 08.Jan 2022
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Jan 09, 2022 |
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The neuronal porosomal and synaptosomal structural anatomy as a product of membrane lipid vesicular trafficking, Dr. Daniel J. Guerra Authentic Biochemistry. 05 January 2022
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Jan 06, 2022 |
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The bioenergetic glucose sensing network of the appetitive reward pathway is linked to the periphery via the neuroendocrine system. DJGPhD. Authentic Biochemistry. 04.Jan.2022
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Jan 05, 2022 |
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The Motor Neuron Association to Reward Pathway: Motor Neuron Disease , an Introduction. Dr. Daniel J. Guerra. 03 January 2022. Authentic Biochemistry Productions.
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Jan 04, 2022 |
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The CNS and Pandemic Obesity: The Appetitive Reward Pathway, Energy Expenditure, and Neuroendocrine Signaling. DJGPhD. 02.Jan.2022 Authentic Biochemistry Productions.
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Jan 02, 2022 |
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A short Pharmacology lecture on New Year's Day 2022. Dr Daniel J. Guerra. Authentic Biochemistry
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Jan 01, 2022 |
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Appetitive Reward Pathway III.-Neurobiochemistry and Epigenetics of Addiction. DJGPhD. 31.12.21 Authentic Biochemistry
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Dec 31, 2021 |
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Anhedonic and MDD- Associated Appetitive Reward Pathway Biochemistry and Pathophysiology II. DJGPhD. Authentic Biochemistry.30..12.21.
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Dec 31, 2021 |
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Appetitive Reward Pathway Biochemistry and Neural Circuitry Regulation I. Dr. Daniel J. Guerra. 29.12.21. An Authentic Biochemistry Production.
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Dec 29, 2021 |
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AMPK and Immuno-Epigenetic Biochemistry Part 2/2/ DJGPhD. Authentic Biochemistry 27.12.21
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Dec 28, 2021 |
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AMPK and Immuno-Epigenetic Biochemistry Part 1. Dr. Daniel J. Guerra. 27.12.21. Authentic Biochemistry
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Dec 27, 2021 |
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AMPK negatively regulates lipogenesis by phosphorylating ACCase 1&2 plus HMGCoA reductase thus supporting beta oxidation of fatty acids . Dr. Daniel J. Guerra. 22.12.21. Authentic Biochemistry
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Dec 23, 2021 |
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AMPK is associated with the POMC vs, NPY neuronal axis under Leptin Control. DJGPhD. 20.12.21 Authentic Biochemistry
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Dec 21, 2021 |
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AMPK Allosteric Regulation and Interaction with the Opposing mTORC Network. Part 2. Dr. Daniel J. Guerra. Authentic Biochemistry 19.12.21
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Dec 20, 2021 |
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Bio-Molecular Regulator Series . AMPK. Part One. Dr. Daniel J. Guerra. Authentic Biochemistry Podcast Production.19.12.21.
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Dec 19, 2021 |
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T-lymphocyte and macrophage membrane CD38 ecto-enzyme mediated NAD catabolism is associated with ageing and the decline in Sirtuin-mediated deacylase activity. DJGPhD.11.Dec.21' Authentic Biochemistry
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Dec 12, 2021 |
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Aposteriori synthesis of neuroendocrine linked clock chronicity and the Senescent associated Secretory Phenotype through the synthetic apriori lens of NAD+. DJGPhD.10Dec21. Authentic Biochemistry
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Dec 10, 2021 |
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How testosterone-aromatase derived estradiol transformation to 2-methoxy-17beta-estradiol can mitigate cell proliferation by promoting a senescent phenotype.DJGPhD. Authentic Biochemistry.8.DEC.21
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Dec 08, 2021 |
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Blocking cellular senescence may suppress autoimmune diseases and reactive oxygen mediated cell death but non-ironically promote oncogenesis and tumor development during ageing. DJGPhD. 06.DEC.21
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Dec 07, 2021 |
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Ageing and Asymmetric Dimethylarginine (ADMA)in Endothelial Nitric Oxide Synthase inhibition-associated decrease in respiratory vasodilation. Dr Dan Guerra 24.11.21 Authentic Biochemistry
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Nov 25, 2021 |
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Closing the window and drawing the curtain: cancer phenotypes are resolute signatures of Immunosenescence and inflammaging induced epigenetic collapse of vital biochemical homeostasis. DJGPhD.20/11/21
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Nov 21, 2021 |
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Sealing Fate: Immunosenescent and inflammatory mechanisms combine the ineffectual with the increscent pathophysiology of sickness unto death. DJGPhD. 17.11.21
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Nov 18, 2021 |
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The interplay between Immunosenescence and inflammaging conduct the innate and acquired immune response toward functional cellular rigidity and incompetence obtaining morbidity and mortality. DJGPhD.
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Nov 14, 2021 |
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Fine detail of Treg cell control over inflammation suppression via FoxP3 transcriptional modulation. Aging and Obesity will limit this control leading to hyperinflammation. DJGPhD. 08Nov2021
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Nov 09, 2021 |
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T cell receptor signaling kinase dynamics after APC activation. Co-activating CD28 becomes deficient via immunosenescence thus corrupting T cell efficiency in the elderly. 26.10.2021 DJGPhD.
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Oct 27, 2021 |
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Indeed oxysterol LDL , circulating hepatic-derived convertase, T lymphocyte differentiation and macrophage to foam cell degeneration obtain the aging cardiovascular/pulmonary pathophysiological state.
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Oct 22, 2021 |
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How Oxysterol LDL associates with macrophage and T lymphocyte infiltration during aging to generate the hyperinflammatory atherosclerotic plaque. DJGPhD. 19.10.21. Authentic Biochemistry.
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Oct 20, 2021 |
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Aging results in corruption of T lymphocyte differentiation associated with chromatin instability and epithelial to mesenchymal transitions leading to the pre-cancerous state. DJGPhD 16.10.21
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Oct 16, 2021 |
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Lymphocyte maturation and the special Innate like Lymphocyte Subclass including Natural Killer and other ILC lineages. DJGPhD.14.10.21. Authentic Biochemistry
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Oct 14, 2021 |
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Immunosenescence and Inflammaging via thymic Involution and comorbid pathophysiology of obesity and aging present a chronic inflammatory phenotype prone to morbidity. DJGPhD. Oct.04,2021. Authentic BC
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Oct 05, 2021 |
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Natural cytotoxicity receptors (NCR's) within group 3 innate lymphoid cells (ILC3): an association of transcription factors in IBD's and aging. DJGPhD. 03.10.21 Authentic Biochemistry.
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Oct 04, 2021 |
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Omega three fatty acids and PE N-methyl transferase are associated with methylation and acetylation patterning in NK cells via AMPK and stress.DJGPhD. 29 September 2021.
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Sep 29, 2021 |
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Natural Killer Cell switching via demethylation of Histone 3 LYS may correlate with the human aging phenotypic hyper-inflammatory state. DJGPhD. 28.9.21
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Sep 28, 2021 |
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The Genome and the Immunoepigenome interact across a three-way trigonal planar field with the Environment to Obtain the Aging Phenomena. DJGPhD.27.9.21
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Sep 28, 2021 |
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Natural Killer cells and the epigenomics of gene expression: implications for the aging -senescent human. DJGPhD. 26 .9.21. Authentic Biochemistry
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Sep 26, 2021 |
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REDOX Biochemistry Primer . DJGPhD Authentic Biochemistry . 24.9.21
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Sep 24, 2021 |
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Video Lecture Announcement. Please Listen to this audio! Grazie, Dr. Daniel J. Guerra 22.9.21
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Sep 23, 2021 |
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The Interferon I role in autoimmune disease and the corruption of mechanisms that lead to age-related morbidity and mortality.DJGPhD. 22.9.21
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Sep 22, 2021 |
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The Aging Immune Response and Cellular Differentiation are characterized by Apoptosis vs. Necroptosis Mechanisms. DJGPhD. 20.9.21.Authentic Biochemistry Productions.
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Sep 20, 2021 |
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Semaphorin works through mToR and thus the abl and AKT kinases in Macrophage reverse switching from lipogenesis to fatty acid oxidation. DJGPhD 18.9.21.
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Sep 19, 2021 |
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Macrophage and T lymphocyte Inclusion to the Aging Human Pathobiochemical Phenotype. DJGPhD.Authentic Biochemistry 18.9.21
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Sep 18, 2021 |
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Invitation to Watch my Youtube lecture I on the Aging Human Dialectic. Link found in the show notes. DJGPhD 16.9.21
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Sep 17, 2021 |
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Membrane Biochemistry Primer and Introduction to Aging. Dr. Daniel J. Guerra. Authentic Biochemistry Productions. 13.9.21
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Sep 13, 2021 |
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Summer Fades and Aging Advances through non-coding RNA's and the Immunological Axes. Dr Daniel J. Guerra. 9.9.2021 Authentic Biochemistry Productions.
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Sep 09, 2021 |
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Hepatic Gluconeogenesis and Glycogen Metabolism: Canonical Allostery. Dr Dan Guerra. Authentic Biochemistry 07 Sept. 2021
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Sep 07, 2021 |
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The hormonal and allosteric control over hepatic PFK2/FBPase2 via adenylate cyclase and Fructose 2,6 bis phosphate. DJGPhD.5Sept.2021. Authentic Biochemistry Productions.
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Sep 05, 2021 |
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Glycerol 3-phosphate dehydrogenase mechanism and the finale of glycolysis. Authentic Biochemistry. Dr. Daniel J. Guerra 27.8.21
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Aug 27, 2021 |
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Haemoglobin: Molecular Oxygen Binding Cooperativity and the role of 2,3 bis phosphoglyceric acid. DJGPhD 19.8.21
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Aug 20, 2021 |
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A Necessary Interruption in Amino Acid Catabolism: Haemoglobin and Oxygen Transport Lecture I. DJGPhD. 11 August 2021
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Aug 11, 2021 |
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Amino Acid Catabolism (Continued): Neurotransmitter and S-adenosyl MET interconversions. DJGPhD 09 Aug 2021
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Aug 09, 2021 |
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Main Frame Amino Acid Degradation Pathways and Skeletal Muscle Performance and Ammonia Toxicity.02.Aug.2021. DJGPhD. Authentic Biochemistry
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Aug 02, 2021 |
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The Urea Cycle and the endothelial ARGININE-Nitric Oxide Connection. DJGPhD 27.7.21.Authentic Biochemistry Podcast
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Jul 27, 2021 |
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The Glutamate Dehydrogenase Axis Further Reveals the Role of Ischaemic Oxygen Availability for Neural Transmission in the Aging Brain. DJGPhD 20.7.21.
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Jul 20, 2021 |
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The Glutamate Axis of Bioenergetics, Neurotransmission and Potential Contribution to the Aging Senescent Phenotype. DJGPhD 20.7.21
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Jul 20, 2021 |
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Amino acid metabolism I: An initial primer for subsequent discussions in Aging. Dr Guerra. 07July2021. Authentic Biochemistry.
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Jul 12, 2021 |
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Mesenchymal stem cell fate and the mediation of age-associated senescence or plasticity in the elderly via immune response valency. DJGPhD 03 July 2021
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Jul 04, 2021 |
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Detailing the Senescent to Mesenchymal Transition in Aging : Links to Cancer vs. Apoptosis. DJGPhD 28 June 2021.
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Jun 28, 2021 |
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Genomic damage, DDR, and the roles of inflammation and DNA epigenetic retailoring in the senescent phenotype. DJGPhD 24.6.21
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Jun 25, 2021 |
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Pharmacodynamics: General Considerations and Clinical Trials. Dr. Dan Guerra. Authentic Biochemistry 12 June 2021
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Jun 12, 2021 |
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Pharmacokinetics Synoptic with an Introduction to Aging Phenomena. Dr Daniel J. Guerra. 09June2021 authentic Biochemistry.
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Jun 10, 2021 |
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Cardiovascular disease risk and malnutrition are associated with aging morbidity and obesity. Dr. Guerra. 8 June 2021. Authentic Biochemistry
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Jun 08, 2021 |
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Ceramide mediated pathophysiology of aging-associated neurodegeneration. Dr. Dan Guerra. Authentic Biochemistry.05 June 2021.
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Jun 05, 2021 |
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Immuno Endocrine Regulation of Metabolism May-June 2021. Dr. Dan Guerra Authentic Biochemistry.
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Jun 03, 2021 |
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Aging and Cancer Via Immunosenescence and Pro-inflammatory Cytokines: Relative loss of Naive T cell Populations in the Elderly. DJGPhD. 26 March 2021
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May 26, 2021 |
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Pathobiochemical linkages between Alzheimer's Disease and Autism Spectrum Disorders: Associative Molecular Patterns with Diverse Pathologies. DJGPhD. 18 May 2021
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May 19, 2021 |
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Immunomodulatory effects on neuropsychiatric states: classic rodent model studies. Dr. Guerra. 17.5.21 Authentic Biochemistry
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May 18, 2021 |
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Linking TLR's with the VTA and NE circuitry: Immune mediated neurodegeneration and neuroprotection in the balance. DJGPhD 16 May 2021
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May 17, 2021 |
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Microglial TLR activation mediates Aging-Associated CNS Neurodegeneration. Dr. Daniel Guerra. Authentic Biochemistry Podcast. 13 May 2021.
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May 14, 2021 |
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The Innate Immune Response Instantiates the Pattern for future Inflammatory Prodromal Neurodegeneration. DJGPhD. 08May 2021
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May 08, 2021 |
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Pattern Recognition Receptors: Some molecular detail. DJGPhD Authentic Biochemistry. 07 May 2021
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May 07, 2021 |
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Ischemic Infarct as a model for immune mediated CNS regeneration or degeneration via microglial stimulation. Dr. Daniel J Guerra. Authentic Biochemistry . 06May2021
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May 06, 2021 |
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Lymphocyte and Resident Microglia participate in CNS formation, Epigenetic Modifications and Neurodegeneration via RAG-Recombinase. Authentic Biochemistry Podcast by DJGPhD. 27 April 2021
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Apr 28, 2021 |
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The RAG Recombinase Interacts with T lymphocyte Programmed Cell Death Loci. Dr Dan Guerra Authentic Biochemistry Podcast 26 April 2021
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Apr 26, 2021 |
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Dr. Guerra presents: The CNS and the Immune System are linked to Recombination and the Epigenome. Lecture IV. 24.4.21 Authentic Biochemistry
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Apr 24, 2021 |
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Authentic Biochemistry Neuroimmune and Epigenetic Interactions in Aging III. DJGPhD 21.4.21
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Apr 21, 2021 |
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The immune system is both genetically programmed and environmentally adaptable to epigenetic states. Lecture II DJGPhD 19 April 2021
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Apr 20, 2021 |
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The Immuno-Epigenome Contribution to Aging Foundation Lecture I. DJGPhD 18.4.21
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Apr 18, 2021 |
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T lymphocyte caveolae and the efficiency of effector cell differentiation. DJGPhD 4.4.21 Authentic Biochemistry
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Apr 04, 2021 |
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Involving Instanence. A Philosophical Episode on Authentic Biochemistry. DJGPhD 31 March 2021
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Mar 31, 2021 |
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Caveolae and Alzheimer's Disease. The Micro-vasculature Paradigm: Endothelial Cell Corruption in the CNS Authentic Biochemistry . Dr Guerra. 26 March 2021
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Mar 27, 2021 |
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Lipoprotein synthesis, turnover and trafficking in concert with caveolae-mediated lipid transport. Dr Dan Guerra Authentic Biochemnistry. 25.3.21.
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Mar 25, 2021 |
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Condensed Bioenergetics : Dr Guerra Drives the Electron Transport Chain via Standard Oxidation Reduction Potentials. 21.3.21
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Mar 22, 2021 |
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Landing on epithelial-mesenchymal transition and T lymphocyte selection to explore Senescence-Associated Cancer-like Stem Cells. DJGPhD 20.3.21
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Mar 21, 2021 |
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ADP- Glucokinase is essential for T lymphocyte activation and pro-inflammatory cytokine synthesis and secretion. DJGPhD. 19.3.21
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Mar 19, 2021 |
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The control of C flux in the liver, pancreas and CNS are coordinated: Potential Axis for Immuno Senescence X Intermediary Metabolic Regulation.Authentic Biochemistry . 15 March 2021. DJG PhD.
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Mar 16, 2021 |
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The pyridoxal phosphate contribution to amino acid metabolism and neurotransmitter turnover Dr Guerra Authentic Biochemistry 10 March 2021
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Mar 11, 2021 |
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Reactive Oxygen and the gamma-glutamyl cycle for GSH redox biochemistry and the prolegomena of neurodegeneration. DJGPhD 09March21'
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Mar 09, 2021 |
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Deacylation regulation of amino acid catabolism as a source of multiple bioenergetic and discrete excitotoxicity phenomena. DJGPhD . 03March2021
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Mar 04, 2021 |
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Amino Acid Catabolism via Sirtuins Modulation and the Redirecting of Hepatic and Intestinal Intermediary Metabolism. Dr Guerra Authentic Biochemistry. 02 March 2021
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Mar 02, 2021 |
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Sirtuins obtain a significant role in mitochondrial metabolism linked to caloric restriction and cancer. Dr Guerra. Authentic Biochemistry.26.02.21
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Feb 26, 2021 |
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Thermodynamics and regulation involving lipoic acid biochemistry of the classical 2-oxo acid dehydrogenase complexes. Dr Guerra 23.02.2021
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Feb 23, 2021 |
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Physical Biochemistry of Free Energy Transfer for Membrane Transport of Molecules and Ions.Dr Dan Guerra 19 Feb 2021
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Feb 20, 2021 |
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Membrane Proteins 1 Mini Lecture Dr Guerra 19 Feb 2021
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Feb 20, 2021 |
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Application of the Principle of Sufficient Reason to Biochemical Thermodynamics. Dr Dan Guerra 13 February 2021
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Feb 14, 2021 |
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Cell Cycle kinase inhibition may improve healthy cardiac aging while promoting global tumorigenesis. Authentic Biochemistry 10Feb2021 by Dr Guerra.
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Feb 11, 2021 |
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Adipokine Update Lecture 2. Authentic Biochemistry Podcast. Dr. Dan Guerra Published 06 Feb 2021
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Feb 07, 2021 |
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Adipokine Mini Review I Daniel J. Guerra, PhD. 03 Feb 2021 Authentic Biochemistry Podcast Publications.
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Feb 04, 2021 |
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Neuropeptide Y and the POMC neuronal antagonism in feeding behaviour maps onto fear conditioning. Dr. Dan Guerra 28 January 2021
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Jan 28, 2021 |
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Neuropeptide Y and the fear conditioning response: are aging and obesity prodromal to anxiety and cognitive decline? Daniel J. Guerra PhD. Published 25 January 2021
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Jan 25, 2021 |
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Corticotropin Releasing Factor and the Monoamine Fear Response in Aging. Sequence II. The reverse learning scenario as cognitive redistribution of neural transmission valency. DJGPhD.21.01.2021.
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Jan 21, 2021 |
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The Corticotropin Releasing Factor and the Somatosensory Catecholamine Circuit in ExtraDimensional (attentional) Shifting. Dr Guerra 20 Jan 2021.AB.
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Jan 20, 2021 |
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Aging-associated SASP vs. MiDAS is a contrarion trade-off that may lead to neurodegeneration and autoinflammation vs tumorigenesis and heart disease respectively. Dr. Dan Guerra.17 Jan 2021. AB
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Jan 17, 2021 |
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An Immunological Distinction between Senescence linked Secretory Phenotypes: SASP vs. Midas. Dr. Dan Guerra. Authentic Biochemistry 16 Jan 2021
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Jan 17, 2021 |
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The stress-induced Neural Network tracks Kantian Epistemology through characteristic action potential and neuromodulator/neurotransmitter phenomenology. Dr Guerra 13 JAN 2021.
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Jan 14, 2021 |
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Fear and Aging associated with neuronal conditioning and synaptogenesis via corticotropin releasing hormone. Dr. Dan Guerra; Authentic Biochemistry 13 JAN 2021
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Jan 13, 2021 |
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Fear associated Corticotropin Releasing Factor and the Immune response are linked to CNS neutral Sphingomyelinase I. Dr Dan Guerra 09 January 2021
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Jan 10, 2021 |
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Glycolysis is inhibited in T cells when Glucose 6 P non-competitively inhibits hexokinase after GLUT1 uptake of serum glucose:Setting the stage for lipogenesis.
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Jan 07, 2021 |
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The Porosomal complex and complex lipid interconversions organizing the transport and secretion of cytokines after T cell Receptor Activation by APC's
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Jan 06, 2021 |
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Inhibitory PFK1 palmitoylation is facillitated by Acid Sphingomyelinase. Daniel J. Guerra, PhD. Authentic Biochemistry Podcast 02 January 2021
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Jan 03, 2021 |
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T lymphocyte maturation and memory cell accumulation are differentially mediated by sphingomyelinase and protein palmitoylation. Dr Dan Guerra. 01 Jan 2021
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Jan 01, 2021 |
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Tumor cells and T lymphocytes carry forward initially similar and subsequently distinct bioenergetic regulation through AMPK. Dr Guerra Authentic Biochemistry 30 Dec. 2020
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Dec 30, 2020 |
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T cell metabolic Dialectics : deriving bioenergetic supremecy from glycolysis through fatty acid and lipid synthesis to ultimate fatty acid oxidation and ATP generation. Dr Daniel J. Guerra
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Dec 30, 2020 |
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On the Concept of Neuro-Correlation: A Theoretical Essay. Dr. Daniel J. Guerra . Authentic Biochemistry. 25 December 2020
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Dec 26, 2020 |
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T Cell signal transduction involves kinase and transcription factor mediated expression of bioenergetic ensemble gene products. Dr DJ Guerra 23 December 2020
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Dec 23, 2020 |
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From Glucose to Triacylglycerol in the developing T lymphocyte. Dr Daniel J. Guerra. Authentic Biochemistry 21 December 2020
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Dec 23, 2020 |
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The Misguided Linkage of Potentially Ablating Aging -Associated Metabolic Syndrome by tracking NAD+ serum levels. Dr. Daniel Guerra. 17 December 2020.
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Dec 17, 2020 |
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Intermediary metabolism plays an essential role in immune cell activation that may lead to tissue degeneration, lipid accumulation and oncogenesis in the aging human. Dr. Guerra. 14 December 2020.
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Dec 15, 2020 |
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Further Inquiries into The Immune System and The Aging Central Nervous System: The PDH/LDH/PDHK1 Axis. Dr. Dan Guerra 13 December 2020.
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Dec 13, 2020 |
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What T -cell Acute Lymphoblastic Leukaemia and Senescing microglial CNS disease have in common relate to Notch and Glucocorticoid signaling. DJGPhD 07 December 2020
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Dec 08, 2020 |
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Dr. Guerra interrogates Notch signalling in T lymphocte early development as prolegomena to immunodystrophy obtained with aging. 05 Decemeber 2020
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Dec 06, 2020 |
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From Bioenergetics to Cardiac Function and Thymocyte differentiation in the Aging Population. Dr. Daniel J. Guerra 02 December 2020.
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Dec 03, 2020 |
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Dr. Guerra herds the Hippo Pathway into T lymphocyte mediated autoimmune disease and cancer in the aging human Authentic Biochemistry 16 November 2020
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Nov 16, 2020 |
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T cell receptor excision circles (TRECs) are generated in the thymus and are potential indicators of acquired immune disorders in neuropsychiatry and senescence.
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Nov 15, 2020 |
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Dr. Guerra explains the ID2 HLH pseudo transcriptional corridor in leukemia and aging. 11 November 2020
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Nov 12, 2020 |
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Multiple Transcription Factor functional integration from immune cell lineages coordinate gene expression that maintains responses to intestinal infection during aging
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Nov 10, 2020 |
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Transcription Factor NFil3 tracks the circadian clock to microbiome linked immune cascade in the gut. Dr. Daniel J. Guerra 09 Nov. 2020
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Nov 10, 2020 |
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Dr Guerra illustrates that NFIL3 represses genes by recruiting Sirtuin 2 and G9a histone methyltransferase eo ipso regulating diverse biological processes,
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Nov 02, 2020 |
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The Circadian clock and the Acquired Immune Response coordinate at the event of transcription factor mediated aging phenotype. Dr Daniel J. Guerra
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Oct 29, 2020 |
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Animals have adapted behavioral responses corresponding with light and temperature events to respond to and anticipate basic bioenergetics due of heterotrophy. Authentic Biochemistry . 28/10/2020
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Oct 29, 2020 |
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While Melatonin binding to the MT1 and MT2 receptors may benefit aging via suppression of oncogenic gene expression and enhancement of the SCN sleep wake cycle, receptor loss occurs with senescence.
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Oct 25, 2020 |
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L-TRP is precursor to MEL and NAD ;Mel regulates Sirtuins which Perform DSB repair; NAD metabolism after SIRT activity yields PAR for SSB repair. DJGPhD 21 Oct 2020.
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Oct 22, 2020 |
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The Association of NAD+, Melatonin, &Sirtuins via DNA Damage Repair and Epigentic Chromatin Remodeling with Immunosenescence is evident
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Oct 21, 2020 |
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DDR and the roles of Sirtuins and the NAD metabolic paradigm in aging. Published by Authentic Biochemistry Dr. Daniel J. Guerra 19 Oct 2020
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Oct 20, 2020 |
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Dr Guerra presents :"Deacetylase Agency in NAD+ and ADP Ribose Metabolism as the Equipoise for Cell Fate In Aging and Disease" 14 Oct.2020
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Oct 15, 2020 |
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Dr Daniel J. Guerra of Authentic Biochemistry lectures on Senescence in Human Aging: The Sirtuin Intrusion
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Oct 12, 2020 |
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Dr. Guerra obtains a dialectical analysis of the pineal hormone melatonin in deacetylase-mediated Respiratory disease and aging
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Oct 08, 2020 |
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Dr. Daniel Guerra presents Immuno Diaeventontological Framing of the Aging Human IV: SASP to cGAS via Melatonin
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Oct 08, 2020 |
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Dr. Guerra finds that the tumor-promoting and suppressing biochemical phenotypes of senescence are phenomenologically contrarion and thus physiologically compatible
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Oct 04, 2020 |
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Is cancer. or survival-achieving chemotherapy to treat early-onset tumorigenesis, linked to late in life senescence and human aging? The CD8+ T lymphocyte link.
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Sep 27, 2020 |
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Dr Guerra suggests targeting senescence as a means to alter the rate of aging is contrarion to healthy outcome because of derepression of tumorigenesis.
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Sep 22, 2020 |
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Senescence and Aging Relative to T lymphocytes may be linked to chemotherapy of testicular cancer and underlying cell cycle-CD transcriptional mutations.
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Sep 20, 2020 |
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Thymic involution-associated naive cd4+/cd8+ Tcell differentiation as observed in care-giver neuropsychological conditioning toward non-chronological immunosenescence.
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Sep 18, 2020 |
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The teleology of Thymus mediated T regulatory cell clonal elimination and expansion via membrane associated receptor ligand interactions with innate and lymphocyte linneages. Dr Daniel J. GUERRA
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Sep 17, 2020 |
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Dr Guerra presents: The Agency of the Immune System Treg Lymphocytes in Senescence and Human Aging. Authentic Biochemistry Podcast.14 September 2020
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Sep 14, 2020 |
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Glucocorticoid Associated Naive Treg Differentiation and the Role of T Memory and Treg Sub-populations in Aging and End Stage Renal Disease
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Sep 09, 2020 |
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Innate Like Lymphocyte and T Regulatory Cell Modulation against a backdrop of Immunostimulatory Effectors 01 September 2020.
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Sep 01, 2020 |
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T lymphocyte and MVA pathway cross-talk in Breast Cancer, Lymphomas, Leukemias, CVD and aging. 24 August 2020
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Aug 24, 2020 |
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The Sterol Response Element Binding Protein expression, cellular translocation and transcription factor pathways in T cell activation. 18 August 2020. by Dr Dan Guerra
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Aug 19, 2020 |
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Dr Guerra lectures about Chronic Genomic Instability as a means to an end called senescence. Published 06 August 2020.
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Aug 07, 2020 |
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Dr Guerra discusses canonical Programmed Cell Death. Published 05 August 2020
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Aug 05, 2020 |
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The Aging biochemical landscape as associated with chromatin organization and the alteration of cell cycle dynamics leading to the Senescence Associated Secretory Phenotype
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Aug 04, 2020 |
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Dr Guerra discusses how Isoprenoid metabolism is linked to T cell activation via glycolysis and glutaminolysis. 02 August 2020
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Aug 02, 2020 |
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Dr Guerra discusses the mTORC -AMPK axis and the control of the rate of aging as central to the slow growth hypothesis to longevity. 01 August 2020
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Aug 01, 2020 |
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Dr Guerra discusses aging associated oxidative phosphorylation, gluconeogenesis, NAD+ sirtuin activity and telomerase. 30 July 2020
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Jul 30, 2020 |
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The Categorical Logic of Aging Systems as Influenced by Nutrition and the Introduction of Pharmacotherapeutics that Target Disease. Lecture VI. Published 27 July 2020.
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Jul 28, 2020 |
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The triad of biological auto-oxidation and the progress of aging as sine qua non to pathology. Published 26 July 2020.
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Jul 26, 2020 |
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Reactive oxygen is generated in biological systems leading to a physiological transit to senescence. Published 24 July 2020
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Jul 25, 2020 |
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The oncogenic intermediary metabolic corruption as contrarion ontology to aging. Published 24 July 2020.
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Jul 24, 2020 |
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Biochemical/Physiological Paradigms of Aging and Tumor Metabolism: the classical Warburg Aerobic Glycolysis and Krebs Cycle Corruption. 21 July 2020.
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Jul 21, 2020 |
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Dr Guerra starts a series on the biochemistry and physiology of human aging and the ontology of sequential phenomenon in living systems. 19 July 2020.
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Jul 19, 2020 |
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Neutrophil Elastase and the extracellular trap mediated hyperinflammatory response leading to pulmonary edema, Na+ hyperabsorption: linkage to coronavirus .
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Jul 12, 2020 |
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Neutrophil elastase-mediated pulmonary disease including Cystic Fibrosis, RDS, COPD and viral pneumonia 10 July 2020
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Jul 10, 2020 |
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A Narrative on the Nature of Belief as Universal within Knowledge yet Regularly Discounted in the Scientific World View. 09 July 2020
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Jul 09, 2020 |
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Serpins and the Neutrophil Extracellular Traps in Respiratory Distress and the Coronavirus. 08 July 2020
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Jul 08, 2020 |
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Dr Guerra examines proteases and protease inhibitors in ovarian and hepatocellular cancers and their pathobiochemical mechanisms. 03 July 2020.
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Jul 03, 2020 |
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The Role of Alpha anti-trypsin in the IL-1 pro-inflammatory cascade. 30 June 2020
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Jun 30, 2020 |
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SERPINs and the Acute Phase Response in the Pathophysiological State. Dr Dan Guerra, 29 June 2020
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Jun 29, 2020 |
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Dr Guerra Presents: Serine Protease Inhibitor Biochemistry in Human Health and Disease I. 25 June 2020
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Jun 25, 2020 |
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Dialectical Event Ontological Analysis of the Scientific Method as Prolegomena to a Recap of PEDF in Hepatocellular Carcinoma
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Jun 19, 2020 |
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Dr. Guerra presents: Contrarion opposition of PEDF in Tumor progression explained via dyslipidaemia and corruption of AMPK mediated control. 12 June 2020.
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Jun 12, 2020 |
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Dr Guerra's second lecture on T2D and its link to Obesity plus a bonus Clinical Misdiagnosis Study Question Review. 31 May 2020
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May 31, 2020 |
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Dr Guerra discusses Obesity-linked Type 2 Diabetes and clinical manifestation of the disease
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May 31, 2020 |
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Nutritional biochemistry and the obesogenic induction of insulin resistance and type-2 diabetes. Dr Daniel J. Guerra. 25 May 2020
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May 26, 2020 |
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Obesity and pathophysiological Implications including hyper-Immunity, increased susceptibility to serious infection and high-mortality disease.
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May 25, 2020 |
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Basic Endocrine Hormone Nomenclature and physiological biochemistry. Authentic Biochemistry 14 May 2020.
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May 14, 2020 |
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General Hormone Lectures II. The Hypothalamic Pituitary Axis. Dr Daniel Guerra. 05 May 2020.
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May 05, 2020 |
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General Human Hormone Physiology and Biochemistry Lecture I. Published by Dr Daniel J. Guerra. 04 May 2020
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May 04, 2020 |
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From Hypothalamic POMC to Palmitate and back again: Lipid Metabolism needs to Be Authenticated. Dr Dan Guerra. 28 April 2020.
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Apr 28, 2020 |
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Chapter V Immuno Endocrinology of Disease Dr Dan Guerra Authentic Biochemistry Podcast 27 April 2020
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Apr 27, 2020 |
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Request to check out my video lectures and subscribe to my podcast and YouTube Channel; This will add tremendous excitement and freedom to your day!
|
Apr 23, 2020 |
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ASM-generated Ceramide Lipid Rafts and the Fatty Acid Transport Protein in the Hyperimmune Disease Response.
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Apr 12, 2020 |
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How do Sphingolipids associate with SSRI's to offer advice to Pharmacologists working on Coronavirus?
|
Apr 11, 2020 |
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Dr. Guerra uses Logical and Scientific Principles to Perform a Dialectic On the Validity of COVID 19 Corona virus Pandemic. 23 March 2020.
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Mar 23, 2020 |
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Dr Guerra's Epistemology and Metaphysics informing a Scientific World View III. Recorded 20 March 2020.
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Mar 20, 2020 |
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Dr. Guerra's Epistemology and Metaphysics of a Scientific World View. Part II. 15 March 2020.
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Mar 16, 2020 |
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Dr. Guerra Introduces his epistemology and metaphysics that ground his scientific world view. 11 March 2020
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Mar 12, 2020 |
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Dr. Dan Guerra further discusses Ceramide and Sphingosine Mediated cell fate in Pathobiochemistry IV. March 04, 2020.
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Mar 04, 2020 |
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Dr Guerra presents today's podcast: Lipid –Associated Pathobiochemistry III. March 3 2020
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Mar 03, 2020 |
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Dr.Guerra authenticates evidence in lung Inflammation and associated resident macrophages in disease. 01 March 2020
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Mar 01, 2020 |
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Sphingolipid linked Coronavirus, Neurodegenerative, Neuropsychiatric and Inflammatory disease.
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Feb 28, 2020 |
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Dr Guerra examines Sphingolipids as mediators of Inflammasome Formation and Potency in Coronavirus
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Feb 20, 2020 |
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Authentic Biochemistry examines the epidemiology of the Novel Coronavirus Infectious Pneumonia of 2020. Episode II.
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Feb 03, 2020 |
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Dr Guerra presents the molecular organization, pathology, and transmission of the Novel Coronavirus Infective Pneumonia (NCIP). I.
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Jan 31, 2020 |
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Lupus Autoimmune Disease involves a specialized set of plasma and T cell lineages: From Dr. Dan Guerra 28 January 2020.
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Jan 28, 2020 |
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Dr Guerra explains how folic acid, homocysteine, and ceramide apprehend the pro-inflammatory neurodegenerative paradigm
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Jan 22, 2020 |
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Part III. Autoimmune Disease : essential background and cellular dynamics. Dr Dan Guerra
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Jan 20, 2020 |
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Dr Guerra brings the autoimmune disease discussion into view. 31 December 2019
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Jan 01, 2020 |
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T lymphocyte mediated autoimmune diseases as arising from immunological networking Dr. Guerra . 18 December 2019
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Dec 19, 2019 |
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T lymphocyte mediated auto inflammation from Dr. Guerra's Authentic BIOCHEMISTRY
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Dec 17, 2019 |
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Episode 2 of Authentic Biochemistry Foray into Epigenetics. Dr Dan Guerra. 01 November 2019
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Nov 02, 2019 |
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Lecture 1 on General Epigenetics from Dr Guerra of Authentic Biochemistry on 29 October 2019
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Oct 30, 2019 |
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Dr Dan Guerra provides a Leptin Coda
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Oct 16, 2019 |
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The Adipokine Leptin in Lupus, Osteoporosis and Glioma
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Oct 10, 2019 |
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The Homeostatic Roles of Leptin in Obesity and Disease: the adaptive biochemical evolution and dysfunction of lipid homeostasis
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Oct 02, 2019 |
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Leptin Molecular Endocrinology #2 Dr Guerra further explores the adipokine-mediated CNS.
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Sep 23, 2019 |
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Leptin's critical role in the HPA hormonal axis: a saturating overview 22 Sept 2019 DJGPhD
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Sep 22, 2019 |
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Primer on Omega 6 and Omega 3 Long chain polyunsaturated fatty acid metabolism in humans with Clinical Event Ontology
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Sep 09, 2019 |
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Dr Guerra provides an in-depth interrogation of lipid metabolism of omega three fatty acids and their complex roles in controlling inflammation.
|
Sep 04, 2019 |
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Do Omega three fatty acids ameliorate obese adipose derived inflammation via a T cell response?
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Sep 03, 2019 |
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Dr. Guerra finishes the Treg lectures by drawing upon on a transcription factor molecular thread of Ariadne to deliver T cell lineage architechtonics.
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Aug 18, 2019 |
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Dr Guerra reports on evidence that Treg cells are negatively controlled by Nfil3 via inhibition of FOXp3 transcription while activating Th1 and Th2
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Aug 17, 2019 |
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Dr Guerra moves onward through the T cell lineages to an event ontology for Treg Stimulation/Activation and Stabilization IV.
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Aug 15, 2019 |
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T-regulatory Transcription Factor modulation directs lineage adaptation and potency in a pro-inflammatory environment
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Aug 13, 2019 |
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Innate lymphoid cells and the frank T lymphocyte family as controlled by cytokinogenesis, co-stimulation, and Tregs. Part I.Dr Dan Guerra
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Aug 04, 2019 |
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Prolegomena to T regulatory cell transcriptional control mechanisms and a request to subscribe from Dr. Guerra
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Aug 04, 2019 |
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The fate of the mammalian CNS is a matter of lipid sponsored program cell death
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Jul 13, 2019 |
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Dr. Guerra provides a clinical discussion of HCC pathogenesis and treatment including the role of HCV. 03 July 2019
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Jul 03, 2019 |
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SERPIN mediates transcriptional control over pro-tumorigenic pathways including a phosphatidyl inositol 1,3 kinase delta mediated mechanism.
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Jun 30, 2019 |
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Dr Guerra admits Serpin mediated cancer ablation is multivalent and pharmaceutically treacherous
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Jun 29, 2019 |
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Introduction to Proteases and Protease Inhibitors as Prolegomena to Specific HCC pathophysiology
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Jun 26, 2019 |
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HCC Episode VII. Dr Guerra tackles the pathogenecity of the serine proteinase inhibitor paradigm . 08 JUne 2019
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Jun 08, 2019 |
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Hepatocellular Carcinoma Pathobiochemistry Chapter/Lecture V from Dr. Daniel J. Guerra. Authentic Biochemistry.28 May 2019.
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May 28, 2019 |
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Dr Guerra Characterizes How Glycolytic Enzymes Proxy Oncogenically in Prodromal Hepatocellular Carcinoma. 26 May 2019
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May 26, 2019 |
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Dr Guerra introduces the pseudo-paradoxical irony of Pyruvate kinase M2 expression toward the biochemical Aetiology of HCC
|
May 23, 2019 |
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Authentic Biochemistry Podcast. Dr. Dan Guerra presents Heptaocellular Carcinoma Part II: Metabolic and Signal Transduction Cascades
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May 17, 2019 |
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Dr Guerra Starts his podcast lecture sequence on Obesity and Hepatocellular Carcinoma. Series session#1
|
May 15, 2019 |
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HDAC 4 is a positive player in ALS muscle since it is not a functional histone deacetylase: The complexity of motor neuron disease reveals not-so-subtle differences in protein function
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Apr 16, 2019 |
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Dr Guerra continues : Glutamate induced ferroptosis involves lipid peroxidation and ceramide production leading to an inflammatory response in neurodegeneration
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Mar 25, 2019 |
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Dr Daniel Guerra introduces a novel PCD pathway- ferroptosis- that is linked to excitotoxicity and lipid peroxidation leading to neurodegeneration. Part I
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Mar 25, 2019 |
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Authentic Biochemistry #3. Dr Guerra verifies the evidence to a future biochemical prolegomena for Alzhiemer's Disease
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Mar 10, 2019 |
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The Diaeventontology of Biological Systems
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Feb 27, 2019 |
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Introduction to Authentic Biochemistry Podcast
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Feb 23, 2019 |