Pearls and Prep

By NP Z

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Episodes: 127

Description

There are two kinds of clinicians — the ones who follow algorithms, and the ones who understand the "why." Be the second: https://www.patreon.com/PearlsandPrep — study guides, psychopharm deep dives & practice questions. 📚 Get the 100 Psychiatric Interview Tips For Your 1st Eval E-Book — $39.99 in the shop (free for Boss Pearl members): https://www.patreon.com/c/pearlsandprep/shop Pearls and Prep: Psychiatric Case Studies helps you get the why and build clinical confidence. Each episode walks you through a real-world psychiatric case — from chart review to treatment plan — covering psychopharmacology (SSRIs, SNRIs, SGAs, mood stabilizers), DSM-5-TR differential diagnosis, and evidence-based prescribing. 💊 Psychopharmacology breakdowns: mechanisms, half-lives, side-effect pearls 🧠 DSM-5-TR differential diagnosis deep-dives 📌 Memory hooks, screening questions & documentation phrases 🎯 Built for PMHNP students prepping for ANCC/AANP boards — and clinicians sharpening their edge New episodes every Tuesday. Hosted by NP Z, Duke-trained Psychiatric Nurse Practitioner. This podcast uses the following third-party services for analysis: Podcorn - https://podcorn.com/privacy

Episode Date
Strattera (Atomoxetine) vs Wellbutrin (Bupropion): Non-Stimulant Uses | PMHNP Boards
Oct 17, 2026
Saphris (Asenapine): Bipolar Mania & Schizophrenia Prescribing | PMHNP Boards
Oct 13, 2026
Wellbutrin (Bupropion) vs Trintellix (Vortioxetine) After SSRI Failure | PMHNP Boards
Oct 11, 2026
Vraylar (Cariprazine) vs Abilify (Aripiprazole): D2, D3 Differences | PMHNP Boards
Oct 06, 2026
Panic Disorder vs PTSD: Differential Diagnosis Case Study | PMHNP Boards
Sep 29, 2026
Schizoid vs Schizotypal Personality Disorder: Clinical Clues | PMHNP Boards
Sep 22, 2026
Latuda (Lurasidone): When It Shines & When It Falls Short | PMHNP Boards
Sep 15, 2026
Effexor (Venlafaxine) vs Cymbalta (Duloxetine): SNRI Differences | PMHNP Boards
Sep 08, 2026
Psychiatric Interview Skills: 4 Techniques for New PMHNPs | PMHNP Boards
Sep 04, 2026
Long-Acting Injectables (LAIs) in Psychiatry: Benefits Explained | PMHNP Boards
Sep 01, 2026
False Positive Drug Screens: What Psychiatric Providers Must Know | PMHNP Boards
Aug 25, 2026
ADHD vs Bipolar Disorder: Key Questions for Differential Diagnosis | PMHNP Boards
Aug 11, 2026
Insomnia in Psychiatric Patients: Depression, Anxiety, ADHD & Trauma | PMHNP Boards
Aug 10, 2026
Effexor (Venlafaxine): When & Why to Choose This SNRI | PMHNP Boards
Aug 08, 2026
Metformin for Antipsychotic Weight Gain: An Easy Win | PMHNP Boards
Aug 04, 2026
Prozac (Fluoxetine) vs Zoloft (Sertraline): Real SSRI Differences | PMHNP Boards
Aug 03, 2026
PTSD vs Depression vs Adjustment Disorder: Differential Diagnosis | PMHNP Boards
Jul 31, 2026
Choosing Antipsychotics for Bipolar Disorder: 4 Prescribing Pearls | PMHNP Boards
Jul 30, 2026
Antipsychotic Switching: Key Concepts & Clinical Considerations | PMHNP Boards
Jul 28, 2026
Psychopharmacology Made Simple: The Grocery Store Trick | PMHNP Boards
Jul 26, 2026
Bipolar Relapse Prevention: The Polarity Index Explained | PMHNP Boards
Jul 24, 2026
Abilify (Aripiprazole) for Depression: Augmentation Explained | PMHNP Boards
Jul 23, 2026
The Polarity Index: Choosing Bipolar Maintenance Medications | PMHNP Boards
Jul 22, 2026
Naltrexone & the Sinclair Method for Alcohol Use Disorder | PMHNP Boards
Jul 21, 2026
ADHD Stimulants Explained: 5 Prescribing Pearls | PMHNP Boards
Jul 16, 2026
PMDD: Why SSRIs Work in Days — Diagnosis & Luteal-Phase Dosing | PMHNP Boards
Jul 15, 2026
Caffeine & Mood Disorders: The Detail That Derails Treatment | PMHNP Boards
Jul 14, 2026
CYP450 for Psychiatric Prescribers: 3 Clinical Pearls | PMHNP Boards
Jul 13, 2026
Same SSRI Dose, Different Outcomes: CYP Enzymes & Protein Binding | PMHNP Boards
Jul 11, 2026
Antidepressant Not Working? 4 Questions to Ask First (Zoloft Case) | PMHNP Boards
Jul 07, 2026
Irritability Differential Diagnosis: Depression, ADHD, Bipolar & More | PMHNP Boards
Jul 05, 2026
Z-Drugs (Zolpidem, Eszopiclone, Zaleplon): Prescribing Pearls | PMHNP Boards
Jul 01, 2026
Lexapro (Escitalopram): Efficacy & Tolerability Evidence | PMHNP Boards
Jun 30, 2026
Depersonalization vs Panic vs PTSD: Diagnostic Case Study | PMHNP Boards
Jun 23, 2026
Kratom: 5 Clinical Pearls for Psychiatric Providers | PMHNP Boards
Jun 19, 2026
ADHD Inattentive Type: DSM-5-TR Criteria Made Memorable | PMHNP Boards
Jun 16, 2026
DSM-5-TR Sleep-Wake Disorders: All 10 Categories Explained | PMHNP Boards
Jun 15, 2026
Adjustment Disorder: 5 Things Clinicians Get Wrong | PMHNP Boards
Jun 14, 2026
Paxil (Paroxetine) Withdrawal vs Depression Relapse | PMHNP Boards
Jun 12, 2026
Borderline Personality Disorder: A New Way to Understand BPD | PMHNP Boards
Jun 11, 2026
Cannabis-Induced Psychosis vs Schizophrenia: How to Tell | PMHNP Boards
Jun 10, 2026
Illness Anxiety vs Somatic Symptom vs Factitious vs Malingering | PMHNP Boards
Jun 09, 2026
ADHD vs Anxiety: The Differential That Changes Everything | PMHNP Boards
Jun 08, 2026
Personality Disorders: 4 Ways They Disrupt Treatment Plans | PMHNP Boards
Jun 07, 2026
Tardive Dyskinesia: How to Spot It & What to Do | PMHNP Boards
Jun 06, 2026
Tardive Dyskinesia Risk Factors: Who's Most at Risk? | PMHNP Boards
Jun 05, 2026
Benzos for Flying Phobia: Pharmacokinetics & Prescribing | PMHNP Boards
Jun 04, 2026
OCD vs PTSD vs GAD vs Psychosis: Differential Case Study | PMHNP Boards
Jun 03, 2026
Major Depressive Disorder with Psychotic Features: 6 Pearls | PMHNP Boards
Jun 02, 2026
Autoreceptors Explained: The Key to Psychopharmacology | PMHNP Boards
Jun 01, 2026
Topamax (Topiramate) Explained: A McDonald's Analogy | PMHNP Boards
May 31, 2026
Ferritin & Mental Health: The Lab That Mimics Half the DSM | PMHNP Boards
May 30, 2026
Hydroxyzine for Anxiety: The Misunderstood Non-Benzo Option | PMHNP Boards
May 29, 2026
Auvelity (Dextromethorphan-Bupropion): NMDA & Sigma-1 Explained | PMHNP Boards
May 28, 2026
Abilify (Aripiprazole) & Impulse Control: The Gambling Side Effect | PMHNP Boards
May 27, 2026
Major Depressive Disorder Specifiers: Mixed, Anxious & Melancholic | PMHNP Boards
May 26, 2026
Luvox (Fluvoxamine): Sigma-1 Receptors, OCD & Anxiety | PMHNP Boards
May 25, 2026
Serotonin, Dopamine & Norepinephrine: Choosing the Right Target | PMHNP Boards
May 24, 2026
OCD vs Delusional Disorder: A Tricky Case Study | PMHNP Boards
May 23, 2026
Antipsychotic Cross-Taper: 4 Switching Pearls | PMHNP Boards
May 22, 2026
OCD Gold Standard Treatment: What Most Clinicians Miss | PMHNP Boards
May 21, 2026
MDD with Mixed Features: Treatment When SSRIs Don't Fit | PMHNP Boards
May 19, 2026
Schizophrenia Negative Symptoms & Vraylar (Cariprazine): D3 Explained | PMHNP Boards
May 18, 2026
Schizophrenia Negative Symptoms: Board Bomb Case Study | PMHNP Boards
May 17, 2026
BPD vs Persistent Depressive Disorder: How to Tell Apart | PMHNP Boards
May 16, 2026
Trazodone: More Than a Sleep Med — Receptors & Prescribing | PMHNP Boards
May 15, 2026
Gabapentin in Psychiatry: Uses, Myths & Prescribing | PMHNP Boards
May 14, 2026
Specific Phobia: The Most Common Anxiety Disorder | PMHNP Boards
May 13, 2026
Post-Discharge Suicide Risk: The Most Dangerous Window | PMHNP Boards
May 12, 2026
Lamictal (Lamotrigine) vs Seroquel (Quetiapine) for Bipolar Depression | PMHNP Boards
May 11, 2026
Antidepressant-Induced Bruxism: The Hidden Side Effect | PMHNP Boards
May 10, 2026
Bipolar Medication Mistakes: Board Bomb Case Study | PMHNP Boards
May 09, 2026
Depakote (Valproate) Toxicity: The Red Flag You Can't Miss | PMHNP Boards
May 08, 2026
Invega Sustenna (Paliperidone): LAI Initiation Board Bomb | PMHNP Boards
May 07, 2026
Positive Drug Screen on Psychiatric Meds: What Now? | PMHNP Boards
May 06, 2026
Spot the Medication Error: Mock Regimen Curveball | PMHNP Boards
May 05, 2026
Metformin with Antipsychotics (SGAs): The Underuse Problem | PMHNP Boards
May 04, 2026
Bipolar vs MDD with Psychosis: Board Bomb Diagnosis | PMHNP Boards
May 01, 2026
Acute Bipolar Depression: 5 Essential Medications | PMHNP Boards
Apr 28, 2026
Ambien (Zolpidem) ER Visits & Psych Med Pharmacokinetics | PMHNP Boards
Apr 27, 2026
Sleep Apnea & Depression: The Untreated Link Doubling Risk | PMHNP Boards
Apr 26, 2026
Affinity, Occupancy & Intrinsic Activity: Nightclub Analogy | PMHNP Boards
Apr 22, 2026
Intrinsic Activity in Pharmacology: Prescribing Explained | PMHNP Boards
Apr 21, 2026
Antidepressants & Anticoagulants: Bleeding Risk Board Question | PMHNP Boards
Apr 19, 2026
Remeron (Mirtazapine): Who It's Perfect For & Who It's Not | PMHNP Boards
Apr 14, 2026
Trazodone for Sleep & Anxiety: Receptors Explained (Case Study) | PMHNP Boards
Apr 07, 2026
ADHD Misdiagnosed as Anxiety: Find the 4 Clinical Errors | PMHNP Boards
Apr 06, 2026
Receptor Occupancy in Pharmacology: A Simple Explanation | PMHNP Boards
Mar 31, 2026
Schizophrenia Case Errors: Can You Spot All 4? | PMHNP Boards
Mar 24, 2026
Board Bombs: 3 High-Yield Psychopharm Questions | PMHNP Boards
Mar 20, 2026
Continuing Antidepressants After Remission: Preventing Relapse | PMHNP Boards
Mar 17, 2026
Drug Affinity (Ki) Explained: The Key to Prescribing | PMHNP Boards
Mar 10, 2026
Modafinil vs Armodafinil: The Subtle Difference That Matters | PMHNP Boards
Mar 03, 2026
Antipsychotic Weight Gain: Histamine, Muscarinic & 5HT2c Mechanisms | PMHNP Boards
Feb 24, 2026
6 Shocking Mental Health Pearls for Clinical Practice | PMHNP Boards
Feb 17, 2026
Second-Generation Antipsychotics: 3 Board-Style Questions | PMHNP Boards
Feb 13, 2026
ADHD with Bipolar Disorder: Stimulant Prescribing Guide | PMHNP Boards
Feb 10, 2026
Serotonin Syndrome: High-Yield Pearls (Zoloft + Tramadol Case) | PMHNP Boards
Feb 03, 2026
Partial Antidepressant Response: Increase, Switch or Augment? | PMHNP Boards
Jan 27, 2026
MDD vs Adjustment Disorder: The Diagnostic Detail That Matters | PMHNP Boards
Jan 25, 2026
Cannabis & Mental Health: 4 High-Yield Pearls | PMHNP Boards
Jan 20, 2026
Remeron (Mirtazapine): 8 Things Every Prescriber Should Know | PMHNP Boards
Jan 13, 2026
Vitamin D & Mental Health: What Clinicians Should Know | PMHNP Boards
Jan 06, 2026
Lexapro (Escitalopram) vs Prozac (Fluoxetine): Full Comparison | PMHNP Boards
Dec 30, 2025
ADHD & Mortality Risk: The 7-Year Life Expectancy Gap | PMHNP Boards
Dec 23, 2025
SSRI Activation & Bipolar Switching: High-Yield Pearls | PMHNP Boards
Dec 22, 2025
Reading Research Like a Pro: P-Values & Stats for PMHNPs | PMHNP Boards
Dec 16, 2025
The Only Transdermal Antidepressant: Selegiline Patch Explained | PMHNP Boards
Dec 09, 2025
Acute Dystonia Management: Clinical Insights (Risperidone Case) | PMHNP Boards
Dec 02, 2025
The Bipolar Blind Spot: 9-Year Diagnosis Delay | PMHNP Boards
Nov 25, 2025
Board Bombs: 3 High-Yield PMHNP Exam Questions | PMHNP Boards
Nov 21, 2025
Caffeine-Induced Anxiety: A Diagnostic Case Study | PMHNP Boards
Nov 18, 2025
Which DSM-5-TR Diagnosis Requires a Rating Scale? | PMHNP Boards
Nov 11, 2025
MDD with Mixed Features: The Case of Gus | PMHNP Boards
Nov 04, 2025
Amitriptyline Side Effects: Board Bomb Question | PMHNP Boards
Oct 28, 2025
ADHD vs Bipolar in Outpatient Care: Avoiding Anchoring Bias | PMHNP Boards
Oct 21, 2025
Board Bombs: Illness Anxiety, Lamotrigine & MAOI Questions | PMHNP Boards
Oct 14, 2025
Prazosin for PTSD Nightmares: Deep Dive & Case Study | PMHNP Boards
Oct 07, 2025
Diagnosing Anxiety Disorders: OCD Case Study (Sarah) | PMHNP Boards
Sep 23, 2025
Abilify (Aripiprazole) Decoded: Dopamine System Stabilizer | PMHNP Boards
Sep 18, 2025
SGA Augmentation for Depression: When SSRIs Aren't Enough | PMHNP Boards
Sep 09, 2025
Performance Anxiety: Diagnosis & Propranolol Treatment | PMHNP Boards
Aug 26, 2025
Depression & Cannabis Use: Treatment Strategies (Case Study) | PMHNP Boards
Aug 26, 2025
Bipolar I Disorder: Diagnosis Through a Mock Patient Case | PMHNP Boards
Aug 26, 2025
Welcome to Pearls & Prep: Psychiatry Cases for PMHNP Students | PMHNP Boards
Aug 12, 2025
MDD with Mixed Features vs Bipolar Spectrum: Demystified | PMHNP Boards
Jan 14, 2025
Vitamin D in Psychiatry: Evidence-Based Pearls | PMHNP Boards
Jan 07, 2025