This Week in Virology

By Vincent Racaniello

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Subscribers: 1159
Reviews: 5

Rachael
 Nov 28, 2020
excellent thanks for doing a great job


 May 29, 2020

excellent
 Apr 23, 2020
great information

Reed
 Jan 15, 2020
amazing in depth podcast on the nuts and bolts of all kinds of viruses. expect in depth discussions of papers by experienced scientists with a decent sense of humour. I can follow along most details even though I have not studied virology.


 May 31, 2019

Description

This Week in Virology is a netcast about viruses - the kind that make you sick.

Episode Date
TWiV 785: COVID-19 Q&A with Dr. Daniel Griffin
59:13

In this special episode, Daniel Griffin answers listener questions on COVID-19 vaccines, vaccine misinformation, long COVID, masking and distancing, school safety, and much more.

Hosts: Daniel Griffin and Vincent Racaniello

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Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to daniel@microbe.tv

Jul 28, 2021
TWiV 784: Virtually live from ASV
01:19:47

Moriah and Joseph join the nearly complete TWiV team to discuss their work on genetic variation and adaptability in herpes simplex virus, and how rotavirus infection disrupts intracellular calcium homeostasis. Live streamed during the 2021 annual meeting of the American Society for Virology.

Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, Alan Dove, and Brianne Barker

Guests: Joseph Hyzer and Moriah Szpara

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Weekly Picks

Dickson Inside of Mars is not like Earth
BrianneAlphaFold
RichTesla motors
Alan Diving for antique beer
Vincent Dolly Parton Tried. But Tennessee Is Squandering a Miracle

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

 

Jul 25, 2021
TWiV 783: COVID-19 clinical update #72 with Dr. Daniel Griffin
44:26

In COVID-19 clinical update #72, Daniel Griffin covers long term symptoms in children, outcomes for MIS-C, recent guidance from the American Academy of Pediatrics, a large well traced outbreak of delta variant, low dose mRNA vaccination generates durable T cell memory and antibodies, protective immunity in recovered patients, assessment of BinaxNOW, no effect of oral azithromycin, post-discharge symptoms in Nigeria, and therapeutics for low and middle income countries.

Hosts: Daniel Griffin and Vincent Racaniello

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Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to daniel@microbe.tv

Jul 23, 2021
TWiV 782: An antibody for all sarbecoviruses
01:02:53

On this episode, broadening of immune responses to SARS-CoV-2 after mRNA vaccine booster to ChAdOx1 nCoV-19, five-fold underestimation of the number of cases in the US during the first six months of the pandemic, and a monoclonal antibody that broadly neutralizes many different sarbecoviruses.

Hosts: Vincent Racaniello and Amy Rosenfeld

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Intro music is by Ronald Jenkees

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Jul 22, 2021
TWiV 781: My genome is left to tell the tale
01:46:40

The Team with Invincible Values discusses whether dogs or cats passively carry SARS-CoV-2 on hair and foot pads, maternal to fetal transfer of antibodies in infected or vaccinated pregnant women, and evidence that retroviruses infected cetaceans before and after they moved into the oceans.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Brianne Barker

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Weekly Picks

DicksonCurrent Map | U.S. Drought Monitor
BrianneA comic strip about immune responses
AlanSuperliminal game
Vincent Birds are dying in NJ

Listener Picks

2listening1Renewal
EmCognitive Surplus

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

Jul 18, 2021
TWiV 780: COVID-19 clinical update #71 with Dr. Daniel Griffin
41:22

In COVID-19 clinical update #71, Daniel Griffin reviews updated school and child care guidance from CDC, transmission in schools, accuracy of lateral flow assays, update to J&J/Janssen vaccine EUA to include GBS, interim immunogenicity of Ad.26.CoV2.s, effectiveness of mRNA vaccines to prevent hospitalization, Bamlanivimab plus Etesevimab for mild or moderate disease, and a meta-analysis of ivermectin results.

Hosts: Daniel Griffin and Vincent Racaniello

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Intro music is by Ronald Jenkees

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Jul 17, 2021
TWiV 779: Evolving boosterism
01:39:57

TWiV reviews evidence that COVID-19 mRNA vaccination of both uninfected and previously infected persons elicits cross-variant neutralizing antibodies, and directed evolution of a bacterial protein to form a virus-like capsid that specifically packages its encoding mRNA.

Hosts: Vincent Racaniello, Alan Dove, and Brianne Barker

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Weekly Picks

Brianne The Science of Chocolate Chip Cookies
AlanKeeping Black students in STEM
VincentAntiviral Program for Pandemics

Listener Pick

Mark Curator on the Loose, Classic Airliners and Vintage Pop Culture, Flying Men, Flying Machines, Thai Flying Club

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

Jul 11, 2021
TWiV 778: COVID-19 clinical update #70 with Dr. Daniel Griffin
37:06

In COVID-19 clinical update #70, Daniel Griffin discusses efficacy of portable air cleaners, vaccine induced serum neutralizing antibodies against variants, prevention and attenuation of disease with mRNA vaccines, ivermectin to prevent hospitalization, IL-6 antagonists and mortality, and impact of vaccination on long COVID.

Hosts: Daniel Griffin and Vincent Racaniello

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Intro music is by Ronald Jenkees

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Jul 10, 2021
TWiV 777: SARS-CoV-2 fitness with Ron Fouchier
01:36:23

Ron Fouchier explains why increased transmission of SARS-CoV-2-variants has not been demonstrated, and their ability to displace ancestral variants is due to greater fitness, much like influenza virus antigenic variation leads to better fitness and replacement of previously circulating variants.

Hosts: Vincent Racaniello, Kathy Spindler, and Brianne Barker

Guest: Ron Fouchier

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Weekly Picks

BrianneThe Science News Cycle
KathymRNA Day Kariko & Weissman lectures and Q&A
VincentJust Planes

Intro music is by Ronald Jenkees

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Jul 08, 2021
TWiV 776: Yes! We have no pangolins
01:48:39

TWiV reviews an analysis of animal sales from Wuhan wet markets before the COVID-19 pandemic, control of dengue by release of Wolbachia-infected mosquitoes, and fatal dengue acquired in Florida.

Hosts: Vincent Racaniello, Alan Dove, and Brianne Barker

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Brianne You Know You’ve Worked Too Long in a Lab When…
Alan – Massachusetts vaccine lottery
VincentCoonhound paralysis

Intro music is by Ronald Jenkees

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Jul 04, 2021
TWiV 775: COVID-19 clinical update #69 with Dr. Daniel Griffin
44:12

In COVID-19 clinical update #69, Daniel Griffin covers effectiveness of mRNA vaccines against the delta variant, depression among public health workers, correlates of protection against asymptomatic and symptomatic infection, BNT162b2 in ChAdOx-1-S primed individuals, prior infection rescues B and T cell responses to variants after vaccination, effect of vaccination on household transmission, germinal responses induced by mRNA vaccines, phase 3 results of Novavax vaccine, and long COVID as our next national health disaster.

Hosts: Daniel Griffin and Vincent Racaniello

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Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to daniel@microbe.tv

Jul 03, 2021
TWiV 774: Kristian Andersen, Robert Garry, and the deleted SARS-CoV-2 sequences
01:44:14

Kristian Andersen and Robert Garry join TWiV to discuss recovery of deleted deep sequencing data from early in the Wuhan SARS-CoV-2 epidemic, and whether they shed light on the early phase of the outbreak.

Hosts: Vincent Racaniello, Kathy Spindler, and Brianne Barker

Guests: Kristian Andersen and Robert Garry

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Weekly Picks

KathySTEVE over Copper Harbor, MI
Vincent Human Behavior During the Pandemic Is More Important Than Any Covid Variant

Intro music is by Ronald Jenkees

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Jul 01, 2021
TWiV 773: Laurie Garrett, pandemic prophet
01:53:26

Laurie Garrett, author of The Coming Plague, joins TWiV for a wide-ranging discussion of infectious disease and public health, including emerging infections, the role of wildlife markets in spillovers, and missteps in handling the COVID-19 pandemic.

Hosts: Vincent Racaniello, Kathy Spindler, and Brianne Barker

Guest: Laurie Garrett

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Brianne A Pivotal Mosquito Experiment Could Not Have Gone Better
Kathy Microbiology at the Movies
Vincent When a Good Scientist Is the Wrong Source

Intro music is by Ronald Jenkees

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Jun 27, 2021
TWiV 772: COVID-19 clinical update #68 with Dr. Daniel Griffin
38:03

In COVID-19 clinical update #68, Daniel Griffin discusses children acquiring infection at birthday parties, immunogenicity of vaccines in solid organ transplant patients, reinfection rates in recovered patients, lack of efficacy of azithromycin, bacterial and fungal infections in hospitalized patients, effect of monoclonal antibody treatment on clinical outcomes of ambulatory patients, and reduction in mortality of hospitalized patients treated with remedesivir.

Hosts: Daniel Griffin and Vincent Racaniello

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Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to daniel@microbe.tv

Jun 26, 2021
TWiV 771: Borna hundred million years ago
01:48:05

A TWiV trio reveals the 100 million year old history of bornavirus infections hidden as EVEs in vertebrate genomes, and identification of novel bat coronaviruses that provide evolutionary insight into the origins of SARS-CoV-2.

Hosts: Vincent Racaniello, Alan Dove, and Amy Rosenfeld

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Weekly Picks

AmyA relic from the Jurassic era
AlanWorld of Wonders, by Aimee Nezhukumatathil
VincentTom Buck’s YouTube Channel

Listener Pick

VictorVaccines: A measured response

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

Jun 20, 2021
TWiV 770: COVID-19 clinical update #67 with Dr. Daniel Griffin
39:25

In COVID-19 clinical update #67, Daniel Griffin reviews antibodies to the virus early in the US, serology testing of blood donations, MIS-C in children under 21, myocarditis in competitive athletes, ER visits for suspected suicide attempts, delta variant in Scotland, Novavax vaccine phase 3 results, vaccine coverage in pregnant women, early monoclonal administration reduces hospitalization and mortality, casirivimab and imdevimab recovery trial results, and CDC guidance on postacute sequelae.

Hosts: Daniel Griffin and Vincent Racaniello

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Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to daniel@microbe.tv

Jun 19, 2021
TWiV 769: MIS-C and leaky gut
01:46:27

On this episode of TWiV, Novavax COVID-19 vaccine demonstrates 90% overall efficacy, preventing an antigenically disruptive change during growth of influenza virus vaccine in chicken eggs, and MIS-C is driven by loss of the gut mucosal barrier.

Hosts: Vincent Racaniello, Kathy Spindler, and Brianne Barker

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Download TWiV 769 (68 MB .mp3, 114 min)
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Weekly Picks

BriannePandemics for Babies, Germ Theory for Babies, and Vaccines for Babies
KathyPlaying with Time
Vincent A Top Virologist in China, at Center of a Pandemic Storm, Speaks Out

Intro music is by Ronald Jenkees

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Jun 17, 2021
TWiV 768: Can nanobody stop these variants?
01:49:29

TWiV describes how human behavior, not increased transmissibility, led to increased spread of a SARS-CoV-2 variant throughout Europe in summer 2020, and nanobodies from camelid mice and llamas that efficiently neutralize variants of concern.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Brianne Barker

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DicksonHotel Magdalena
BrianneAntibody Song by Raven the Science Maven
AlanHow to play Magic: the Gathering
VincentSteve Gibson’s rant on Security Now

Listener Pick

David Coronavirus set to mu

Intro music is by Ronald Jenkees

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Jun 13, 2021
TWiV 767: COVID-19 clinical update #66 with Dr. Daniel Griffin
40:10

In COVID-19 clinical update #66, Daniel Griffin covers treatment guidelines from IDSA, hospitalization of adolescents, estimating epidemiological dynamics from viral load distributions, incidence of infection according to baseline antibody status, assessment of reinfection in Italy, need for vaccination in previously infected individuals, assessment of protection against reinfection, antimicrobial use in hospitalized patients, effect of single dose ivermectin, and a trial of aspirin in hospitalized patients.

Hosts: Daniel Griffin and Vincent Racaniello

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Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to daniel@microbe.tv

Jun 12, 2021
TWiV 766: The CORONA project with David Fajgenbaum
01:26:18

David joins TWiV to relate how his near-death experience with Castleman’s disease motivated him to found the Center for Cytokine Storm Treatment & Laboratory and the CORONA project to identify and track all treatments reported for COVID-19 in an open-source data repository.

Hosts: Vincent Racaniello, Kathy Spindler, and Brianne Barker

Guest: David Fajgenbaum

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Weekly Picks

Brianne How Giraffes Beat High Blood Pressure
KathyOrangutan optical illusion
Vincent – Two quotes from Chasing My Cure by David Fajgenbaum

John Paul II: Dear young people, whether you are believers or not, accept the call to be virtuous. This means being strong within, having a big heart, being rich in the highest sentiments, bold in the truth, courageous in freedom, constant in responsibility, generous in love, invincible in hope.

David: Never stop questioning and always follow the data.

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

Jun 10, 2021
TWiV 765: Potpourri of COVID-19
01:52:43

TWiV reviews the new nomenclature for SARS-CoV-2 variants, effectiveness of Pfizer/BioNTech vaccine against variants, modified Moderna vaccine against variants, impact of COVID-19 interventions on influenza in China and the US, and binding of RaTG13 spike protein to ACE2 of multiple species.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Brianne Barker

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Dickson NASA’s Juno to Get a Close Look at Jupiter’s Moon Ganymede
Brianne Send in the Bugs. The Michelangelos Need Cleaning.
Rich All landers and rovers on Mars  animated in video with human scale
AlanWeird case cluster reported in MMWR 40 years ago; update on disease
VincentVirus isolates, strains, variants – what are they?

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

Jun 06, 2021
TWiV 764: COVID-19 clinical update #65 with Dr. Daniel Griffin
39:49

In COVID-19 clinical update #65, Daniel Griffin summarizes effects of non-pharmaceutical interventions, updated summer camp guidance from CDC, serology testing not recommended by FDA, antigen tests during a music event, inhibition of vaccine immunogenicity by methotrexate, phase 3 trial results for colchicine, and small airway disease as a post-acute sequelae.

Hosts: Daniel Griffin and Vincent Racaniello

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Intro music is by Ronald Jenkees

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Jun 05, 2021
TWiV 763: Cap-snatch fever
01:49:04

TWiV explains how cap-snatching, the priming of viral mRNA synthesis with fragments of host mRNAs, can lead to the synthesis of novel viral proteins.

Hosts: Vincent Racaniello, Rich Condit, and Kathy Spindler

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Kathy – Flat pasta that turns into shapes here and here
RichAd Fontes Media Bias Chart (wiki)
VincentMartin Beck police mysteries

Listener Picks

GregStewart Lee on Loch Ness monster

Intro music is by Ronald Jenkees

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Jun 03, 2021
TWiV 762: SARS-CoV-2 origins with Robert Garry
01:53:39

Robert Garry joins TWiV to explain how the molecular biology of SARS-CoV-2 shows that it came from Nature and not a lab, including the receptor binding domain, the furin cleavage site, and the two lineages circulating in Wuhan wildlife markets.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Brianne Barker

Guest: Robert Garry

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Dickson143 Optical Illusions and Visual Phenomena
Brianne The Arcane Research that Prepared Us for COVID-19
RichHidden Brain podcast
AlanA scientific theory of gist communication
VincentDivisive COVID ‘lab leak’ debate prompts dire warnings from researchers

Listener Picks

JonModerna Science Day

Intro music is by Ronald Jenkees

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May 30, 2021
TWiV 761: COVID-19 clinical update #64 with Dr. Daniel Griffin
43:32
In COVID-19 clinical update #64, Daniel Griffin covers new guidance from NY on day camps, mitigation and infection rates in schools, testing to sustain in person instruction, Moderna mRNA vaccine highly effective in adolescents, longer storage of Pfizer vaccine, FDA EUA for sotrovimab, and persistent illness in UK children.

Hosts: Daniel Griffin and Vincent Racaniello

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Intro music is by Ronald Jenkees

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May 29, 2021
TWiV 760: SARS-CoV-2 origins with Peter Daszak, Thea Kølsen Fischer, Marion Koopmans
01:27:52

Peter Daszak, Thea Kølsen Fischer, and Marion Koopmans, members of the WHO team investigating the origins of SARS-CoV-2 join TWiV to explain the work done by the committee during phase one, their conclusions, and the extent of work that remains to be done in phase two.

Hosts: Vincent Racaniello, Rich Condit, and Kathy Spindler

Guests: Peter Daszak, Thea Kølsen Fischer, and Marion Koopmans

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KathyMy Octopus Teacher
RichJohn Wyndam classic Sci Fi: The Chrysalids, The Day of the Triffids
VincentSARS-CoV-2 Phylogeny and Spatiotemporal Spread (paper)

Intro music is by Ronald Jenkees

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May 27, 2021
TWiV 759: Pork dogs and an evolutionary pickle
02:07:49

TWiV examines spillovers of porcine and canine coronaviruses into humans in Haiti and Malaysia, and how antigenic evolution of measles virus is constrained by multiple co-dominant epitopes on the viral glycoproteins.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Amy Rosenfeld

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DicksonAnts: workers of the world
AmyLet The Record Show by Sarah Schulman
Rich QAnon resembles the games I design
AlanLibrivox
VincentStratechery

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Fernando The 60-year old scientific screwup that helped COVID kill

Intro music is by Ronald Jenkees

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May 23, 2021
TWiV 758: COVID-19 clinical update #63 with Dr. Daniel Griffin
44:55

In COVID-19 clinical update #63, Daniel Griffin reviews cases at child care facilities, estimates of mRNA vaccine effectiveness, risk of reinfection in university students, enhanced antibody generation with extended interval of mRNA vaccination, no benefit of convalescent plasma in hospitalized patients, and risk of clinical sequelae after acute infection.

Hosts: Daniel Griffin and Vincent Racaniello

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Intro music is by Ronald Jenkees

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May 22, 2021
TWiV 757: Supershedders and super vaccines
02:01:47

TWiV reveals that 2% of SARS-CoV-2−positive individuals carry 90% of the virus circulating in a college campus, and a nanoparticle vaccine that induces cross-reactive immunity against multiple pandemic and pre-emergent coronaviruses.

Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker

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Brianne Darwin’s Arch Collapses
KathyThe woman who discovered the first coronavirus
Rich“Richard Feynman: The pleasure of finding things out”
VincentCORONA Project

Listener Picks

JH Fungus kills cicadas
AlanLiftoff by Eric Berger

Intro music is by Ronald Jenkees

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May 20, 2021
TWiV 756: Precluding problematic polio prophylaxis
02:13:44

TWiV returns to the 2012 brouhaha over transmission experiments with avian H5N1 influenza virus, re-examines the claim of SARS-CoV-2 RNA integration into human DNA, and reviews the engineering and testing of a genetically stable version of the attenuated type 2 Sabin poliovirus vaccine.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Amy Rosenfeld

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DicksonFive Deeps
AmyPremonition by Michael Lewis
AlanThe Secret Life of Groceries by Benjamin Lorr
Rich The Way Ferrofluid Floats Above a Superconductor Is Unreal
VincentThreading the NEIDL

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IradisSN15 Launch and Landing
Blue Pilgrim Howland Garden Tools

Intro music is by Ronald Jenkees

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May 16, 2021
TWiV 755: COVID-19 clinical update #62 with Dr. Daniel Griffin
41:29

In COVID-19 clinical update #62, Daniel Griffin covers outdoor transmission of the virus, safe use of NSAIDS, expansion of Pfizer/BioNTech vaccine to include 12-15 year olds, post-disease Mucormycosis, and hydroxychloroquine treatment associated with increased mortality.

Hosts: Daniel Griffin and Vincent Racaniello

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Intro music is by Ronald Jenkees

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May 15, 2021
TWiV 754: Tuesday two: SARS-CoV-2 and TLR2
01:36:13

TWiV discusses the finding that the envelope (E) protein of SARS-CoV-2 is sensed by toll-like receptor 2 on cells, leading to the production of inflammatory cytokines that cause damage to cells and tissues in COVID-19.

Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker

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BrianneLab.Hacks Lab Assistant App
RichWeird viral DNA spills secrets to biologists; COVAX
Kathy Planet Earth Now
VincentVariants at ViralZone

Intro music is by Ronald Jenkees

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May 13, 2021
TWiV 753: The ferret nose where the virus goes
01:43:13

TWiV revisits Brazil’s rejection of Sputnik vaccine, examines influenza transmission via the air from the nasal epithelium of ferrets, and a history of accidental releases of polioviruses and their relevance for eradication of poliomyelitis.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Brianne Barker

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DicksonExotic mantis
BrianneTypes of Scientific Paper
AlanRusty Lake Games / Cube Escape Collection
Rich The Departed Could Soon Become Compost in Colorado; Recompose (wiki)
VincentPublic Health Image Library

Listener Pick

Ivan Apollo 11: As They Shot It

Intro music is by Ronald Jenkees

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May 09, 2021
TWiV 752: COVID-19 clinical update #61 with Dr. Daniel Griffin
43:49

In COVID-19 clinical update #61, Daniel Griffin reviews a modeling of future hospitalizations and deaths by vaccination rates and non pharmaceutical intervention scenarios, performance evaluation of rapid antigen tests, children making up a growing share of new cases, antibody response to mRNA vaccine in solid organ transplant recipients, and outcomes in hospitalized patients treated with tocilizumab.

Hosts: Daniel Griffin and Vincent Racaniello

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Intro music is by Ronald Jenkees

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May 08, 2021
TWiV 751: Sputnik spat and furin in ferrets
01:33:53

TWiV examines the claim by Brazil’s ANVISA that the Sputnik vaccine contains replication-competent adenovirus, and a role for the furin cleavage site in SARS-CoV-2 spike for efficient reproduction in the respiratory tract, evasion of antiviral IFITM proteins, and transmission in ferrets.

Hosts: Vincent Racaniello, Rich Condit, and Kathy Spindler

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RichThe diversity and function of sourdough starter microbiomes; Dunn Lab Wild Sourdough Project
KathyISS, Crew Dragon, and the sun  Doubly warped world of binary black holes
VincentMr. Labman

Listener Picks

JoyAbandoned America: Matthew Christopher’s Autopsy of the American Dream

Intro music is by Ronald Jenkees

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May 06, 2021
TWiV 750: To err is viral
02:09:30

The TWiVmeisters discuss how copy-back defective viral genomes might modulate the clinical outcome of respiratory syncytial virus infection, and detection of antibodies to henipa- and filo-like viruses in Trinidad bats.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler

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DicksonOlympus Image of the Year Award
AlanWe need to improve the welfare of life science trainees
RichSheldrick Wildlife Trust; The Reteti Elephant Sanctuary
Kathy Aria Code Nessun dorma podcast
VincentCovariants

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JustinHow Pfizer Makes Its Covid-19 Vaccine

Intro music is by Ronald Jenkees

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May 02, 2021
TWiV 749: COVID-19 clinical update #60 with Dr. Daniel Griffin
40:15

In COVID-19 clinical update #60, Daniel Griffin summarizes CDC guidance for summer camps, how to protect yourself when fully vaccinated, updated recommendation for J&J vaccine, declining global case fatality rate, and characterization of post-acute sequelae.

Hosts: Daniel Griffin and Vincent Racaniello

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Intro music is by Ronald Jenkees

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May 01, 2021
TWiV 748: SARS-CoV-2 gets a sense of humoral
01:46:23

A TWiV trio explains a method for sequencing single genomes of SARS-CoV-2 and its use to explore in-host evolution drive by antibody responses, and incidence of cerebral venous thrombosis in COVID-19 patients and vaccine recipients.

Hosts: Vincent Racaniello, Alan Dove, and Brianne Barker

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Brianne Show Your Immune System Some Love
Alan Cyborg sea turtle
Vincent Thomas Brock dies

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AprilThe High Line
MichelWhy you can’t compare Covid-19 vaccines

Intro music is by Ronald Jenkees

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Apr 25, 2021
TWiV 747: COVID-19 clinical update #59 with Dr. Daniel Griffin
43:02

Daniel Griffin discusses a front-line health care worker survey, pre-exposure seropositivity and subsequent infection in healthy young adults, fitted filtration efficiency of double masking, BinaxNow rapid in-home antigen test, postvaccination infections in a nursing facility, safety of mRNA vaccine in pregnant women, case control study of Bamlanivimab, no evidence for brain infection in patients with neurolgical symptoms, and mortality among US patients hospitalized with COVID-19.

Hosts: Daniel Griffin and Vincent Racaniello

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Intro music is by Ronald Jenkees

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Apr 24, 2021
TWiV 746: Encephalitis viruses dine on caveolae
01:52:16

Team TWiV explains how alphaviruses like Western equine encephalitis virus cross into the brain from capillaries by caveolin-mediated transcytosis, and reveal scientists’ incentives and attitudes towards public communication.

Hosts: Vincent Racaniello, Dickson Despommier, Kathy Spindler, and Brianne Barker

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Dickson NASA ingenuity helicopter ride
BrianneVaccine Efficacy Animation
KathyAirglow over the Azores
VincentGisaid

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Apr 22, 2021
TWiV 745: Gorilla COVID with Nadine Lamberski
01:48:25

Nadine Lamberski joins TWiV to discuss an outbreak of COVID-19 among gorillas at the San Diego Zoo, and the use of a spike protein-based vaccine to immunize the animals.

Hosts: Vincent Racaniello, Alan Dove, Kathy Spindler, and Brianne Barker

Guest: Nadine Lamberski

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BrianneThe Dream Vaccine
AlanTaking vaccines to Smith Island
Kathy Daily Overviews Subscribe Tulips
VincentNextstrain

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Apr 18, 2021
TWiV 744: COVID-19 clinical update #58 with Dr. Daniel Griffin
45:24

In COVID-19 clinical update #58, Daniel Griffin provides the latest update on the J&J vaccine pause, healthcare worker deaths, children and COVID, physical inactivity associated with higher risk, using monoclonal antibodies for prophylaxis, and shows us how to properly wear a face mask.

Hosts: Daniel Griffin and Vincent Racaniello

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Apr 17, 2021
TWiV 743: Shape-shifting viruses
01:54:55

The TWiVsters explain how the shape of pleomorphic virus particles – spherical or filamentous – determines the probability of virus attachment and fusion, and resistance to selective pressure such as antibodies that block cell entry.

Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Amy Rosenfeld

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Dickson A tiny particle’s wobble could upend the laws of physics
RichCOVID-19/SARS-CoV-2: Viruses, Vaccines & Variants Made Easy
Amy Vaccine Anthems
VincentDarkNet Diaries Ep. 86

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SteveCover Your Freakin’ Face

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Apr 15, 2021
TWiV 742: De-fusing COVID-19
01:47:33

TWiV reviews a drug screen for inhibitors of syncytium formation, the fusing of cells caused by SARS-CoV-2, which reveals that the process is regulated by a calcium-activated ion channel and scramblase that is inhibited by the anti-parasite drug Niclosamide.

Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Brianne Barker

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BrianneCOVID-19: a disaster five years in the making
AlanThe Tyranny of Merit
Rich Racism Makes Me Question Everything. I Got the Vaccine Anyway
Kathy – The Transcontinental Burrito Tunnel
VincentTrudy Rey’s YouTube Channel

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Jeff Rebecca Lee Smith on Left Right and Center
RyanPerfect Strangers (clip)

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Apr 11, 2021
TWiV 741: COVID-19 clinical update #57 with Dr. Daniel Griffin
43:19

In COVID-19 clinical update #57, Daniel Griffin covers children and MIS-C, school opening plans, transmission event with masks, fomite transmission, diagnostic test performance, AZ vaccine and blood clots, and long COVID and the effect of vaccines.

Hosts: Daniel Griffin and Vincent Racaniello

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Apr 10, 2021
TWiV 740: Complementation will get you everywhere
01:36:39

The Guardians of the TWiV-o-verse discuss the process of codon deoptimization for the production of experimental infectious attenuated viral vaccines, and how a respiratory syncytial virus with 619 base changes was rescued by genomes with very large internal deletions.

Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, Kathy Spindler, and Brianne Barker

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Dickson Let us now praise tiny ants
BrianneSmall-school science
Rich Smallpox ‘virus squads’ and the mandatory vaccinations upheld by the Supreme Court
KathyThe Transcontinental Burrito Tunnel
VincentGlass music by Robert Tiso

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Apr 08, 2021
TWiV 739: COVID-19 convalescent plasma with Arturo Casadevall
01:55:12

Arturo Casadevall joins TWiV to discuss the use of convalescent plasma to treat COVID-19, including a history of the process, how plasma is prepared and tested, why it is difficult to conduct randomized clinical trials, how this treatment has fared and his hopes for the future.

Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Brianne Barker

Guest: Arturo Casadevall

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Brianne The Ocean’s Youngest Monsters Are Ready for Glamour Shots
Alan7 Billion Humans
Rich15 Fascinating Animal X-Rays From the Oregon Zoo
Vincent Respiratory pathogen trends

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Apr 04, 2021
TWiV 738: COVID-19 clinical update #56 with Dr. Daniel Griffin
35:15

In COVID-19 clinical update #56, Daniel Griffin note increasing hospitalization in children and young adults, Pfizer vaccine efficacy results in 12-15 year olds, rapid self administered nucleic acid and antigen tests, mRNA vaccine efficacy in real world conditions, and improvement of long COVID after vaccination.

Hosts: Daniel Griffin and Vincent Racaniello

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Intro music is by Ronald Jenkees

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Apr 03, 2021
TWiV 737: SARS-CoV-2 in NYC wastewater
01:55:15

John, Monica, and Davida join TWiV to discuss development of a method to detect SARS-CoV-2 in raw sewage from all 14 of New York City’s treatment plants, and its use to determine the presence of the genome throughout the pandemic and detection of genome mutations from variants of concern.

Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Kathy Spindler

Guest: John Dennehy, Davida Smyth, and Monica Trujillo

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Dickson250,000 Dominoes
BrianneUsing RT-PCR in COVID-19 Testing
Rich Beaded Lacewings Can Take Down Six Termites With A Single Fart
Kathy Tracking the COVID code
VincentAdministering vaccines to adults

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Apr 01, 2021
TWiV 736: Rhapsody in T with Alessandro Sette
02:01:46

Alessandro Sette joins TWiV to discuss the role of T cells in COVID-19, the finding that amino acid changes in SARS-CoV-2 variants of concern have a negligible impact on T cell reactivity in convalescent patients and vaccinees, and whether a next generation vaccine should include more viral proteins than spike.

Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler

Guest: Alessandro Sette

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Alan – The Disinformation Dozen report
Rich No needle, but the damage was done
KathyZinn art  David Zinn
Vincent Clueless Wall Street Journal Op-Ed Endorses PACE as “Prevailing View” Among Docs

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Justin Finnish astrophotographer spends 12 years creating a Milky Way mosaic

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Mar 28, 2021
TWiV 735: COVID-19 clinical update #55 with Dr. Daniel Griffin
39:37

In COVID-19 clinical update #55, Daniel Griffin reviews recommendations for keeping transmission low in school settings, optimal testing strategies for schools and businesses, impact of vaccines on asymptomatic infections, vaccine safety in PASC patients, and early use of aspirin associated with decreased mortality.

Hosts: Daniel Griffin and Vincent Racaniello

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Mar 26, 2021
TWiV 734: Weiss hath no furin like a virus scorned
02:10:57

Susan Weiss returns to TWiV to discuss coronavirus entry into cells and the role of spike protein cleavage by proteases, why lab escaped hypotheses for SARS-CoV-2 are unlikely, and modulation of innate immune responses during infection.

Hosts: Vincent Racaniello, Rich Condit, Alan Dove, Brianne Barker, and Amy Rosenfeld

Guest: Susan Weiss

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Brianne Tiktok of How mRNA Vaccines Work
AlanDark
RichUnmixing Color Machine (Ultra Laminar Reversible Flow) – Smarter Every Day 217
AmyMOMA Calder exhibit, reviewed in NYTimes
VincentRipple Training (free YouTube channel)

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Ruth 100 million year old seafloor bacteria resuscitated
IradisLinda Zall, CIA spy for science

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Mar 21, 2021
TWiV 733: COVID-19 clinical update #54 with Dr. Daniel Griffin
34:27

In COVID-19 clinical update #54, Daniel Griffin covers effectiveness of 3 vs 6 ft physical distancing, effectiveness of masks, physical distancing, and eye shields, second vaccine dose completion, alleviation of COVID-19 symptoms after vaccination, vaccine trials in children, and IDSA approval of a mAb cocktail.

Hosts: Daniel Griffin and Vincent Racaniello

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Mar 20, 2021
TWiV 732: Citizen science with Forest Rohwer and Maria-Isabel Rojas
01:52:15

Forest and Maria-Isabel join TWiV to discuss their their project to engage thousands of citizens to swab inanimate surfaces in the San Diego area, then send the samples to the Rohwer Lab for nucleic acid analysis.

Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, Kathy Spindler, and Brianne Barker

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Dickson10 amazing science tricks with liquids
Brianne How Do Blind Worms See the Color Blue?
Rich Statewide Study Shows Evidence Of Significant COVID-19 Antibodies In Children
Kathy Dark side of the moon as it crosses Earth
VincentWasdkeyboards and Novelkeys

Listener Pick

Bronwen COVID Performance Index

Intro music is by Ronald Jenkees

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Mar 18, 2021
TWiV 731: The kids aren't alright
01:54:32

On a TWiV tetramer, we review the ongoing outbreaks of Ebolavirus disease in DRC and Guinea, evidence that SARS-CoV-2 infections in children are far more prevalent than are being detected, and recent long COVID estimates from the UK.

Hosts: Vincent Racaniello, Rich Condit, Alan Dove, and Brianne Barker

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Brianne Who Would Kidnap a Space Telescope?
AlanRadio Garden
Rich Countries with more obesity have had  more covid deaths on average
VincentConcord Aerospace

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Mar 14, 2021
TWiV 730: COVID-19 clinical update #53 with Dr. Daniel Griffin
44:35

In COVID-19 clinical update #53, Daniel Griffin reviews underreporting of infections and long term disease in children, a blood test for T cells, results of phase 3 trials for monoclonal antibodies, preliminary findings on an oral antiviral, clinical trial of ivermectin, and recommendations for upcoming gatherings.

Hosts: Daniel Griffin and Vincent Racaniello

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Mar 13, 2021
TWiV 729: A floret of spikes with Matt Frieman
01:57:22

Matt Frieman returns to TWiV to discuss the COVID-19 pandemic from the point of view of a coronavirologist, including his work with Novavax on their spike protein-based vaccine.

Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, Kathy Spindler, and Brianne Barker

Guest: Matt Frieman

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Dickson Covid-19 deaths per million ranked by average income
Brianne KFF COVID-19 Vaccine Monitor for Feb 2021 and KFF COVID-19 Vaccine Monitor Dashboard
Rich The Woman Who Stood Between America and a Generation of ‘Thalidomide Babies’(wiki)
KathyQuadrantid meteor (Quadrantids)
VincentHigher Superstition by Paul Gross and Norman Levitt

Intro music is by Ronald Jenkees

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Mar 11, 2021
TWiV 728: Cover your nose and mouse
02:11:38

TWiV notes the passing of Mavis Agbandje-McKenna, and reviews data on maximizing fit for cloth and medical procedure masks, SARS-CoV-2 total and subgenomic viral load in hospitalized patients, and effect of changes in spike protein on efficacy in a mouse model of infection.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Brianne Barker

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Dickson Wild animal photos
Brianne Greater than COVID
Alan WHO report on infodemic response
Rich Reference Guide to the International Space Station
Vincent3D Molecular Designs

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LisbethHave the new jab
Karen Cholera exhibit at Museum of Trades and Crafts

Intro music is by Ronald Jenkees

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Mar 07, 2021
TWiV 727: COVID-19 clinical update #52 with Dr. Daniel Griffin
35:20

In COVID-19 clinical update #52, Daniel Griffin reviews differences in attack rates between children and adults, J&J vaccine phase III data, G6PD deficiency and vaccines, NIH halts convalescent plasma trial, dexamethasone in hospitalized patients, data on tocilizumab, and long COVID in children.

Hosts: Daniel Griffin and Vincent Racaniello

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Intro music is by Ronald Jenkees

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Mar 06, 2021
TWiV 726: Molecular animator Janet Iwasa
01:52:34

Janet Iwasa joins TWiV to recount how she became a molecular animator, including a pivot during her Ph.D. thesis research, the value of animations in science, and their latest animation of SARS-CoV-2 entry into cells.

Hosts: Vincent Racaniello, Rich Condit, Brianne Barker and Kathy Spindler

Guest: Janet Iwasa

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Brianne – How T cells see SARS-CoV2
Rich Ice bubbles in Lago Bianco, Switzerland
Kathy Music in COVID-19 control tents
Vincent Perseverance runs on processors used in 1990s iMacs

Intro music is by Ronald Jenkees

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Mar 04, 2021
TWiV 725: Eva Harris and Janet Smith clip flavivirus wings
01:59:15

Eva Harris and Janet Smith join TWiV to discuss how an antibody against dengue virus NS1 protein blocks endothelial dysfunction and the potential of treating infections by multiple flaviviruses.

Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler

Guest: Eva Harris and Janet Smith

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AlanScience Photographer of the Year Awards
RichBar Keeper’s Friend
Kathy Perseverance secret message and other Easter eggs, 11 million Earthlings’ names, “Name the Rover” essay contest. Sign up to send your name on a future Mars mission.
VincentCOVID-19 dataset

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Matthew - Remembering the colleagues we lost to COVID-19
Lori - Iceberger

Intro music is by Ronald Jenkees

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Feb 28, 2021
TWiV 724: COVID-19 clinical update #51 with Dr. Daniel Griffin
36:57

In COVID-19 clinical update #51, Daniel Griffin reviews use of two masks, effectiveness of testing in nursing homes, updates on vaccines, use of nonsteroidal anti-inflammatory drugs, little effect of vitamin D and remdesivir in clinical studies, and a long COVID research initiative from NIH.

Hosts: Daniel Griffin and Vincent Racaniello

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Feb 27, 2021
TWiV 723: COVID-19 palliative care with Ginger Campbell, MD
01:48:27

Ginger Campbell joins TWiV to discuss palliative care for COVID-19 patients, and how to approach the disease from a goals of care perspective.

Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Brianne Barker

Guest: Ginger Campbell, MD

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DicksonSoapbox Gallery
BrianneCell Picture Show
RichPerseverance Rover’s Descent and Touchdown on Mars (Official NASA Video)
VincentOur World in Data (see COVID-19 vaccinations)

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Feb 25, 2021
TWiV 722: More coronaviruses in the pipeline
02:02:11

The entire TWiV team assembles to discuss resurgence of COVID-19 in Manaus, Brazil, discovery of SARS-CoV-2 related viruses in bats in Southeast Asia, and increased Ct values after administration of mRNA vaccine.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, Kathy Spindler, and Brianne Barker

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DicksonWhat is the polar vortex?
Brianne Cloning of the black-footed ferret
Alan – Explaining mRNA vaccines with Star Wars
RichBrighton Collaboration (BRAVATO); Ad26 vector template
Kathy Target public health ads to zipcodes
Vincent And Then the Gorillas Started Coughing

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Kim – Virus getting the shot (jpg)

Intro music is by Ronald Jenkees

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Feb 21, 2021
TWiV 721: COVID-19 clinical update #50 with Dr. Daniel Griffin
30:21

In COVID-19 clinical update #50, Daniel Griffin discusses CDC guidance on school opening, decreased viral load after vaccination, randomized clinical trial of vitamin D treatment, a study of zinc plus vitamin C, anticoagulation therapy effect on mortality, and multi system inflammatory phase in children.

Hosts: Daniel Griffin and Vincent Racaniello

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Feb 20, 2021
TWiV 720: With vaccines, Offit is on it
02:00:57

Paul Offit joins TWiV to discuss all things vaccine, including how COVID-19 vaccine development was accelerated, whether the vaccines are safe and efficacious, the difference between an EUA and a licensed vaccine, sterilizing immunity, herd immunity, and much more.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Brianne Barker

Guest: Paul Offit

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DicksonLife in a Day 2020
Brianne Microcosms in Glass
AlanNEJM article on promoting vaccination, interview with lead author
Rich The Microbescope
VincentAutism’s False Prophets by Paul Offit

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EarlScience is Real Pins

Intro music is by Ronald Jenkees

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Feb 14, 2021
TWiV 719: COVID-19 clinical update #49 with Dr. Daniel Griffin
27:41

In COVID-19 clinical update #49, Daniel Griffin discusses CDC guidelines on mask use, drop in test frequency in the US, resurgence of COVID-19 in Brazil, possible impact of Pfizer vaccine on viral load, EUA for bamlanivimab and etesevimab administered together, and preliminary results of Tocilizumab in hospitalized patients.

Hosts: Daniel Griffin and Vincent Racaniello

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Intro music is by Ronald Jenkees

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Feb 13, 2021
TWiV 718: Recombining vaccine schedules
01:52:10

TWiV explores single dose administration and timing of second dose of AZD1222 COVID-19 vaccine, safety and efficacy of Sputnik V, and control of coronavirus recombination by a viral proofreading exonuclease.

Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker

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BrianneDo scientists read enough fiction?
Rich Insects in flight; Insect flight|Capturing takeoff
KathyBadger seal
VincentMicrobeTV merchandise

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Feb 11, 2021
TWiV 717: Paul and Theodora, pandemic explorers
01:57:02

Theodora and Paul return to TWiV to explain how they quickly pivoted their retrovirus laboratories towards SARS-CoV-2, their work on the antibody response to infection and its durability, and the emergence of variants with increased resistance to neutralization.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Rich Condit

Guests: Paul Bieniasz and Theodora Hatziioannou

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DicksonMars Perseverance Rover
AlanThe Outlaw Ocean
RichAnand Varma Photography
Vincent Virology Lectures 2021

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Feb 07, 2021
TWiV 716: COVID-19 clinical update #48 with Dr. Daniel Griffin
51:46

In COVID-19 clinical update #48, Daniel Griffin reviews effect of spike amino acid changes on neutralization with monoclonal antibodies, Sputnik V safety and efficacy results, increased reactogenicity after a single vaccine dose in seropositive individuals, single dose vaccination in seropositive health care workers, and results of three clinical trials on the use of anticoagulants.

Hosts: Daniel Griffin and Vincent Racaniello

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Feb 06, 2021
TWiV 715: Fauci ouchy
01:49:59

TWiV explains why hydroxychloroquine failed in humans despite showing antiviral effects in cells, and reviews the published data on the Pfizer/BioNTech mRNA vaccine.

Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker

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BrianneHow the Body Reacts to Viruses
Rich How do wombats poop cubes?
Kathy The Verse by the Side of the Road
Vincent Janet Iwasa’s SARS-CoV-2 entry animation

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Feb 04, 2021
TWiV 714: The shape of spike with Jason McLellan
02:06:48

Jason McLellan joins TWiV to reveal all we know about the SARS-CoV-2 spike protein, followed by Novavax and J&S phase 3 results and a discussion of variants of concern: neutralization by vaccine-induced antibodies, transmission, and virulence.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Amy Rosenfeld

Guest: Jason McLellan

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Dickson Pandemic Pivot and Tuba Skinny
Alan Technological challenges in vaccine rollout
Rich I was lucky to find this vaccine anywhere
VincentLady Gaga’s MIXED METER Star Spangled Banner?!

Intro music is by Ronald Jenkees

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Jan 31, 2021
TWiV 713: COVID-19 clinical update #47 with Dr. Daniel Griffin
34:57

In COVID-19 clinical update #47, Daniel Griffin reviews phase 3 results for Novavax and J&J vaccines, transmission in K-12 settings in Wisconsin, data on Lilly and Regeneron monoclonal antibody therapy, and a study of colchicine for treatment of disease.

Hosts: Daniel Griffin and Vincent Racaniello

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Intro music is by Ronald Jenkees

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Jan 30, 2021
TWiV 712: Deutscher Virus Wahnsinn
01:38:05

Gisa, Steffi, and César join TWiV to discuss their careers, their research, and the COVID-19 pandemic in Germany.

Hosts: Vincent Racaniello, Rich Condit, and Kathy Spindler

Guests: Gisa Gerold, Stefanie Becker, and César Muñoz-Fontela

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Intro music is by Ronald Jenkees

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Jan 28, 2021
TWiV 711: The New Heal
02:00:27

The TWiVers review Biden’s national strategy for the COVID-19 responses and pandemic preparedness, and an evaluation of the BinaxNOW rapid antigen test for SARS-CoV-2 infection.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Brianne Barker

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DicksonSpelling Bee
Brianne He Made a Viral Bernie Meme Site. Now He Has to Keep it Going
Alan – America’s Cup AC75 capsize and aftermath in qualifying race
RichGame Theory’s UNCENSORED Interview With Dr. Fauci | The Truth About COVID-19 Vaccines
Vincent Top Science Podcasts

Intro music is by Ronald Jenkees

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Jan 24, 2021
TWiV 710: COVID-19 clinical update #46 with Dr. Daniel Griffin
34:36

In COVID-19 clinical update #46, Daniel Griffin discusses the BinaxNow rapid antigen test, efficacy of Bamlanivimab in nursing homes, associations of serum vitamin D concentrations with in-hospital mortality and need for invasive mechanical ventilation, trials of IL-6 receptor antagonists, effects of anticoagulants on in-hospital mortality, and symptom persistence in outpatients.

Hosts: Daniel Griffin and Vincent Racaniello

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Intro music is by Ronald Jenkees

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Jan 23, 2021
TWiV 709: COVID cherry picking
01:29:42

In this episode, President Biden elevates his science advisor to his Cabinet, a review of the current flu season, the scientific goals of the WHO-convened Global Study of the Origins of SARS-CoV-2, and answers to listener questions.

Hosts: Vincent Racaniello, Rich Condit, and Kathy Spindler

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Kathy15 YouTubers play Telestrations
VincentVince Beiser

Listener Picks

Bob, David, Janet – Sea Shanty by A Cappella Science (YouTube, TikTok, Bandcamp)

Intro music is by Ronald Jenkees

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Jan 21, 2021
TWiV 708: Alpaca llama full of nanobodies
02:01:11

The TWiVy team deconstructs CoronaVac, the inactivated SARS-CoV-2 vaccine produced by Sinovac Biotech, and production of multivalent camelid nanobodies that block infection with the virus and suppress selection of neturalization-resistant variants.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Brianne Barker

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Dickson Photos of mob attacking Capitol
Brianne Video of Neutrophil Phagocytosis
AlanFishing Through the Apocalypse
Rich A Word on Statistics by Wislawa Szymborska
Vincent Letters from an American

Listener Pick

Mike – Have the new jab

Intro music is by Ronald Jenkees

Jan 17, 2021
TWiV 707: COVID-19 clinical update #45 with Dr. Daniel Griffin
39:38

In COVID-19 clinical update #45, Daniel Griffin discusses J&J Ad26 vaccine results, reactogenicity after the second dose of mRNA vaccines, expansion of vaccine eligibility, and the finding that encephalitis after SARS-CoV-2 infection is a cytokine release syndrome.

Hosts: Daniel Griffin and Vincent Racaniello

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Jan 16, 2021
TWiV 706: Do as Dr. Fauci says
01:36:14

TWiV answers listener questions about pandemic response, excess deaths in 25-44 year olds, vaccines, vaccines, and vaccines.

Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker

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Brianne We Know Almost Nothing About Giant Viruses
Rich The Coccolithophores Project
Kathy v-safe and  Vaccine Handbook
Vincent – Gorillas at San Diego Zoo infected with SARS-CoV-2 (pdf)

Intro music is by Ronald Jenkees

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Jan 14, 2021
TWiV 705: Rocky Mountain COVID with Emily Travanty
01:50:55

Emily Travanty from the Colorado Department of Public Health and Environment joins TWiV to discuss how her laboratory was the first in the US to detect the SARS-CoV-2 variant VOC 202012/01.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Brianne Barker

Guest: Emily Travanty

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DicksonRandal Despommier on saxophone
BrianneGiant Microbes SARS-CoV2
AlanWest of Loathing
Rich Draft landscape of COVID-19 candidate vaccines
VincentSARS-CoV-2 spillover events

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Daniel – His Vaccine Story Inspired His Father To Write A Disney Classic

Intro music is by Ronald Jenkees

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Jan 10, 2021
TWiV 704: COVID-19 clinical update #44 with Dr. Daniel Griffin
32:03

In this COVID-19 clinical update, Daniel Griffin summarizes current status of vaccination in the US, discusses a study on convalescent sera from Argentina, use of remdesivir in patients with kidney disease, and provides further considerations on the use of Ct values in patient management.

Hosts: Daniel Griffin and Vincent Racaniello

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Intro music is by Ronald Jenkees

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Jan 09, 2021
TWiV 703: Does dose matter?
02:04:55

On this episode, a discussion of why modifying the dose schedule of the mRNA vaccines in the US is not a good idea, evidence that lower Ct values on hospital admission is associated with higher mortality, and dose-dependent response to SARS-CoV-2 infection of ferrets.

Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker

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BrianneLinsey Marr on masks
KathyStriped Martian Sand Dunes and
RichHow Microwaving Grapes Makes Plasma
Vincent Musings of an anonymous, pissed off virologist

Listener Pick

LauraAuld Lang Syne follow-up

Intro music is by Ronald Jenkees

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Jan 07, 2021
TWiV 702: Year of the Pandemic
01:37:10

For this first episode of 2021, the complete TWiV team reviews compelling virology stories of 2020, and thanks the multitude of guests who have helped us to navigate the pandemic, and our many listeners who turn to us for scientific facts.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, Kathy Spindler, and Brianne Barker

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Dickson Best of 2020 by NASA and The Plague Year
Brianne Where Year Two of the Pandemic Will Take Us
Alan – Japan’s distinct form of vaccine hesitancy
Kathy Paul Offit updates on the vaccine rollout and Choral Scholars of University College Dublin (John Greene’s videoessay on the song)
Rich Do You Love Me?
Vincent Story on Katalin Kariko’s career

Listener Pick

LouiseVirus socks

Intro music is by Ronald Jenkees

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Jan 03, 2021
TWiV 701: COVID-19 clinical update #43 with Dr. Daniel Griffin
38:57

In Daniel Griffin’s final clinical report for 2020, he summarizes what we have learned about the clinical management of COVID-19 patients in the past year.

Hosts: Daniel Griffin and Vincent Racaniello

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Intro music is by Ronald Jenkees

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Jan 02, 2021
TWiV 700: 'Twas COVID and the aerosols
02:08:37

TWiV reviews additional data on the UK variant of SARS-CoV-2, the distinct variant spreading in South Africa, association of afucosylated antiviral IgG with severe COVID-19, approval of AstraZeneca vaccine in the UK, and winners of the pandemic poem contest.

Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker

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BrianneReady Player Two
Kathy Bert Hubert’s Reverse Engineering of the Pfizer/BioNTech vaccine
RichBoston Dynamics running robots
VincentFever by John Fuller

Intro music is by Ronald Jenkees

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Dec 31, 2020
TWiV 699: Arboviruses at ASTMH
01:27:11

From the 2020 online meeting of the American Society for Tropical Medicine and Hygiene, Vincent speaks with Jonathan Auguste, Carol Blair, Desiree LaBeaud, Louis Lambrechts, and Mauricio Nogueira about their careers and their research on arthropod-borne viruses.

Host: Vincent Racaniello

Guests: Jonathan Auguste, Carol Blair, Desiree LaBeaud, Louis Lambrechts, and Mauricio Nogueira

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Intro music is by Ronald Jenkees

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Dec 27, 2020
TWiV 698: COVID-19 clinical update #42 with Dr. Daniel Griffin
40:09

Daniel Griffin provides his weekly clinical report on COVID-19, including his own experience with vaccination, guidelines for vaccine distribution, reasons for under-utilization of monoclonal antibody therapy, and much more.

Hosts: Daniel Griffin and Vincent Racaniello

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Intro music is by Ronald Jenkees

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Dec 26, 2020
TWiV 697: The sky is NOT falling
02:15:56

TWiV reviews the latest data on the UK variant of SARS-CoV-2, including some properties of the variant and why it is being closely studied, development of liver cancer in a participant in a adenovirus-associated virus gene therapy trial, and answers to listener questions.

Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker

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Brianne EM Rap Podcast COVID update
KathyConjunction of Jupiter and Saturn and Tony Fauci vaccinated Santa Claus
RichChicken LIttle (wiki)
Vincentvirological.org

Listener Pick

GregSomeone who wants to make a difference
UliXKCD on statistics

Intro music is by Ronald Jenkees

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Dec 24, 2020
TWiV 696: Tear down that SARS-CoV-2 manuscript
02:11:13

TWiV explains that COVID-19 is not harmless for young adults, FAA approval for Pfizer mRNA vaccine, lack of justification for the claim of reverse transcription of SARS-CoV-2 RNA and integration into the human genome, and lack of evidence for increased transmission by new variants in the UK.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Brianne Barker

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Dickson 2020 Audubon Photography Winners
Brianne COVID-19 Changed Science Forever
AlanEntangled Life by Merlin Sheldrake
Rich Lie of the Year: Coronavirus downplay and denial; John 18:38
Vincent How New York City Vaccinated 6 Million People in Less Than a Month (my article from 2009)

Intro music is by Ronald Jenkees

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Dec 20, 2020
TWiV 695: COVID-19 clinical update #41 with Dr. Daniel Griffin
41:33

Daniel Griffin provides his weekly clinical report on COVID-19, including thoughts on the first immunizations with Pfizer mRNA vaccine, the anticipated EUA for the Moderna vaccine, whether the vaccine prevents infection, not just disease, monoclonal antibody therapy, and much more.

Hosts: Daniel Griffin and Vincent Racaniello

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Intro music is by Ronald Jenkees

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Dec 18, 2020
TWiV 694: Mitigating COVID-19
01:50:33

On this episode, TWiV makes Bloomberg Business News 2020 Jealousy List, crushing of CDC revealed by insiders, seasonal influenza during the COVID-19 pandemic, FDA briefing documents from Moderna, and three-quarters attack rate of SARS-CoV-2 during an unmitigated epidemic in Brazil.

Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker

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Brianne Fears of a ‘Twindemic’ Recede as Flu Lies Low
Kathy Faculty Equity & COVID-19 UM ADVANCE
Rich ‘Sistine Chapel of the ancients’ rock art
Vincent Winners of ASM Agar Art Contest 2020

Listener Pick

Johnye2020 Year of the Vax t-shirt (and more)

Intro music is by Ronald Jenkees

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Dec 17, 2020
TWiV 693: Vax to the future
01:55:05

On this episode, FDA EUA for Pfizer mRNA vaccine, efficacy of AstraZeneca ChAdOx1 COVID-19 vaccine, and an orally administered drug that blocks SARS-CoV-2 transmission in ferrets.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Brianne Barker

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Dickson 2020 In Photos: A Year Like No Other
BrianneCooking for Geeks
AlanOn Food and Cooking
RichNASA Artemis (Wiki)
Vincent The virus, the bats, and us

Intro music is by Ronald Jenkees

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Dec 13, 2020
TWiV 692: COVID-19 clinical update #40 with Dr. Daniel Griffin
38:12

Daniel Griffin provides his weekly clinical report on COVID-19, including the anticipated EUA for the Pfizer mRNA vaccine, mitigation strategies in early care and education settings, expressive aphasia, and much more.

Hosts: Daniel Griffin and Vincent Racaniello

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Intro music is by Ronald Jenkees

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Dec 11, 2020
TWiV 691: SciArt with Laura Splan
02:11:55

SciArtist Laura Splan joins TWiV to reveal her transdisciplinary work that intersects science, technology, design and culture, then we discuss an inverse correlation between mumps virus antibodies induced by MMR vaccine and COVID-19 severity, and whether ivermectin is indicated for treatment of COVID-19.

Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker

Guest: Laura Splan

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Brianne – Patterns for Virus snowflakes
Kathy – 2020 Nobel Prize lectures (hepatitis C) (link to all and concert) Historical review by Harvey Alter
Rich New Data Confirm 2020 SO is Upper Centaur Rocket Booster from 1960’s (Wiki)
VincentThe Right Stuff

Listener Pick

Miikael Tiny tweak behind COVID-19 vaccines

Intro music is by Ronald Jenkees

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Dec 10, 2020
TWiV 690: This is your brain on SARS-CoV-2
01:59:02

TWiV reviews the difficulties in predicting species susceptibility to SARS-CoV-2 infection by only examining the ACE2 protein, and the olfactory mucosa as a portal of entry into the central nervous system in COVID-19 patients.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Rich Condit

Guest: Amy Rosenfeld

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Weekly Science Picks

Dickson National Geographic best animal photos of 2020
AmyAmerican Contagions: Epidemics and the law from Smallpox to COVID-19 by John Fabian Witt
AlanHamSCI citizen science organization
RichDeepMind’s AI makes gigantic leap in solving protein structures
VincentArmy Ants: Nature’s Ultimate Social Hunters by Daniel Kronauer

Intro music is by Ronald Jenkees

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Dec 06, 2020
TWiV 689: COVID-19 clinical update #39 with Dr. Daniel Griffin
37:11

Daniel Griffin provides his weekly clinical report on COVID-19, including analysis of vitamin D levels in patients, information on Moderna and Pfizer vaccines, distribution plans suggested by ACIP, and more.

Hosts: Daniel Griffin and Vincent Racaniello

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Intro music is by Ronald Jenkees

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Dec 05, 2020
TWiV 688: We put COVID-19 papers through a sieve
01:50:30

TWiV 688: We put COVID-19 papers through a sieve

December 2, 2020

On this episode, UK grants EUA for Pfizer vaccine, advice for CDC on who to immunize first, news from Das Coronavirus, SARS-CoV-2 protease regulates innate responses, and viral mRNAs are not an indication of viral replication.

Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker

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BriannePedromics
KathyGlobal map at Mars opposition
RichJaneway’s Immunobiology
VincentJanet Iwasa’s Animation Lab

Listener Pick

Cheryl – BioRender.com holiday card templates

Intro music is by Ronald Jenkees

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Dec 03, 2020
TWiV 687: Peter Hotez sticks to the vax
02:18:04

Peter Hotez joins TWiV to discuss the COVID-19 pandemic, including why it went out of control in the US, the hijacking of public health practices by anti-science extremist groups, prospects for control, and whether we will be prepared for the next one.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Brianne Barker

Guest: Peter Hotez

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Weekly Science Picks

Dickson The World’s First Energy-Positive Hotel to Open in Norway
Brianne The Food Lab: Better Home Cooking Through Science
Alan ACIP’s ethical principles for COVID-19 vaccine allocation
RichThe Mandolorian
VincentT. rex and the Crater of Doom by Walter Alvarez

Intro music is by Ronald Jenkees

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Nov 29, 2020
TWiV 686: COVID-19 clinical update #38 with Dr. Daniel Griffin
34:26

Daniel Griffin provides his weekly clinical report on COVID-19, including new post-exposure guidelines from CDC, clinical trials of Remdesivir and convalescent plasma, FDA EUA for baricitinib and Regeneron’s monoclonal antibody and more.

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Intro music is by Ronald Jenkees

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Nov 28, 2020