Guidewire is a behind-the-scenes peek into the world of medical device innovation and problem discovery. Our team of medical device design engineers dive into the nuances, challenges and considerations that go into finding and solving high-impact unmet medical needs at a large university hospital. Hosted by Devin Hubbard of FastTraCS and the Joint Department of Biomedical Engineering at the University of North Carolina and North Carolina State University. The project described was supported by the National Center for Advancing Translational Sciences (NCATS), National Institutes of Health, through Grant Award Number UL1TR002489. The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH.