Inspired by the idiomatic expression that signifies a profound shift in perspective, Sea Change explores how cutting-edge computational tools are transforming our understanding of biodiversity. Hosted by the Biodiversity Data Science Research Group, this podcast delves into the mechanisms driving life on Earth, from genes to ecosystems, and from past climate fluctuations to future change scenarios. Through the power of machine learning, artificial intelligence, and big-data analytics, we reveal the patterns shaping biodiversity and the challenges posed by climate change, habitat loss, and human impact. Our mission is to make science accessible—sharing insights, methodologies, and open data following the FAIR principles so that policymakers, managers, and citizens alike can make informed decisions for the future of our planet.