This Week in Virology

By Vincent Racaniello

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Subscribers: 1224
Reviews: 6


 Aug 8, 2021

Rachael
 Nov 28, 2020
excellent thanks for doing a great job


 May 29, 2020

excellent
 Apr 23, 2020
great information

Reed
 Jan 15, 2020
amazing in depth podcast on the nuts and bolts of all kinds of viruses. expect in depth discussions of papers by experienced scientists with a decent sense of humour. I can follow along most details even though I have not studied virology.

Description

This Week in Virology is a netcast about viruses - the kind that make you sick.

Episode Date
TWiV 821: Public clonotype #1
02:00:39

A TWiV trio reveal the isolation of novel paramyxoviruses from rodents and bats in Arizona, and isolation of naive B cells from seronegative donors that produce germline encoded antibodies which engage the receptor binding domain of SARS-CoV-2, variants of concern, and related sarbecoviruses from bats.

Hosts: Vincent Racaniello, Rich Condit, and Brianne Barker

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Weekly Picks

Brianne – Apod: The Dolphin Head Nebula
Rich The Tree That Could Help Stop The Pandemic; Elucidating the Mechanisms of Action of Saponin-Derived Adjuvants
Vincent – Discovery of RNA splicing in Sharp and Roberts laboratories

Listener Picks

JasonHome Assistant
AlenaVirusCraft

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

Oct 24, 2021
TWiV 820: COVID-19 clinical update #85 with Dr. Daniel Griffin
41:20

In COVID-19 clinical update #85, Dr. Griffin reviews cases and deaths by vaccination status, mRNA vaccine effectiveness in 12-18 year olds, standard and extended dosing of mRNA vaccines, immune responses after vaccination, Moderna booster dose approved, giving monoclonals at home, no benefit from colchicine, and IFN does not help remdesivir.

Hosts: Daniel Griffin and Vincent Racaniello

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Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to daniel@microbe.tv

Oct 23, 2021
TWiV 819: How to stall a copy machine
01:40:32

TWiV explains how remdesivir inhibits the SARS-CoV-2 RNA polymerase: the drug is incorporated into the growing RNA chain and causes synthesis to stall when the drug clashes with an amino acid in the active site.

Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler

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Weekly Picks

Kathy – Great Lakes Science Center, Cleveland
Rich How to Temporarily Disable Your Keyboard with a Keyboard Shortcut in Windows
Alan – How to Make a Slave and Other Essays by Jerald Walker
VincentA structure for deoxyribose nucleic acid

Listener Picks

SteveHow the immune system actually works
LiseLise Meitner: A Life in Physics

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

Oct 21, 2021
TWiV 818: Thor's hammer
01:56:19

The TWiVers review phase 3 efficacy and safety results for the Novavax COVID-19 vaccine, effects on the neonatal immune system caused by maternal infection with SARS-CoV-2, and NHC, the metabolite of molnupiravir, causes mutations in cellular DNA.

Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, Kathy Spindler, and Brianne Barker

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Weekly Picks

Dickson –  John Clease
BrianneAstronomy Picture of the Day: Swirl in the Southern Sky
Kathy – Lise Meitner  Statue is at the Humboldt University
Rich Google has the cleanest cloud. Now it’s helping other companies go green
Vincent – Discovery of reverse transcriptase by Baltimore and Temin

Listener Picks

SamAir Travel Packing List
JustinPFAS: Last Week Tonight with John Oliver and EPA targets greenhouse emissions

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

Oct 17, 2021
TWiV 817: COVID-19 clinical update #84 with Dr. Daniel Griffin
45:51

In COVID-19 clinical update #84, Dr. Griffin discusses childrens’ antibody response to vaccination, phase 3 results of Novavax vaccine, heterologous vaccination, antithrombotic therapy, EUA for molnupiravir, phase 3 results of AZD7442, serum ferritin levels and outcomes, heparin therapy, and WHO strategy for global vaccination.

 
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Intro music is by Ronald Jenkees

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Oct 16, 2021
TWiV 816: Long COVID and ME/CFS with David Tuller
01:09:38

David Tuller returns to TWiV to revisit his work to expose the methodological and ethical problems with the PACE trial, and the post-acute sequelae to SARS-CoV-2 infection, also known as long COVID.

Host: Vincent Racaniello

Guest: David Tuller

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Intro music is by Ronald Jenkees

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Oct 15, 2021
TWiV 815: MIS-C with Moshe Arditi and Ivet Bahar
02:02:51

Moshe and Ivet join TWiV to discuss their finding that MIS-C is a consequence of a superantigen in the spike protein of SARS-CoV-2 that causes activation of a skewed population of T cell receptor bearing lymphocytes, leading to hyperinflammation.

Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit and Kathy Spindler

Guests: Moshe Arditi and Ivet Behar

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Weekly Picks

Dickson –  Mel Brooks
Kathy – Dickson’s art show at Fordham
RichSaildrone captures footage from inside Hurricane Sam
VincentA Shot to Save the World: The Inside Story of the Life-or-Death Race for a COVID-19 Vaccine by Gregory Zuckerman

Listener Picks

KathrynProject Drawdown and the book
CharlesArrowsmith by Sinclair Lewis

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

Oct 10, 2021
TWiV 814: COVID-19 clinical update #83 with Dr. Daniel Griffin
49:49

In COVID-19 clinical update #83, Daniel Griffin discusses upcoming FDA discussions on vaccines, strategies to prevent transmission at youth camps, outbreaks at summer camps, impact of vaccination on transmission, AZD7442 request for EUA filed, EUA issued for home antigen test, phase 3 data on AZD1222 vaccine, 6 month effectiveness of Pfizer/BioNTech vaccine, estimates of durability of immunity against reinfection, Molnupiravir interim results, optimal time for monoclonal antibody infusion, IVIG plus Infliximab for MIS-C, and effect of vaccination on long COVID.

Hosts: Daniel Griffin and Vincent Racaniello

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Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to daniel@microbe.tv

Oct 09, 2021
TWiV 813: COVID-19 at the European Society for Clinical Virology
01:59:47

From the 2021 online meeting of the European Society for Clinical Virology, Vincent speaks with meeting speakers on COVID-19 vaccines, immunity, how countries responded to the pandemic, and how to prepare for the next one.

Host: Vincent Racaniello

Guests: Sarah Gilbert, Florian Krammer, Fausto Baldanti, Thea Fischer, Ron Fouchier, and Catherine Moore

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Intro music is by Ronald Jenkees

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Oct 07, 2021
TWiV 812: Bespoke capsids delivered
01:51:38

TWiV considers lessons learned from COVID-19 about emergency drug use during a pandemic, and selection of AAV capsids to produce vectors that efficiently deliver genes to muscle cells.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit and Brianne Barker

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Weekly Picks

Dickson -  Sid Caesar - The German General
Brianne - These Sea Slugs Break a Cardinal Rule of Animal Life
Rich - Seek by iNaturalist
Alan - The hard part of making a game is ... everything
Vincent - Columbia Pledges That All Future Campus Construction Will Be Fossil Free

Listener Picks

Bruce - Bat Superpowers
Gary - We’re Already Barreling Toward the Next Pandemic

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

 

Oct 03, 2021
TWiV 811: COVID-19 clinical update #82 with Dr. Daniel Griffin
40:26

In COVID-19 clinical update #82, Daniel Griffin reviews vaccines for 5-12 years old, safety of a third vaccine dose, Oklahoma reinfection data, Regencov outcomes, Pfizer protease inhibitor, impact of Tocilizumab, and incidence of long COVID.

Hosts: Daniel Griffin and Vincent Racaniello

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Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv

Oct 02, 2021
TWiV 810: Opening Pandora's box
02:00:03

TWiV reviews how a novel technology enabled development of COVID-19 mRNA vaccines, and discovery of a proton gradient and an incomplete TCA cycle in a giant. virus.

Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker

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Weekly Picks

Brianne –  PhD Comics: Words Said By No Academic Ever
Kathy – Bach Cello Suite #1 visualization
RichHypnagogia
VincentLandsat 9 and Wiki

Listener Picks

LoriProject Hail Mary by Andy Weir
KevinOak Savannahs

Intro music is by Ronald Jenke

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Sep 30, 2021
TWiV 809: Vampire vax
01:39:47

TWiV reveals isolation from bats in Laos of a SARS-CoV-2 like virus with a spike protein that allows entry into human cells, and exploration of a herpesvirus vector for immunization of vampire bats against rabies virus.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit and Amy Rosenfeld

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Weekly Picks

Dickson –  George Carlin: “Stuff”
Amy – The best of me by David Sedaris
Rich You could have a secret twin (but not the way you think)
Alan Nuclear powered Gameboy
Vincent No, Vaccinated People Are Not ‘Just as Likely’ to Spread the Coronavirus as Unvaccinated People by Craig Spencer

Listener Picks

MichaelThe tangled history mRNA vaccines
Fernando1493 by Charles Mann

Intro music is by Ronald Jenkees

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Sep 26, 2021
TWiV 808: Clinical update #81 with Dr. Daniel Griffin
51:39

In COVID-19 clinical update #81, Daniel Griffin discusses vaccine boosters, vaccination during pregnancy, mRNA vaccine comparison, J&J vaccine booster, EUA expansion for Lilly monoclonals, remdesivir reduces risk of hospitalization, and anticoagulation regimens.

Hosts: Daniel Griffin and Vincent Racaniello

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Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to daniel@microbe.tv

Sep 25, 2021
TWiV 807: The shot yearned 'round the world with Chadi Saad-Roy and Caroline Wagner
01:42:04

Chadi and Caroline join TWiV to describe the potential epidemiological and evolutionary impacts of vaccine nationalism, and their modeling which emphasizes the importance of rapid equitable vaccine distribution for global control of the pandemic.

Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit and Brianne Barker

Guests: Chadi Saad-Roy and Caroline Wagner

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Weekly Picks

Dickson –  Ernie Kovaks-Nairobi Trio
Brianne – XKCD Summarizes this Episode
RichTexas Coronavirus Antibody REsponse Survey (CARES) (Dashboard)
Vincent Elmer Pfefferkorn

Listener Picks

CatherineA Life on Our Planet
Attila How to improve your chances of nudging the vaccine hesitant away from hesitancy and toward vaccinationIntro music is by Ronald Jenke

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Sep 19, 2021
TWiV 806: COVID-19 clinical update #80 with Dr. Daniel Griffin
49:22

In COVID-19 clinical update #80, Daniel Griffin reviews infections in children, masking, testing to limit transmission, high barrier for monoclonal antibody escape, are boosters needed, use of steroids, grants for long COVID, and how the pandemic unfolds in Africa.

Hosts: Daniel Griffin and Vincent Racaniello

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Intro music is by Ronald Jenkees

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Sep 18, 2021
TWiV 805: Delta and boosters
01:34:10

The TWiVotopes review current evidence which does not show the need for widespread COVID-19 booster vaccination, and results of experiments to examine the replication and immune evasion of the SARS-CoV-2 delta variant.

Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker

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Weekly Picks

BrianneSloan Foundation Theater
Kathy – COVID vaccines work, even if you don’t have side effects lay article  primary article
Rich Science Alone Can’t Heal a Sick Society by Jay S. Kaufman
VincentSandra Black SciArt

Listener Pick

RuthRadio Lento podcast

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

Sep 16, 2021
TWiV 804: A tangled web of viruses with Mya Breitbart
01:51:12

Virus hunter Mya Breitbart joins TWiV to describe her laboratory’s work on viruses in spiders, insects, millipedes, freshwater springs, seawater, plants, human feces and much more.

Hosts: Vincent Racaniello, Alan Dove, and Dickson Despommier

Guest: Mya Breitbart

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Weekly Picks

DicksonOfficial-Droodles-Home
Alan – The 31st First Annual Ig Nobel Prize Ceremony video (and the text version)
Vincent Biden’s federal and business vaccine mandates

Listener Pick

AnonymousThe Ivermectin Episode – Behind the Bastards

Intro music is by Ronald Jenkees

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Sep 12, 2021
TWiV 803: COVID-19 clinical update #79 with Dr. Daniel Griffin
45:15

In COVID-19 clinical update #79, Daniel Griffin discusses clinical management guidelines, ER visits and hospitalization among children, infection and vaccine induced seroprevalence in the US, antibodies in Kenyan blood donors, infections after vaccination, anticoagulation for thromboprophylaxis, baracitinib efficacy, long-term symptoms in adults, and sustained symptoms after severe disease.

 
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Intro music is by Ronald Jenkees

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Sep 11, 2021
TWiV 802: Another epitope with Shane Crotty
01:46:50

Shane Crotty returns to TWiV to review the immunology of COVID-19, including differences between infection and vaccination, increased breadth of antibodies after infection followed by vaccination, the roles of T cells, and whether booster vaccinations are needed.

Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker

Guest: Shane Crotty

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Weekly Picks

Brianne How the cat gets its stripes
KathyKurzgesagt on Giruses (giant viruses) and beautiful APOD
RichThe 1911 Triangle Factory Fire; Triangle: The Fire That Changed America by David Von Drehle
Vincent Two Top F.D.A. Vaccine Regulators Are Set to Depart During a Crucial Period

Listener Picks

DebbyRiver Runner
Lin Your Vaccinated Immune System Is Ready for Breakthroughs

Intro music is by Ronald Je

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Sep 09, 2021
TWiV 801: We can hear the coffin
01:57:21

The meteorologicomaniacs discuss the COVID-19 pandemic global death toll, effectiveness of vaccines against the delta variant, and how analysis of ancient viral DNA reveals that two pathogenic human viruses were brought into Mexico during the transatlantic slave trade.

Hosts: Vincent Racaniello, Alan Dove, Dickson Despommier, Rich Condit, and Brianne Barker

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Weekly Picks

DicksonVictor Borge, Phonetic Punctuation
BrianneCat TV
Rich Cochrane review: Ivermectin for preventing and treating COVID‐19
Alan – Cockpit video of flying into Oshkosh
VincentMedical News Network Morning Medical Update

Listener Pick

JodyHuman Body Theatre and Plagues: The Microscopic Battlefield

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

Sep 05, 2021
TWiV 800: COVID-19 clinical update #78 with Dr. Daniel Griffin
52:30

In COVID-19 clinical update #78, Daniel Griffin covers ivermectin, convalescent plasma, disease in pregnant women, children and COVID, delta outbreak in an elementary school, validation of at-home antigen test, shedding in infected vaccinated people, mRNA vaccine antibody responses compared, AZD7442, fluvoxamine, one year outcomes in hospitalized patients, and post-vaccination disease.

Hosts: Daniel Griffin and Vincent Racaniello

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Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to daniel@microbe.tv

Sep 04, 2021
TWiV 799: A very model of a modern TWiV
02:08:21

TWiV reviews models for determining correlates of neutralizing antibody protection against COVID-19, and for identifying key vector and host species that drive transmission of zoonotic pathogens.

Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker

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Weekly Picks

Brianne A microscopic video shows the coronavirus on the rampage
KathySabin Oral Sundays in Cuyahoga County, 1962
RichThe Continuing COVID-19 Pandemic: Current Issues and Glimpse Into the Future
Vincent Demand Surges for Deworming Drug for Covid, Despite Scant Evidence It Works

Listener Picks

Ronald Immunity to COVID-19 could last longer than you’d think
AgnesSpace Shuttle Prints

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

Sep 02, 2021
TWiV 798: Rats, more coronaviruses!
01:56:56

The TWiV team explains what the Biden report on SARS-CoV-2 origins did not: evidence that the virus came from Nature, not a lab; and reveals new coronaviruses in rodents that inhabit populated areas in southern China.

Hosts: Vincent Racaniello, Alan Dove, Dickson Despommier, Rich Condit, and Kathy Spindler

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Weekly Picks

DicksonThe Brilliant Abyss by Helen Scales
KathySolar System ball drop
RichDr. Fox effect
Alan – Patty Wagstaff virtual airshow cockpit video
VincentOffice Hours

Listener Picks

Karen The Dog Will See You Now
AliciaBio-Rad GTCA Song

Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv

Aug 29, 2021
TWiV 797: COVID-19 clinical update #77 with Dr. Daniel Griffin
40:45

In COVID-19 clinical update #77, Daniel Griffin discusses children becoming increasingly infected, virological characteristics of infections in vaccinated health care workers, transmission dynamics among close contacts, licensing of Pfizer mRNA vaccine, cost of hospitalization of unvaccinated patients, 29 times higher hospitalization rates in unvaccinated patients, boost in neutralizing antibody potency and breadth by third vaccine dose, and use of J&J vaccine as second dose.

Hosts: Daniel Griffin and Vincent Racaniello

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Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to daniel@microbe.tv

Aug 28, 2021
TWiV 796: The vary hungry spike with Paul and Theodora
01:53:40

Paul and Theodora return to TWiV to explain their research on determining the number of neutralizing epitopes on the SARS-CoV-2 spike that are recognized by antibodies, and engineering of a polymutant spike with twenty amino acid changes that demonstrates the high genetic barrier to escape from convalescent serum.

Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Brianne Barker

Guests: Paul Bieniasz and Theodora Hatiziiouannou

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Weekly Picks

DicksonNIF and Photon Science: fusion reaction generates 1.3 MJ
BrianneThe PCR Song
Rich – 1) How Boston Dynamics’ Spot Robot Works! 2) Inside the lab: How does Atlas work?3) Atlas | Partners in Parkour
Theodora – Kevin Parry turning into random objects
VincentLex Fridman

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

Aug 22, 2021
TWiV 795: COVID-19 clinical update #76 with Dr. Daniel Griffin
36:52

In COVID-19 clinical update #76, Daniel Griffin covers association of age and pediatric household transmission, rapid antigen testing in remote communities, shedding of infectious virus in vaccinated individuals, FDA amendment of mRNA vaccine EUA to allow a third dose, new vaccine mandate for NY state, full vaccination suppresses selection of variants, effectiveness of mRNA vaccines in nursing homes, sustained effectiveness of mRNA vaccines against hospitalization, and no benefit from early convalescent serum in high-risk outpatients.

Hosts: Daniel Griffin and Vincent Racaniello

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Intro music is by Ronald Jenkees

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Aug 21, 2021
TWiV 794: PAMS spray SARS-CoV-2
01:57:53

TWiV summarizes cases of arbovirus disease during 2019 in the US, and explains a study that estimates infectiousness throughout the SARS-CoV-2 course of infection.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Brianne Barker

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Weekly Picks

DicksonClimate Reports | United Nations
BrianneAstronomy Picture of the Day: A Perfect Spiral
Rich COVID-19 false dichotomies
Alan – Fixing broken machines
VincentMKBHD Studio Tour 2021

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

Aug 15, 2021
TWiV 793: COVID-19 clinical update with Dr. Daniel Griffin
41:26

In COVID-19 clinical update #75, Daniel Griffin reviews vaccine effectiveness against transmission, modeling effectiveness of daily antigen tests, updated CDC guidance for fully vaccinated, risk of infection with time after mRNA vaccination, reduced risk of infection after vaccination, therapeutic anticoagulants in critically ill patients, and 6 month outcomes in hospitalized patients.

Hosts: Daniel Griffin and Vincent Racaniello

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Intro music is by Ronald Jenkees

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Aug 14, 2021
TWiV 792: Transmission with Jeffrey Shaman
01:39:37

Jeffrey Shaman returns to TWiV to explain how epidemiologists measure SARS-CoV-2 movement among humans, including calculation of the reproductive index, secondary transmission, and what factors affect transmission.

Hosts: Vincent Racaniello, Kathy Spindler, and Brianne Barker

Guest: Jeffrey Shaman

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Weekly Picks

Brianne The Social Lives of Giraffes
KathySaturn’s Iapetus, moon in 3-D
Vincent Arkansas Governor Wants To Reverse A Law That Forbids Schools To Require Masks

Intro music is by Ronald Jenkees

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Aug 12, 2021
TWiV 791: A mad virologists' T party
02:03:47

TWiV reviews SARS-CoV-2 infection of wild white-tailed deer in the US, mRNA vaccine-mediated protection by spike-specific T cells before detection of neutralizing antibodies, and recovery from SARS-CoV-2 infection in T-cell depleted rhesus macaques.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Brianne Barker

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Dickson Virgin Hyperloop shows off the future
BrianneBioNumbers
Rich Advice will evolve as COVID situation changes
Alan – Mars Perseverance-themed geocaching swag
Vincent Mattel’s Barbie Turns Women Of Science, Including COVID Vaccine Developer, Into Dolls

Listener Picks

NancyVaccines at a Party
Jeff How to Survive a Plague, Part 2

Intro music is by Ronald Jenkees

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Aug 08, 2021
TWiV 790: COVID-19 clinical update #74 with Dr. Daniel Griffin
49:27

In COVID-19 clinical update #74, Daniel Griffin covers infections in vaccinated individuals, expansion of Regeneron monoclonal antibody cocktail for prophylaxis, neutralization of variants by antibodies produced by infection or vaccination, longer hospital stays associated with remdesivir treatment, and post-acute sequelae of infection and impact on quality of life 1-6 months after illness.

Hosts: Daniel Griffin and Vincent Racaniello

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Intro music is by Ronald Jenkees

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Aug 07, 2021
TWiV 789: Does delta mean a change?
01:48:32

TWiV reviews a leaked CDC document on virulence and spread of the delta variant, and how anti-alphavirus antibodies that do not neutralize infection can nevertheless protect mice from disease.

Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker

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Weekly Picks

BrianneNobel Prize Games
KathySnail sensors
RichIn Shock: My Journey from Death to Recovery and the Redemptive Power of Hope by Rana Awdish
Vincent The Provincetown Covid data is actually good news (if you are vaccinated) and I Was the Architect of Operation Warp Speed. I Have a Message for All Americans.

Listener Pick

JakeNASA spinoff
PeterBernard, the Extraordinary Moth

Intro music is by Ronald Jenkees

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Aug 05, 2021
TWiV 788: neuroCOVID with Kiran Thakur, MD
02:01:44

Kiran joins TWiV to discuss the findings of a team at Columbia University Medical Center on COVID-19 neuropathology, and the conclusion that SARS-CoV-2 does not reproduce in the central nervous system.

Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Brianne Barker

Guest: Kiran Thakur

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Weekly Picks

Dickson – Simone Biles and Suni Lee
Brianne How Speed and Distance Dictate the Way Olympians Run
Rich CDC reversal on indoor masking prompts experts to ask, ‘Where’s the data?’
VincentPaul and the Mosquitos

Listener Pick

Lin Your Vaccinated Immune System is Ready For Breakthroughs

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Aug 01, 2021
TWiV 787: COVID-19 clinical update #73 with Dr. Daniel Griffin
46:09

In COVID-19 clinical update #73, Daniel Griffin reviews updated mask guidance from CDC, infections in public school district employees, effectiveness of vaccines against delta variant, antibody response after third vaccine dose in kidney transplant recipients, protection afforded by mRNA vaccines fully vaccinated people with and without prior infections, correlates of protection in nonhuman primates, lack of effectiveness of doxycycline, neurological manifestations of COVID-19, and infection in vaccinated health care workers.

Hosts: Daniel Griffin and Vincent Racaniello

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Intro music is by Ronald Jenkees

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Jul 31, 2021
TWiV 786: You make mucus and you move it
01:43:31

TWiVsters review off-season epidemics of respiratory syncytial virus in Australia after easing of COVID-19 restrictions, and impaired innate immune responses in upper respiratory tract cells from patients with severe COVID-19.

Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker

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BrianneThe Science of Swimming
Kathy Talking to the vaccine hesitant  and covidactnow.org
RichThe Disinformation Dozen | Center for Countering Digital Hate (CCDH on wiki)
Vincent Russia discards Pirs docking port to clear way for new space station module (IG post)

Listener Pick

April – Pemberton Aviation (Facebook, YouTube)

Intro music is by Ronald Jenkees

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Jul 29, 2021
TWiV 785: COVID-19 Q&A with Dr. Daniel Griffin
59:13

In this special episode, Daniel Griffin answers listener questions on COVID-19 vaccines, vaccine misinformation, long COVID, masking and distancing, school safety, and much more.

Hosts: Daniel Griffin and Vincent Racaniello

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Jul 28, 2021
TWiV 784: Virtually live from ASV
01:19:47

Moriah and Joseph join the nearly complete TWiV team to discuss their work on genetic variation and adaptability in herpes simplex virus, and how rotavirus infection disrupts intracellular calcium homeostasis. Live streamed during the 2021 annual meeting of the American Society for Virology.

Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, Alan Dove, and Brianne Barker

Guests: Joseph Hyzer and Moriah Szpara

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Dickson Inside of Mars is not like Earth
BrianneAlphaFold
RichTesla motors
Alan Diving for antique beer
Vincent Dolly Parton Tried. But Tennessee Is Squandering a Miracle

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Jul 25, 2021
TWiV 783: COVID-19 clinical update #72 with Dr. Daniel Griffin
44:26

In COVID-19 clinical update #72, Daniel Griffin covers long term symptoms in children, outcomes for MIS-C, recent guidance from the American Academy of Pediatrics, a large well traced outbreak of delta variant, low dose mRNA vaccination generates durable T cell memory and antibodies, protective immunity in recovered patients, assessment of BinaxNOW, no effect of oral azithromycin, post-discharge symptoms in Nigeria, and therapeutics for low and middle income countries.

Hosts: Daniel Griffin and Vincent Racaniello

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Jul 23, 2021
TWiV 782: An antibody for all sarbecoviruses
01:02:53

On this episode, broadening of immune responses to SARS-CoV-2 after mRNA vaccine booster to ChAdOx1 nCoV-19, five-fold underestimation of the number of cases in the US during the first six months of the pandemic, and a monoclonal antibody that broadly neutralizes many different sarbecoviruses.

Hosts: Vincent Racaniello and Amy Rosenfeld

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Jul 22, 2021
TWiV 781: My genome is left to tell the tale
01:46:40

The Team with Invincible Values discusses whether dogs or cats passively carry SARS-CoV-2 on hair and foot pads, maternal to fetal transfer of antibodies in infected or vaccinated pregnant women, and evidence that retroviruses infected cetaceans before and after they moved into the oceans.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Brianne Barker

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DicksonCurrent Map | U.S. Drought Monitor
BrianneA comic strip about immune responses
AlanSuperliminal game
Vincent Birds are dying in NJ

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2listening1Renewal
EmCognitive Surplus

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Jul 18, 2021
TWiV 780: COVID-19 clinical update #71 with Dr. Daniel Griffin
41:22

In COVID-19 clinical update #71, Daniel Griffin reviews updated school and child care guidance from CDC, transmission in schools, accuracy of lateral flow assays, update to J&J/Janssen vaccine EUA to include GBS, interim immunogenicity of Ad.26.CoV2.s, effectiveness of mRNA vaccines to prevent hospitalization, Bamlanivimab plus Etesevimab for mild or moderate disease, and a meta-analysis of ivermectin results.

Hosts: Daniel Griffin and Vincent Racaniello

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Jul 17, 2021
TWiV 779: Evolving boosterism
01:39:57

TWiV reviews evidence that COVID-19 mRNA vaccination of both uninfected and previously infected persons elicits cross-variant neutralizing antibodies, and directed evolution of a bacterial protein to form a virus-like capsid that specifically packages its encoding mRNA.

Hosts: Vincent Racaniello, Alan Dove, and Brianne Barker

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Brianne The Science of Chocolate Chip Cookies
AlanKeeping Black students in STEM
VincentAntiviral Program for Pandemics

Listener Pick

Mark Curator on the Loose, Classic Airliners and Vintage Pop Culture, Flying Men, Flying Machines, Thai Flying Club

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Jul 11, 2021
TWiV 778: COVID-19 clinical update #70 with Dr. Daniel Griffin
37:06

In COVID-19 clinical update #70, Daniel Griffin discusses efficacy of portable air cleaners, vaccine induced serum neutralizing antibodies against variants, prevention and attenuation of disease with mRNA vaccines, ivermectin to prevent hospitalization, IL-6 antagonists and mortality, and impact of vaccination on long COVID.

Hosts: Daniel Griffin and Vincent Racaniello

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Jul 10, 2021
TWiV 777: SARS-CoV-2 fitness with Ron Fouchier
01:36:23

Ron Fouchier explains why increased transmission of SARS-CoV-2-variants has not been demonstrated, and their ability to displace ancestral variants is due to greater fitness, much like influenza virus antigenic variation leads to better fitness and replacement of previously circulating variants.

Hosts: Vincent Racaniello, Kathy Spindler, and Brianne Barker

Guest: Ron Fouchier

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BrianneThe Science News Cycle
KathymRNA Day Kariko & Weissman lectures and Q&A
VincentJust Planes

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Jul 08, 2021
TWiV 776: Yes! We have no pangolins
01:48:39

TWiV reviews an analysis of animal sales from Wuhan wet markets before the COVID-19 pandemic, control of dengue by release of Wolbachia-infected mosquitoes, and fatal dengue acquired in Florida.

Hosts: Vincent Racaniello, Alan Dove, and Brianne Barker

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Brianne You Know You’ve Worked Too Long in a Lab When…
Alan – Massachusetts vaccine lottery
VincentCoonhound paralysis

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Jul 04, 2021
TWiV 775: COVID-19 clinical update #69 with Dr. Daniel Griffin
44:12

In COVID-19 clinical update #69, Daniel Griffin covers effectiveness of mRNA vaccines against the delta variant, depression among public health workers, correlates of protection against asymptomatic and symptomatic infection, BNT162b2 in ChAdOx-1-S primed individuals, prior infection rescues B and T cell responses to variants after vaccination, effect of vaccination on household transmission, germinal responses induced by mRNA vaccines, phase 3 results of Novavax vaccine, and long COVID as our next national health disaster.

Hosts: Daniel Griffin and Vincent Racaniello

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Jul 03, 2021
TWiV 774: Kristian Andersen, Robert Garry, and the deleted SARS-CoV-2 sequences
01:44:14

Kristian Andersen and Robert Garry join TWiV to discuss recovery of deleted deep sequencing data from early in the Wuhan SARS-CoV-2 epidemic, and whether they shed light on the early phase of the outbreak.

Hosts: Vincent Racaniello, Kathy Spindler, and Brianne Barker

Guests: Kristian Andersen and Robert Garry

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KathySTEVE over Copper Harbor, MI
Vincent Human Behavior During the Pandemic Is More Important Than Any Covid Variant

Intro music is by Ronald Jenkees

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Jul 01, 2021
TWiV 773: Laurie Garrett, pandemic prophet
01:53:26

Laurie Garrett, author of The Coming Plague, joins TWiV for a wide-ranging discussion of infectious disease and public health, including emerging infections, the role of wildlife markets in spillovers, and missteps in handling the COVID-19 pandemic.

Hosts: Vincent Racaniello, Kathy Spindler, and Brianne Barker

Guest: Laurie Garrett

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Brianne A Pivotal Mosquito Experiment Could Not Have Gone Better
Kathy Microbiology at the Movies
Vincent When a Good Scientist Is the Wrong Source

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Jun 27, 2021
TWiV 772: COVID-19 clinical update #68 with Dr. Daniel Griffin
38:03

In COVID-19 clinical update #68, Daniel Griffin discusses children acquiring infection at birthday parties, immunogenicity of vaccines in solid organ transplant patients, reinfection rates in recovered patients, lack of efficacy of azithromycin, bacterial and fungal infections in hospitalized patients, effect of monoclonal antibody treatment on clinical outcomes of ambulatory patients, and reduction in mortality of hospitalized patients treated with remedesivir.

Hosts: Daniel Griffin and Vincent Racaniello

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Intro music is by Ronald Jenkees

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Jun 26, 2021
TWiV 771: Borna hundred million years ago
01:48:05

A TWiV trio reveals the 100 million year old history of bornavirus infections hidden as EVEs in vertebrate genomes, and identification of novel bat coronaviruses that provide evolutionary insight into the origins of SARS-CoV-2.

Hosts: Vincent Racaniello, Alan Dove, and Amy Rosenfeld

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AmyA relic from the Jurassic era
AlanWorld of Wonders, by Aimee Nezhukumatathil
VincentTom Buck’s YouTube Channel

Listener Pick

VictorVaccines: A measured response

Intro music is by Ronald Jenkees

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Jun 20, 2021
TWiV 770: COVID-19 clinical update #67 with Dr. Daniel Griffin
39:25

In COVID-19 clinical update #67, Daniel Griffin reviews antibodies to the virus early in the US, serology testing of blood donations, MIS-C in children under 21, myocarditis in competitive athletes, ER visits for suspected suicide attempts, delta variant in Scotland, Novavax vaccine phase 3 results, vaccine coverage in pregnant women, early monoclonal administration reduces hospitalization and mortality, casirivimab and imdevimab recovery trial results, and CDC guidance on postacute sequelae.

Hosts: Daniel Griffin and Vincent Racaniello

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Intro music is by Ronald Jenkees

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Jun 19, 2021
TWiV 769: MIS-C and leaky gut
01:46:27

On this episode of TWiV, Novavax COVID-19 vaccine demonstrates 90% overall efficacy, preventing an antigenically disruptive change during growth of influenza virus vaccine in chicken eggs, and MIS-C is driven by loss of the gut mucosal barrier.

Hosts: Vincent Racaniello, Kathy Spindler, and Brianne Barker

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BriannePandemics for Babies, Germ Theory for Babies, and Vaccines for Babies
KathyPlaying with Time
Vincent A Top Virologist in China, at Center of a Pandemic Storm, Speaks Out

Intro music is by Ronald Jenkees

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Jun 17, 2021
TWiV 768: Can nanobody stop these variants?
01:49:29

TWiV describes how human behavior, not increased transmissibility, led to increased spread of a SARS-CoV-2 variant throughout Europe in summer 2020, and nanobodies from camelid mice and llamas that efficiently neutralize variants of concern.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Brianne Barker

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DicksonHotel Magdalena
BrianneAntibody Song by Raven the Science Maven
AlanHow to play Magic: the Gathering
VincentSteve Gibson’s rant on Security Now

Listener Pick

David Coronavirus set to mu

Intro music is by Ronald Jenkees

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Jun 13, 2021
TWiV 767: COVID-19 clinical update #66 with Dr. Daniel Griffin
40:10

In COVID-19 clinical update #66, Daniel Griffin covers treatment guidelines from IDSA, hospitalization of adolescents, estimating epidemiological dynamics from viral load distributions, incidence of infection according to baseline antibody status, assessment of reinfection in Italy, need for vaccination in previously infected individuals, assessment of protection against reinfection, antimicrobial use in hospitalized patients, effect of single dose ivermectin, and a trial of aspirin in hospitalized patients.

Hosts: Daniel Griffin and Vincent Racaniello

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Intro music is by Ronald Jenkees

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Jun 12, 2021
TWiV 766: The CORONA project with David Fajgenbaum
01:26:18

David joins TWiV to relate how his near-death experience with Castleman’s disease motivated him to found the Center for Cytokine Storm Treatment & Laboratory and the CORONA project to identify and track all treatments reported for COVID-19 in an open-source data repository.

Hosts: Vincent Racaniello, Kathy Spindler, and Brianne Barker

Guest: David Fajgenbaum

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Brianne How Giraffes Beat High Blood Pressure
KathyOrangutan optical illusion
Vincent – Two quotes from Chasing My Cure by David Fajgenbaum

John Paul II: Dear young people, whether you are believers or not, accept the call to be virtuous. This means being strong within, having a big heart, being rich in the highest sentiments, bold in the truth, courageous in freedom, constant in responsibility, generous in love, invincible in hope.

David: Never stop questioning and always follow the data.

Intro music is by Ronald Jenkees

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Jun 10, 2021
TWiV 765: Potpourri of COVID-19
01:52:43

TWiV reviews the new nomenclature for SARS-CoV-2 variants, effectiveness of Pfizer/BioNTech vaccine against variants, modified Moderna vaccine against variants, impact of COVID-19 interventions on influenza in China and the US, and binding of RaTG13 spike protein to ACE2 of multiple species.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Brianne Barker

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Dickson NASA’s Juno to Get a Close Look at Jupiter’s Moon Ganymede
Brianne Send in the Bugs. The Michelangelos Need Cleaning.
Rich All landers and rovers on Mars  animated in video with human scale
AlanWeird case cluster reported in MMWR 40 years ago; update on disease
VincentVirus isolates, strains, variants – what are they?

Intro music is by Ronald Jenkees

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Jun 06, 2021
TWiV 764: COVID-19 clinical update #65 with Dr. Daniel Griffin
39:49

In COVID-19 clinical update #65, Daniel Griffin summarizes effects of non-pharmaceutical interventions, updated summer camp guidance from CDC, serology testing not recommended by FDA, antigen tests during a music event, inhibition of vaccine immunogenicity by methotrexate, phase 3 trial results for colchicine, and small airway disease as a post-acute sequelae.

Hosts: Daniel Griffin and Vincent Racaniello

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Jun 05, 2021
TWiV 763: Cap-snatch fever
01:49:04

TWiV explains how cap-snatching, the priming of viral mRNA synthesis with fragments of host mRNAs, can lead to the synthesis of novel viral proteins.

Hosts: Vincent Racaniello, Rich Condit, and Kathy Spindler

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Kathy – Flat pasta that turns into shapes here and here
RichAd Fontes Media Bias Chart (wiki)
VincentMartin Beck police mysteries

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GregStewart Lee on Loch Ness monster

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Jun 03, 2021
TWiV 762: SARS-CoV-2 origins with Robert Garry
01:53:39

Robert Garry joins TWiV to explain how the molecular biology of SARS-CoV-2 shows that it came from Nature and not a lab, including the receptor binding domain, the furin cleavage site, and the two lineages circulating in Wuhan wildlife markets.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Brianne Barker

Guest: Robert Garry

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Dickson143 Optical Illusions and Visual Phenomena
Brianne The Arcane Research that Prepared Us for COVID-19
RichHidden Brain podcast
AlanA scientific theory of gist communication
VincentDivisive COVID ‘lab leak’ debate prompts dire warnings from researchers

Listener Picks

JonModerna Science Day

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May 30, 2021
TWiV 761: COVID-19 clinical update #64 with Dr. Daniel Griffin
43:32
In COVID-19 clinical update #64, Daniel Griffin covers new guidance from NY on day camps, mitigation and infection rates in schools, testing to sustain in person instruction, Moderna mRNA vaccine highly effective in adolescents, longer storage of Pfizer vaccine, FDA EUA for sotrovimab, and persistent illness in UK children.

Hosts: Daniel Griffin and Vincent Racaniello

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Intro music is by Ronald Jenkees

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May 29, 2021
TWiV 760: SARS-CoV-2 origins with Peter Daszak, Thea Kølsen Fischer, Marion Koopmans
01:27:52

Peter Daszak, Thea Kølsen Fischer, and Marion Koopmans, members of the WHO team investigating the origins of SARS-CoV-2 join TWiV to explain the work done by the committee during phase one, their conclusions, and the extent of work that remains to be done in phase two.

Hosts: Vincent Racaniello, Rich Condit, and Kathy Spindler

Guests: Peter Daszak, Thea Kølsen Fischer, and Marion Koopmans

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KathyMy Octopus Teacher
RichJohn Wyndam classic Sci Fi: The Chrysalids, The Day of the Triffids
VincentSARS-CoV-2 Phylogeny and Spatiotemporal Spread (paper)

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May 27, 2021
TWiV 759: Pork dogs and an evolutionary pickle
02:07:49

TWiV examines spillovers of porcine and canine coronaviruses into humans in Haiti and Malaysia, and how antigenic evolution of measles virus is constrained by multiple co-dominant epitopes on the viral glycoproteins.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Amy Rosenfeld

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DicksonAnts: workers of the world
AmyLet The Record Show by Sarah Schulman
Rich QAnon resembles the games I design
AlanLibrivox
VincentStratechery

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Fernando The 60-year old scientific screwup that helped COVID kill

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May 23, 2021
TWiV 758: COVID-19 clinical update #63 with Dr. Daniel Griffin
44:55

In COVID-19 clinical update #63, Daniel Griffin reviews cases at child care facilities, estimates of mRNA vaccine effectiveness, risk of reinfection in university students, enhanced antibody generation with extended interval of mRNA vaccination, no benefit of convalescent plasma in hospitalized patients, and risk of clinical sequelae after acute infection.

Hosts: Daniel Griffin and Vincent Racaniello

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Intro music is by Ronald Jenkees

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May 22, 2021
TWiV 757: Supershedders and super vaccines
02:01:47

TWiV reveals that 2% of SARS-CoV-2−positive individuals carry 90% of the virus circulating in a college campus, and a nanoparticle vaccine that induces cross-reactive immunity against multiple pandemic and pre-emergent coronaviruses.

Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker

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Brianne Darwin’s Arch Collapses
KathyThe woman who discovered the first coronavirus
Rich“Richard Feynman: The pleasure of finding things out”
VincentCORONA Project

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JH Fungus kills cicadas
AlanLiftoff by Eric Berger

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May 20, 2021
TWiV 756: Precluding problematic polio prophylaxis
02:13:44

TWiV returns to the 2012 brouhaha over transmission experiments with avian H5N1 influenza virus, re-examines the claim of SARS-CoV-2 RNA integration into human DNA, and reviews the engineering and testing of a genetically stable version of the attenuated type 2 Sabin poliovirus vaccine.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Amy Rosenfeld

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DicksonFive Deeps
AmyPremonition by Michael Lewis
AlanThe Secret Life of Groceries by Benjamin Lorr
Rich The Way Ferrofluid Floats Above a Superconductor Is Unreal
VincentThreading the NEIDL

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IradisSN15 Launch and Landing
Blue Pilgrim Howland Garden Tools

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May 16, 2021
TWiV 755: COVID-19 clinical update #62 with Dr. Daniel Griffin
41:29

In COVID-19 clinical update #62, Daniel Griffin covers outdoor transmission of the virus, safe use of NSAIDS, expansion of Pfizer/BioNTech vaccine to include 12-15 year olds, post-disease Mucormycosis, and hydroxychloroquine treatment associated with increased mortality.

Hosts: Daniel Griffin and Vincent Racaniello

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May 15, 2021
TWiV 754: Tuesday two: SARS-CoV-2 and TLR2
01:36:13

TWiV discusses the finding that the envelope (E) protein of SARS-CoV-2 is sensed by toll-like receptor 2 on cells, leading to the production of inflammatory cytokines that cause damage to cells and tissues in COVID-19.

Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker

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BrianneLab.Hacks Lab Assistant App
RichWeird viral DNA spills secrets to biologists; COVAX
Kathy Planet Earth Now
VincentVariants at ViralZone

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May 13, 2021
TWiV 753: The ferret nose where the virus goes
01:43:13

TWiV revisits Brazil’s rejection of Sputnik vaccine, examines influenza transmission via the air from the nasal epithelium of ferrets, and a history of accidental releases of polioviruses and their relevance for eradication of poliomyelitis.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Brianne Barker

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DicksonExotic mantis
BrianneTypes of Scientific Paper
AlanRusty Lake Games / Cube Escape Collection
Rich The Departed Could Soon Become Compost in Colorado; Recompose (wiki)
VincentPublic Health Image Library

Listener Pick

Ivan Apollo 11: As They Shot It

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May 09, 2021
TWiV 752: COVID-19 clinical update #61 with Dr. Daniel Griffin
43:49

In COVID-19 clinical update #61, Daniel Griffin reviews a modeling of future hospitalizations and deaths by vaccination rates and non pharmaceutical intervention scenarios, performance evaluation of rapid antigen tests, children making up a growing share of new cases, antibody response to mRNA vaccine in solid organ transplant recipients, and outcomes in hospitalized patients treated with tocilizumab.

Hosts: Daniel Griffin and Vincent Racaniello

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Intro music is by Ronald Jenkees

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May 08, 2021
TWiV 751: Sputnik spat and furin in ferrets
01:33:53

TWiV examines the claim by Brazil’s ANVISA that the Sputnik vaccine contains replication-competent adenovirus, and a role for the furin cleavage site in SARS-CoV-2 spike for efficient reproduction in the respiratory tract, evasion of antiviral IFITM proteins, and transmission in ferrets.

Hosts: Vincent Racaniello, Rich Condit, and Kathy Spindler

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RichThe diversity and function of sourdough starter microbiomes; Dunn Lab Wild Sourdough Project
KathyISS, Crew Dragon, and the sun  Doubly warped world of binary black holes
VincentMr. Labman

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JoyAbandoned America: Matthew Christopher’s Autopsy of the American Dream

Intro music is by Ronald Jenkees

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May 06, 2021
TWiV 750: To err is viral
02:09:30

The TWiVmeisters discuss how copy-back defective viral genomes might modulate the clinical outcome of respiratory syncytial virus infection, and detection of antibodies to henipa- and filo-like viruses in Trinidad bats.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler

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DicksonOlympus Image of the Year Award
AlanWe need to improve the welfare of life science trainees
RichSheldrick Wildlife Trust; The Reteti Elephant Sanctuary
Kathy Aria Code Nessun dorma podcast
VincentCovariants

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JustinHow Pfizer Makes Its Covid-19 Vaccine

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May 02, 2021
TWiV 749: COVID-19 clinical update #60 with Dr. Daniel Griffin
40:15

In COVID-19 clinical update #60, Daniel Griffin summarizes CDC guidance for summer camps, how to protect yourself when fully vaccinated, updated recommendation for J&J vaccine, declining global case fatality rate, and characterization of post-acute sequelae.

Hosts: Daniel Griffin and Vincent Racaniello

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Intro music is by Ronald Jenkees

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May 01, 2021
TWiV 748: SARS-CoV-2 gets a sense of humoral
01:46:23

A TWiV trio explains a method for sequencing single genomes of SARS-CoV-2 and its use to explore in-host evolution drive by antibody responses, and incidence of cerebral venous thrombosis in COVID-19 patients and vaccine recipients.

Hosts: Vincent Racaniello, Alan Dove, and Brianne Barker

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Brianne Show Your Immune System Some Love
Alan Cyborg sea turtle
Vincent Thomas Brock dies

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AprilThe High Line
MichelWhy you can’t compare Covid-19 vaccines

Intro music is by Ronald Jenkees

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Apr 25, 2021
TWiV 747: COVID-19 clinical update #59 with Dr. Daniel Griffin
43:02

Daniel Griffin discusses a front-line health care worker survey, pre-exposure seropositivity and subsequent infection in healthy young adults, fitted filtration efficiency of double masking, BinaxNow rapid in-home antigen test, postvaccination infections in a nursing facility, safety of mRNA vaccine in pregnant women, case control study of Bamlanivimab, no evidence for brain infection in patients with neurolgical symptoms, and mortality among US patients hospitalized with COVID-19.

Hosts: Daniel Griffin and Vincent Racaniello

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Intro music is by Ronald Jenkees

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Apr 24, 2021
TWiV 746: Encephalitis viruses dine on caveolae
01:52:16

Team TWiV explains how alphaviruses like Western equine encephalitis virus cross into the brain from capillaries by caveolin-mediated transcytosis, and reveal scientists’ incentives and attitudes towards public communication.

Hosts: Vincent Racaniello, Dickson Despommier, Kathy Spindler, and Brianne Barker

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Dickson NASA ingenuity helicopter ride
BrianneVaccine Efficacy Animation
KathyAirglow over the Azores
VincentGisaid

Intro music is by Ronald Jenkees

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Apr 22, 2021
TWiV 745: Gorilla COVID with Nadine Lamberski
01:48:25

Nadine Lamberski joins TWiV to discuss an outbreak of COVID-19 among gorillas at the San Diego Zoo, and the use of a spike protein-based vaccine to immunize the animals.

Hosts: Vincent Racaniello, Alan Dove, Kathy Spindler, and Brianne Barker

Guest: Nadine Lamberski

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BrianneThe Dream Vaccine
AlanTaking vaccines to Smith Island
Kathy Daily Overviews Subscribe Tulips
VincentNextstrain

Intro music is by Ronald Jenkees

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Apr 18, 2021
TWiV 744: COVID-19 clinical update #58 with Dr. Daniel Griffin
45:24

In COVID-19 clinical update #58, Daniel Griffin provides the latest update on the J&J vaccine pause, healthcare worker deaths, children and COVID, physical inactivity associated with higher risk, using monoclonal antibodies for prophylaxis, and shows us how to properly wear a face mask.

Hosts: Daniel Griffin and Vincent Racaniello

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Intro music is by Ronald Jenkees

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Apr 17, 2021
TWiV 743: Shape-shifting viruses
01:54:55

The TWiVsters explain how the shape of pleomorphic virus particles – spherical or filamentous – determines the probability of virus attachment and fusion, and resistance to selective pressure such as antibodies that block cell entry.

Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Amy Rosenfeld

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Dickson A tiny particle’s wobble could upend the laws of physics
RichCOVID-19/SARS-CoV-2: Viruses, Vaccines & Variants Made Easy
Amy Vaccine Anthems
VincentDarkNet Diaries Ep. 86

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SteveCover Your Freakin’ Face

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Apr 15, 2021
TWiV 742: De-fusing COVID-19
01:47:33

TWiV reviews a drug screen for inhibitors of syncytium formation, the fusing of cells caused by SARS-CoV-2, which reveals that the process is regulated by a calcium-activated ion channel and scramblase that is inhibited by the anti-parasite drug Niclosamide.

Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Brianne Barker

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BrianneCOVID-19: a disaster five years in the making
AlanThe Tyranny of Merit
Rich Racism Makes Me Question Everything. I Got the Vaccine Anyway
Kathy – The Transcontinental Burrito Tunnel
VincentTrudy Rey’s YouTube Channel

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Jeff Rebecca Lee Smith on Left Right and Center
RyanPerfect Strangers (clip)

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Apr 11, 2021
TWiV 741: COVID-19 clinical update #57 with Dr. Daniel Griffin
43:19

In COVID-19 clinical update #57, Daniel Griffin covers children and MIS-C, school opening plans, transmission event with masks, fomite transmission, diagnostic test performance, AZ vaccine and blood clots, and long COVID and the effect of vaccines.

Hosts: Daniel Griffin and Vincent Racaniello

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Intro music is by Ronald Jenkees

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Apr 10, 2021
TWiV 740: Complementation will get you everywhere
01:36:39

The Guardians of the TWiV-o-verse discuss the process of codon deoptimization for the production of experimental infectious attenuated viral vaccines, and how a respiratory syncytial virus with 619 base changes was rescued by genomes with very large internal deletions.

Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, Kathy Spindler, and Brianne Barker

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Dickson Let us now praise tiny ants
BrianneSmall-school science
Rich Smallpox ‘virus squads’ and the mandatory vaccinations upheld by the Supreme Court
KathyThe Transcontinental Burrito Tunnel
VincentGlass music by Robert Tiso

Intro music is by Ronald Jenkees

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Apr 08, 2021
TWiV 739: COVID-19 convalescent plasma with Arturo Casadevall
01:55:12

Arturo Casadevall joins TWiV to discuss the use of convalescent plasma to treat COVID-19, including a history of the process, how plasma is prepared and tested, why it is difficult to conduct randomized clinical trials, how this treatment has fared and his hopes for the future.

Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Brianne Barker

Guest: Arturo Casadevall

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Brianne The Ocean’s Youngest Monsters Are Ready for Glamour Shots
Alan7 Billion Humans
Rich15 Fascinating Animal X-Rays From the Oregon Zoo
Vincent Respiratory pathogen trends

Intro music is by Ronald Jenkees

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Apr 04, 2021
TWiV 738: COVID-19 clinical update #56 with Dr. Daniel Griffin
35:15

In COVID-19 clinical update #56, Daniel Griffin note increasing hospitalization in children and young adults, Pfizer vaccine efficacy results in 12-15 year olds, rapid self administered nucleic acid and antigen tests, mRNA vaccine efficacy in real world conditions, and improvement of long COVID after vaccination.

Hosts: Daniel Griffin and Vincent Racaniello

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Intro music is by Ronald Jenkees

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Apr 03, 2021
TWiV 737: SARS-CoV-2 in NYC wastewater
01:55:15

John, Monica, and Davida join TWiV to discuss development of a method to detect SARS-CoV-2 in raw sewage from all 14 of New York City’s treatment plants, and its use to determine the presence of the genome throughout the pandemic and detection of genome mutations from variants of concern.

Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Kathy Spindler

Guest: John Dennehy, Davida Smyth, and Monica Trujillo

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Dickson250,000 Dominoes
BrianneUsing RT-PCR in COVID-19 Testing
Rich Beaded Lacewings Can Take Down Six Termites With A Single Fart
Kathy Tracking the COVID code
VincentAdministering vaccines to adults

Intro music is by Ronald Jenkees

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Apr 01, 2021
TWiV 736: Rhapsody in T with Alessandro Sette
02:01:46

Alessandro Sette joins TWiV to discuss the role of T cells in COVID-19, the finding that amino acid changes in SARS-CoV-2 variants of concern have a negligible impact on T cell reactivity in convalescent patients and vaccinees, and whether a next generation vaccine should include more viral proteins than spike.

Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler

Guest: Alessandro Sette

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Alan – The Disinformation Dozen report
Rich No needle, but the damage was done
KathyZinn art  David Zinn
Vincent Clueless Wall Street Journal Op-Ed Endorses PACE as “Prevailing View” Among Docs

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Justin Finnish astrophotographer spends 12 years creating a Milky Way mosaic

Intro music is by Ronald Jenkees

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Mar 28, 2021
TWiV 735: COVID-19 clinical update #55 with Dr. Daniel Griffin
39:37

In COVID-19 clinical update #55, Daniel Griffin reviews recommendations for keeping transmission low in school settings, optimal testing strategies for schools and businesses, impact of vaccines on asymptomatic infections, vaccine safety in PASC patients, and early use of aspirin associated with decreased mortality.

Hosts: Daniel Griffin and Vincent Racaniello

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Intro music is by Ronald Jenkees

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Mar 26, 2021
TWiV 734: Weiss hath no furin like a virus scorned
02:10:57

Susan Weiss returns to TWiV to discuss coronavirus entry into cells and the role of spike protein cleavage by proteases, why lab escaped hypotheses for SARS-CoV-2 are unlikely, and modulation of innate immune responses during infection.

Hosts: Vincent Racaniello, Rich Condit, Alan Dove, Brianne Barker, and Amy Rosenfeld

Guest: Susan Weiss

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Brianne Tiktok of How mRNA Vaccines Work
AlanDark
RichUnmixing Color Machine (Ultra Laminar Reversible Flow) – Smarter Every Day 217
AmyMOMA Calder exhibit, reviewed in NYTimes
VincentRipple Training (free YouTube channel)

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Ruth 100 million year old seafloor bacteria resuscitated
IradisLinda Zall, CIA spy for science

Intro music is by Ronald Jenkees

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Mar 21, 2021
TWiV 733: COVID-19 clinical update #54 with Dr. Daniel Griffin
34:27

In COVID-19 clinical update #54, Daniel Griffin covers effectiveness of 3 vs 6 ft physical distancing, effectiveness of masks, physical distancing, and eye shields, second vaccine dose completion, alleviation of COVID-19 symptoms after vaccination, vaccine trials in children, and IDSA approval of a mAb cocktail.

Hosts: Daniel Griffin and Vincent Racaniello

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Intro music is by Ronald Jenkees

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Mar 20, 2021
TWiV 732: Citizen science with Forest Rohwer and Maria-Isabel Rojas
01:52:15

Forest and Maria-Isabel join TWiV to discuss their their project to engage thousands of citizens to swab inanimate surfaces in the San Diego area, then send the samples to the Rohwer Lab for nucleic acid analysis.

Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, Kathy Spindler, and Brianne Barker

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Dickson10 amazing science tricks with liquids
Brianne How Do Blind Worms See the Color Blue?
Rich Statewide Study Shows Evidence Of Significant COVID-19 Antibodies In Children
Kathy Dark side of the moon as it crosses Earth
VincentWasdkeyboards and Novelkeys

Listener Pick

Bronwen COVID Performance Index

Intro music is by Ronald Jenkees

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Mar 18, 2021
TWiV 731: The kids aren't alright
01:54:32

On a TWiV tetramer, we review the ongoing outbreaks of Ebolavirus disease in DRC and Guinea, evidence that SARS-CoV-2 infections in children are far more prevalent than are being detected, and recent long COVID estimates from the UK.

Hosts: Vincent Racaniello, Rich Condit, Alan Dove, and Brianne Barker

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Brianne Who Would Kidnap a Space Telescope?
AlanRadio Garden
Rich Countries with more obesity have had  more covid deaths on average
VincentConcord Aerospace

Intro music is by Ronald Jenkees

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Mar 14, 2021
TWiV 730: COVID-19 clinical update #53 with Dr. Daniel Griffin
44:35

In COVID-19 clinical update #53, Daniel Griffin reviews underreporting of infections and long term disease in children, a blood test for T cells, results of phase 3 trials for monoclonal antibodies, preliminary findings on an oral antiviral, clinical trial of ivermectin, and recommendations for upcoming gatherings.

Hosts: Daniel Griffin and Vincent Racaniello

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Intro music is by Ronald Jenkees

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Mar 13, 2021
TWiV 729: A floret of spikes with Matt Frieman
01:57:22

Matt Frieman returns to TWiV to discuss the COVID-19 pandemic from the point of view of a coronavirologist, including his work with Novavax on their spike protein-based vaccine.

Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, Kathy Spindler, and Brianne Barker

Guest: Matt Frieman

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Dickson Covid-19 deaths per million ranked by average income
Brianne KFF COVID-19 Vaccine Monitor for Feb 2021 and KFF COVID-19 Vaccine Monitor Dashboard
Rich The Woman Who Stood Between America and a Generation of ‘Thalidomide Babies’(wiki)
KathyQuadrantid meteor (Quadrantids)
VincentHigher Superstition by Paul Gross and Norman Levitt

Intro music is by Ronald Jenkees

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Mar 11, 2021
TWiV 728: Cover your nose and mouse
02:11:38

TWiV notes the passing of Mavis Agbandje-McKenna, and reviews data on maximizing fit for cloth and medical procedure masks, SARS-CoV-2 total and subgenomic viral load in hospitalized patients, and effect of changes in spike protein on efficacy in a mouse model of infection.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Brianne Barker

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Dickson Wild animal photos
Brianne Greater than COVID
Alan WHO report on infodemic response
Rich Reference Guide to the International Space Station
Vincent3D Molecular Designs

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LisbethHave the new jab
Karen Cholera exhibit at Museum of Trades and Crafts

Intro music is by Ronald Jenkees

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Mar 07, 2021
TWiV 727: COVID-19 clinical update #52 with Dr. Daniel Griffin
35:20

In COVID-19 clinical update #52, Daniel Griffin reviews differences in attack rates between children and adults, J&J vaccine phase III data, G6PD deficiency and vaccines, NIH halts convalescent plasma trial, dexamethasone in hospitalized patients, data on tocilizumab, and long COVID in children.

Hosts: Daniel Griffin and Vincent Racaniello

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Intro music is by Ronald Jenkees

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Mar 06, 2021
TWiV 726: Molecular animator Janet Iwasa
01:52:34

Janet Iwasa joins TWiV to recount how she became a molecular animator, including a pivot during her Ph.D. thesis research, the value of animations in science, and their latest animation of SARS-CoV-2 entry into cells.

Hosts: Vincent Racaniello, Rich Condit, Brianne Barker and Kathy Spindler

Guest: Janet Iwasa

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Brianne – How T cells see SARS-CoV2
Rich Ice bubbles in Lago Bianco, Switzerland
Kathy Music in COVID-19 control tents
Vincent Perseverance runs on processors used in 1990s iMacs

Intro music is by Ronald Jenkees

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Mar 04, 2021
TWiV 725: Eva Harris and Janet Smith clip flavivirus wings
01:59:15

Eva Harris and Janet Smith join TWiV to discuss how an antibody against dengue virus NS1 protein blocks endothelial dysfunction and the potential of treating infections by multiple flaviviruses.

Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler

Guest: Eva Harris and Janet Smith

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AlanScience Photographer of the Year Awards
RichBar Keeper’s Friend
Kathy Perseverance secret message and other Easter eggs, 11 million Earthlings’ names, “Name the Rover” essay contest. Sign up to send your name on a future Mars mission.
VincentCOVID-19 dataset

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Matthew - Remembering the colleagues we lost to COVID-19
Lori - Iceberger

Intro music is by Ronald Jenkees

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Feb 28, 2021
TWiV 724: COVID-19 clinical update #51 with Dr. Daniel Griffin
36:57

In COVID-19 clinical update #51, Daniel Griffin reviews use of two masks, effectiveness of testing in nursing homes, updates on vaccines, use of nonsteroidal anti-inflammatory drugs, little effect of vitamin D and remdesivir in clinical studies, and a long COVID research initiative from NIH.

Hosts: Daniel Griffin and Vincent Racaniello

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Intro music is by Ronald Jenkees

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Feb 27, 2021
TWiV 723: COVID-19 palliative care with Ginger Campbell, MD
01:48:27

Ginger Campbell joins TWiV to discuss palliative care for COVID-19 patients, and how to approach the disease from a goals of care perspective.

Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Brianne Barker

Guest: Ginger Campbell, MD

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DicksonSoapbox Gallery
BrianneCell Picture Show
RichPerseverance Rover’s Descent and Touchdown on Mars (Official NASA Video)
VincentOur World in Data (see COVID-19 vaccinations)

Intro music is by Ronald Jenkees

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Feb 25, 2021
TWiV 722: More coronaviruses in the pipeline
02:02:11

The entire TWiV team assembles to discuss resurgence of COVID-19 in Manaus, Brazil, discovery of SARS-CoV-2 related viruses in bats in Southeast Asia, and increased Ct values after administration of mRNA vaccine.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, Kathy Spindler, and Brianne Barker

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DicksonWhat is the polar vortex?
Brianne Cloning of the black-footed ferret
Alan – Explaining mRNA vaccines with Star Wars
RichBrighton Collaboration (BRAVATO); Ad26 vector template
Kathy Target public health ads to zipcodes
Vincent And Then the Gorillas Started Coughing

Listener Pick

Kim – Virus getting the shot (jpg)

Intro music is by Ronald Jenkees

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Feb 21, 2021