This Week in Virology

By Vincent Racaniello

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Category: Science

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Subscribers: 1404
Reviews: 6
Episodes: 100


 Aug 8, 2021

Rachael
 Nov 28, 2020
excellent thanks for doing a great job


 May 29, 2020

excellent
 Apr 23, 2020
great information

Reed
 Jan 15, 2020
amazing in depth podcast on the nuts and bolts of all kinds of viruses. expect in depth discussions of papers by experienced scientists with a decent sense of humour. I can follow along most details even though I have not studied virology.

Description

This Week in Virology is a netcast about viruses - the kind that make you sick.

Episode Date
TWiV 1013: Bird flu around the world
01:56:07

TWiV reviews remarkable changes in the epidemiology of avian H5N1 influenza virus leading to previously uninfected areas, involvement of previously unaffected wild birds, and devastating outbreaks in farmed poultry, and isolation of a monoclonal antibody against the influenza virus neuraminidase that inhibits infection with a wide range of A and B isolates.

Hosts: Vincent RacanielloAlan DoveRich ConditKathy Spindler, and Angela Mingarelli

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Weekly Picks

Angela – May’s best science images – Nature
Kathy – Historical reasons for resistance to recognizing airborne transmission
Rich – Scan of Titanic reveals wreck as never seen before – BBC News
Alan – Science Education in an Age of Misinformation
Vincent
 – Equity, Diversity and Inclusion: When communication all changed

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

Jun 04, 2023
TWiV 1012: Clinical update with Dr. Daniel Griffin
37:46

In his weekly clinical update, Dr. Griffin discusses the potential for recurrent Mpox outbreaks among gay, bisexual, and other men who have sex with men, association between SARS-CoV-2 variants and frequency of acute symptoms, prospective study of key correlates for household transmission of SARS-CoV-2, Pfizer’s PAXLOVID™ receiving FDA approval for adult patients at high risk of progression to severe COVID-19, efficacy and safety of antimicrobial stewardship prospective audit and feedback in patients hospitalized with COVID-19, development of a definition of postacute sequelae of SARS-CoV-2 infection, COVID-19 and risk for mental disorders among adults in Denmark, risk of new post-COVID mental disorders higher only in older patients.

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Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to daniel@microbe.tv

Jun 03, 2023
TWiV 1011: Aquatic viruses
01:05:47

Vincent travels to Québec City, Canada and the 11th Aquatic Virus Workshop, where he speaks with Fred Aylward and Jed Furman about the research of their laboratories on the ecology and evolution of aquatic viruses and their microbial communities.

Host: Vincent Racaniello

Guests: Frank Aylward and Jed Fuhrman

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Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

May 28, 2023
TWiV 1010: Clinical update with Dr. Daniel Griffin
35:41

In his weekly clinical update, Dr. Griffin discusses the CDC HIV surveillance report, FDA voted in favor of approving the Abrysvo vaccine, canine olfactory detection of SARS-CoV-2-infected humans, safety of the BNT162b2 COVID-19 vaccine in children aged 5 to 17 years, and statement on the antigen composition of COVID-19 vaccines.

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Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to daniel@microbe.tv

May 27, 2023
TWiV 1009: Nidovirus on the water
01:06:49

Vincent travels to Montreux, Switzerland and the 16th International Nidovirus Symposium, where he speaks with Maria von Kerkhove, the face of COVID-19 for the World Health Organization, and Kanta Subbarao, Director of the WHO Collaborating Centre on Influenza in Melbourne.

Host: Vincent Racaniello

Guests: Kanta Subbarao and Maria von Kerkhove

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Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

May 21, 2023
TWiV 1008: Clinical update with Dr. Daniel Griffin
32:15

In his weekly clinical update, Dr. Griffin discusses variant specific clinical performance of a SARS-CoV-2 rapid antigen test with focus on omicron VOC, ventilation in buildings, COVID-19 mortality among selective serotonin reuptake inhibitor users, risk of post-acute sequelae of SARS-CoV-2 infection associated with pre-coronavirus disease obstructive sleep apnea diagnoses, trajectories of the evolution of post COVID-19 condition, and efficacy of cognitive behavioral therapy targeting severe fatigue following COVID-19.

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Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to daniel@microbe.tv

May 20, 2023
TWiV 1007: Fragile DNA, viruses, cancer
01:40:51

TWiV explains genetic changes in nOPV2 strains that paralyzed children, outbreak of raccoon distemper in Toronto, EcoHealth Alliance gets its NIH grant back, and breakage at chromosomal fragile sites caused by the EBNA1 protein of Epstein-Barr virus as a mechanism for carcinogenesis.

Hosts: Vincent RacanielloRich ConditKathy Spindler, and Angela Mingarelli

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Weekly Picks

Angela – Night Science
Kathy – Kermit, Jim Henson, Rainbow Connection
Rich – Alexander Skarsgård Explains the Answer to Everything
Vincent
 – Beyond the Noise with Dr. Paul Offit

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

May 14, 2023
TWiV 1006: Clinical update with Dr. Daniel Griffin
43:27

In his weekly clinical update, Dr. Griffin discusses immunogenicity and tolerability of a bivalent virus-like particle norovirus vaccine candidate in children from 6 months up to 4 years of age, influenza hemagglutinin stem nanoparticle vaccine induces cross-group 1 neutralizing antibodies in healthy adults, COVID-19 surveillance after expiration of the public health emergency declaration, provisional mortality data, targeted vaccine messaging to promote COVID-19 vaccines for children and youth, vaccines and related biological products advisory committee meeting June 15, 2023 announcement, how to overhaul the CDC, impact of SARS-CoV-2 variants on inpatient clinical outcome, prevalence of post-coronavirus disease condition 12 weeks after Omicron infection compared with negative controls and association with vaccination status, gut bacteria cocktail helps long COVID, and gut microbiota‐derived symbiotic formula (SIM01) as a novel adjuvant therapy for COVID‐19.

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Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to daniel@microbe.tv

May 13, 2023
TWiV 1005: COVID T vax and a virus from the blue
01:38:26

TWiV reveals plankton-infecting relatives of herpesviruses in the sunlit oceans, and a vaccine encoding non-spike T cell antigens that protects animals from severe SARS-CoV-2 infection.

Hosts: Vincent RacanielloAlan DoveKathy Spindler, and Brianne Barker

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Weekly Picks

Brianne – Immune #67: Can T cells Live Forever?
Kathy – Hazel Scott, Trinidad Jazz star
Alan – The Last Navigator, Steve Thomas
Vincent
 – Nasal Spray Covid Vaccines: Hope or Hype?

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

May 07, 2023
TWiV 1004: Clinical update with Dr. Daniel Griffin
52:59

In his weekly clinical update, Dr. Griffin discusses the U.S. Food and Drug Administration approving Arexvy: the first respiratory syncytial virus (RSV) vaccine approved for use in the United State, association between SARS-CoV-2 and metagenomic content of samples from the Huanan Seafood Market, researchers disagree over how bad it is to be reinfected and whether COVID-19 can cause lasting changes to the immune system, virtual care and emergency department use during the COVID-19 pandemic among patients of family physicians in Canada, vaccination with BCG-Denmark did not result in a lower risk of COVID-19 among health care workers than placebo, NVX-CoV2373 vaccine efficacy against hospitalization, comparative effectiveness of the SARS-COV-2 vaccines during Delta dominance, assessment of gender-specific COVID-19 case fatality risk per malignant neoplasm type, clinical outcomes following treatment for COVID-19 with Nirmatrelvir/Ritonavir and Molnupiravir among patients living in nursing homes, timing of intubation and ICU mortality in COVID-19 patients, real-life experience with Remdesivir for treatment of COVID-19 among older adults, and how long COVID brain fog and muscle pain are associated with longer time to clearance of SARS-CoV-2 RNA from the upper respiratory tract during acute infection.

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Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to daniel@microbe.tv

May 06, 2023
TWiV 1003: Going clinically viral
01:26:09

Vincent and Kathy travel to Atlanta for APHL ID Lab Con, a conference focused on the latest developments in detecti​​on and characterization of infectious diseases of public health concern, and speak with Megan, Ryan, and Kirsten about the workings of public health and clinical laboratories.

Hosts: Vincent Racaniello and Kathy Spindler

Guests: Megan CrumplerRyan Relich, and Kirsten St. George

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Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

Apr 30, 2023
TWiV 1002: Clinical update with Dr. Daniel Griffin
44:23

In his weekly clinical update, Dr. Griffin discusses completeness and spin of medRxiv preprints and associated published abstracts of COVID-19 randomized clinical trials, lessons learned from a COVID-19 dog screening pilot in California K-12 schools, SARS-CoV-2 reinfection and severity of the disease, effectiveness of COVID-19 bivalent vaccine, Molnupiravir and risk of post-acute sequelae of COVID-19, risk of new-onset long Covid following reinfection with SARS-CoV-2, low vitamin D levels associated with long COVID syndrome in COVID-19 survivors, and clinical experience with the α2A-adrenoceptor agonist, guanfacine, and N-acetylcysteine for the treatment of cognitive deficits in “Long-COVID19”.

Click arrow to play Download TWiV 1002 (27 MB .mp3, 44 min)

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Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to daniel@microbe.tv

Apr 29, 2023
TWiV 1001: Clinical update with Dr. Daniel Griffin
54:15

In his weekly clinical update, Dr. Griffin discusses an update on vaccine-derived poliovirus outbreaks, how the dream of wiping out polio might need a rethink, risk of death in patients hospitalized for COVID-19 vs seasonal Influenza in fall-winter, French Mpox cluster includes fully vaccinated patients, two individuals with potential Mpox virus reinfection, epidemiologic and clinical features of Mpox-associated deaths, FDA authorizes changes to simplify use of bivalent mRNA COVID-19 vaccines, SARS-CoV-2 during Omicron variant predominance among infants born to people with SARS-CoV-2, severe maternal morbidity and mortality of pregnant patients with COVID-19 infection during the early pandemic period in the US, sickness presenteeism in healthcare workers during the COVID-19 pandemic, ventilation improvements among k–12 public school districts, risk factors and vectors for SARS-CoV-2 household transmission, SARS-CoV-2 neutralizing antibodies after bivalent versus monovalent, durability of bivalent boosters against Omicron subvariants, Nirmatrelvir and risk of hospital admission or death in adults with COVID-19, evolving real-world effectiveness of monoclonal antibodies for treatment of COVID-19, effect of angiotensin-converting enzyme inhibitor and angiotensin receptor blocker initiation on organ support–free days in patients hospitalized with COVID-19, efficacy and safety of Anakinra plus standard of care for patients with severe COVID-19, higher dose corticosteroids in patients admitted to hospital with COVID-19 who are hypoxic but not requiring ventilatory support, risk of autoimmune diseases in patients with COVID-19, definition of post–COVID-19 condition among published research studies, and sleep disturbance severity and correlates in post-acute sequelae of COVID-19. 

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Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to daniel@microbe.tv

Apr 23, 2023
TWiV 1000: Live from New York, 1k epitopes of virology
01:15:51

The entire TWiV team gathers at a theatre in New York City to celebrate a milestone in science podcasting, to reminisce how they joined the show, and to play a game of TWiV Jeopardy.

Hosts: Vincent RacanielloDickson Despommier, Alan Dove, Rich Condit, Kathy Spindler, Brianne Barker, Daniel Griffin, and Angela Mingarelli

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Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

Apr 23, 2023
TWiV 999: Vaccinated to the nines
01:54:33

TWiV notes Ashish Jha’s call for doctors to combat a vacuum of medical information while ignoring our contributions, China CDC’s surveillance of SARS-CoV-2 at the Huanan Seafood Market, and an experimental infectious attenuated COVID-19 vaccine that elicits superior mucosal and systemic immunity in hamsters.

Hosts: Vincent RacanielloDickson Despommier, Alan Dove, Kathy Spindler, and Brianne Barker

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Weekly Picks

Dickson – Jazz Project: Conductor/composer: Gill Evans. Produced Sketches of Spain, Porgy And Bess. Quincey Jones. Numerous albums, all kinds of music. Duke Ellington. Prolific musician, pianist, and composer. Antonio Carlos Jobim. Signature album: Sound track from the film – Black Orpheus. Signature songs: Girl From Ipanema; The Waters of March.
Brianne This is what it sounds like when plants cry
Kathy I know who you are by Barbara Rae-Venter
Alan – Svalbard seed vault virtual tour
Vincent
 – We’re Asking the Impossible of Vaccines by Katherine Wu

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

Apr 09, 2023
TWiV 998: Clinical update with Dr. Daniel Griffin
52:17

In his weekly clinical update, Dr. Griffin discusses the White House COVID adviser calling on doctors to combat a vacuum of medical information, adeno-associated virus type 2 in US children with acute severe hepatitis, genomic investigations of unexplained acute hepatitis in children, surveillance of SARS-CoV-2 at the Huanan seafood market, vaccine effectiveness against hospitalization among adolescent and pediatric SARS-CoV-2 cases between May 2021 and January 2022 in Canada, effectiveness of BNT162b2 after extending the primary series dosing interval in children and adolescents aged 5–17, prevalence and characteristics associated with post–COVID-19 condition among non-hospitalized adolescents and young adults, within-host genetic diversity of SARS-CoV-2 lineages in unvaccinated and vaccinated individuals, live-attenuated vaccine sCPD9 elicits superior mucosal and systemic immunity to SARS-CoV-2 variants in hamsters, Fc-γR-dependent antibody effector functions are required for vaccine-mediated protection against antigen-shifted variants of SARS-CoV-2, COVID-19 convalescent plasma utilization in the United States, FDA authorizes Gohibic (vilobelimab) injection for the treatment of COVID-19, anti-C5a antibody IFX-1 (vilobelimab) treatment versus best supportive care for patients with severe COVID-19 (PANAMO), anti-C5a antibody (vilobelimab) therapy for critically ill, invasively mechanically ventilated patients with COVID-19, triple combination therapy with two antivirals and monoclonal antibodies for persistent or relapsed SARS-CoV-2 infection in immunocompromised patients, and the breadth of the neutralizing antibody response to original SARS-CoV-2 infection is linked to the presence of long COVID symptoms.

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Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to daniel@microbe.tv

Apr 08, 2023
TWiV 997: Inside Omicron with Mohsan Saeed
01:54:35

Mohsan joins TWiV to discuss the work of his laboratory showing that spike and nsp6 are determinants of Omicron attenuation, and why the work was widely misinterpreted by the press and the public.

Hosts: Vincent RacanielloAlan Dove, and Rich Condit

Guest: Mohsan Saeed

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MicrobeTV Discord Server
Spike and nsp6 determinants of Omicron attenuation (Nature)
•China releases genomic data from Wuhan market (Science)
•Timestamps by Jolene. Thanks!

Weekly Picks

Rich For pianist Dan Tepfer, improvisation is the mother of Bach’s Inventions
Alan – HMS Victory 3D animated tour
Vincent
The Fight Over Penn Station and Madison Square Garden

Listener Picks

Douglas How’s Your City Doing? Ask the Honeybees.

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

Apr 02, 2023
TWiV 996: Clinical update with Dr. Daniel Griffin
40:12

In his weekly clinical update, Dr. Griffin discusses how antibiotics don’t reduce risk of death from viral respiratory infections, norovirus infections continue to rise in the US, ABO blood types and SARS-CoV-2 infection assessed using seroprevalence data in a large population-based sample, maternal third dose of BNT162b2 mRNA vaccine and risk of infant COVID-19 hospitalization, association of treatment with Nirmatrelvir and the risk of Post–COVID-19 condition, mechanically ventilated patients with COVID-19 had a higher chance of in-hospital death if treated with high-flow nasal cannula oxygen before intubation, high-flow nasal cannula and outcomes in COVID-19, severe infection and risk of Cardiovascular disease, and the risk factors associated with post−COVID-19 condition.

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Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to daniel@microbe.tv

Apr 01, 2023
TWiV 995: Viral origin stories
02:03:07

TWiV discusses genetic evidence of susceptible wildlife in SARS-CoV-2 positive samples at the Huanan Wholesale Seafood Market, polio cases in African linked to a new polio vaccine that was designed to not cause the disease, and structural conservation of hepatitis B virus capsid proteins over millions of years despite a shift from a naked to an enveloped capsid.

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Download TWiV 995 (74 MB .mp3, 123 min)
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MicrobeTV Discord Server
• More evidence for SARS-CoV-2 spillover (Zenodo)
•Polio cases linked to nOPV2 (Science; GPEI statement)
•nOPV2 on TWiV 756
•Engineering OPV to prevent reversion to neurovirulence (Cell Host Microbe)
Stability of nOPV2 in children (npj Vaccines)
•2A changes compensate for 5′-UTR disruptions (Virology)
•HBV shifts from naked to enveloped (Nat Comm)
Letters read on TWiV 995
•Timestamps by Jolene. Thanks!

Weekly Picks

Dickson – Jazz Project: Bass: Ray Brown, Ron Carter, Percy Heath
Angela The nervous system may play a role in severe allergic reactions through immune cell (mast cells) cross-talk with neurons
Brianne Science Museums Take Stock of 1.1 Billion Objects from Around the World
Vincent
Architect Breaks Down 5 of the Most Common Skyscraper Styles In New York

Listener Picks

Gary Tony Fauci on PBS
StefanieWhat Do You Find Beautiful about Viruses? A Post-COVID Assessment Strategy

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

Mar 26, 2023
TWiV 994: Clinical update with Dr. Daniel Griffin
42:50

In his weekly clinical update, Dr. Griffin discusses the detection of circulating vaccine-derived poliovirus type 2 in Burundi and the Democratic Republic of the Congo, the novel oral polio vaccine type 2 story, prior COVID-19 infection associated with increased risk of newly diagnosed erectile dysfunction, adverse maternal, fetal, and newborn outcomes among pregnant women with SARS-CoV-2 infection, correlates of protection against COVID-19 infection and intensity of symptomatic disease in vaccinated individuals exposed to SARS-CoV-2 in households in Israel, effectiveness of Nirmatrelvir–Ritonavir in preventing hospital admissions and deaths in people with COVID-19, projected COVID-19 mortality reduction from Paxlovid rollout, and SARS-CoV-2 mRNA vaccines decouple anti-viral immunity from humoral autoimmunity.

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Links for this episode


Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to daniel@microbe.tv

Mar 25, 2023
TWiV 993: COVID-19 drives autoimmunity
01:48:21

TWiV reveals how treatment with remdesivir for COVID-19 resolved a chronic poliovirus infection in an immunocompromised patient, and the finding that infection with SARS-CoV-2 leads to an increase in new and preexisting autoantibodies.

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•Janet Sinsheimer on TWiV 653
•Clearance of chronic poliovirus infection by remdesivir (Front Immunol)
Autoimmunity induced by SARS-CoV-2 infection (Nat Comm)
Letters read on TWiV 993
•Timestamps by Jolene. Thanks!

Weekly Picks

BrianneXkcd: Lymphocytes
KathyA brief history of Parafilm with video
Alan – Mapping and exploring the USS Monitor wreck
Vincent
Skype a Scientist

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

Mar 19, 2023
TWiV 992: Clinical update with Dr. Daniel Griffin
31:34

In his weekly clinical update, Dr. Griffin discusses clearance of longstanding, immune-deficiency-associated, vaccine-derived poliovirus infection following remdesivir therapy for chronic SARS-CoV-2 infection, SARS-CoV-2 exposure in New York City rats, clinical characteristics and outcomes of children with SARS-CoV-2 infection during the Delta and Omicron variant-dominant periods in Korea, exhaled breath aerosol shedding of SARS-CoV-2 variants, outpatient treatment of COVID-19 and the development of long COVID over 10 months, Nirmatrelvir and the risk of post-acute sequelae of COVID-19, assessment of the risk of venous thromboembolism in nonhospitalized patients with COVID-19, and the optimal duration of systemic corticosteroids in COVID-19 treatment.

Click arrow to play Download TWiV 992 (19 MB .mp3, 32 min)

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Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to daniel@microbe.tv

Mar 18, 2023
TWiV 991: The cancer mRNA shot
02:03:53

On this episode of TWiV, the observation that the 1918 influenza virus is not lethal in nonhuman primates and implications for studies on viral virulence, and mRNA vaccines that control and resolve human papillomavirus-associated cancers in mice.

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•1918 influenza virus not lethal in nonhuman primates (J Virol)
•mRNA vaccines control HPV-associated tumors (Sci Trans Med)
Letters read on TWiV 991
•Timestamps by Jolene. Thanks!

Weekly Picks

Dickson – Jazz Project: Piano: Art Tatum/Thelonius S. Monk/Dave Brubeck/Bill Evans/George Shearing/Herbie Hancock/Chick Corea/Keith Jarret/Diana Krall/Eliane Elias/Horace Silver. Honorable mention: Oscar Peterson/Erroll Garner/Ramsey Lewis/Dr. John/Duke Ellington
RichProtein synthesis: an epic on the cellular level
AlanThomas Was Alone
Vincent
I called for more research on the COVID ‘lab leak theory.’ Here’s what I found out

Listener Pick

Carol The Exceptions: Nancy Hopkins, MIT, and the fight for Women in Science

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

Mar 12, 2023
TWiV 990: Clinical update with Dr. Daniel Griffin
28:57

In his weekly clinical update Dr. Griffin discusses confronting the evolution and expansion of anti-vaccine activism in the USA in the COVID-19 era, the effectiveness of maternal Influenza vaccination in Peru, characteristics and predictors of persistent symptoms post-COVID-19 in children and young people, parental nonadherence to health policy recommendations for prevention of COVID-19 transmission among children, community-onset bacterial coinfection in children critically ill with SARS-CoV-2 infection, bivalent booster effectiveness against severe COVID-19 outcomes in Finland, viral kinetics of sequential SARS-CoV-2 infections, risk of COVID-19 associated pulmonary aspergillosis based on corticosteroid duration in intensive care patients, immunomodulators for severe COVID19 in transplant patients: do they increase the risk of secondary infection, long-term cardiovascular outcomes in COVID-19 survivors among non-vaccinated population, cardiac abnormalities in Long COVID 1-year post-SARS-CoV-2 infection, one-year adverse outcomes among us adults with Post–COVID-19 condition vs those without COVID-19 in a large commercial insurance database, and long-term gastrointestinal outcomes of COVID-19.

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Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to daniel@microbe.tv

Mar 11, 2023
TWiV 989: Antibody cross-reactivity is metal
01:52:18

TWiV to explains a study on presence of COVID-19 vaccine mRNA in the blood, and the isolation of cross-protective monoclonal antibodies against common endemic respiratory viruses.

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MicrobeTV Discord Server
Paul Berg obituary
•Spike mRNA in blood (J Path Micro Imm)
•Spike mRNA in blood (Biomedicine)
Cross-protective mAbs against respiratory viruses (Nat Comm)
•RSV prefusion F protein vaccine in older adults (NEJM)
Ad26.RSV.preF–RSV preF protein vaccine (NEJM)
Letters read on TWiV 989
•Timestamps by Jolene. Thanks!

Weekly Picks

Dickson – Jazz Project: Drums: Sunny Payne (Count Basie Orchestra); Buddy Rich (Count Basie Orchestra); Rufus Jones (Maynard Ferguson Orchestra); Joe Morello (Dave Brubeck Quartet).
Brianne A Scientific Investigation of ‘The Last of Us’ Fungal Pandemic
Kathy “That’s What They Say” podcast about pronunciation of “primer.”
Rich – Slow motion art:  1 and 2
Vincent
Grammarly

Listener Pick

Charles Psychologist Daniel Levitin dissects Pink Floyd’s ‘Dark Side of the Moon’

Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

Mar 05, 2023
TWiV 988: Clinical update with Dr. Daniel Griffin
41:25

In his weekly clinical update Dr. Griffin discusses FDA authorizing the first over-the-counter at-home test to detect both influenza and COVID-19, monoclonal antibody for the prevention of respiratory syncytial virus infection in infants and children, epidemiologic characteristics of SARS-CoV-2 recombinant variant XBB.1.5, COVID-19 vaccines vs pediatric hospitalization, maternal SARS-CoV-2 vaccination and infant protection against SARS-CoV-2 during the first six months of life, immunoglobulin, glucocorticoid, or combination therapy for multisystem inflammatory syndrome in children, fatal fulminant cerebral edema in six children with SARS-CoV-2 Omicron BA.2 infection in Taiwan, certifying deaths due to COVID-19, efficacy of first dose of COVID-19 vaccine vs no vaccination on symptoms of patients with long COVID, and the effect of COVID-19 vaccination on long COVID.

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Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to daniel@microbe.tv

Mar 04, 2023
TWiV 987: Convalescing with Casadevall
01:56:06

Arturo Casadevall returns to TWiV to explain the use of convalescent plasma to treat COVID-19 patients, and the need to support virology at a time when more regulation of experiments is envisioned.

Hosts: Vincent Racaniello, Alan Dove, and Rich Condit

Guest: Arturo Casadevall

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Weekly Picks

Rich - Flammarion engraving
Alan - What Remains of Edith Finch
Vincent
- The CDC’s Long-Covid Deception

Listener Pick

Bill - General Relativity For Babies

Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

Feb 26, 2023
TWiV 986: Clinical update with Dr. Daniel Griffin
42:58

In his weekly clinical update Dr. Griffin discusses the efficacy and safety of two RSV vaccines in older adults, health care vaccine mandate remains as some push for an end, past SARS-CoV-2 infection protection against re-infection, a third vaccine dose equalizes the levels of effectiveness and immunogenicity of heterologous or homologous COVID-19 vaccine regimens, Sotrovimab retains activity against SARS-CoV-2 Omicron variant BQ.1.1 in a non-human primate model, effect of higher-dose Ivermectin for 6 Days vs placebo on time to sustained recovery in outpatients with COVID-19, viral burden rebound in hospitalized patients with COVID-19 receiving oral antivirals in Hong Kong, serological response to vaccination in post-acute sequelae of COVID, sex differences in cardiovascular complications and mortality in hospital patients with COVID-19, association of COVID-19 vaccination with risk for incident diabetes after COVID-19, postacute sequelae of SARS-CoV-2 in university setting, the CDC’s long-Covid deception, and podcast companies, once walking on air, feel the strain of gravity.

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Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to daniel@microbe.tv

Feb 25, 2023
TWiV 985: Bambi's revenge
01:41:47

TWiV reviews an outbreak of Marburg hemorrhagic fever in Equatorial Guinea, wild poliovirus type 3 shedding from a laboratory in the Netherlands, and white-tailed deer as a reservoir for previous SARS-CoV-2 variants of concern.

Hosts: Vincent RacanielloDickson Despommier, and Rich Condit

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•Register for ASV 2023
MicrobeTV Discord Server
Marburg virus disease outbreak in Equatorial Guinea (WHO)
Wild-type poliovirus type 3 from laboratory (Eurosurveillance)
•Extinct SARS-CoV-2 VOC in white-tailed deer (PNAS)
Letters read on TWiV 985
•Timestamps by Jolene. Thanks!

Weekly Picks

Dickson – Jazz Project: Vibraphone: Lionel Hampton/Gary Burton/Cal Jader. Lionel Hampton: Signature album: The Classics Album Collection, Signature song: Flying Home. Gary Burton: Signature album: A Genuine Tong Funeral. Signature song: General Mojo’s Well Laid Plan. Cal Jader: Signature album: Latin Kick. Signature song: Soul Sauce (Wachi Wara).  Milt Jackson (a member of the Modern Jazz Quartet). Signature song: Ice Skating in Central Park.
Rich – The American Phage Group: Founders of Molecular Biology by William C. Summers
Vincent – DJ Miss Monique aka Olesia Arkusha

Listener Pick

Megan – The Day The Music Stopped: How a 1942 recording ban changed America forever and The Weather Channel presents the best of smooth Jazz

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

Feb 19, 2023
TWiV 984: Clinical update with Dr. Daniel Griffin
43:04

In his weekly clinical update Dr. Griffin discusses the political polarization of COVID-19 treatments among physicians and laypeople in the United States, seven alternatives to evidence-based medicine, Malawi’s cholera death toll crosses 1,300 in its deadliest outbreak on record, impact of coronavirus infections on pediatric patients at a tertiary pediatric hospital, maternal mRNA COVID-19 vaccination during pregnancy and delta or omicron infection or hospital admission in infants, yes masks reduce the risk of spreading infection, despite a review saying they don’t, COVID-19 and airborne transmission: science rejected, lives lost. can society do better, what were the historical reasons for the resistance to recognizing airborne transmission during the COVID-19 pandemic, a randomized trial comparing Omicron-containing boosters with the original COVID-19 vaccine mRNA-1273, SARS-CoV-2 neutralizing antibodies after bivalent vs. monovalent booster, the impacts of SARS-CoV-2 vaccine dose separation and targeting on the COVID-19 epidemic in England, intra-host evolution provides for the continuous emergence of SARS-CoV-2 variants, real-world use of Nirmatrelvir–Ritonavir in outpatients with COVID-19 during the era of Omicron variants including BA.4 and BA.5 in Colorado, viral burden rebound in hospitalized patients with COVID-19 receiving oral antivirals in Hong Kong, and guidance on the use of convalescent plasma to treat immunocompromised patients with COVID-19.

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Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to daniel@microbe.tv

Feb 18, 2023
TWiV 983: One flu vaccine for them all with Scott Hensley
01:49:13

Scott returns to TWiV to explain the development of an experimental mRNA vaccine that encodes hemagglutinin antigens against all known influenza A virus subtypes and influenza B virus lineages, and why he is worried about avian H5N1 influenza virus.

Hosts: Vincent RacanielloDickson Despommier, and Brianne Barker

Guest: Scott Hensley

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•Research assistant position at FDA (pdf)
•Register for ASV 2023
MicrobeTV Discord Server
•Multivalent influenza mRNA vaccine (Science)
•Influenza virus mRNA vaccines circumvent egg adaptation problems (J Virol)
Letters read on TWiV 983
•Timestamps by Jolene. Thanks!

Weekly Picks

Dickson – Jazz Project:  Guitar. Django Reinhardt; Pat Metheny. Signature album: Still Life Talking. Signature song: Last Train Home; Joe Pass (Ella Fitzgerald’s favorite guitar accompanist). Signature album: Virtuoso. Signature song: Round Midnight.
Brianne – HHMI Virus Explorer
Vincent – Chris Luno

Listener Picks

John – White-tail deer density and SARS-CoV-2 in white-tail deer
Jessica – Classic cases revisited: Oscar the cat and predicting death

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

Feb 12, 2023
TWiV 982: Clinical update with Dr. Daniel Griffin
48:43

In his weekly clinical update Dr. Griffin discusses the consistency of COVID-19 trial preprints with published reports and impact for decision making, the negative effect of preexisting immunity on Influenza vaccine responses transcends the impact of vaccine formulation type and vaccination history, highly pathogenic avian influenza A(H5N1) virus infection in farmed minks in Spain, Peru confirms H5N1 avian flu in marine mammals, prior vaccination enhances immune responses during SARS-CoV-2 breakthrough infection with early activation of memory T cells followed by production of potent neutralizing antibodies, bacillus Calmette-Guérin vaccine for prevention of COVID-19 and other respiratory tract infections in older adults with comorbidities, incidence of chronic spontaneous urticaria following receipt of the COVID-19 vaccine booster in Switzerland, relationship between immune response to SARS-CoV2 vaccines and development of breakthrough infection in solid organ transplant recipients, early treatment with pegylated interferon lambda for COVID-19, and how long-term high-dose immunoglobulin successfully treats long COVID patients with pulmonary, neurologic, and cardiologic symptoms. 

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Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to daniel@microbe.tv

Feb 11, 2023
TWiV 981: Tastes like chikungunya
02:04:25

TWiV explains the recent meeting of the National Science Advisory Board for Biosecurity (NSABB) where stricter guidelines for research involving human, animal, and plant pathogens were considered, and how the consumption of viruses by small protists returns energy to food chains.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler

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•Research assistant position at FDA (pdf)
•Register for ASV 2023
MicrobeTV Discord Server
•NSABB proposed oversight framework (pdf)
Stricter US guidelines for research (Nature)
•Information on NSABB (NIH)
Consumption of viruses by protists (PNAS)
Letters read on TWiV 981
•Timestamps by Jolene. Thanks!

Weekly Picks

Dickson – Jazz Project: Trombone: Steve Turre/Conrad Herwig; Steve Turre; Curtis Fuller; J.J. Johnson and Kai Winding. Steve Turre: Signature album: Sanctified Shells. Signature song: Sanctified Shells. Conrad Herwig. Signature album: A Jones For Bones Tones. Signature song: Slide’s Routine; Curtis Fuller: Signature album: BLUES ette. Signature song: Bluesette. J.J. Johnson (with Kai Winding). Signature album: The Great Kai and J.J. : Signature song: Monk’s Blues.
KathyMeasles virus ‘cooperates’ with itself to cause fatal encephalitis. Primary research article: Shirogane et al.
Rich Firm hatches plan to bring back dodo (Colossal Biosciences – Dodo)
AlanMt. Washington Observatory webcam
VincentAsk the Experts

Listener Picks

Roberto The Contagion of Liberty: The Politics of Smallpox in the American Revolution

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

Feb 05, 2023
TWiV 908: Clinical update with Dr. Daniel Griffin
39:46

In his weekly clinical update Dr. Griffin discusses prevalence and clinical outcomes of respiratory syncytial virus versus influenza virus in adults hospitalized with acute respiratory Illness, reconsideration of antinucleocapsid IgG antibody as a marker of SARS-CoV-2 infection postvaccination for mild COVID-19 patients, assessment of COVID-19 as the underlying cause of death among children and young people aged 0 to 19 years in the US, information for persons who are immunocompromised regarding prevention and treatment of SARS-CoV-2 Infection in the context of currently circulating Omicron sublineages, association of culturable-virus detection and household transmission of SARS-CoV-2,  effectiveness of bivalent boosters against severe Omicron infection, Covid vaccines and playing the long game, efficacy and safety of antimicrobial stewardship prospective audit and feedback in patients hospitalized with COVID-19, and severe fatigue and persistent symptoms at three months following SARS-CoV-2 Infections during the pre-Delta, Delta, and Omicron time periods.

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Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to daniel@microbe.tv

Feb 04, 2023
TWiV Special: One COVID vaccine for them all with Paul Offit
38:39

Paul Offit returns to TWiV to unpack the recent FDA Advisory Panel on COVID vaccines, with discussions on giving everyone the same bivalent vaccine, simplifying the immunization schedule, and how to know when the vaccine should be updated.

Hosts: Vincent Racaniello and Rich Condit

Guest: Paul Offit

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  • FDA briefing document (pdf)
  • Effectiveness of bivalent booster against severe infection (NEJM)
  • Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

Feb 03, 2023
TWiV 979: Flushing out the viroids
01:48:18

TWiV gives an update on poliovirus in wastewater, and reveals a vast world of viroids that infect a wide range of host species in diverse ecosystems.

Hosts: Vincent RacanielloAlan DoveRich Condit, and Kathy Spindler

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•Research assistant position at FDA (pdf)
•Register for ASV 2023
MicrobeTV Discord Server
Nick Muzyczka passes
•CDC planning wastewater testing for polio (CDC)
•Wastewater testing for poliovirus (MMWR)
•NY state poliovirus wastewater surveillance (NYSDOH)
•CDC wastewater poliovirus surveillance in select communities (CDC)
•Vast world of viroid-like RNAs (Cell)
•Timestamps by Jolene. Thanks!

Weekly Picks

Kathy – 3B new Milky Way objectsGreen comet
Rich – Virology under the Microscope—a Call for Rational Discourse
Alan – Indie story-driven games series #3: Valiant Hearts: The Great War
Vincent – Vaccines and Related Biological Products Advisory Committee Meeting January 26, 2023 – pdf

Listener Picks

Florencia – An elegant way to stop deadly Hendra virus spillovers from bats to horses … to us (Nature article)

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

Jan 29, 2023
TWiV 978: Clinical update with Dr. Daniel Griffin
39:17

In his weekly clinical update Dr. Griffin discusses co-detections of other respiratory viruses among children hospitalized with COVID-19, preprint review should form part of PhD programs and postdoc training, early and increased Influenza activity among children, COVID-19 vaccines versus pediatric hospitalization, SARS-CoV-2 variant-related abnormalities detected by prenatal MRI, protective effectiveness of previous SARS-CoV-2 infection and hybrid immunity against the Omicron variant and severe disease, protective effectiveness of previous SARS-CoV-2 infection and hybrid immunity against the omicron variant and severe disease, persistent COVID-19 Symptoms at 6 months after onset and the role of vaccination before or after SARS-COV-2 infection, effect of Dexamethasone use on viral clearance among patients with COVID-19, and the impact of vaccination on post-acute sequelae of SARS CoV-2 infection in patients with rheumatic diseases.

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Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to daniel@microbe.tv

Jan 28, 2023
TWiV 977: Ageing is infectious
01:44:38

TWiV covers a study of SARS-CoV-2 persistence at multiple sites in the human body, and the role of endogenous retroviruses in ageing and senescence.

Hosts: Vincent RacanielloDickson DespommierAlan DoveBrianne Barker, and Angela Mingarelli

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•Research assistant position at FDA (pdf)
•Register for ASV 2023
MicrobeTV Discord Server
Persistence of SARS-CoV-2 (Nature)
•Endogenous retroviruses and senescence (Cell)
•Timestamps by Jolene. Thanks!

Weekly Picks

Dickson – Baritone Saxophone: Gerry Mulligan. No one else comes close Signature songBernie’s Tune
Angela – World’s Longest Animal
Brianne – Green Comet to Pass By Earth for first time in 50,000 years
Alan – Indie games series: Golf Club Wasteland
Vincent – Bivalent Covid-19 Vaccines — A Cautionary Tale

Listener Picks

Lisa – The River and the Wall

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

Jan 22, 2023
TWiV 976: Clinical update with Dr. Daniel Griffin
41:35

In his weekly clinical update Dr. Griffin discusses China reporting almost 60,000 Covid-related deaths after abrupt shift in policy, detection of SARS-CoV-2 IgA and IgG in human milk and breastfeeding infant stool 6 months after maternal COVID-19 vaccination, effect of Fluvoxamine vs placebo on time to sustained recovery in outpatients with mild to moderate COVID-19, hyperimmune globulin for severely immunocompromised patients hospitalized with COVID-19, long COVID outcomes at one year after mild SARS-CoV-2 infection, long COVID: major findings, mechanisms and recommendations, a systematic review of trials currently investigating therapeutic modalities for post-acute COVID-19 syndrome and registered on World Health Organization international clinical trials platform, and the effect of using a structured pacing protocol on post-exertional symptom exacerbation and health status in a longitudinal cohort with the post-COVID-19 syndrome.

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Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to daniel@microbe.tv

Jan 21, 2023
TWiV 975: Crossing the Ts with Daniela Weiskopf
01:37:37

Daniela joins TWiV to discuss her career and her research on T cells, their role in infection with SARS-CoV-2, T cell epitopes and why a variant that evades T cell immunity is not likely to emerge.

Hosts: Vincent Racaniello, Alan Dove, and Brianne Barker

Guest: Daniela Weiskopf

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•Research assistant position at FDA (pdf)
•Register for ASV 2023
Cross reactive T cells to SARS-CoV-2 (Science)
•SARS-CoV-2 exposure history and T cell response (Cell Rep Med)
•Spike T cells cross- recognize Omicron (Nature)
•Ancestral SARS-CoV-2 T cells recognize Omicron (Nature)
NVX-CoV2373 induces T cell responses (J Clin Inves)
Letters read on TWiV 975
•Timestamps by Jolene. Thanks!

Weekly Picks

Brianne Video of viral attachment (based on this article)
Alan – Starting a series of innovative indie video games. First up: The Longing.
VincentThe Amy Papers and Calendar for live events

Listener Picks

JudyInnate immune evasion strategies of SARS-CoV-2
Charles Who’s Talking to Chris Wallace? Season 1, epitope 30: Dr. Anthony Fauci on HBO Max

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

Jan 15, 2023
TWiV 974: Clinical update with Dr. Daniel Griffin
46:33

In his weekly clinical update Dr. Griffin discusses poliovirus returns to New York wastewater, COVID-19 is more widespread in animals than we thought, increasing ventilation reduces SARS-CoV-2 airborne transmission in schools, the use of carbon dioxide monitoring to assess ventilation at a national infectious diseases conference, effectiveness of the bivalent mRNA vaccine in preventing severe COVID-19 outcomes, 7-month duration of SARS-CoV-2 mucosal immunoglobulin-A responses and protection, and long COVID outcomes at one year after mild SARS-CoV-2 infection.

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Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to daniel@microbe.tv

Jan 14, 2023
TWiV 973: Crouching virus, hidden triggers with Felicia Goodrum
01:47:37

Felicia joins TWiV to discuss her career and her research on human cytomegalovirus, which infects most of us for our entire lives yet mainly causes disease in the immunosuppressed.

Hosts: Vincent RacanielloAlan Dove, and Brianne Barker

Guest: Felicia Goodrum

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•Research assistant position at FDA (pdf)
The loss of binary (Curr Clin Micro Rep)
Virology in Peril (mBio)
•Letters read on TWiV 973
•Timestamps by Jolene. Thanks!

Weekly Picks

Brianne – “Leukocyte” immunology video parody
Alan – West Point Removing Confederate Monuments, and Ty Seidule’s book on that subject
Vincent – The works of Haruki Murakami – South of the Border, West of the Sun; also short stories (First Person Singular, particularly Confessions of a Shinagawa Monkey; and Men Without Women, particularly Drive My Car)

Listener Picks

Karen – On All Fours: Transient Laborers, the Threat of Movement, and the Aftermath of Disease
Kevin – James Hoffmann and Bald and Bankrupt

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

Jan 08, 2023
TWiV 972: Clinical update with Dr. Daniel Griffin
42:12

In his weekly clinical update Dr. Griffin discusses the infectiousness of SARS-CoV-2 breakthrough infections and reinfections during the Omicron wave, virological characteristics of the SARS-CoV-2 XBB variant derived from recombination of two Omicron subvariants, antibody evasion properties of rising SARS-CoV-2 BQ and XBB subvariants, comparative effectiveness of third doses of mRNA-based COVID-19 vaccines in US veterans, time to negative PCR conversion among high-risk patients with mild-to-moderate Omicron BA.1 and BA.2 COVID-19 treated by Sotrovimab or Nirmatrelvir, COVID drug Paxlovid was hailed as a game-changer, what happened?, the Fc-effector function of COVID-19 convalescent plasma contributes to SARS-CoV-2 treatment efficacy in mice, SARS-CoV-2 infection and persistence in the human body and brain at autopsy, long-term cardiovascular outcomes of COVID-19, and how heart-disease risk soars after COVID — even with a mild case.

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Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to daniel@microbe.tv

Jan 07, 2023
TWiV 971: Another year is viral
01:53:50

In the first epitope of 2023, TWiV reviews our coverage of virology in 2022, including favorite story arcs, episodes, show titles, and much more.

Hosts: Vincent RacanielloDickson DespommierRich ConditKathy Spindler, and Brianne Barker

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Our favorite 2022 virology stories:
•Vincent: Paul Offit on bivalent boosters (TWiV 917942Special)
•Dickson: Interviews with Paul Offit and Andy Slavitt
•Rich: TWiV 948: Breathless with David Quammen
•Kathy: TWiV 915: Mouse mouth to mouse mom
•Brianne: Spillovers (TWiV 923 and 876)
•Vincent: Giant viruses (TWiV 873906968)
•Dickson: TWiV 960 – Getting Funky with Dan Wilson
•Rich: TWiV 927: Merchlinsky vs monkeypox
•Kathy: TWiV 958: Pass the RNA and have some venison pi
•Brianne: TWiV 869: Epstein-Barr virus and MS, a perfect storm
Twiverse
•Letters read on TWiV 968
•Timestamps by Jolene. Thanks!

Weekly Picks

Dickson – Jazz Project: Tenor saxophone: John Coltrane/Dexter Gordon/Stan Getz: John Coltrane: Signature album: Giant Steps: Signature song: Blue Train; Dexter Gordon: Signature album: The Other Side Of Round Midnight. Signature song: Round Midnight; Stan Getz (with Charlie Byrd on guitar): Signature Album: Jazz Samba; Signature song: Desafinado
Brianne – A Full Circle Rainbow over Norway
Kathy – Frozen soap bubbles
Rich – It’s Turtles All the Way Down in the Fossil Record by Asher Elbein
Vincent – Vincent’s Top Ten Music

Listener Picks

Charles – Wayne Bergeron and Vince DiMartino MacArthur Park

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

Jan 01, 2023
TWiV 970: Clinical update with Dr. Daniel Griffin
51:58

In his weekly clinical update Dr. Griffin discusses modelling the adjustment of COVID-19 response and exit from dynamic zero-COVID in China, canine real-time detection of SARS-CoV-2 infections in the context of a mass screening event, two masks can be worse than one: N95 respirator failure caused by an overlying face mask, airflow patterns in double-occupancy patient rooms may contribute to roommate-to-roommate transmission of severe SARS-CoV-2, clinical validation of a novel T-Cell receptor sequencing assay for identification of recent or prior SARS-CoV-2 infection, antibody-dependent cellular cytotoxicity against SARS-CoV-2 Omicron sub-lineages is reduced in convalescent sera, regardless of the infecting variant, VV116 versus Nirmatrelvir–Ritonavir for oral treatment of Covid-19, Nirmatrelvir plus Ritonavir for early COVID-19 in a U.S. health system, Molnupiravir plus usual care versus usual care alone as early treatment for adults with COVID-19 at increased risk of adverse outcomes, higher dose corticosteroids in hospitalized COVID-19 patients with hypoxia but not requiring ventilatory support, FDA approves Roche’s Actemra (tocilizumab) for the treatment of COVID-19 in hospitalized adults, structural brain changes in post-acute COVID-19 patients with persistent olfactory dysfunction, persistent post–COVID-19 smell loss is associated with immune cell infiltration and altered gene expression in olfactory epithelium, epidemiology of long COVID in US adults, persistent symptoms and sequelae after SARS-CoV-2 infection not requiring hospitalization, and outpatient treatment of Covid-19 with metformin, ivermectin, and fluvoxamine and the development of Long Covid over 10-month follow-up.

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Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to daniel@microbe.tv

Dec 31, 2022
TWiV 969: Carl Zimmer on COVID-19
48:17

Carl Zimmer visits the Incubator to record a wide-ranging conversation about COVID-19, including origins, vaccines, public health responses, and impact on society.

Host: Vincent Racaniello

Guest: Carl Zimmer

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Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

Dec 28, 2022
TWiV 968: A spillover waiting in the wings
01:49:19

TWiV reviews eukaryotic viruses recovered from ancient permafrost, a mistake made by scientists on Omicron origins, and close relatives of MERS-CoV from bats that bind ACE2 for entry into cells.

Hosts: Vincent RacanielloDickson DespommierAlan DoveRich Condit, and Brianne Barker

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Weekly Picks

Dickson – Alto Saxophone: Paul Desmond/Cannonball Adderley/Charlie Parker/Randal Despommier: Paul Desmond: Signature album: Paul Desmond:The Complete RCA Victor Recordings (1961-1965). Signature song: Take Five (Dave Brubeck Quartet). Cannonball Adderley: Signature album: The Cannonball Adderley Quintet: Mercy, Mercy, Mercy. Signature song: Mercy, Mercy, Mercy. Charlie Parker (Bird): played in many groups: Signature album: Dizzy Gillespie and His Allstars. Signature song: A Night In Tunisia; Randal Despommier: Signature album: A Midsummer Odyssey. Signature song: I Hope It’s Spring For You.
Brianne – How a See-Through Frog Hides its Red Blood from Predators (also covered in The Atlantic)
Rich – Mindfulness in Plain English by Ven. Henepola Gunaratana
Vincent – Unveiling skin macrophage dynamics explains both tattoo persistence and strenuous removal

Listener Picks

Rona – WKCR, FM 89.9 Columbia‘s radio station
Alan – XKCD Proxy Variable

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

Dec 25, 2022
TWiV 967: Clinical update with Dr. Daniel Griffin
50:45

In his weekly clinical update Dr. Griffin discusses how immunological dysfunction persists for 8 months following initial mild-to-moderate SARS-CoV-2 infection, prevalence of SARS-CoV-2 and influenza coinfection and clinical characteristics among children and adolescents aged <18 years who were hospitalized or died with Influenza, WHO estimates of excess mortality associated with the COVID-19 pandemic, reconsideration of anti-nucleocapsid IgG antibody as a marker of SARS-CoV-2 infection post-vaccination for mild COVID-19 patients, impact of SARS-CoV-2 variants on inpatient clinical outcome, clinical features and burden of post-acute sequelae of SARS-CoV-2 infection in children and adolescents, similar SARS-CoV-2 Ct value distributions in anterior nares versus nasopharyngeal samples from symptomatic children during Delta and Omicron surges, early estimates of bivalent mRNA vaccine effectiveness in preventing COVID-19, effect of Nirmatrelvir/Ritonavir vs Placebo on COVID-19─related hospitalizations and other medical visits, COVID-19 Convalescent Plasma outpatient therapy to prevent outpatient hospitalization, bacterial co-infection and empirical antibiotic therapy in patients with COVID-19, association of time to surgery after COVID-19 infection with risk of postoperative cardiovascular morbidity, demonstration of stable clusters of symptoms in long COVID, and how longitudinal analysis of t cells in COVID-19 survivors with post-acute sequelae of COVID-19 reveals associations between individual symptoms and inflammatory indexes.

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Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to daniel@microbe.tv

Dec 24, 2022
TWiV 966: 1918 influenza with Jeffery Taubenberger
01:52:06

Vincent travels to the NIH campus to speak with Jeffery Taubenberger about his career, the 1918 influenza pandemic, deciphering the genome sequence of the virus from tissues of disease victims and using it to rescue infectious virus.

Host: Vincent Racaniello

Guest: Jeffery Taubenberger

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Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

Dec 23, 2022
TWiV 965: Asking Esper Kallas for some I.D.
01:34:48

Brazilian infectious diseases physician Esper Kallas returns to TWiV to discuss the state of viral diseases in his country, including those cause by Zika, dengue, and yellow fever viruses, MPOX, and SARS-CoV-2.

Hosts: Vincent Racaniello and Alan Dove

Guest: Esper Kallas

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Weekly Picks

Alan – A Voyage for Madmen
Vincent – Some favorite holiday cookies: pignoli cookies and pfeffernusse

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

Dec 18, 2022
TWiV 964: Clinical update with Dr. Daniel Griffin
42:04

In his weekly clinical update Dr. Griffin discusses Dr. Griffin discusses progress toward poliomyelitis eradication in Afghanistan, reduced risk for Mpox after receipt of 1 or 2 doses of JYNNEOS vaccine compared with risk among unvaccinated persons, reduced airborne transmission of SARS-CoV-2 BA.1 Omicron virus in Syrian hamsters, authorized updated (Bivalent) COVID-19 vaccines for children down to 6 months of age, low neutralization of SARS-CoV-2 Omicron BA.2.75.2, BQ.1.1, and XBB.1 by parental mRNA vaccine or a BA.5-bivalent booster, efficacy of antiviral agents against omicron subvariants BQ.1.1 and XBB, incidence of viral rebound after treatment with Nirmatrelvir-Ritonavir and Molnupiravir, and the effectiveness of coronavirus disease 2019 (COVID-19) vaccine in the prevention of post–COVID-19 conditions.

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Intro music is by Ronald Jenkees

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Dec 17, 2022
TWiV 963: Feline coronavirus with Gary Whittaker
53:29

Vincent travels to Cornell University to speak with Gary Whittaker about regulation by proteolytic processing of the fusion activity of the spike protein of SARS-CoV-2, and feline coronavirus transmission, replication and disease.

Hosts: Vincent Racaniello

Guest: Gary Whittaker

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Intro music is by Ronald Jenkees

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Dec 14, 2022
TWiV Special: Bivalent boosters with Paul Offit
30:24

Paul Offit returns to TWiV to discuss why the bivalent booster dosing story should be a cautionary tale of how not to move forward in this pandemic.

Hosts: Vincent Racaniello and Rich Condit

Guest: Paul Offit

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Intro music is by Ronald Jenkees

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Dec 12, 2022
TWiV 962: Chiara Mingarelli takes the pulse of the universe
01:53:56

Astrophysicist Chiara Mingarelli joins TWiV to discuss her career and her work using pulse timing arrays to study the gravitational wave background, ripples in the fabric of spacetime that are caused by events such as the merging of black holes.

Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Angela Mingarelli

Guest: Chirara Mingarelli

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Weekly Picks

AngelaOpenAI Playground and Nature Milestones: T cells
ChiaraThe Biggest Ideas in the Universe by Sean Carroll
Kathy Recycling PVC and here and here
RichBrome Bird Care Squirrel Buster Plus  (Bonus pick: 1971 Volvo 142 Commercial – With John Cameron Swayze)
VincentJourney to the Microcosmos

Intro music is by Ronald Jenkees

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Dec 11, 2022
TWiV 961: Clinical update with Dr. Daniel Griffin
27:37

In his weekly clinical update Dr. Griffin discusses Mpox (formerly monkeypox) in women: epidemiological features and clinical characteristics of mpox cases in Spain, April to November 2022, triage of patients with Ebola virus disease, SARS-CoV-2 serology and self-reported infection among adults, serological markers of SARS-CoV-2 infection; anti-nucleocapsid antibody positivity may not be the ideal marker of natural infection in vaccinated individuals, sensitivity of anti-SARS-CoV-2 nucleocapsid protein antibody for breakthrough infections during the epidemic of the Omicron variants, effect of wearing glasses on risk of infection with SARS-CoV-2 in the community, and data-driven identification of post-acute SARS-CoV-2 infection subphenotypes.

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Intro music is by Ronald Jenkees

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Dec 10, 2022
TWiV 960: Getting funky with Dan Wilson
02:09:45

Dan Wilson of Debunk the Funk joins TWiV to explain why he decided to take on science misinformation and how he critiques people who promulgate incorrect information.

Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Brianne Barker

Guest: Dan Wilson

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Weekly Picks

Dickson – Jazz Project:  InstrumentalTrumpet: Clifford Brown/Miles Davis/Winton Marsalis. Clifford Brown: Signature album: Study In Brown, Signature song: Sandu; Miles Davis: Signature albums: Kind Of Blue; Sketches Of Spain; Porgy And Bess; Miles. Signature song: Time After Time. Wynton Marsalis: Signature album: Standard Time. Signature song: Do You Know What It Means To Miss New Orleans
Brianne Physicists Create a Wormhole
RichDec 1 APOD: Artemis 1 Flight Day 13
Vincent An Ancient Language, Once on the Brink, Is a British Isle’s Talk of the Town

Intro music is by Ronald Jenkees

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Dec 04, 2022
TWiV 959: Clinical update with Dr. Daniel Griffin
48:08

In his weekly clinical update Dr. Griffin discusses effectiveness of influenza vaccination of pregnant women for prevention of maternal and early infant Influenza-associated hospitalizations in South Africa, a multivalent nucleoside-modified mRNA vaccine against all known influenza virus subtypes, single and 2-dose vaccinations with modified vaccinia Ankara-Bavarian Nordic induce durable B cell memory responses comparable to replicating smallpox vaccines, whether the risk of still and preterm birth is affected by the timing of symptomatic SARS-CoV-2 infection during pregnancy, medical masks versus N95 respirators for preventing COVID-19 among health care workers, alarming antibody evasion properties of rising SARS-CoV-2 BQ and XBB subvariants, real-world evidence of novel treatments for COVID-19 on mortality: a nationwide comparative cohort study of hospitalized patients in the 1st, 2nd, 3rdand 4th wave in the Netherlands, and effectiveness and safety of extended thromboprophylaxis in post-discharge patients with COVID-19.

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Intro music is by Ronald Jenkees

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Dec 03, 2022
TWiV 958: Pass the RNA and have some venison pi
01:48:33

The TWiV team reveals a variant SARS-CoV-2 that emerged in deer with deer-to-human transmission, and hybrid virus particles produced by co-infection with influenza virus and respiratory syncytial virus particles.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Kathy Spindler, and Brianne Barker

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Weekly Picks

Dickson – Jazz Project: Vocals
Best female vocalists: Ella Fitzgerald/Billie Holiday, Betty Carter
Best Male Vocalists: Mel Tormé/Joe Williams/Tony Bennett
BrianneASV Curriculum Guidelines for Virology Courses
KathyThe Snow Cruiser
Alan Rescuing bats in Ukraine
VincentWoodpeckers: The Hole Story PBS

Listener Picks

FlorenciaWorld of Viruses
MiguelFoldscope

Intro music is by Ronald Jenkees

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Nov 27, 2022
TWiV 957: Clinical update with Dr. Daniel Griffin
43:28

In his weekly clinical update Dr. Griffin discusses human monkeypox virus infection in women and non-binary individuals during the 2022 outbreaks, changes in population immunity against infection and severe disease from SARS-CoV-2 Omicron variants in the United States, updates on COVID-19–related mortality, impact of community masking on COVID-19, effectiveness of the COVID-19 vaccines against hospitalization with Omicron sub-lineages BA.4 and BA.5 in England, cardiovascular outcomes after Tixagevimab and Cilgavimab use for pre-exposure prophylaxis against COVID-19, how Paxlovid is associated with decreased hospitalization rate among adults with COVID-19, inside the mind of an anti-paxxer, and angiotensin receptor blockers for the treatment of COVID-19.

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Intro music is by Ronald Jenkees

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Nov 26, 2022
TWiV 956: A domesticated viral envelope with Cedric Feschotte and John Anthony Frank
01:40:57

Cedric and John join TWiV to discuss their research showing that a human protein derived from an ancient retrovirus infection can protect against infection by other retroviruses.

Hosts: Vincent Racaniello, Rich Condit, and Kathy Spindler

Guest: Cedric Feschotte and John Anthony Frank

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Weekly Picks

KathyWastewater Dashboard
Rich Artemis I MissionArtemis I launch; Artemis I Map
VincentPasta Grammar

Listener Picks

Rich Watch a virus in the moments before it attacks
JustinRespiratory syncytial virus

Intro music is by Ronald Jenkees

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Nov 20, 2022
TWiV 955: Clinical update with Dr. Daniel Griffin
46:50

In his weekly clinical update Dr. Griffin discusses the four things to know about RSV, the burden of respiratory syncytial virus in healthy term-born infants in Europe, the diagnostic accuracy of rapid diagnostic tests for Ebola virus disease, evaluating the accuracy of self-collected swabs for the diagnosis of monkeypox, tecovirimat is effective against human monkeypox virus in vitro at nanomolar concentrations, acute and postacute sequelae associated with SARS-CoV-2 reinfection, clinical course of SARS-CoV-2 infection and recovery in lung transplant recipients, effectiveness of a third BNT162b2 mRNA COVID-19 vaccination during pregnancy, maternal antibody response and transplacental transfer following SARS-CoV-2 infection or vaccination in pregnancy, impact of community masking on COVID-19, Lifting Universal Masking in Schools – Covid-19 Incidence among Students and Staff, systematic review of the clinical effectiveness of Tixagevimab/Cilgavimab for prophylaxis of COVID-19 in immunocompromised patients, comparative effectiveness of sotrovimab and molnupiravir for prevention of severe COVID-19 outcomes in patients in the community, early adoption of anti–SARS-CoV-2 pharmacotherapies among us veterans with mild to moderate COVID-19, evaluation of viral and symptom rebound differences between Paxlovid and untreated COVID-19 participants, monoclonal antibodies for treatment of SARS-CoV-2 infection during pregnancy, twice daily oral zinc in the treatment of patients with COVID-19, cognitive deficits in long Covid-19, severe Neuro-COVID is associated with peripheral immune signatures, autoimmunity and neurodegeneration, and long-lasting symptoms after an acute COVID-19 infection and factors associated with their resolution.

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Nov 19, 2022
TWiV 954: Speculating sarbecovirus spillovers with Michael Letko
01:50:06

Michael Letko joins TWiV to discuss his research on understanding cell receptors required for sarbecovirus entry, including an ACE2-dependent isolate from Russian bats that is resistant to vaccine-induced antibodies.

Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit,  Kathy Spindler, and Brianne Barker

Guest: Michael Letko

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Weekly Picks

Brianne Sometimes This Octopus is So Mad it Just Wants to Throw Something or The Cosmic Bat Nebula
Kathy – APODs  JupiterLunar Eclipse Blood Moon, Ice Giant
Rich Mirror-image T7 transcription of chirally inverted ribosomal and functional RNAs (Wiki: Mirror Life)
Vincent The 2022-2023 Respiratory Virus Season Hits Early and Hard: Part 1

Listener Pick

DebbyCelebrate Bob McDonald’s 30 years as host of Quirks & Quarks

Intro music is by Ronald Jenkees

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Nov 13, 2022
TWiV 953: Clinical update with Dr. Daniel Griffin
54:56

In his weekly clinical update Dr. Griffin discusses high demand for Amoxicillin causing shortages amid child RSV surge, epidemiologic and clinical features of children and adolescents aged <18 years with monkeypox, low risk of SARS-Cov-2 transmission by fomites, nucleocapsid antigenemia is a marker of acute SARS-CoV-2 infection, impact of community masking on COVID-19,  protection against Omicron from vaccination and previous infection in a prison system, Nirmatrelvir and the risk of post-acute sequelae of COVID-19, Bebtelovimab for high-risk outpatients with early COVID-19 in a large US health system, imprinted SARS-CoV-2 humoral immunity induces convergent Omicron RBD evolution, can SARS-CoV-2 trigger new onset of autoimmune disease in adults? A case-based review, and retrospectively modeling the effects of increased global vaccine sharing on the COVID-19 pandemic.

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Intro music is by Ronald Jenkees

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Nov 12, 2022
TWiV 952: Jake Scott put the ID in COVID-19
01:44:30

Infectious Disease physician Jake Scott joins TWiV to provide a west coast clinical perspective on the evolution of the COVID-19 pandemic with respect to the impact of vaccines, antivirals, variants of concern and mortality.

Hosts: Vincent Racaniello, Alan Dove, Rich Condit,  and Kathy Spindler

Guest: Jake Scott

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Weekly Picks

Kathy 10 moments for Jazz at Lincoln Center Orchestra Residency (Item 7) and Alan’s pick from TWiV 931 The Kissing Bug by Daisy Hernandez
Rich Wilderness Safaris Photographic Competition 2022
AlanMassachusetts Science Education Leadership Association, and the talk I gave to them last week
Vincent Andrea Camillieri and his protagonist Inspector Montalbano

Listener Pick

Frank Economics for the Future: Beyond the Superorganism
Debby As routine vaccination rates fall, polio survivor hopes her story reverses urgent trend

Intro music is by Ronald Jenkees

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Nov 06, 2022
TWiV 951: Clinical update with Dr. Daniel Griffin
49:45

In his weekly clinical update Dr. Griffin discusses Influenza incidence and vaccine effectiveness during the southern hemisphere influenza season in Chile, Nirsevimab for prevention of RSV infection in healthy late-preterm and term infants, severe Monkeypox in hospitalized patients, reinfections with different SARS-CoV-2 Omicron subvariants, impact of community masking on COVID-19 in Bangladesh, unadjuvanted intranasal spike vaccine elicits protective mucosal immunity against sarbecoviruses, antibody responses to Omicron BA.4/BA.5 bivalent mRNA vaccine booster shot, immunogenicity of bivalent mRNA vaccine boosters, long-term gastrointestinal sequelae following COVID-19, evaluation of an automated text message–based program to reduce use of acute health care resources after hospital discharge, and how in adults with COVID-19, melatonin was assessed for effects on inflammatory markers, clinical signs and symptoms, and mortality.

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Intro music is by Ronald Jenkees

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Nov 05, 2022
TWiV 950: Prion diseases with Richard Knight
43:23

From the European Society for Clinical Virology 2022 Conference in Manchester UK, Vincent speaks with Richard Knight about prion diseases and the outbreak of bovine spongiform encephalitis that led to cases of variant Creutzfeldt-Jakob disease in humans.

Host: Vincent Racaniello

Guest: Richard Knight

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Intro music is by Ronald Jenkees

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Oct 30, 2022
TWiV 949: Clinical update with Dr. Daniel Griffin
45:09

In his weekly clinical update Dr. Griffin discusses progress toward poliomyelitis eradication in Pakistan, polio by the numbers , influenza and COVID-19 vaccination coverage among health care personnel, phase 1/2a safety and immunogenicity of an adenovirus 26 vector RSV vaccine encoding prefusion F in adults 18–50 years and RSV seropositive children 12–24 months, receipt of first and second doses of JYNNEOS vaccine for prevention of Monkeypox, distinguishing SARS-CoV-2 persistence and reinfection, Novavax NVX-COV2373 triggers potent neutralization of Omicron sub-lineages, association between regular physical activity and the protective effect of vaccination against SARS-CoV-2 in a South African case, COVID-19 outcomes in solid organ transplant recipients who received Tixagevimab-cilgavimab Prophylaxis and/or Bebtelovimab treatment, Omicron sublineage BA.2.75.2 exhibits extensive escape from neutralizing antibodies, and Tocilizumab versus Baricitinib in hospitalized patients with severe COVID-19.

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Intro music is by Ronald Jenkees

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Oct 29, 2022
TWiV 948: Breathless with David Quammen
01:49:35

David Quammen returns to TWiV to discuss how he wrote his new book ‘Breathless’, a story about the science and the scientists behind the race to understand the pandemic coronavirus SARS-CoV-2.

Hosts: Vincent Racaniello, Rich Condit,  Kathy Spindler, and Brianne Barker

Guest: David Quammen

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Weekly Picks

David – Shepherd
Brianne – Adventure Aquarium
Kathy – DART results (Narrative, images)
Rich “Elementary” TV series
VincentStop passing the buck on intro science

Listener Pick

RichConsensus

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Oct 23, 2022
TWiV 947: Clinical update with Dr. Daniel Griffin
33:44

In his weekly clinical update Dr. Griffin discusses the prediction of upcoming global infection burden of influenza seasons after relaxation of public health and social measures during the COVID-19 pandemic, severe COVID-19 outcomes after full vaccination of primary schedule and initial boosters, and how successful immunomodulators for treatment of COVID-19 have opened the pathway for comparative trials.

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Intro music is by Ronald Jenkees

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Oct 22, 2022
TWiV 946: Poo versus flu
01:49:15

Angela Mingarelli joins TWiV to discuss whether the gut microbiota of bats confers tolerance to influenza virus infection in mice, and primate hemorrhagic fever-causing arteriviruses that can reproduce in human cells and might be capable of infecting humans.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit,  and Brianne Barker

Guest: Angela Mingarelli

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Weekly Picks

Dickson – Jazz pics: #5. Small group.  Art Blakey and the Jazz Messenger: Art Blakey, Drums; Lee Morgan, Trumpet; Benny Golson, Tenor saxophone; Bobby Timmons, Piano; Jymie Merrit, Bass (1958-1964). Signature album: Art Blakey And The Jazz Messengers: Blues March: Signature song: Blues March
Brianne – Why Chimps and Gorillas Form Rainforest Friendships
Rich Fly Water – FPV to New Depths
Alan – The Seven Words You Can’t Say on Television, by George Carlin, and its repercussions
Angela – Nature’s Inspiring Women in Science Award
Vincent – Mysteries of Nevada Barr and her protagonist Anna Pigeon

Intro music is by Ronald Jenkees

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Oct 16, 2022
TWiV 945: Clinical update with Dr. Daniel Griffin
44:29

In his weekly clinical update Dr. Griffin discusses a healthcare-associated infection with Monkeypox virus, air and surface sampling for monkeypox virus in a UK hospital, misrepresentation and nonadherence regarding COVID19 public health measures, tolerability and immunogenicity of an intranasally-administered adenovirus-vectored COVID-19 vaccine, clinical, virologic, and immunologic evaluation of symptomatic rebound following Nirmatrelvir/Ritonavir treatment, early outpatient treatment with Eemdesivir in patients at high risk for severe COVID-19, Molnupiravir plus usual care versus usual care alone as early treatment for adults with COVID-19 at increased risk of adverse outcomes, and outcomes among confirmed cases and a matched comparison group in the long-COVID in Scotland.

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Intro music is by Ronald Jenkees

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Oct 15, 2022
TWiV 944: Hacking through Borneo with Kathryn Hanley
01:53:47

Kathryn Hanley joins TWiV to discuss her career and the research in her laboratory on the molecular biology, evolution and ecology of emerging RNA viruses and their insect vectors.

Hosts: Vincent Racaniello, Rich Condit,  and Kathy Spindler

Guest: Kathryn Hanley

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Weekly Picks

Kathy – Car Talk Puzzler Archive
Rich The Molecular Biologist Who Exposed the Soviet Union”  by Sean B. Carroll
Vincent NYU Chemistry prof fired because his course was too difficult

Listener Pick

JackThe Everything Virus

Intro music is by Ronald Jenkees

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Oct 09, 2022
TWiV 943: Clinical update with Dr. Daniel Griffin
42:34

In his weekly clinical update Dr. Griffin discusses high points of the multi-national monkeypox outbreaks, monkeypox virus genome mutations, possible occupational infection of healthcare workers with monkeypox virus, rates of monkeypox cases by vaccination status, protection of SARS-CoV-2 infection against reinfection, Paxlovid significantly reduces COVID-19 hospitalizations and deaths, and rebound in COVID19 with and without Paxlovid treatment.

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Intro music is by Ronald Jenkees

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Oct 08, 2022
Public Health with Laurie Garrett: Wastewater Testing
01:00:47

Laurie Garrett discusses the role of wastewater testing in public health and her idea of a device that could be used by anyone to analyze water samples.

This podcast is not an episode of TWiV, but I thought it would be of interest to listeners.

Laurie Garrett and Vincent Racaniello

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Intro music is by Ronald Jenkees

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Oct 04, 2022
TWiV 942: Omicron boosters with Paul Offit
01:53:54

Paul Offit returns to TWiV for a discussion of SARS-CoV-2 bivalent boosters containing ancestral and Omicron spike mRNAs, including their composition, why they are being recommended by CDC, and who would benefit the most from them.

Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit,  Kathy Spindler, and Brianne Barker

Guest: Paul Offit

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Weekly Picks

Dickson – Jazz favorites: Small group #4: Gerry Mulligan Quartet with Chet Baker: Gerry Mulligan, Baritone saxophone; Carson Smith, Bass; Larry Bunker, Drums, Chet Baker, Trumpet. Signature album: The Best Of The Gerry Mulligan Quartet With Chet Baker: Signature song: My Funny Valentine.

Second pick: Wonder: Childhood and the Lifelong love of Science. Frank C. Keil.

Brianne – A Devious Cellular Trick Cancers Can Use to Escape Your Immune System
Kathy – Durable antimicrobial coating
RichOne Health
Vincent – The works of Dashiell Hammett

Intro music is by Ronald Jenkees

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Oct 02, 2022
TWiV 941: Clinical update with Dr. Daniel Griffin
50:12

In his weekly clinical update Dr. Griffin discusses increased acute respiratory illnesses among children and adolescents, estimates of monkeypox incubation period, generation time, and reproduction number, rapid increase in suspected SARS-CoV-2 reinfections, interim infection prevention and control recommendations for healthcare personnel during COVID-19, SARS-CoV-2 secondary attack rates in vaccinated and unvaccinated household contacts during replacement of delta with omicron variant, breakthrough infection by SARS-CoV-2 delta and omicron variants elicited immune response comparable to mRNA booster vaccination, interval between prior SARS-CoV-2 infection and booster vaccination impacts magnitude and quality of antibody and B cell responses, further humoral immunity evasion of emerging SARS-CoV-2 BA.4 and BA.5 subvariants, short-course early outpatient Remdesivir prevents severe disease due to COVID-19 in organ transplant recipients during the Omicron BA.2 wave, effectiveness of Molnupiravir in high risk patients, and primary care and a distinct symptom pattern for long COVID.

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Intro music is by Ronald Jenkees

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Oct 01, 2022
TWiV 940: Eddie Holmes in on viral origins
01:32:02

Eddie Holmes joins TWiV to discuss his role in the first release of the SARS-CoV-2 genome sequence, what really happened during the infamous Fauci teleconference, and evidence that the virus came from Nature and not from a lab.

Hosts: Vincent Racaniello and Dickson Despommier

Guest: Eddie Holmes

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Intro music is by Ronald Jenkees

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Sep 28, 2022
TWiV 939: From lizards to Lassa with Tom Monath
02:01:05

Tom Monath joins TWiV to discuss his wide-ranging career that includes medicine, field work and vaccine development while working for the US government, the US military, and multiple biotechnology companies.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Rich Condit

Guest: Tom Monath

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Weekly Picks

Dickson – Jazz – Small Group #3:  Dave Brubeck Quartet. Dave Brubeck, Piano; Joe Morello, Drums, Paul Desmond, Alto Saxophone, Eugene Wright, Bass: Signature Album: Time Out. Signature Song: Take Five.
RichWilderness Safaris (wiki)
Alan – Madhouse at the End of the Earth, by Julian Sancton
VincentRaymond Chandler and his protagonist Philip Marlowe.

Listener Picks

Philip Students bitten by bats inside college residence hall

Intro music is by Ronald Jenkees

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Sep 25, 2022
TWiV 938: Clinical update with Dr. Daniel Griffin
53:03

In his weekly clinical update Dr. Griffin reviews the public health response to poliovirus in New York, impact of mandatory influenza vaccination, monkeypox in a young infant, health care worker exposure to monkeypox virus, monkeypox testing delays, transmission potential of monkeypox virus, TPOXX trial for monkeypox, detection of SARS-CoV-2 subgenomic mRNA, mucosal IgA against SARS-CoV-2, BNT262b2 against Omicron, awareness and use of SARS-CoV-2 antivirals, comparable outcomes for Bebtelovimab and Nirmatrelvir, and COVID-19 and Alzheimer's disease.

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Intro music is by Ronald Jenkees

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Sep 24, 2022
TWiV 937: Pediatric hepatitis with Emma Thomson
01:00:55

From the European Society for Clinical Virology 2022 Conference in Manchester UK, Vincent speaks with Emma Thomson about the recent outbreak of pediatric hepatitis of unknown etiology and the finding that it is linked to infection by adenovirus-associated virus 2.

Hosts: Vincent Racaniello

Guest: Emma Thomson

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Intro music is by Ronald Jenkees

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Sep 18, 2022
TWiV 936: Clinical update with Dr. Daniel Griffin
52:06

In his weekly clinical update Dr. Griffin discusses detection of a highly divergent type 3 vaccine-derived poliovirus in a child with a severe primary immunodeficiency disorder, severe respiratory illnesses associated with rhinoviruses and/or enteroviruses including EV-D68, effects of vaccination and previous infection on Omicron infections in children, COVID-19-associated hospitalizations among vaccinated and unvaccinated adults 18 years or older in 13 US states, effectiveness of COVID-19 vaccines over time prior to Omicron emergence in Ontario, Canada, nasal IgA wanes 9 months after hospitalization with COVID-19 and is not induced by subsequent vaccination,  resistance of SARS-CoV-2 Omicron subvariant BA.4.6 to antibody neutralization, persistent circulating SARS-CoV-2 spike associated with post-acute COVID-19 sequelae, and impact of COVID-19 vaccination on the risk of developing long-covid and on existing long-covid symptoms.

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Intro music is by Ronald Jenkees

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Sep 17, 2022
TWiV 935: Mobile DNA with Cedric Feschotte
01:23:13

Vincent travels to Cornell University to speak with Cedric about his career and his research on mobile genetic elements such as transposons and endogenous viruses and how they have shaped the evolution of nearly all organisms.

Hosts: Vincent Racaniello

Guest: Cedric Feschotte

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Intro music is by Ronald Jenkees

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Sep 11, 2022
TWiV 934: Clinical update with Dr. Daniel Griffin
52:27

In his weekly clinical update Dr. Griffin discusses variant influenza virus infections: recommendations for identification, treatment, and prevention for summer and fall 2022, low levels of monkeypox virus neutralizing antibodies after MVA-BN vaccination in healthy individuals, using the right tools at the right time for SARS-COV-2 infection, onset and window of SARS-COV-2 infectiousness and temporal correlation with symptom onset, transmission of SARS-COV-2: a review of viral, host, and environmental factors, antibody persistence and safety through 6 months after heterologous orally aerosolized Ad5-nCoV in individuals primed with two-dose vaccine, timely administration of tocilizumab improves outcome of hospitalized COVID-19 patients, administration of anti–SARS-COV-2 monoclonal antibodies after US Food and Drug Administration deauthorization, and clinical and genetic risk factors for acute incident venous thromboembolism in ambulatory patients with COVID-19.

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Intro music is by Ronald Jenkees

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Sep 10, 2022
TWiV 933: Island-hopping bats
01:47:41

TWiV discusses a new henipavirus from fruit bats in Madagascar, and attenuation of SARS-CoV-2 Omicron disease in mice caused by genome mutations outside of the spike protein coding region.

Hosts: Vincent Racaniello, Dickson Despommier, Kathy Spindler, and Brianne Barker

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Weekly Picks

Dickson – Small groups: 3.  Modern Jazz Quartet. Signature song: Skating in Central Park. Signature album: Django.
BrianneTo Prevent a Martian Plague, NASA Needs to Build a Very Special Lab
Kathy – Physics Girl – Overnight in the Most Remote Camp on Earth
VincentLab leaders wrestle with paucity of postdocs

Listener Picks

GaryStan Kenton Orchestra
MiguelMicrosoft Premonition

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Sep 04, 2022
TWiV 932: Clinical update with Dr. Daniel Griffin
49:47

In his weekly clinical update Dr. Griffin discusses vaccine effectiveness against influenza illness in children, clinical manifestations of infection with poliovirus, spike protein-independent attenuation of SARS-CoV-2 Omicron variant in laboratory mice, concordance of SARS-CoV-2 results in self-collected nasal swabs vs swabs collected by health care workers in children and adolescents, probable animal-to-human transmission of SARS-CoV-2 causing a pet shop-related outbreak, laboratory-confirmed COVID-19–associated hospitalizations among adults during BA.2 variant, SARS-CoV-2 specific T-cells and antibodies, Nirmatrelvir use and outcomes during the Omicron surge, real-world effectiveness of early Molnupiravir or Nirmatrelvir–ritonavir in hospitalized patients, and distinguishing features of long COVID.

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Intro music is by Ronald Jenkees

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Sep 03, 2022
TWiV 931: Driven to immunodistraction
02:01:20

TWiV reviews the genetic characterization of a new strain of type 2 oral polio vaccine and its implications for eradication, and how a polymorphism in humans comprising a single amino acid change in an antibody molecule regulates vaccine elicitation of broadly neutralizing antibodies against influenza virus HA.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Kathy Spindler, and Brianne Barker

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Weekly Picks

Dickson - Small groups: 1.  Miles Davis Quintet. Signature album: Kind Of Blue. Signature song: So What.
Brianne - World Excel Championships
Kathy - Lyre bird background and video
Alan The Kissing Bug, by Daisy Hernandez
Vincent -Five top detective fiction writers. #1 Martin Beck by Maj Sjöwall and Per Wahlöö

Listener Picks

John Fevers, Feuds and Diamonds: Ebola and the Ravages of History by Paul Farmer
CarolThe Social Dilemma

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Aug 28, 2022
TWiV 930: Clinical update with Dr. Daniel Griffin
48:18

In his weekly clinical update Dr. Griffin discusses antibody response against nonpoliovirus enteroviruses, clinical presentation and virological assessment of confirmed human monkeypox virus cases in Spain, object and surface contamination with monkeypox virus, monkeypox virus infection in humans across 16 countries, clinical characteristics of ambulatory and hospitalized patients with monkeypox virus infection, compassionate use of Tecovirimat for the treatment of monkeypox infection, monitoring of Pfizer-BioNTech vaccine among children, Pfizer and BioNTech announce updated vaccine data supporting efficacy in children, direct capture of neutralized RBD enables rapid point-of-care assessment of SARS-CoV-2 neutralizing antibody titer, Pfizer and BioNTech submit application for bivalent vaccine, and Oral Nirmatrelvir and Ritonavir in non-hospitalized vaccinated patients with COVID-19.

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Intro music is by Ronald Jenkees

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Aug 27, 2022
TWiV 929: Empathyology with Andy Slavitt
02:00:21

Andy Slavitt joins TWiV to discuss his book, Preventable and how failures in leadership, politics, and selfishness doomed the U.S. response to SARS-CoV-2.

Hosts: Vincent Racaniello, Dickson Despommier, Kathy Spindler, and Brianne Barker

Guest: Andy Slavitt

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Weekly Picks

Dickson – Best big band #5: 1. Glenn Miller’s Orchestra -1940-1944: Signature song: In The Mood. Signature album: An Album Of Outstanding Arrangements
BrianneCross-stitched Microbes
Kathy – Time trials for bottle emptying
AlanMeow Parlor
VincentVIRUS x1,000,000 (2022) by Drew Berry wehi.tv

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Aug 21, 2022
TWiV 928: Clinical update with Dr. Daniel Griffin
41:32

In his weekly clinical update Dr. Griffin discusses the public health response to a polio case in a unvaccinated NY state resident, human to dog transmission of monkeypox virus, Tecovirimat and the treatment of monkeypox, detection of asymptomatic monkeypox virus infections among male sexual health clinic attendees in Belgium, what to do if you are exposed to SARS-CoV-2 and isolation and precautions for people with COVID-19, risk of SARS-CoV-2 infection in health care workers, effectiveness of HEPA filters at removing infectious SARS-CoV-2 from the air, Pfizer reports additional data on Paxlovid, hospitalization encounters for infection after Paxlovid, a randomized trial of Metformin, Ivermectin, and Fluvoxamine, and readmissions, post-discharge mortality and sustained recovery among patients admitted to hospital with COVID-19.

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Intro music is by Ronald Jenkees

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Aug 20, 2022
TWiV 927: Merchlinsky vs monkeypox
01:50:18

Michael Merchlinsky joins TWiV to discuss the development of two smallpox antiviral drugs and two smallpox vaccines and their uses during the monkeypox outbreak.

Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Kathy Spindler

Guest: Michael Merchlinsky

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Weekly Picks

Dickson – Duke Ellington and his Orchestra. Signature song: Take The A Train; Signature album: Black, Brown, And Beige and Herding Cats: Harlem 1958
Kathy – How the US Postal Service reads terrible handwriting
Rich JWST/chorizo gag
VincentBat Conservation Trust

Listener Picks

Bill The End of Manual Transmission
JHow the Krebs cycle powers life and death – with Nick Lane

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Aug 14, 2022
TWiV 926: Clinical update with Dr. Daniel Griffin
40:38

In his weekly clinical update Dr. Griffin discusses guidance for prevention and treatment of monkeypox, post-infectious symptoms among children and adolescents, profiling post-infectious syndromes of different variants, comparison of vaccine Ankara vs intradermal routes of administration, infection in vaccinated individuals treated with or without PAXLOVID, duration of symptoms with positive rapid antigen after infection, epidemiologic characteristics of monkeypox, and sequelae of post-acute infection.

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Intro music is by Ronald Jenkees

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Aug 13, 2022
TWiV 925: First kisses and second doses
01:43:05

TWiV discusses monkeypox virus, poliovirus in NY, Marburg virus in Ghana, ancient herpes simplex virus type 1 genomes, and immunogenicity of different combinations of SARS-CoV-2 vaccines.

Hosts: Vincent Racaniello, Alan Dove, Rich Condit, Kathy Spindler, and Brianne Barker

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Weekly Picks

Brianne Everyone Loses on Jeopardy Eventually
Kathy – Climate spiral  followed by Carl Sagan
RichMost Popular Desktop Browsers 1993 – 2022
Alan – I Am Promise
VincentPolio in New York

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Aug 07, 2022
TWiV 924: TWiV clinical update with Dr. Daniel Griffin
46:24

In his weekly clinical update Dr. Griffin discusses Tecovirimat for treatment of monkeypox, the safety and acceptance of vaccination after multisystem inflammatory syndrome, variants in solid organ transplant recipients, masks for prevention of respiratory virus infections, pre-exposure prophylaxis with Evusheld, the association between Evusheld administration and infection,  if repeat administration of casirivimab and imdevimab is well-tolerated, viral and symptom rebound in untreated infection, extended Remdesivir infusion for persistent infection, Baricitinib in patients admitted with infection, and cognitive impairment 13 months after hospitalization.

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Intro music is by Ronald Jenkees

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Aug 06, 2022
TWiV 923: If a bat pees in a forest, does anyone care?
01:05:11

From The Third International Symposium on Infectious Diseases of Bats in Ft. Collins, Colorado, TWiV speaks with Vincent Munster and Raina Plowright about their careers and their research on bats, bat viruses, bat ecology and spillover events.

Hosts: Vincent Racaniello and Brianne Barker

Guests: Vincent Munster and Raina Plowright

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Intro music is by Ronald Jenkees

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Jul 31, 2022
TWiV 922: TWiV clinical update with Dr. Daniel Griffin
42:20

In his weekly clinical update Dr. Griffin discusses monkeypox infection in humans across 16 countries, pregnancy outcomes after SARS-CoV-2 infection by trimester, vaccination intent and belief, antiviral drug treatment for non-severe disease, the association of smoking with infected hospitalized patients, the association of Paxlovid on negative conversion rates among high-risk patients with COVID-19, safety and efficacy of Molnupiravir, usage of enoxaparin for primary thromboprophylaxis, statin and aspirin as therapy in infected patients, post-COVID-19 conditions among children 90 days after SARS-CoV-2 Infection, and symptoms and risk factors for long COVID in non-hospitalized adults.

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Intro music is by Ronald Jenkees

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Jul 30, 2022
TWiV 920: Science will break your heart
01:01:12

From ASV 2022 in Madison, Wisconsin, TWiV speaks with Pamela Bjorkman and Andy Mehle about their careers and their research on influenza virus, HIV-1, SARS-CoV-2, and influenza virus.

Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker

Guests: Pamela Bjorkman and Andy Mehle

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Intro music is by Ronald Jenkees

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Jul 24, 2022
TWiV 921: COVID-19 clinical update #124 with Dr. Daniel Griffin
35:13

In COVID-19 clinical update #124, Dr. Griffin discusses the results of a variant vaccine booster trial, the neutralization of variant sub-lineages by Novavax, the CDC’s recommendation of Novavax’s COVID-19 vaccine in adults, Paxlovid in patients who are immunocompromised and hospitalized, and inhaled fluticasone for outpatient treatment.

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Intro music is by Ronald Jenkees

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Jul 23, 2022
TWiV 919: Motivated by volatiles
01:41:49

TWiV reviews the FDA decision to update COVID-19 vaccine boosters in the fall, the meaning of fatigue with respect to long COVID, and a skin volatile induced by flavivirus reproduction that attracts mosquitoes to the infected host.

Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker

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Weekly Picks

BrianneRedactle
KathyKirigami paper replacing plastic bubble wrap
RichFirst Images from the James Webb Space Telescope (Gravitational lens; Einstein ring)
Vincent Spotted lanternfly

Listener Picks

Ann NASA Engineer Who Made the James Webb Space Telescope Work
Sonrisa Aloft – the pleasures and risks of flying

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Jul 17, 2022
TWiV 918: COVID-19 clinical update #123 with Dr. Daniel Griffin
40:33

In COVID-19 clinical update #123, Dr. Griffin discusses rapid diagnostic testing in response to the monkeypox outbreak, leading causes of death in the US during the COVID-19 pandemic, antibody evasion by subvariants, broadly-neutralizing antibodies against emerging variants, factors associated with severe outcomes among hospitalized immunocompromised adults, measurement of the burden of hospitalizations during the pandemic, parental vaccine hesitancy in diverse communities, evaluating saliva sampling to improve access to diagnosis in low-resource settings, oral sabizabulin for high-risk hospitalized adults, lower-risk of multisystem inflammatory syndrome in children, and neurovascular injury with complement activation and inflammation during infection.

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Intro music is by Ronald Jenkees

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Jul 16, 2022
TWiV 917: Boosters on, Paul Offit
01:43:21

Paul Offit returns to TWiV to discuss why, during the recent FDA advisory committee meeting, he voted against releasing revised COVID-19 vaccines containing an Omicron component, and the reasons why children must be vaccinated against the disease.

Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Kathy Spindler

Guest: Paul Offit

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Weekly Picks

Dickson – Woody Herman and his orchestra. 1955-1965. Signature song: The Preacher. Signature album: Woody Herman and His Orchestra (1956)
KathySolargraphic analemmas
Rich – Windy (desktop; app)
Vincent Why monkeypox is mostly hitting men who have sex with men

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MarkHand Wash Dance – NHK WORLD-JAPAN

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Jul 10, 2022