This Week in Virology

By Vincent Racaniello

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Category: Science

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Subscribers: 1323
Reviews: 6


 Aug 8, 2021

Rachael
 Nov 28, 2020
excellent thanks for doing a great job


 May 29, 2020

excellent
 Apr 23, 2020
great information

Reed
 Jan 15, 2020
amazing in depth podcast on the nuts and bolts of all kinds of viruses. expect in depth discussions of papers by experienced scientists with a decent sense of humour. I can follow along most details even though I have not studied virology.

Description

This Week in Virology is a netcast about viruses - the kind that make you sick.

Episode Date
TWiV 915: Mouse mouth to mouse mom
01:55:02

TWiV discusses the recent decision by an FDA advisory committee to update COVID vaccines for the fall, the monkeypox virus outbreak, and the finding that enteric viruses infect the salivary glands and are transmitted through saliva.

Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, Kathy Spindler, and Brianne Barker.

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Weekly Picks

Dickson – Jazz big bands #2: Maynard Ferguson: Signature song: Theme From Rocky: Signature album: Color Him Wild
Brianne Origami antibody and virus
Kathy Turbines resistant to high winds
RichObi-Wan Kenobi (TV Series)
Vincent The next epidemic may be here. The US isn’t ready for it.

Listener Picks

David: DALL E 2
DouglasJazz Online

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

Jul 03, 2022
TWiV 914: COVID-19 clinical update #121 with Dr. Daniel Griffin
37:17

In COVID-19 clinical update #121, Dr. Griffin discusses age as a risk factor for severe disease, updated vaccine boosters for the fall, pediatric infection and antibody seroprevalence in Arkansas over the first year of the COVID-19 pandemic, all-cause maternal mortality in the United States before and during the pandemic, and the effect of 2-week interruption in methotrexate treatment and how it impacts vaccine immunity.

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Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to daniel@microbe.tv

Jul 02, 2022
TWiV 913: Twinkle twinkle little SARS
01:56:54

TWiV explains the meaning of vaccine-derived poliovirus found in London sewage, risk of long COVID after infections with Delta or Omicron variants of SARS-CoV-2, and enhancers of innate immune signaling as broad-spectrum antivirals.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler.

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Weekly Picks

Dickson – Count Basie: April in Paris
Kathy – Bird aerodynamics & inertia: lay article, video, Nature
RichNASA Gateway (Thanks Ellis)
Alan Polio Eradication in Nigeria
VincentThe Tyranny of Merit by Michael J. Sandel

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

Jun 26, 2022
TWiV 912: COVID-19 clinical update #120 with Dr. Daniel Griffin
45:07

In COVID-19 clinical update #120, Dr. Griffin discusses outcomes of SARS-CoV-2 reinfection, CDC recommendation for vaccines in young children, neurodevelopment outcomes in infants of mothers testing positive for COVID during pregnancy, efficacy of monoclonal antibodies and antivirals in hamsters, rebound phenomenon after PAXLOVID in high-risk persons, hospitalization for infection after PAXLOVID treatment, and risk of long COVID with different variants.

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Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to daniel@microbe.tv

Jun 25, 2022
TWiV 911: Antibody can get vaccinated now
01:54:41

TWiV provides an update on hepatitis of unknown etiology in children, an experimental nanoparticle vaccine for Epstein-Barr virus, and minimal impact of bamlanivimab therapy on antiviral antibodies induced by vaccination.

Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker

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Weekly Picks

Brianne A Frog So Small, It Could Not Frog
KathyA Grand Night In: The Story of Aardman
RichArchive
VincentBandwagoning by Heran Darwin

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

Jun 19, 2022
TWiV 910: COVID-19 clinical update #119 with Dr. Daniel Griffin
46:42

In COVID-19 clinical update #119, Dr. Griffin reviews tixagevimab for infection prevention, ivermectin for outpatient infection treatment, symptom rebound after PAXLOVID treatment, bamlanivimab minimally impacting immune response to vaccination, in-hospital mortality among infection patients, residual viral antigen in patients following infection, usage of Casirvimab/Imdevimab and Remdesivir in infected patients with depleted B-cells, and rheumatic symptoms following infection.

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Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to daniel@microbe.tv

Jun 18, 2022
TWiV 909: Art of science
47:21

From ASM Microbe 2022 in Washington DC, Vincent and Michael speak with science artists Michele Banks and Jane Hartman about their work and their inspiration.

Hosts: Vincent Racaniello and Michael Schmidt

Guests: Michele Banks and Jane Hartman

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Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

Jun 16, 2022
TWiV 907: When the cats and mice are away, the viruses play
01:44:49

TWiV discusses the situation with monkeypox, risk factors for SARS-CoV-2 infections of cats and dogs, and a lineage-tracing mouse model for studying papillomavirus infections.

Hosts: Vincent Racaniello, Rich Condit, and Brianne Barker

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Weekly Picks

BrianneMicrobes Rule! at Liberty Science Center
RichArtemis I update:  Mission diagram, mission in photos, launch dates
VincentEco-sustainable 3D printed house – Tecla

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

Jun 12, 2022
TWiV 908: COVID-19 clinical update #118 with Dr. Daniel Griffin
46:23

In COVID-19 clinical update #118, Dr. Griffin discusses management of hair loss after infection, FDA announcements on vaccine schedule and recommendations, Moderna announcement on bivalent booster candidate, association between vaccination and infection during pregnancy, population-level implications of Israel’s booster campaign, PAXLOVID outcomes during recent infection surge, efficacy and safety of Tixagevimab-cilgavimab, diagnostic accuracy of infection by canines, efficacy of colchicine in hospitalized patients, and factors associated with hospital readmission.  

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Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to daniel@microbe.tv

Jun 11, 2022
TWiV 906: Long COVID, giant viruses, and smallish pox
01:46:11

TWiV reviews human monkeypox infections, evidence for human Mimivrus infections, and incidence of long COVID in post-vaccine SARS-CoV-2 infections.

Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Brianne Barker

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Weekly Picks

Dickson Lake Mead water level very low
Brianne Transplantation of a 3D printed ear made out of human cells
Richnderstanding Vaccine Safety and the Roles of the FDA and the CDC and The Facts About Vaccine Safety
Vincent My new favorite backpack

Listener Pick

GregAgainst the Rules

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

Jun 05, 2022
TWiV 905: COVID-19 clinical update #117 with Dr. Daniel Griffin
44:24

In COVID-19 clinical update #117, Dr. Griffin discusses duration of virus shedding, association between pre-exposure to steroids and infection outcome, post-infection subtypes, rehabilitation for post-acute infection, Tixagevimab/Cilgavimab for infection prevention, antibody prophylaxis and vaccination in kidney transplant recipients, remdesivir and bebtelovimab fact sheets for providers, the updated guidelines on treatment with Famotidine, Paxlovid rebound symptom characterizations, antigen test positivity duration, viral dynamics of variants and isolation, association of inflammation in CS fluid, and transmission dynamics in Ghana.

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Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to daniel@microbe.tv

Jun 04, 2022
TWiV 904: 50 years of reverse transcriptase
58:58

Vincent travels to Cold Spring Harbor Laboratory to speak with David Baltimore, John Coffin, and Harold Varmus about the discovery in 1970 of retroviral reverse transcriptase and its impact on life sciences research.

Hosts: Vincent Racaniello

Guests: David Baltimore, John Coffin, and Harold Varmus

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Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

May 29, 2022
TWiV 903: COVID-19 clinical update #116 with Dr. Daniel Griffin
47:47

In COVID-19 clinical update #115, Dr. Griffin discusses croup association with infection surge, rhinovirus co-circulation in children, shedding following vaccination, high vaccine efficacy in children 6 mo-5 yr, vaccine protection for hospitalized patients, convalescent plasma as post-exposure prophylaxis, real-world effectiveness of PAXLOVID, effectiveness of PAXLOVID in reducing hospitalization, infection rebound after PAXLOVID, relapse of symptomatic infection after PAXLOVID, remdesivir and bebtelovimab fact sheets for providers, guidelines on usage of anticoagulation drugs, long covid symptoms after vaccination, excess mortality in MA, infection sequelae and immunity, and post infection conditions among adults.

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Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to daniel@microbe.tv

May 28, 2022
TWiV Special: Monkeypox clinical update with Dr. Daniel Griffin
26:01

In this special episode, Dr. Griffin answers questions about the recent cases of monkeypox including their origin, clinical presentation, diagnosis, treatment, and overall risk.

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  • Monkeypox multi-country outbreak risk assessment (pdf, ECDC)
  • Monkeypox update (ProMedMail)
  • Monkeypox virus genome sequences (Nextstrain)

Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to daniel@microbe.tv

May 26, 2022
TWiV 902: Autoantibodies drive severe COVID-19
02:06:39

TWiV reviews recent cases of monkeypox, presence of SARS-CoV-2 RNA but not infectious virus in feces, and the association of autoantibodies to interferons with severe COVID-19.

Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, Kathy Spindler, and Brianne Barker

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Weekly Picks

Dickson How to grow food on the moon
BrianneAPod May 16: Milky Way over French Alp Hoodoos
KathyCovid Nationwide data visualization
RichNIH All of Us Research Program
Vincent Physicians Spreading Misinformation on Social Media — Do Right and Wrong Answers Still Exist in Medicine?

Listener Pick

Lisa E.H. Danner Museum of Telephony

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

May 22, 2022
TWiV 901: COVID-19 clinical update #115 with Dr. Daniel Griffin
01:00:11

In COVID-19 clinical update #115, Dr. Griffin reviews cross-variant immunity without vaccination, EUA for boosters in 5-11 year olds, B.1.1.529 attack rate, scent dogs, Omicron and pets, Paxlovid, Veklury, Fluvoxamine, antigen positivity after isolation, inflammasome activation and severe disease, and GI persistence and fecal shedding.

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Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to daniel@microbe.tv

May 21, 2022
TWiV 900: Burning down the mouse
01:35:17

TWiV celebrates 900 episodes, Vincent gives the Richard R. Ernst lecture, and we discuss why inflammasome activation in infected macrophages drives severe COVID-19.

Hosts: Vincent Racaniello, Alan Dove, Rich Condit, Kathy Spindler, and Brianne Barker

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Weekly Picks

BrianneThe Milky Way’s Black Hole Comes to Light
Kathy River dolphins playing with anaconda
Rich Smallpox vaccination techniques; from knives and forks to needles and pins
AlanVacuum Tubes: a Modern Aladdin’s Lamp
VincentBooks by Pamela Jane

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

May 15, 2022
TWiV 899: COVID-19 clinical update #114 with Dr. Daniel Griffin
55:56

In COVID-19 clinical update #114, Dr. Griffin discusses early treatment with ivermectin, procalcitonin not a reliable biomarker, vaccine in 6-11 year olds, FDA limits use of Janssen vaccine, does site of vaccine booster matter, sniffer dogs, monoclonals for hospitalized patients, risk assessment for public events, Paxlovid eligibility, and persistence of pediatric anosmia.

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Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to daniel@microbe.tv

May 14, 2022
TWiV 898: Immunity is skin deep
01:38:23

TWiV explains why the concept of herd immunity might not apply to COVID-19, and the observation that smallpox vaccination causes an increase in skin bacteria that promote pathology and influence the immune response.

Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker

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Weekly Picks

Brianne Bacteria and Me Coloring Book
Kathy Smarter 3D printing
RichBig Ben Restoring the Worlds Most Famous Clock 2021
VincentScientific review articles as antivaccine disinformation

Listener Pick

SuellenYour Fantastic Mind Season 3 Ep 2: Long COVID and Making of a Brain Surgeon (Full Episode)

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

May 08, 2022
TWiV 897: COVID-19 clinical update #113 with Dr. Daniel Griffin
47:48

In COVID-19 clinical update #113, Dr. Griffin discusses tocilizumab use in hospitalized Patients, IL-6 inhibitors and mortality, Baricitinib in hospitalized patients, post-infection neurological sequelae, comparative effectiveness of Pfizer and Moderna vaccines, phase 2/3 study of Paxlovid, infection relapse following Paxlovid, pre-hospital administration of Remdesivir, and hospitalization with different variants.

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Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to daniel@microbe.tv

May 07, 2022
TWiV 896: Memory B cells, the way we were
01:41:55

TWiV explains a study of how climate change is predicted to increase cross-species viral transmission risk, and increased memory B cell potency and breadth after a SARS-CoV-2 mRNA vaccine boost.

Hosts: Vincent Racaniello, Dickson Despommier, and Amy Rosenfeld

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Weekly Picks

DicksonToots Thilelemans
Amy Largest comet ever identified
Vincent Scientific review articles as antivaccine disinformation

Intro music is by Ronald Jenkees

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May 01, 2022
TWiV 895: COVID-19 clinical update #112 with Dr. Daniel Griffin
35:37

In COVID-19 clinical update #112, Dr. Griffin reviews seroprevalence of infection-induced antibodies, Moderna filing for vaccine authorization in young children, public health impact of vaccines in US, FDA approval of first treatment for young children, phase 2 data for Sabizabulin, and post infection inflammation.

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Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to daniel@microbe.tv

Apr 30, 2022
TWiV 894: Dinner with the TMPRSS family
01:39:55

TWiV explains what is known about cases of acute, severe hepatitis of unknown origin in children, and discovery of an inhibitor of TMPRSS2 protease that blocks SARS-CoV-2 infection.

Hosts: Vincent Racaniello, Alan Dove, Kathy Spindler, and Brianne Barker

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Weekly Picks

Brianne Apple AirTag
Kathy Dental art/sculpture/mobile/chandelier
AlanVintage Radio and Communications Museum of Connecticut
Vincent For the Love of Enzymes by Arthur Kornberg

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

Apr 28, 2022
TWiV 893: Yellow fever virus escapes antibodies
01:28:29

Kartik, Denise, and Gorka join TWiV to discuss their finding that changes in the surface glycoprotein of South American yellow fever virus lead to reduced neutralization by antibodies induced by the vaccine, which is derived from an African isolate.

Hosts: Vincent Racaniello, Dickson Despommier, and Brianne Barker

Guests: Kartik Chandran, Denise Haslwanter, and Gorka Lasso Cabrera

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Weekly Picks

DicksonEarth Day and Earth Day History
BrianneXKCD: Family Reunion
VincentTokaido: A Journey (DVD)

Intro music is by Ronald Jenkees

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Apr 24, 2022
TWiV 892: COVID-19 clinical update #111 with Dr. Daniel Griffin
54:13

In COVID-19 clinical update #111, Dr. Griffin discusses vaccine coverage and mortality in Hong Kong, immune response to boosters in kids, hospitalization of kids, breath based diagnostic test, viral co-infections, bivalent mRNA vaccine, intramuscular Evusheld, and global long COVID.

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Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to daniel@microbe.tv

Apr 23, 2022
TWiV 891: LLOV in the time of Ebola
01:24:31

Elke, Adam, and Gabor join TWiV to discuss their work on Lloviu virus, a filovirus, including recovery of infectious virus from a DNA copy of the genome and from Schreiber’s bats in Hungary.

Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker

Guests: Elke Muhlberger, Adam Hume, and Gabor Kemenesi

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Weekly Picks

BrianneAPod Stars and Globules in the Running Chicken Nebula
KathyBioRender Poster Builder
Rich The Sins of Our Fathers: An Expanse Novella (The Expanse) by James S. A. Corey
VincentBaumgartner Restoration

Listener Pick

JTime, Einstein, and the coolest stuff in the Universe

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

Apr 21, 2022
TWiV 890: Looking into a booster crystal ball
01:55:07

This episode of TWiV is focused on COVID-19 vaccines and antibodies: who should get boosters, whether a variant matched mRNA vaccine is superior to a historical vaccine, and how the interval between vaccination and infection influences the quality of the antibody response.

Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Brianne Barker

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Weekly Picks

Dickson Webb Telescope’s coldest instrument reaches operating temperature
Brianne Video of a CTL killing a tumor cell
Rich Our Unfinished Pandemic (On the Media Podcast)
VincentLý Thị Ca

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

Apr 17, 2022
TWiV 889: COVID-19 clinical update #110 with Dr. Daniel Griffin
53:16

In COVID-19 clinical update #110, Dr. Griffin covers hospital admissions during variant outbreaks, viral load in vaccinated and unvaccinated individuals, predictive capacity of symptoms in children, comparison of antigen tests, incidence of myocarditis after vaccination, steroids during replication phase, Paxlovid efficacy and safety, fluvoxamine, sabizabutin, colchicine, and prevalence of infection in Africa.

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Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to daniel@microbe.tv

Apr 16, 2022
TWiV 888: Molnupiravir with Richard Plemper
01:29:57

Richard joins TWiV to discuss the SARS-CoV-2 antiviral drug Molnupiravir , including how it was discovered, its mechanism of action, whether it is a mutagen for cells, and the future of drugs for treatment of COVID-19.

Hosts: Vincent Racaniello, Alan Dove, and Brianne Barker

Guest: Richard Plemper

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Weekly Picks

BrianneBioRender Poster Builder
AlanHexbug cat toys
Vincent US Mint 2019 American Innovation Coin – PA – Polio Vaccine

Listener Picks

SueAmerican Visionary Art Museum
FrazerVaccine trial for killer elephant virus

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

Apr 14, 2022
TWiV 887: Bonfire of the monocytes
01:48:27

TWiV explains why this season’s influenza vaccine is not protecting against mild to moderate disease caused by H3N2 virus, and that antibody-dependent entry of SARS-CoV-2 into monocytes is a major contributor to severe COVID-19.

Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Amy Rosenfeld

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Weekly Picks

Dickson Ketanji Brown Jackson confirmed to US Supreme Court
Amy Some threats just keep coming in waves
RichLady Bird Johnson Wildflower Center
VincentMartijn Doolaard

Listener Picks

AnnImmunological memory to SARS-CoV-2 infection and vaccines
ChrisIsoplexis

Intro music is by Ronald Jenkees

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Apr 10, 2022
TWiV 886: COVID-19 clinical update #109 with Dr. Daniel Griffin
39:29

In COVID-19 clinical update #109, Daniel Griffin discusses cardiac complications after infection or vaccination, long COVID in children, fourth vaccine dose in Israel, no need for fourth vaccine dose in EU, dexamethasone dosing, immunomodulation therapy, MIS outcomes in children, US long COVID effort launched, and herd immunity.

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Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to daniel@microbe.tv

Apr 09, 2022
TWiV 885: Russian bats and Ankara vectors
01:44:06

TWiV reveals an ACE2-dependent sarbecovirus from Russian bats that is not inhibited by anti-SARS-CoV-2 antibodies, and a modified vaccinia virus Ankara vectored vaccine that protects nonhuman primates from Delta infection.

Hosts: Vincent Racaniello, Rich Condit, and Brianne Barker

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Weekly Picks

Brianne The Search for a Model Octopus That Won’t Die After Laying Its Eggs
RichVaccine Pioneers and Opponents with Paul Offit (Podcast: Connected by Controversy by Chris White)  and The Cutter Incident by Paul Offit
VincentSimply Put: Vaccines Save Lives

Listener Picks

Rich‘Stolen’ Charles Darwin notebooks left on library floor in pink gift bag
NevaElin Thomas, UK textile artist
VikiHistory of English Podcast

Intro music is by Ronald Jenkees

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Apr 07, 2022
TWiV 884: Cytokines and viral mimicry
02:01:51

Vincent and Amy explain how asthmatic bronchial smooth muscle increases rhinovirus replication in the bronchial epithelium, and mimicry of IL-17 by the ORF8 protein of SARS-CoV-2.

Hosts: Vincent Racaniello and Amy Rosenfeld

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Weekly Picks

AmyBen Franklin by Ken Burns
Vincent – Thoughts on a second booster: Offit and Krause/Borio

Listener Picks

PhilipHistory of Clemson Blue Cheese
JackPipeline and A Special Report on Polio

Intro music is by Ronald Jenkees

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Apr 03, 2022
TWiV 883: COVID-19 clinical update #108 with Dr. Daniel Griffin
45:25

In COVID-19 clinical update #107, Daniel Griffin reviews vaccine booster doses, at-home testing, transmission in ferrets, improving indoor air quality, trials of BCG, ivermectin, and fluvoxamine, vaccination during pregnancy, mRNA vaccines and Fc functions, anti-platelet and aspirin therapy and a trial of prone positioning.

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Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to daniel@microbe.tv

Apr 02, 2022
TWiV 882: Elispot on about T cells and lipids
01:49:18

Vincent and Brianne review the need to better understand T cell responses to SARS-CoV-2 infection to better inform public health decisions, and how IL-1 and IL-1ra are important regulators of the inflammatory response to RNA vaccines.

Hosts: Vincent Racaniello and Brianne Barker

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Weekly Picks

Brianne Covid restrictions prevented dengue in hundreds of thousands of people in 2020
Vincent Scotch Dual Lock 250 Reclosable Fastener

Listener Picks

ErinJWT Preparation and Xploration Outer Space

Intro music is by Ronald Jenkees

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Mar 31, 2022
TWiV 881: 50 ways to zap your virus
01:52:13

TWiV describes the identification of a monoclonal antibody that provides broad protection against a variety of hantaviruses, and development of an oral remdesivir-like antiviral that ameliorates viral disease in mice.

Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Amy Rosenfeld

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Weekly Picks

Dickson World’s tallest wooden building
Amy Virus hunter in the Wuhan market
RichWorldPop (example)
VincentKarst Stone Paper

Listener Picks

Neva Can we vaccinate against EBV? and Paul Sutter reading a science paper

Intro music is by Ronald Jenkees

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Mar 27, 2022
TWiV 880: COVID-19 clinical update #107 with Dr. Daniel Griffin
47:31

In COVID-19 clinical update #107, Daniel Griffin discusses Moderna vaccine results in children, hospitalization by ethnicity, BA.2 severity in children, placentitis and thrombohematoma during pregnancy, predictive value of symptoms for diagnosis, Evusheld activity against BA.1 and BA.2, Remdesivir resistance, Ivermectin with and without strongyloidiasis, inhaled ciclesonide, home telemonitoring, pulse oximetry for remote monitoring, effectiveness of anti-platelet therapy, and deaths in Zambia.

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Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to daniel@microbe.tv

Mar 26, 2022
TWiV 879: Indolent, resistant, and losing our TMPRSS
01:39:21

TWiV reviews the emergence of remdesivir-resistant SARS-CoV-2 during treatment of a persistently infected immunocompromised patient, and how altered TMPRSS2 utilization by the Omicron variant influences infectivity and fusion.

Hosts: Vincent Racaniello, Alan Dove, Rich Condit, Kathy Spindler, and Brianne Barker

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BrianneNSURP 2022
KathyVirology Jobs
Rich10 Steps from Seed to Cup (Graphic)
Alan Fathoms: The World in The Whale, by Rebecca Giggs
VincentWorldwaterday.org

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JeremyArchaeology of Light

Intro music is by Ronald Jenkees

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Mar 24, 2022
TWiV 878: Shape matters sometimes
02:04:15

TWiV revisits chronic wasting disease of cervids and the ability of the prions to infect meadow voles and raccoons, and the suggestion that stochastic assembly of influenza virus particles may play a role in phenotypic diversity.

Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Amy Rosenfeld

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Weekly Picks

DicksonJames Webb Space Telescope and Nature Conservancy Photo Contest
Amy A new strategy for staying one step ahead of the virus
RichSearching for the origin of the smallpox vaccine: Edward Jenner and his little-known horsepox hypothesis
VincentBlacktail Studio

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RichardWater Structure and Science

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Mar 20, 2022
TWiV 877: COVID-19 clinical update #106 with Dr. Daniel Griffin
28:13

In COVID-19 clinical update #106, Daniel Griffin covers failure of ivermectin to improve hospitalization, increased hospitalization of children with Omicron, seroconversion of children versus adults, effectiveness of Pfizer mRNA vaccine in children, high vaccine effectiveness in Finland against Omicron, distinct long COVID clinical phenotypes, and estimating worldwide excess mortality.

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Intro music is by Ronald Jenkees

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Mar 19, 2022
TWiV 876: Spillover market with Michael Worobey
01:36:32

Michael Worobey joins TWiV to explain evidence that SARS-CoV-2 emerged via the wildlife trade and that the Huanan market was the unambiguous epicenter of the COVID-19 pandemic.

Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker

Guest: Michael Worobey

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Weekly Picks

BrianneKartchner Caverns (info from Wikipedia here)
KathyLaminar flow and turbulent flow
RichWikipedia
VincentThe Human Lake by Carl Zimmer

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BradNASASpaceflight

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Mar 17, 2022
TWiV 875: Animal house
01:32:32

TWiV discusses the virome of game animals in China, and the finding that binding of sarbecoviruses to ACE2 is an ancestral and evolvable trait.

Hosts: Vincent Racaniello, Dickson Despommier, and Amy Rosenfeld

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Dickson Ship found at the bottom of the sea
Amy Vaccinating kids has never been easy
Vincent State data and CDC data on children and COVID-19

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Andrew – Books by Randall Munroe

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Mar 13, 2022
TWiV 874: COVID-19 clinical update #105 with Dr. Daniel Griffin
40:39

In COVID-19 clinical update #105, Daniel Griffin discusses changes in brain structure after infection, dementia in patients with pneumonia, Paxlovid in children, mask effectiveness in schools, host factors and severe disease, post-acute symptoms, and the mission of CEPI.

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Mar 12, 2022
TWiV 873: Pig viruses and big viruses
01:56:43

TWiV reviews the six known coronaviruses that infect pigs and what can be learned about human infections, and how the giant Mimivirus DNA genome is organized into a nucleocapsid.

Hosts: Vincent Racaniello, Alan DoveRich Condit, and Brianne Barker

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Weekly Picks

Brianne The Dinosaur Age May Have Ended in Springtime
AlanThe Track of the Typhoon, and me reading it.
Rich12 Monkeys
VincentAnna Mason’s Art Channel

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Richard SARS-CoV-2 in animals: Situation report #9
Jason Counting App and CountThings from Photos

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Mar 06, 2022
TWiV 872: COVID-19 clinical update #104 with Dr. Daniel Griffin
56:03

In COVID-19 clinical update #104, Daniel Griffin reviews effectiveness of mRNA vaccines among children, number of children affected by disease, accuracy of rapid antigen tests, CDC guidance for prevention strategies, monoclonal antibody effectiveness, predicting progression to severe respiratory failure from pneumonia, risk of long COVID after two vaccine doses, and peripheral neuropathy in long COVID.

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Intro music is by Ronald Jenkees

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Mar 05, 2022
TWiV 871: If the ACE2 fits, ferret
01:42:03

TWiV discusses whether or not Omicron should be designated a new serotype of SARS-CoV-2, and the finding that amino acid changes that adapt SARS-CoV-2 to mink or ferret do not increase fitness in the human airway.

Hosts: Vincent Racaniello, Alan Dove, and Rich Condit

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Weekly Picks

Alan Which Immune Cell Are You? and Michaeleen Doucleff’s article
Rich Vaccinated: One Man’s Quest to Defeat the World’s Deadliest Diseases by Paul A. Offit
VincentEbola on Canvas

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LesOlogies podcast

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Feb 27, 2022
TWiV 870: COVID-19 clinical update #103 with Dr. Daniel Griffin
43:37

In COVID-19 clinical update #102, Daniel Griffin covers immunocompromised people, hospitalization of children, vaccine usage update, Omicron and cross-reactive neutralizing antibodies, reinfection prevents disease in hamsters, repeated infections with endemic coronaviruses, global burden of antimicrobial resistance, ivermectin not protective in hamsters, and Omicron evades therapeutic monoclonals.

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Feb 26, 2022
TWiV 869: Epstein-Barr virus and MS, a perfect storm
01:47:45

TWiV reviews epidemiological and experimental evidence that infection with Epstein-Barr virus leads to the production of antibodies against a viral protein that cross-react with a human protein, leading to multiple sclerosis.

Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Brianne Barker

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Weekly Picks

Dickson – Rapid intensification of the emerging southwestern North American megadrought in 2020–2021
Brianne Which Immune Cell Are You?
RichNikola Tesla – 3D Anamorphosis
Vincent Paul’s Uncle Doesn’t Want to Get Vaccinated

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BobThe 1969 Apollo Guidance Computer
Anne Decoding the Gurus with Dan Wilson
BethFrenchGuyCooking

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Feb 20, 2022
TWiV 868: COVID-19 clinical update #102 with Dr. Daniel Griffin
46:12

In COVID-19 clinical update #102, Daniel Griffin reviews children and COVID, effectiveness of maternal vaccination, vaccines for immunocompromised, primary care physicians and vaccination rates, booster safety among adults, placentitis, azithromycin, oral Nirmatrelvir, Omicron antibody evasion, EUA for bebtelovimab, IL-1 blocking agents, thromboprophylaxis, effectiveness of vaccines against long COVID, and risks of mental health outcomes.

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Feb 19, 2022
TWiV 867: I love the smell of vaccines in the morning
01:57:59

TWiV reviews an experimental, intranasally administered SARS-CoV-2 vaccine that utilizes adenovirus vectors to deliver three viral proteins and induces immunity to ancestral and variant isolates.

Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler

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Weekly Picks

Kathy – 477-mile-long megaflash lightning in Seattle Times (originally Washington Post) and extra info from Rich World Meteorological Org
RichNIAID Global Research (Mali)
Alan – New method for recycling electric car batteries
Vincent Q&A with A&V

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AddieVaccine Podcast
Jennie Dr. Katelyn Jetelina, aka Your Local Epidemiologist

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Feb 17, 2022
TWiV 866: EV antibodies rEVolutionize our thinking
01:39:45

Amy returns to TWiV to discuss her work on the identification of cross-reactive antibody responses among diverse enteroviruses, and the implications for our understanding of viral pathogenesis and seroprevalence studies.

Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit Brianne Barker, and Amy Rosenfeld

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Dickson European scientists set new record in production of nuclear fusion energy
Amy – Alfredo’s Magic Wand
Brianne What Happened After the Chicken-Pox Vaccine?
RichYear Three of COVID-19: Harsh Truths, Realities, and Glimmers of Hope
Vincent Economists Are Fueling the War Against Public Health

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Feb 13, 2022
TWiV 865: COVID-19 clinical update #101 with Dr. Daniel Griffin
47:58

In COVID-19 clinical update #101, Daniel Griffin discusses children and COVID, human challenge study results, effectiveness of mask use, Omicron boost in macaques, mucosal vaccine candidate, long-term cardiovascular outcomes, and global vaccine perceptions.

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Feb 12, 2022
TWiV 864: A game of thrones
01:46:40

Monica, John, David, and Marc join TWiV to discuss their work on identifying cryptic SARS-CoV-2 lineages in New York City wastewater, and understanding whether they were shed from humans or other animals.

Hosts: Vincent Racaniello, Rich Condit, and Brianne Barker

Guests: John Dennehy, Marc Johnson, Davida Smyth, and Monica Trujillo

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  • SARS-CoV-2 in NYC wastewater (TWiV 737)
  • Cryptic SARS-CoV-2 in NYC wastewater (Nat Comm)
  • Timestamps by Jolene. Thanks!

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Brianne – When scientific conferences went online, diversity and inclusion soared
RichTraffic flow measured on 30 different 4-way junctions
Vincent A Slot Machine, a Broken Test Tube by S.E. Luria

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Feb 10, 2022
TWiV 863: Does this challenge study pass the smell test?
01:41:37

TWiV reviews the results of a study in which 36 volunteers were infected with SARS-CoV-2, and what was learned about the kinetics of virus reproduction in the nose and throat, development of symptoms, and reliability of lateral flow antigen assays.

Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Brianne Barker

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Dickson Webb team begins aligning telescope
Brianne – Our Solar System in True Color Is Really Something Else
Rich When the International Space Station retires, it will plunge into the ocean to die
Vincent Gateway Program and What One Really Expensive Means to US Train Travel

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JackDr. Becky and Pasta or composer

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Feb 06, 2022
TWiV 862: COVID-19 clinical update #100 with Dr. Daniel Griffin
37:37

In COVID-19 clinical update #100, Daniel Griffin, from Accra, Ghana, reviews the challenges in evaluating Omicron severity, over 800 deaths in children, Pfizer vaccine EUA application for under 5 year olds, false positives from soft drinks, Novavax vaccine EUA application, childhood experiences and vaccine hesitancy, fourth vaccine dose in Israel, effects of antivirals and monoclonals against Omicron, and multiple factors associated with PASC.

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Intro music is by Ronald Jenkees

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Feb 05, 2022
TWiV 861: Rough draft of Omicron origins
01:54:12

Nels joins TWiV to discuss hypotheses for the origins of Omicron, including that it came from mice or arose during chronic infection of an immunocompromised patient.

Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker

Guest: Nels Elde

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Brianne Groundhogs Emerge From the Scientific Shadows
Kathy – Zig-zag Coast Guard search pattern
RichMoon Phases 2022 (Lunar Reconnaissance Orbiter)
VincentKevin Cowtan’s Book of Fourier and Live Fourier Transformation
NelsBiology versus bias

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Dusty Fighting bias in space

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Feb 04, 2022
TWiV 860: Evading a Toll on the road to RNA vaccines
01:48:47

TWiV reviews a seminal paper showing that chemically modified bases in RNAs suppress recognition by Toll-like receptors, a finding that that was essential for the development of COVID-19 mRNA vaccines.

Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Kathy Spindler

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Dickson - NASA Research Launches a New Generation of Indoor Farming
Kathy -
How Pfizer scientists transformed an old drug lead into a COVID-19 antiviral
Rich -
Fermi paradox
Vincent -
Racism not Race by Joe Graves

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JayRestoration of Ave Maria
John Pandemic humor

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Jan 30, 2022
TWiV 859: COVID-19 clinical update #99 with Dr. Daniel Griffin
37:49

In COVID-19 clinical update #99, Daniel Griffin discusses Omicron disease severity, neurologic manifestations in children, testing outcomes during multiple infections, boosters improve VE and VD, booster efficacy for ED and UC encounters, vaccines induce cross-protective T cell memory, and indications for monoclonal antibody therapy.C

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Jan 29, 2022
TWiV 858: The vax of life with John Mascola
01:48:42

John Mascola joins TWiV to discuss the history and mission of the NIH Vaccine Research Center, how it prepared for devising pandemic vaccines, and development of the COVID-19 vaccines.

Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Brianne Barker

Guest: John Mascola

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Brianne – How Sesame Street is Handling the Pandemic
RichZamboni: How it works
Alan How lightning starts
VincentBuon-A-Petitti

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MeikaWordle

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Jan 28, 2022
TWiV 857: Not just antibody, Jon Yewdell
01:39:44

Jon Yewdell returns to TWiV to discuss how antibodies are made, vaccination against SARS-CoV-2, antigenic variation of the virus, booster shots, and more.

Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Brianne Barker

Guest: Jon Yewdell

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JonThe Premonition by Michael Lewis
Dickson Nature photographer of the year 2021
Brianne – Should BioBank Volunteers Be Warned About Mutations?
Rich Czech singer Hanka Horká dies after intentionally getting infected by the coronavirusand Dena Dietrich Dies at 91
VincentCuore di Cioccolato

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Bronwen Schools must stay open
John Pandemic humor

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Jan 23, 2022
TWiV 856: COVID-19 clinical update #98 with Dr. Daniel Griffin
51:24

In COVID-19 clinical update #98, Daniel Griffin reviews COVID-19 in South Africa, recognition of Omicron by ancestral T cells, booster effectiveness against disease, infection and vaccination in pregnant women, early Remdesivir to prevent progression to severe disease, management of hospitalized adults, Tocilizumab in hospitalized patients, vaccination and long COVID, and the true toll of the pandemic.

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Jan 22, 2022
TWiV 855: T time with Alessandro Sette
01:36:42

Alessandro Sette returns to TWiV to discuss the observation that SARS-CoV-2 vaccination induces T cells that are able to cross-recognize variants Alpha to Omicron.

Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker

Guest: Alessandro Sette

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  • Travel Award Applications (ASV) 3:20
  • Impact of variants on T cells (Cell Rep Med)
  • Timestamps by Jolene. Thanks!
  • Letters read on TWiV 855

Weekly Picks

Brianne – 75 years of research on human diseases in 1 minute
Kathy 10 second video of COVID-19 spread
RichDiffraction spike
VincentJohn’s Furniture Repair and Transcend Furniture Gallery

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AlisonFDA drug shortages
Ingrid One woman’s mission to get vaccines to her rural Alabama town

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Jan 21, 2022
TWiV 854: Omicron is evasive
02:05:58

TWiV reviews findings that increased fitness of the Omicron variant is due to immune evasion, not an increase in intrinsic transmissibility, and determination of infectious viral load in patients infected with wild type, Delta and Omicron viruses reveals lack of correlation with RNA loads determined by RT-PCR, similar levels of shedding among Delta and Omicron, and greatly reduced shedding in vaccinated people.

Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, Kathy Spindler, and Brianne Barker

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Dickson Favorite Science Photos of 2021
Brianne – Viruses, Vaccines, and COVID-19 videos from American Museum of Natural History
KathyKlompas et al. “Current insights into respiratory virus transmission…”
RichLeviathan Falls by James S.A. Corey
VincentEbola (1996) by David Molesky at The Incubator

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Randall Robert Malone & Peter McCullough: A litany of untruths
Suellen Omicron and the case of the hidden evolution – Understanding Evolution

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Jan 16, 2022
TWiV 853: COVID-19 clinical update #97 with Dr. Daniel Griffin
53:39

In COVID-19 clinical update #97, Daniel Griffin covers immunity after infection recognized by CDC, outcomes before and after Omicron, infectious viral load in Delta vs Omicron, PCR vs rapid antigen tests, booster interval shortened to 5 months, risk factors for severe outcomes in vaccinated, cross-reactive memory T cells, vaccine effectiveness vs MIS-C, and Rivaroxiban for thromboprophylaxis.

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Jan 15, 2022
TWiV 852: Tree man syndrome
01:44:27

A TWiV threesome explains the observation that humans with inherited T cell CD28 deficiency are susceptible to severe warts driven by human papilloma virus infection, but are otherwise healthy.

Hosts: Vincent Racaniello, Rich Condit, and Brianne Barker

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Brianne – Every Pore on Your Face Is a Walled Garden
Rich“On Warts” by Lewis Thomas (Pdf)
VincentCells at Work Code Black 1

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ChrisRia Lina on the Guilty Feminist podcast
Duncan Meet the green kleptos of the animal kingdom

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Jan 13, 2022
TWiV 851: Questions are tricky
01:50:53

The TWiV team reviews the observation that infection with the SARS-CoV-2 Omicron variant causes reduced reproduction and pathogenesis in mice and hamsters.

Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, Brianne Barker, and Amy Rosenfeld

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DicksonEngineering the James Webb Space Telescope
Amy T cells might be our bodies’ best shot against Omicron
Brianne – Where is Webb?
Rich First U.S. vaccine mandate in 1809 launched 200 years of court battles
VincentThe Secret of Life by Howard Markel

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JenAntidote
DavidRosie Revere, Engineer

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Jan 09, 2022
TWiV 850: COVID-19 clinical update #96 with Dr. Daniel Griffin
55:56

In COVID-19 clinical update #96, Daniel Griffin reviews Omicron in South Africa, rapid antigen tests, viral coinfections, isolation and quarantine, saliva preferred for Omicron, risk factors for severe disease in vaccinated, Paxlovid dosing, and long COVID.

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Jan 08, 2022
TWiV 849: Arc of the epitope
02:04:16

TWiV kicks off 2022 with a review of the virology highlights of 2021, from three virologists, one immunologist, a science writer, and a partridge in a pear tree.

Hosts: Vincent Racaniello, Alan Dove, Rich Condit, Kathy Spindler, and Brianne Barker

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BrianneDon’t Look Up
Kathy – spaceweather.com
RichVideo of a Green Flash  (wiki)
Alan Fungally-modified violins
VincentThis Old Tony especially this segment

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Paul Deep Mind and AlphaFold
GrantSARS-CoV-2 reproduction cycle

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Jan 07, 2022
TWiV 847: On Dasher, on Dancer, on Corona and Lassa
01:46:47

For the final episode of 2021, TWiV reviews an experimental infectious attenuated Lassa fever vaccine based on a codon-deoptimized glycoprotein gene, and SARS-CoV-2 infection of free-ranging white-tailed deer.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Kathy Spindler, and Brianne Barker

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Dickson – EO Wilson (Ants and The Conversation)
Brianne The Best Fun Science Stories of 2021
Kathy – Using sound for data analysis; chemotactic bacteria and Moo loo story
AlanOwls of the Easern Ice, by Jonathan Slaght
Vincent TWiV 9: Fever! The discovery of Lassa virus and TWiV 548: Mice, shrews, and caterpillars

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LarryImmunity
Jeff Daily Hospital Surveillance Report

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Jan 02, 2022
TWiV 848: COVID-19 clinical update #95 with Dr. Daniel Griffin
36:39

In COVID-19 clinical update #95, Daniel Griffin discusses new CDC guidelines for isolation and quarantine, EUA for Molnupiravir, children and COVID, vaccine safety in 5-11 year olds, Omicron outbreaks in Nebraska and Denmark, Baylor's COVID vaccine, and COVID-OUT for ivermectin.

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Jan 01, 2022
TWiV 846: Beta was stirring, and now in a mouse
01:38:39

TWiV explores the impact of the intestinal virome on seroconversion after rotavirus vaccination, and implications of the ability of the SARS-CoV-2 beta variant to infect wild-type laboratory mice.

Hosts: Vincent Racaniello, Alan Dove, Rich Condit, Kathy Spindler, and Brianne Barker

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BrianneXKCD on Immune Responses and Immunity
Kathy – UVA Rotunda astrophotograph with Heart and Soul Nebulae by Brennan Gilmore
Rich – James Webb Space Telescope Videos: 29 Days On The Edge; Launch And Deployment
AlanSokobond puzzle game
Vincent International Space Station shines in gorgeous fly-around photos by Crew Dragon astronauts

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Dec 26, 2021
TWiV 845: COVID-19 clinical update #94 with Dr. Daniel Griffin
47:55

In COVID-19 clinical update #94, Daniel Griffin reviews the FDA EUA for Paxlovid, test to stay in school, immunity after infection, variants and therapeutics, quarantine and isolation guidelines, Molnupiravir in non-hospitalized patients, and convalescent serum in outpatients.

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Dec 25, 2021
TWiV 844: Paul Offit on children, COVID, and boosters
01:41:39

Paul Offit returns to TWiV to discuss new CDC guidance on J&J vaccine, why children should be immunized against COVID-19, and whether or not booster doses are scientifically justified.

Hosts: Vincent Racaniello, Dickson Despommier, and Brianne Barker

Guest: Paul Offit

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Brianne - Virus snowflakes
Dickson - The Year in Pictures 2021
Vincent - Our Life is Plasticized

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Gerry - Dan Barouch: COVID-19 Vaccine Development
Louise - Pandora's Lab by Paul Offit

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Dec 19, 2021
TWiV 843: COVID-19 clinical update #93 with Dr. Daniel Griffin
42:52

In COVID-19 clinical update #93, Dr. Griffin summarizes Omicron fitness, S-gene target failure, monoclonal efficacy against Omicron, vaccination, monoclonals, and disease in children, persistence of memory B cells in the elderly, infection and vaccine induced immunity, protection against severe illness and death by a third mRNA vaccine dose, high flow oxygen versus intubation, and therapeutic anticoagulation.

Hosts: Daniel Griffin and Vincent Racaniello

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Intro music is by Ronald Jenkees

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Dec 18, 2021
TWiV 842: The clot thickens
01:15:22

TWiV reviews the results of serum neutralization assays which show that a third vaccine dose restores neutralization of the Omicron variant, and interaction of platelet factor 4 with the adenovirus capsid, suggesting a mechanism for thrombosis with thrombocytopenia syndrome.

Hosts: Vincent Racaniello, Kathy Spindler, and Brianne Barker

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BrianneVaccine Scientists: Time’s 2021 Heroes of the Year
Kathy – Snake dietary diversity
VincentAlfred Wegener Institute on Instagram

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Niclas Once upon a time… Life

Intro music is by Ronald Jenkees

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Dec 16, 2021
TWiV 841: Unmasking immunity
01:45:23

TWiV provides an update on immunity to Omicron, results of a randomized controlled trial of face masks, and a study of correlates of protection against respiratory syncytial virus infection in the upper and lower respiratory tract of nonhuman primates.

Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Amy Rosenfeld

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DicksonCities at Night
Amy I’m an E.R. Doctor in Michigan, Where Unvaccinated People Are Filling Hospital Beds
RichInternational Dark Sky Association
Vincent SARS-CoV-2 variants

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Keith – Ventusky

Intro music is by Ronald Jenkees

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Dec 12, 2021
TWiV 840: COVID-19 clinical update #92 with Dr. Daniel Griffin
45:37

In COVID-19 clinical update #92, Dr. Griffin reviews emerging data on the Omicron variant, much information about monoclonal antibody treatment, including expansion of EUA for Lilly’s cocktail, FDA EUA for pre-exposure prophylaxis, outcomes after treatment, and investigation of subcutaneous or intramuscular administration; effect of adding immunomodulatory agents to usual care on thromboembolic events, and long COVID following infection in previously vaccinated individuals.

Hosts: Daniel Griffin and Vincent Racaniello

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Intro music is by Ronald Jenkees

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Dec 11, 2021
TWiV 839: The long and the short of it: get vaccinated
01:46:56

TWiV reviews the impact of vaccination on SARS-CoV-2, the latest information on Omicron, West Nile virus transmission by organ transplantation, and why a 16 week interval between doses of BNT162b2 vaccine is better than a shorter interval.

Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler

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Weekly Picks

Kathy – CDC U-M flu report (lay version, MMWR)
RichThagomizer
AlanDescent into Darkness by Edward Raymer
VincentFunding: Blinding peer review

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Lynne ACE2 in chewing gum

Intro music is by Ronald Jenkees

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Dec 09, 2021
TWiV 838: The magic virus bus
01:39:33

The New York City Virus Hunters join TWiV to reveal how local students engage in safe virus surveillance and conduct science research right in their neighborhoods, followed by an update on variant of concern Omicron.

Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Brianne Barker

Guests: Teresa Bautista, Isabel Francisco, Jesus Gonzales, Joel Gonzalez, Florian Krammer, and Christine Marizzi,

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DicksonPlant Habitat-04
Brianne The Coronavirus in a Tiny Drop
Rich Prophet in Purgatory by Jon Cohen
Vincent – “ ’—All You Zombies—’ ” by Robert A. Heinlein (pdf)

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Mike The Coronavirus in a Tiny Drop

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Dec 05, 2021
TWiV 837: COVID-19 clinical update #91 with Dr. Daniel Griffin
39:24

In COVID-19 clinical update #91, Dr. Griffin discusses final results of molnupiravir trial, Omicron variant of concern, outcomes in B-cell depleted patients, recovery in T-cell depleted macaques, peptide for induction of T cell immunity, high respiratory viral RNA loads in infants, IgA and T cells transferred to breast milk after vaccination, sensitivity and specificity of ID NOW, post-acute sequelae at 12 months, disease in low and middle income countries.

Hosts: Daniel Griffin and Vincent Racaniello

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Dec 04, 2021
TWiV 836: OMG, Omicron!
01:50:41

TWiV reveals all that we know so far about the variant of concern B.1.1.529, also called Omicron, and describes a study on the ability of the alpha, beta, and delta variants to reproduce in cells in culture and induce membrane fusion.

Hosts: Vincent Racaniello, Alan Dove, Kathy Spindler, and Brianne Barker

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BrianneImmune
Kathy – Elizabeth Lee Hazen and Rachel Fuller Brown, discoverers of nystatin oneand two
AlanFour Lost Cities by Analee Newitz
VincentDeadly Choices by Paul Offit

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Ryan – Ronny Jackson (one and two)

Intro music is by Ronald Jenkees

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Dec 02, 2021
TWiV 835: Giving thanks for antibodies
01:39:01

TWiV reviews why children should be vaccinated against COVID-19, increased risk of infection with SARS-CoV-2 Beta, Gamma, and Delta variant compared to Alpha variant in vaccinated but not recovered individuals, and immune correlates of protection from the mRNA-1273 vaccine efficacy trial.

Hosts: Vincent Racaniello, Dickson Despommier, and Brianne Barker

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Dickson – Pee Wee Herman aka Paul Rubens
BrianneAPOD: Pleiades
VincentA History of Poliomyelitis by JR Paul

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RichardLet’s talk about a familiar problem and a new tactic….
SherriHave the New Jab

Intro music is by Ronald Jenkees

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Nov 28, 2021
TWiV 834: COVID-19 clinical update #90 with Dr. Daniel Griffin
41:10

In COVID-19 clinical update #90, Dr. Griffin covers FDA expansion for booster doses, 3 more at home antigen tests approved by FDA, immune correlates analysis of mRNA-1273 vaccine, risk for stillbirth, PROVENT prophylaxis trial results, fluvoxamine recommendations, advice on molnupiravir, automated text messaging service for monitoring illness, and long COVID-19 after vaccination and infection.

Hosts: Daniel Griffin and Vincent Racaniello

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Intro music is by Ronald Jenkees

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Nov 27, 2021
TWiV 833: Grand theft kinesin
01:32:25

TWiV reviews Michael Worobey’s dissection of the early COVID-19 cases in Wuhan, and the discovery that herpesviruses assimilate cellular kinesin to produce motorized virus particles.

Hosts: Vincent Racaniello, Alan Dove, and Kathy Spindler

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Kathy Power of poop
AlanUnder the Sky We Make, by Kimberly Nicholas
VincentEnzymatic amplification of beta-globing sequences

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PaulaReasons to be Cheerful and The Night Witches by Bruce Myles
GrantGeorge Carlin – Germs, Immune System

Intro music is by Ronald Jenkees

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Nov 25, 2021
TWiV 832: Heavy metal flu fighters
01:51:36

TWiV reviews the vials labeled smallpox that were not, re-emergence of enterovirus D68 in Europe, efficacy of inactivated SARS-CoV-2 vaccine, and cellular correlates of protection for an oral influenza virus vaccine.

Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Amy Rosenfeld

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Dickson – Rodney Dangerfield
AmyCalder at MoMA
Rich ‘Useless Specks of Dust’ Turn Out to Be Building Blocks of All Vertebrate Genomes
VincentStructure of small viruses

Listener Picks

Charles It is raining you lied to me
DaveA Whole New Ball Game

Intro music is by Ronald Jenkees

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Nov 21, 2021
TWiV 831: COVID-19 clinical update #89 with Dr. Daniel Griffin
41:04

In COVID-19 clinical update #89, Dr. Griffin reviews upcoming meeting on FDA emergency use authorization for molnupiravir, 25% of US cases in children, reinfection associates with presence of antibodies, national surveillance for acute flaccid myelitis in the US, and monoclonal antibody treatment of infection in vaccinated, high-risk individuals.

Hosts: Daniel Griffin and Vincent Racaniello

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Intro music is by Ronald Jenkees

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Nov 20, 2021
TWiV 830: A culture of resistance
02:08:13

TWiV explains that a recent report suggesting that the SARS-CoV-2 spike protein inhibits V(D)J recombination in vitro would not impact immunity after infection or vaccination, and describes the isolation of remdesivir resistant mutants in cells in culture, and the emergence of amino acid changes in the spike protein identical to those in variants of concern, in the absence of immune selection.

Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler

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Kathy – When do we get back to normal? Maybe now.
Rich The Covid-19 Pandemic
AlanYaupon Brothers American tea
VincentCracking the genetic code (and Niremberg’s account)

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Justin Partisan vaccination
LisaThe Red Flag

Intro music is by Ronald Jenkees

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Nov 18, 2021
TWiV 829: Antiviral and cytotoxically empowered for COVID-19
01:43:31

A TWiV duo reviews how SARS-CoV-2 attacks the olfactory mucosa but spares the olfactory bulb, vaccination with BNT162b2 induces virus-specific stem cell memory T cells, and development of an oral protease inhibitor for the treatment of COVID-19.

Hosts: Vincent Racaniello and Brianne Barker

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BrianneCoronavirus Neutralizing Antibodies and mRNA Vaccine Video
VincentMHC restriction of cytotoxic T cell lysis (Nobel description)

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Lisa Shall Furnish Medicine
BistraSaving the World by Julia Alvarez

Intro music is by Ronald Jenkees

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Nov 14, 2021
TWiV 828: COVID-19 clinical update #88 with Dr. Daniel Griffin
33:17

In COVID-19 clinical update #88, Dr. Griffin covers vaccine protection among US veterans, absence of long COVID in vaccinated who are infected, single dose of REGEN-COV monoclonal antibody cocktail provides long term protection, and Pfizer protease inhibitor Paxlovid is 89% effective in preventing hospitalization or death.

Hosts: Daniel Griffin and Vincent Racaniello

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Intro music is by Ronald Jenkees

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Nov 13, 2021
TWiV 827: A shot to save the world with Greg Zuckerman
01:51:39

Greg Zuckerman joins TWiV to discuss his book that explores the race to produce COVID-19 vaccines, with insights into the companies, scientists, and executives involved and the rivalries, ambitions, ego, and a desire to save the world.

Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Kathy Spindler

Guest: Greg Zuckerman

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Weekly Picks

DicksonMichael Palin
Kathy – Science News Centennial
Rich Diverse variola virus (smallpox) strains were widespread in northern Europe in the Viking Age
VincentEvidence for somatic rearrangement of immunoglobulin genes (and commentary)

Listener Picks

Matt Clinical evidence that the pandemic from 1889 to 1891 commonly called the Russian flu might have been an earlier coronavirus pandemic
BrigitteThe Obscure Virus Club
Justin Eddie Holmes wins Prime Minister’s Prize for Science

Intro music is by Ronald Jenkees

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Nov 07, 2021
TWiV 826: COVID-19 clinical update #87 with Dr. Daniel Griffin
48:50

In COVID-19 clinical update #87, Dr. Griffin reviews PCR cycle threshold and RNA copy number, rapid antigen tests, hospitalization rate after infection or vaccination, allergies and vaccination, community transmission and viral RNA load, early treatment with sotrovimab, meta-analysis of tocilizumab treatment, antibiotic overuse, and guidelines on the use of anticoagulation for thromboprophylaxis.

Hosts: Daniel Griffin and Vincent Racaniello

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Intro music is by Ronald Jenkees

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Nov 06, 2021
TWiV 825: COVID-19 Q&A with Dr. Daniel Griffin
57:54

In this special live-streamed episode of TWiV, Dr. Daniel Griffin fields questions on SARS-CoV-2 and COVID-19 from listeners.

Hosts: Daniel Griffin and Vincent Racaniello

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Intro music is by Ronald Jenkees

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Nov 01, 2021
TWiV 824: Immunogoblins in the nose and lungs
02:06:34

TWiV explores the properties of the spike glycoproteins of an influenza B virus discovered in the Wuhan spiny eel, and protection against SARS-CoV-2 infection one year after mRNA-1273 vaccination of nonhuman primates.

Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Brianne Barker

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Dickson Best of Gilda Radner
Brianne – This polio survivor is one of the last still relying on an iron lung
Rich WHO Announces Proposed Members of its Scientific Advisory Group for the Origins of Novel Pathogens (SAGO); (members)
Vincent – Discovery of mRNA (paper one and two)

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Doris History of smallpox and smallpox vaccine
JudithHow the immune system works

Intro music is by Ronald Jenkees

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Oct 31, 2021
TWiV 823: COVID-19 clinical update #86 with Dr. Daniel Griffin
46:31

In COVID-19 clinical update #86, Dr. Griffin discusses virologic features of infection in children, antibody tests should not be used to asses level of protection, test-to-stay programs in schools, FDA authorizes Moderna boosters, results of TOGETHER trial for fluvoxamine, statins and 28 day mortality, and cognitive function in patients.

Hosts: Daniel Griffin and Vincent Racaniello

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Intro music is by Ronald Jenkees

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Oct 30, 2021
TWiV 822: Viking variola variants
02:01:25

Rich reviews the history of smallpox and the discovery of variola viral genomes in ancient DNA from human remains throughout Northern Europe, which pushes back the earliest date of smallpox virus infection to ~600–1050 CE, overlapping the Viking Age.

Hosts: Vincent Racaniello, Alan Dove, Rich Condit, Kathy Spindler, and Brianne Barker

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Brianne – The Animal Kingdom is Full of Genetic Screwballs
KathyScience dresses, accessories from Svaha and Rosalind Franklin’s DNA diffraction dress
RichThe Saxon Stories
AlanCincinnati’s “Old Cunny,” and audiobook version
VincentInfectious QBeta viral DNA

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Jeff The unvaccinated may not be who you think

Intro music is by Ronald Jenkees

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Oct 28, 2021
TWiV 821: Public clonotype #1
02:00:39

A TWiV trio reveal the isolation of novel paramyxoviruses from rodents and bats in Arizona, and isolation of naive B cells from seronegative donors that produce germline encoded antibodies which engage the receptor binding domain of SARS-CoV-2, variants of concern, and related sarbecoviruses from bats.

Hosts: Vincent Racaniello, Rich Condit, and Brianne Barker

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Brianne – Apod: The Dolphin Head Nebula
Rich The Tree That Could Help Stop The Pandemic; Elucidating the Mechanisms of Action of Saponin-Derived Adjuvants
Vincent – Discovery of RNA splicing in Sharp and Roberts laboratories

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JasonHome Assistant
AlenaVirusCraft

Intro music is by Ronald Jenkees

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Oct 24, 2021
TWiV 820: COVID-19 clinical update #85 with Dr. Daniel Griffin
41:20

In COVID-19 clinical update #85, Dr. Griffin reviews cases and deaths by vaccination status, mRNA vaccine effectiveness in 12-18 year olds, standard and extended dosing of mRNA vaccines, immune responses after vaccination, Moderna booster dose approved, giving monoclonals at home, no benefit from colchicine, and IFN does not help remdesivir.

Hosts: Daniel Griffin and Vincent Racaniello

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Intro music is by Ronald Jenkees

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Oct 23, 2021
TWiV 819: How to stall a copy machine
01:40:32

TWiV explains how remdesivir inhibits the SARS-CoV-2 RNA polymerase: the drug is incorporated into the growing RNA chain and causes synthesis to stall when the drug clashes with an amino acid in the active site.

Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler

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Kathy – Great Lakes Science Center, Cleveland
Rich How to Temporarily Disable Your Keyboard with a Keyboard Shortcut in Windows
Alan – How to Make a Slave and Other Essays by Jerald Walker
VincentA structure for deoxyribose nucleic acid

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SteveHow the immune system actually works
LiseLise Meitner: A Life in Physics

Intro music is by Ronald Jenkees

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Oct 21, 2021
TWiV 818: Thor's hammer
01:56:19

The TWiVers review phase 3 efficacy and safety results for the Novavax COVID-19 vaccine, effects on the neonatal immune system caused by maternal infection with SARS-CoV-2, and NHC, the metabolite of molnupiravir, causes mutations in cellular DNA.

Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, Kathy Spindler, and Brianne Barker

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Dickson –  John Clease
BrianneAstronomy Picture of the Day: Swirl in the Southern Sky
Kathy – Lise Meitner  Statue is at the Humboldt University
Rich Google has the cleanest cloud. Now it’s helping other companies go green
Vincent – Discovery of reverse transcriptase by Baltimore and Temin

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SamAir Travel Packing List
JustinPFAS: Last Week Tonight with John Oliver and EPA targets greenhouse emissions

Intro music is by Ronald Jenkees

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Oct 17, 2021
TWiV 817: COVID-19 clinical update #84 with Dr. Daniel Griffin
45:51

In COVID-19 clinical update #84, Dr. Griffin discusses childrens’ antibody response to vaccination, phase 3 results of Novavax vaccine, heterologous vaccination, antithrombotic therapy, EUA for molnupiravir, phase 3 results of AZD7442, serum ferritin levels and outcomes, heparin therapy, and WHO strategy for global vaccination.

 
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Intro music is by Ronald Jenkees

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Oct 16, 2021
TWiV 816: Long COVID and ME/CFS with David Tuller
01:09:38

David Tuller returns to TWiV to revisit his work to expose the methodological and ethical problems with the PACE trial, and the post-acute sequelae to SARS-CoV-2 infection, also known as long COVID.

Host: Vincent Racaniello

Guest: David Tuller

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Intro music is by Ronald Jenkees

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Oct 15, 2021