TWiV reviews remarkable changes in the epidemiology of avian H5N1 influenza virus leading to previously uninfected areas, involvement of previously unaffected wild birds, and devastating outbreaks in farmed poultry, and isolation of a monoclonal antibody against the influenza virus neuraminidase that inhibits infection with a wide range of A and B isolates.

Hosts: Vincent Racaniello, Alan Dove, Rich Condit, Kathy Spindler, and Angela Mingarelli

Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email

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Links for this episode

• Register for ASV 2023
• Research assistant position at FDA (pdf)
• MicrobeTV Discord Server
• Avian influenza H5N1 (Eurosurveillance)
• Pan-influenza NA antibody (Nature)
• World Animal Health Information System
• Timestamps by Jolene. Thanks!

Weekly Picks

Angela – May’s best science images – Nature
Kathy – Historical reasons for resistance to recognizing airborne transmission
Rich – Scan of Titanic reveals wreck as never seen before – BBC News
Alan – Science Education in an Age of Misinformation
Vincent – Equity, Diversity and Inclusion: When communication all changed

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

In his weekly clinical update, Dr. Griffin discusses the potential for recurrent Mpox outbreaks among gay, bisexual, and other men who have sex with men, association between SARS-CoV-2 variants and frequency of acute symptoms, prospective study of key correlates for household transmission of SARS-CoV-2, Pfizer’s PAXLOVID™ receiving FDA approval for adult patients at high risk of progression to severe COVID-19, efficacy and safety of antimicrobial stewardship prospective audit and feedback in patients hospitalized with COVID-19, development of a definition of postacute sequelae of SARS-CoV-2 infection, COVID-19 and risk for mental disorders among adults in Denmark, risk of new post-COVID mental disorders higher only in older patients.

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Links for this episode

• Potential for recurrent Mpox outbreaks among men who have sex with men (CDC)
• Association between SARS-CoV-2 variants and frequency of acute symptoms (OFID)
• Key correlates for household transmission of SARS-CoV-2 (OFID)
• PAXLOVID receiving FDA approval for patients at high risk of severe COVID-19 (Pfizer)
• Efficacy and safety of antimicrobial stewardship prospective audit and feedback in patients with COVID-19 (The Lancet)
• Development of a definition of postacute sequelae of SARS-CoV-2 (JAMA)
• COVID-19 and risk for mental disorders among adults in Denmark (JAMA)
• Risk of new post-COVID mental disorders higher only in older patients (CIDRAP)
• Contribute to our FIMRC fundraiser at PWB
• Letters read on TWiV 1012
• Dr. Griffin’s COVID treatment summary (pdf)
• Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to daniel@microbe.tv

Vincent travels to Québec City, Canada and the 11th Aquatic Virus Workshop, where he speaks with Fred Aylward and Jed Furman about the research of their laboratories on the ecology and evolution of aquatic viruses and their microbial communities.

Host: Vincent Racaniello

Guests: Frank Aylward and Jed Fuhrman

Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email

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Links for this episode

• MicrobeTV Discord Server
• 11th Aquatic Virus Workshop
• Endogenization of giant virus genomes in green algae (Nature)
• Red Queen dynamics in marine viruses (Nature)
• Biogeography of marine giant viruses (ISME Commun)
• Marine prokaryotic community structure (Nat Commun)
• Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

In his weekly clinical update, Dr. Griffin discusses the CDC HIV surveillance report, FDA voted in favor of approving the Abrysvo vaccine, canine olfactory detection of SARS-CoV-2-infected humans, safety of the BNT162b2 COVID-19 vaccine in children aged 5 to 17 years, and statement on the antigen composition of COVID-19 vaccines.

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Links for this episode

• HIV surveillance report (CDC)
• FDA voted in favor of approving Abrysvo vaccine (Pfizer)
• Canine olfactory detection of SARS-CoV-2-infected humans (Annals of Epidemiology)
• Safety of the BNT162b2 COVID-19 vaccine in children (JAMA)
• Statement on the antigen composition of COVID-19 vaccines (WHO)
• Contribute to our FIMRC fundraiser at PWB
• Letters read on TWiV 1010
• Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to daniel@microbe.tv

Vincent travels to Montreux, Switzerland and the 16th International Nidovirus Symposium, where he speaks with Maria von Kerkhove, the face of COVID-19 for the World Health Organization, and Kanta Subbarao, Director of the WHO Collaborating Centre on Influenza in Melbourne.

Host: Vincent Racaniello

Guests: Kanta Subbarao and Maria von Kerkhove

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Links for this episode

• MicrobeTV Discord Server
• Nidovirus Symposium, Montreux
• WHO Collaborating Centre for Influenza, Melbourne
• Maria von Kerkhove (Wikipedia)
• Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

In his weekly clinical update, Dr. Griffin discusses variant specific clinical performance of a SARS-CoV-2 rapid antigen test with focus on omicron VOC, ventilation in buildings, COVID-19 mortality among selective serotonin reuptake inhibitor users, risk of post-acute sequelae of SARS-CoV-2 infection associated with pre-coronavirus disease obstructive sleep apnea diagnoses, trajectories of the evolution of post COVID-19 condition, and efficacy of cognitive behavioral therapy targeting severe fatigue following COVID-19.

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Links for this episode

• Virus variant clinical performance of a SARS-CoV-2 rapid antigen test (CID)
• Ventilation in buildings (CDC)
• COVID-19 mortality among SSRI users (CMI)
• Risk of post-acute sequelae of SARS-CoV-2 infection associated with sleep apnea (SLEEP)
• Trajectories of the evolution of post COVID-19 condition (IJID)
• Efficacy of cognitive behavioral therapy targeting fatigue following COVID-19 (CAD)
• Contribute to our FIMRC fundraiser at PWB
• Letters read on TWiV 1008
• Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to daniel@microbe.tv

TWiV explains genetic changes in nOPV2 strains that paralyzed children, outbreak of raccoon distemper in Toronto, EcoHealth Alliance gets its NIH grant back, and breakage at chromosomal fragile sites caused by the EBNA1 protein of Epstein-Barr virus as a mechanism for carcinogenesis.

Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Angela Mingarelli

Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email

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Links for this episode

• Register for ASV 2023
• Research assistant position at FDA (pdf)
• MicrobeTV Discord Server
• nOPV2 after two years (Polioeradication)
• Raccoon distemper in Toronto (CityNews Everywhere)
• NIH reinstates EcoHealth grant (Nature)
• Chromosomal breakage by EBNA1 (Nature)
• Agent of chromosomal instability (Nature)
• Timestamps by Jolene. Thanks!

Weekly Picks

Angela – Night Science
Kathy – Kermit, Jim Henson, Rainbow Connection
Rich – Alexander Skarsgård Explains the Answer to Everything
Vincent – Beyond the Noise with Dr. Paul Offit

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

In his weekly clinical update, Dr. Griffin discusses immunogenicity and tolerability of a bivalent virus-like particle norovirus vaccine candidate in children from 6 months up to 4 years of age, influenza hemagglutinin stem nanoparticle vaccine induces cross-group 1 neutralizing antibodies in healthy adults, COVID-19 surveillance after expiration of the public health emergency declaration, provisional mortality data, targeted vaccine messaging to promote COVID-19 vaccines for children and youth, vaccines and related biological products advisory committee meeting June 15, 2023 announcement, how to overhaul the CDC, impact of SARS-CoV-2 variants on inpatient clinical outcome, prevalence of post-coronavirus disease condition 12 weeks after Omicron infection compared with negative controls and association with vaccination status, gut bacteria cocktail helps long COVID, and gut microbiota‐derived symbiotic formula (SIM01) as a novel adjuvant therapy for COVID‐19.

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Links for this episode

• Immunogenicity and tolerability of a bivalent norovirus vaccine in children (HVI)
• Influenza hemagglutinin stem nanoparticle vaccine induces neutralizing antibodies in healthy adults (STM)
• COVID-19 surveillance after expiration of the public health emergency declaration (CDC)
• Provisional mortality data (CDC)
• Targeted messaging to promote COVID-19 vaccines for children and youth (Pediatrics)
• Vaccines and biological products advisory committee meeting announcement (FDA)
• How to overhaul the C.D.C (NYTIMES)
• Impact of SARS-CoV-2 variants on inpatient clinical outcome (CID)
• Prevalence of post-COVID19 condition 12 weeks after Omicron infection and vaccination status (CID)
• Gut bacteria cocktail helps long COVID (MedPage)
• Gut microbiota‐derived synbiotic formula as a therapy for COVID‐19 (NIH)
• Contribute to our FIMRC fundraiser at PWB
• Letters read on TWiV 1006
• Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to daniel@microbe.tv

TWiV reveals plankton-infecting relatives of herpesviruses in the sunlit oceans, and a vaccine encoding non-spike T cell antigens that protects animals from severe SARS-CoV-2 infection.

Hosts: Vincent Racaniello, Alan Dove, Kathy Spindler, and Brianne Barker

Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email

Become a patron of TWiV!

Links for this episode

• Register for ASV 2023
• Research assistant position at FDA (pdf)
• MicrobeTV Discord Server
• Mirusviruses link herpesvirus to giant viruses (Nature)
• Tara Oceans expeditions
• T cell vaccine protects against severe COVID (Cell)
• Letters read on TWiV 1005
• Timestamps by Jolene. Thanks!

Weekly Picks

Brianne – Immune #67: Can T cells Live Forever?
Kathy – Hazel Scott, Trinidad Jazz star
Alan – The Last Navigator, Steve Thomas
Vincent – Nasal Spray Covid Vaccines: Hope or Hype?

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

In his weekly clinical update, Dr. Griffin discusses the U.S. Food and Drug Administration approving Arexvy: the first respiratory syncytial virus (RSV) vaccine approved for use in the United State, association between SARS-CoV-2 and metagenomic content of samples from the Huanan Seafood Market, researchers disagree over how bad it is to be reinfected and whether COVID-19 can cause lasting changes to the immune system, virtual care and emergency department use during the COVID-19 pandemic among patients of family physicians in Canada, vaccination with BCG-Denmark did not result in a lower risk of COVID-19 among health care workers than placebo, NVX-CoV2373 vaccine efficacy against hospitalization, comparative effectiveness of the SARS-COV-2 vaccines during Delta dominance, assessment of gender-specific COVID-19 case fatality risk per malignant neoplasm type, clinical outcomes following treatment for COVID-19 with Nirmatrelvir/Ritonavir and Molnupiravir among patients living in nursing homes, timing of intubation and ICU mortality in COVID-19 patients, real-life experience with Remdesivir for treatment of COVID-19 among older adults, and how long COVID brain fog and muscle pain are associated with longer time to clearance of SARS-CoV-2 RNA from the upper respiratory tract during acute infection.

Become a patron of TWiV!

Links for this episode

• FDA approves Arexvy, the first RSV vaccine approved in the US (FDA)
• Association between SARS-CoV-2 and content of samples from the Huanan Seafood Market (bioRxiv)
• Researchers disagree over how bad it is to be reinfected with COVID-19 and lasting changes to the immune system (Nature)
• Virtual care and emergency department use during the COVID-19 Pandemic among patients of family physicians (JAMA)
• Vaccination with BCG-Denmark did not result in a lower risk of COVID-19 among health care workers (NEJM)
• NVX-CoV2373 vaccine efficacy against hospitalization (Vaccine)
• Comparative effectiveness of the SARS-COV-2 vaccines during Delta (Cell)
• Assessment of gender-specific COVID-19 case fatality risk (JAMA)
• Clinical outcomes following treatment for COVID-19 with Nirmatrelvir/Ritonavir and Molnupiravir (JAMA)
• Timing of intubation and ICU mortality in COVID-19 patients (BMC)
• Real-life experience with Remdesivir for treatment of COVID-19 (JAC)
• Long COVID brain fog and muscle pain are associated with longer time to clearance of SARS-CoV-2 RNA (Frontiers)
• Contribute to our FIMRC fundraiser at PWB
• Letters read on TWiV 1004
• Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to daniel@microbe.tv

Vincent and Kathy travel to Atlanta for APHL ID Lab Con, a conference focused on the latest developments in detecti​​on and characterization of infectious diseases of public health concern, and speak with Megan, Ryan, and Kirsten about the workings of public health and clinical laboratories.

Hosts: Vincent Racaniello and Kathy Spindler

Guests: Megan Crumpler, Ryan Relich, and Kirsten St. George

Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email

Become a patron of TWiV!

Links for this episode

• MicrobeTV Discord Server
• APHL Lab ID CON
• Association of Public Health Laboratories
• Orange County Public Health Laboratory
• Division of Clinical Microbiology, Indiana University Health
• Virology Laboratory, NYSDOH
• Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

In his weekly clinical update, Dr. Griffin discusses completeness and spin of medRxiv preprints and associated published abstracts of COVID-19 randomized clinical trials, lessons learned from a COVID-19 dog screening pilot in California K-12 schools, SARS-CoV-2 reinfection and severity of the disease, effectiveness of COVID-19 bivalent vaccine, Molnupiravir and risk of post-acute sequelae of COVID-19, risk of new-onset long Covid following reinfection with SARS-CoV-2, low vitamin D levels associated with long COVID syndrome in COVID-19 survivors, and clinical experience with the α2A-adrenoceptor agonist, guanfacine, and N-acetylcysteine for the treatment of cognitive deficits in “Long-COVID19”.

Click arrow to play Download TWiV 1002 (27 MB .mp3, 44 min)

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Links for this episode

• Completeness and spin of medRxiv preprint and published abstracts of COVID-19 randomized clinical trials (JAMA)
• Lessons learned from a COVID-19 dog screening pilot (JAMA)
• SARS-CoV-2 reinfection and severity of the disease (Viruses)
• Effectiveness of COVID-19 bivalent vaccine (medRxiv)
• Molnupiravir and risk of post-acute sequelae of COVID-19 (BMJ)
• Risk of new-onset long Covid following reinfection with SARS-CoV-2 (medRxiv)
• Low vitamin D levels are associated with Long COVID in COVID-19 survivors (JCEM)
• Clinical experience with the α2A-adrenoceptor agonist, guanfacine, and N-acetylcysteine for treatment of Long-COVID19 (NIH)
• Contribute to our ASTMH fundraiser at PWB
• Letters read on TWiV 1002
• Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to daniel@microbe.tv

In his weekly clinical update, Dr. Griffin discusses an update on vaccine-derived poliovirus outbreaks, how the dream of wiping out polio might need a rethink, risk of death in patients hospitalized for COVID-19 vs seasonal Influenza in fall-winter, French Mpox cluster includes fully vaccinated patients, two individuals with potential Mpox virus reinfection, epidemiologic and clinical features of Mpox-associated deaths, FDA authorizes changes to simplify use of bivalent mRNA COVID-19 vaccines, SARS-CoV-2 during Omicron variant predominance among infants born to people with SARS-CoV-2, severe maternal morbidity and mortality of pregnant patients with COVID-19 infection during the early pandemic period in the US, sickness presenteeism in healthcare workers during the COVID-19 pandemic, ventilation improvements among k–12 public school districts, risk factors and vectors for SARS-CoV-2 household transmission, SARS-CoV-2 neutralizing antibodies after bivalent versus monovalent, durability of bivalent boosters against Omicron subvariants, Nirmatrelvir and risk of hospital admission or death in adults with COVID-19, evolving real-world effectiveness of monoclonal antibodies for treatment of COVID-19, effect of angiotensin-converting enzyme inhibitor and angiotensin receptor blocker initiation on organ support–free days in patients hospitalized with COVID-19, efficacy and safety of Anakinra plus standard of care for patients with severe COVID-19, higher dose corticosteroids in patients admitted to hospital with COVID-19 who are hypoxic but not requiring ventilatory support, risk of autoimmune diseases in patients with COVID-19, definition of post–COVID-19 condition among published research studies, and sleep disturbance severity and correlates in post-acute sequelae of COVID-19. 

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Links for this episode

• Update on vaccine-derived poliovirus outbreaks (CDC)
• The dream of wiping out polio might need a rethink (NPR)
• Risk of death in patients hospitalized for COVID-19 vs influenza (JAME)
• French mpox cluster includes fully vaccinated patients (CIDRAP)
• Two individuals with potential Monkeypox reinfection (The Lancet)
• Epidemiologic and clinical features of Mpox-associated deaths (CDC)
• FDA authorizes changes to simplify use of Bivalent mRNA COVID-19 vaccines (FDA)
• Omicron variant predominance among infants born to people with SARS-CoV-2 (Pediatrics)
• Severe maternal morbidity and mortality of pregnant patients with COVID-19 (JAMA) 
• Sickness presenteeism in healthcare workers during the COVID-19 pandemic (ICHE)
• Ventilation improvements among K–12 public school districts (CDC)
• Risk factors and vectors for SARS-CoV-2 household transmission (The Lancet)
• SARS-CoV-2 neutralising antibodies after bivalent vs monovalent (The Lancet)
• Durability of bivalent boosters against Omicron subvariants (NEJM)
• Nirmatrelvir and risk of hospital admission or death in adults with COVID-19 (BMJ)
• Real world effectiveness of Monoclonal Antibodies for treatment of COVID-19 (AIM)
• Study on ACE inhibitor and ARB effect on COVID-19 patient outcomes (JAMA)
• Efficacy and safety of Anakinra plus standard of care for patients with severe COVID-19 (JAMA)
• High-dose corticosteroids in non-ventilated COVID-19 patients with hypoxia (The Lancet)
• Risk of autoimmune diseases in patients with COVID-19 (eClinical)
• Definition of post–COVID-19 condition (JAMA)
• Sleep disturbance severity and correlates in Post-acute Sequelae of COVID-19 (JGIM)
• Contribute to our ASTMH fundraiser at PWB
• Letters read on TWiV 1001
• Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to daniel@microbe.tv

The entire TWiV team gathers at a theatre in New York City to celebrate a milestone in science podcasting, to reminisce how they joined the show, and to play a game of TWiV Jeopardy.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, Kathy Spindler, Brianne Barker, Daniel Griffin, and Angela Mingarelli

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Links for this episode

• TWiV #1: West Nile virus
• TWiV #100: TWiV catches a big fish
• TWiV #200: Threading the NEIDL
• TWiV #300: So happy together
• TWiV #400: Harold ‘400’ Varmus, a scientist for all seasons
• TWiV #500: Keep virology weird
• Randal Despommier
• Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

TWiV notes Ashish Jha’s call for doctors to combat a vacuum of medical information while ignoring our contributions, China CDC’s surveillance of SARS-CoV-2 at the Huanan Seafood Market, and an experimental infectious attenuated COVID-19 vaccine that elicits superior mucosal and systemic immunity in hamsters.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Kathy Spindler, and Brianne Barker

Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email

Become a patron of TWiV!

Links for this episode

• Register for ASV 2023
• MicrobeTV Discord Server
• Jha ignores TWiV contribution to disseminating science information (STAT)
• Surveillance of SARS-CoV-2 at the Huanan Market (Nature)
• Pandas in the Huanan Market? (ArsTechnica)
• Infectious attenuated COVID-19 vaccine candidate (Nature Micro)
• Virus attenuation by codon pair deoptimization (Cell Rep)
• Timestamps by Jolene. Thanks!

Weekly Picks

Dickson – Jazz Project: Conductor/composer: Gill Evans. Produced Sketches of Spain, Porgy And Bess. Quincey Jones. Numerous albums, all kinds of music. Duke Ellington. Prolific musician, pianist, and composer. Antonio Carlos Jobim. Signature album: Sound track from the film – Black Orpheus. Signature songs: Girl From Ipanema; The Waters of March.
Brianne – This is what it sounds like when plants cry
Kathy – I know who you are by Barbara Rae-Venter
Alan – Svalbard seed vault virtual tour
Vincent – We’re Asking the Impossible of Vaccines by Katherine Wu

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

In his weekly clinical update, Dr. Griffin discusses the White House COVID adviser calling on doctors to combat a vacuum of medical information, adeno-associated virus type 2 in US children with acute severe hepatitis, genomic investigations of unexplained acute hepatitis in children, surveillance of SARS-CoV-2 at the Huanan seafood market, vaccine effectiveness against hospitalization among adolescent and pediatric SARS-CoV-2 cases between May 2021 and January 2022 in Canada, effectiveness of BNT162b2 after extending the primary series dosing interval in children and adolescents aged 5–17, prevalence and characteristics associated with post–COVID-19 condition among non-hospitalized adolescents and young adults, within-host genetic diversity of SARS-CoV-2 lineages in unvaccinated and vaccinated individuals, live-attenuated vaccine sCPD9 elicits superior mucosal and systemic immunity to SARS-CoV-2 variants in hamsters, Fc-γR-dependent antibody effector functions are required for vaccine-mediated protection against antigen-shifted variants of SARS-CoV-2, COVID-19 convalescent plasma utilization in the United States, FDA authorizes Gohibic (vilobelimab) injection for the treatment of COVID-19, anti-C5a antibody IFX-1 (vilobelimab) treatment versus best supportive care for patients with severe COVID-19 (PANAMO), anti-C5a antibody (vilobelimab) therapy for critically ill, invasively mechanically ventilated patients with COVID-19, triple combination therapy with two antivirals and monoclonal antibodies for persistent or relapsed SARS-CoV-2 infection in immunocompromised patients, and the breadth of the neutralizing antibody response to original SARS-CoV-2 infection is linked to the presence of long COVID symptoms.

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Links for this episode

• White House COVID adviser calls on doctors to combat medical information (STAT)
• Adeno-associated virus type 2 in US children with acute severe hepatitis (Nature)
• Genomic investigations of unexplained acute hepatitis in children (Nature)
• Surveillance of SARS-CoV-2 at the Huanan Seafood Market (ChinaXiv)
• Vaccine effectiveness against hospitalization among pediatric SARS-CoV-2 cases (PLOS)
• Effectiveness of BNT162b2 after extending the series dosing interval in children (Nature)
• Prevalence and characteristics associated with post–COVID-19 condition (JAMA)
• Within-host genetic diversity of SARS-CoV-2 lineages in unvaccinated and vaccinated individuals (Nature)
• Replication-competent-attenuated vaccine sCPD9 elicits immunity to SARS-CoV-2 variants (Nature)
• Fc-γR antibody functions needed for SARS-CoV-2 variant protection via vaccination (Nature)
• COVID-19 convalescent plasma utilization in the United States (CID)
• FDA authorizes Gohibic injection for the treatment of COVID-19  (FDA)
• IFX-1 antibody vs. supportive care for severe COVID-19 patients (Lancet)
• Vilobelimab therapy for COVID-19 critically ill patients on mechanical ventilation (Lancet)
• Triple combo therapy for relapsed SARS-CoV-2 in immunocompromised patients with antivirals and antibodies (CID)
• Neutralizing antibody response breadth to SARS-CoV-2 tied to Long COVID presence (medRxiv)
• Neurological Long COVID pathogenesis and potential therapies (Journal Cells)
• Contribute to our ASTMH fundraiser at PWB
• Dr. Griffin’s treatment guide (pdf)
• Letters read on TWiV 998
• Don’t crush Paxlovid (pdf)
• Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to daniel@microbe.tv

Mohsan joins TWiV to discuss the work of his laboratory showing that spike and nsp6 are determinants of Omicron attenuation, and why the work was widely misinterpreted by the press and the public.

Hosts: Vincent Racaniello, Alan Dove, and Rich Condit

Guest: Mohsan Saeed

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Links for this episode

•Register for ASV 2023
•MicrobeTV Discord Server
• Spike and nsp6 determinants of Omicron attenuation (Nature)
•China releases genomic data from Wuhan market (Science)
•Timestamps by Jolene. Thanks!

Weekly Picks

Rich – For pianist Dan Tepfer, improvisation is the mother of Bach’s Inventions
Alan – HMS Victory 3D animated tour
Vincent – The Fight Over Penn Station and Madison Square Garden

Listener Picks

Douglas – How’s Your City Doing? Ask the Honeybees.

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

In his weekly clinical update, Dr. Griffin discusses how antibiotics don’t reduce risk of death from viral respiratory infections, norovirus infections continue to rise in the US, ABO blood types and SARS-CoV-2 infection assessed using seroprevalence data in a large population-based sample, maternal third dose of BNT162b2 mRNA vaccine and risk of infant COVID-19 hospitalization, association of treatment with Nirmatrelvir and the risk of Post–COVID-19 condition, mechanically ventilated patients with COVID-19 had a higher chance of in-hospital death if treated with high-flow nasal cannula oxygen before intubation, high-flow nasal cannula and outcomes in COVID-19, severe infection and risk of Cardiovascular disease, and the risk factors associated with post−COVID-19 condition.

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Links for this episode

• Antibiotics don’t reduce risk of death from viral respiratory infections (CIDRAP)
• ABO blood types and SARS-CoV-2 infection (Nature)
• Maternal third dose of BNT162b2 mRNA vaccine and risk of infant COVID-19 hospitalization (Nature Medicine)
• Association of treatment with Nirmatrelvir and risk of post–COVID-19 (JAMA)
• Ventilated patients with COVID-19 had a higher chance of in-hospital death with usage of nasal cannula oxygen (IARS)
• High-flow nasal cannula and outcomes in COVID-19 (IARS)
• Severe infection and risk of cardiovascular disease (AHA)
• Risk factors associated with post−COVID-19 condition (JAMA)
• Contribute to our ASTMH fundraiser at PWB
• Dr. Griffin’s treatment guide (pdf)
• Letters read on TWiV 996
• Don’t crush Paxlovid (pdf)
• Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to daniel@microbe.tv

TWiV discusses genetic evidence of susceptible wildlife in SARS-CoV-2 positive samples at the Huanan Wholesale Seafood Market, polio cases in African linked to a new polio vaccine that was designed to not cause the disease, and structural conservation of hepatitis B virus capsid proteins over millions of years despite a shift from a naked to an enveloped capsid.

Click arrow to play
Download TWiV 995 (74 MB .mp3, 123 min)
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Links for this episode

•Register for ASV 2023
•MicrobeTV Discord Server
• More evidence for SARS-CoV-2 spillover (Zenodo)
•Polio cases linked to nOPV2 (Science; GPEI statement)
•nOPV2 on TWiV 756
•Engineering OPV to prevent reversion to neurovirulence (Cell Host Microbe)
•Stability of nOPV2 in children (npj Vaccines)
•2A changes compensate for 5′-UTR disruptions (Virology)
•HBV shifts from naked to enveloped (Nat Comm)
•Letters read on TWiV 995
•Timestamps by Jolene. Thanks!

Weekly Picks

Dickson – Jazz Project: Bass: Ray Brown, Ron Carter, Percy Heath
Angela – The nervous system may play a role in severe allergic reactions through immune cell (mast cells) cross-talk with neurons
Brianne – Science Museums Take Stock of 1.1 Billion Objects from Around the World
Vincent – Architect Breaks Down 5 of the Most Common Skyscraper Styles In New York

Listener Picks

Gary – Tony Fauci on PBS
Stefanie – What Do You Find Beautiful about Viruses? A Post-COVID Assessment Strategy

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

In his weekly clinical update, Dr. Griffin discusses the detection of circulating vaccine-derived poliovirus type 2 in Burundi and the Democratic Republic of the Congo, the novel oral polio vaccine type 2 story, prior COVID-19 infection associated with increased risk of newly diagnosed erectile dysfunction, adverse maternal, fetal, and newborn outcomes among pregnant women with SARS-CoV-2 infection, correlates of protection against COVID-19 infection and intensity of symptomatic disease in vaccinated individuals exposed to SARS-CoV-2 in households in Israel, effectiveness of Nirmatrelvir–Ritonavir in preventing hospital admissions and deaths in people with COVID-19, projected COVID-19 mortality reduction from Paxlovid rollout, and SARS-CoV-2 mRNA vaccines decouple anti-viral immunity from humoral autoimmunity.

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Links for this episode

• cVDPV2 detections in Burundi and the DRC (PGEI)
• Novel oral polio vaccine type 2 story (The Lancet)
• Prior COVID-19 infection associated with risk of diagnosed erectile dysfunction (IJIR)
• Adverse maternal, fetal, and newborn outcomes among pregnant women with SARS-CoV-2 infection (BMJ) 
• Protection against COVID-19 infection and intensity of symptomatic disease in vaccinated individuals(The Lancet)
• Effectiveness of Nirmatrelvir–Ritonavir in preventing hospital admissions and deaths (The Lancet)
• Projected COVID-19 mortality reduction from Paxlovid rollout (JAMA)
• SARS-CoV-2 mRNA vaccines decouple anti-viral immunity (Nature) 
• Contribute to our ASTMH fundraiser at PWB
• Dr. Griffin’s treatment guide (pdf)
• Letters read on TWiV 994
• Don’t crush Paxlovid (pdf)
• Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to daniel@microbe.tv

TWiV reveals how treatment with remdesivir for COVID-19 resolved a chronic poliovirus infection in an immunocompromised patient, and the finding that infection with SARS-CoV-2 leads to an increase in new and preexisting autoantibodies.

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Links for this episode

•Register for ASV 2023
•MicrobeTV Discord Server
•Janet Sinsheimer on TWiV 653
•Clearance of chronic poliovirus infection by remdesivir (Front Immunol)
•Autoimmunity induced by SARS-CoV-2 infection (Nat Comm)
•Letters read on TWiV 993
•Timestamps by Jolene. Thanks!

Weekly Picks

Brianne – Xkcd: Lymphocytes
Kathy – A brief history of Parafilm with video
Alan – Mapping and exploring the USS Monitor wreck
Vincent – Skype a Scientist

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

In his weekly clinical update, Dr. Griffin discusses clearance of longstanding, immune-deficiency-associated, vaccine-derived poliovirus infection following remdesivir therapy for chronic SARS-CoV-2 infection, SARS-CoV-2 exposure in New York City rats, clinical characteristics and outcomes of children with SARS-CoV-2 infection during the Delta and Omicron variant-dominant periods in Korea, exhaled breath aerosol shedding of SARS-CoV-2 variants, outpatient treatment of COVID-19 and the development of long COVID over 10 months, Nirmatrelvir and the risk of post-acute sequelae of COVID-19, assessment of the risk of venous thromboembolism in nonhospitalized patients with COVID-19, and the optimal duration of systemic corticosteroids in COVID-19 treatment.

Click arrow to play Download TWiV 992 (19 MB .mp3, 32 min)

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Links for this episode

• Clearance of vaccine-derived poliovirus following remdesivir therapy for SARS-CoV-2 infection (Frontiers) 
• SARS-CoV-2 exposure in Norway rats from New York City (mBio)
• Clinical characteristics and outcomes of children with SARS-CoV-2 Infection in Korea (JKMS)
• Exhaled breath aerosol shedding of SARS-CoV-2 variants (CID)
• Outpatient treatment of COVID-19 and the development of Long COVID (The Lancet) 
• Nirmatrelvir and the risk of post-acute sequelae of COVID-19 (medRxiv)
• Risk of venous thromboembolism in nonhospitalized patients with COVID-19 (JAMA)
• Optimal duration of systemic corticosteroids in COVID-19 treatment (OFID)
• Contribute to our ASTMH fundraiser at PWB
• Dr. Griffin’s treatment guide (pdf)
• Letters read on TWiV 992
• Don’t crush Paxlovid (pdf)
• Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to daniel@microbe.tv

On this episode of TWiV, the observation that the 1918 influenza virus is not lethal in nonhuman primates and implications for studies on viral virulence, and mRNA vaccines that control and resolve human papillomavirus-associated cancers in mice.

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Links for this episode

•Register for ASV 2023
•MicrobeTV Discord Server
•1918 influenza virus not lethal in nonhuman primates (J Virol)
•mRNA vaccines control HPV-associated tumors (Sci Trans Med)
•Letters read on TWiV 991
•Timestamps by Jolene. Thanks!

Weekly Picks

Dickson – Jazz Project: Piano: Art Tatum/Thelonius S. Monk/Dave Brubeck/Bill Evans/George Shearing/Herbie Hancock/Chick Corea/Keith Jarret/Diana Krall/Eliane Elias/Horace Silver. Honorable mention: Oscar Peterson/Erroll Garner/Ramsey Lewis/Dr. John/Duke Ellington
Rich – Protein synthesis: an epic on the cellular level
Alan – Thomas Was Alone
Vincent – I called for more research on the COVID ‘lab leak theory.’ Here’s what I found out

Listener Pick

Carol – The Exceptions: Nancy Hopkins, MIT, and the fight for Women in Science

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

TWiV to explains a study on presence of COVID-19 vaccine mRNA in the blood, and the isolation of cross-protective monoclonal antibodies against common endemic respiratory viruses.

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Links for this episode

•Register for ASV 2023
•MicrobeTV Discord Server
•Paul Berg obituary
•Spike mRNA in blood (J Path Micro Imm)
•Spike mRNA in blood (Biomedicine)
•Cross-protective mAbs against respiratory viruses (Nat Comm)
•RSV prefusion F protein vaccine in older adults (NEJM)
•Ad26.RSV.preF–RSV preF protein vaccine (NEJM)
•Letters read on TWiV 989
•Timestamps by Jolene. Thanks!

Weekly Picks

Dickson – Jazz Project: Drums: Sunny Payne (Count Basie Orchestra); Buddy Rich (Count Basie Orchestra); Rufus Jones (Maynard Ferguson Orchestra); Joe Morello (Dave Brubeck Quartet).
Brianne – A Scientific Investigation of ‘The Last of Us’ Fungal Pandemic
Kathy – “That’s What They Say” podcast about pronunciation of “primer.”
Rich – Slow motion art:  1 and 2
Vincent – Grammarly

Listener Pick

Charles – Psychologist Daniel Levitin dissects Pink Floyd’s ‘Dark Side of the Moon’

Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

In his weekly clinical update Dr. Griffin discusses FDA authorizing the first over-the-counter at-home test to detect both influenza and COVID-19, monoclonal antibody for the prevention of respiratory syncytial virus infection in infants and children, epidemiologic characteristics of SARS-CoV-2 recombinant variant XBB.1.5, COVID-19 vaccines vs pediatric hospitalization, maternal SARS-CoV-2 vaccination and infant protection against SARS-CoV-2 during the first six months of life, immunoglobulin, glucocorticoid, or combination therapy for multisystem inflammatory syndrome in children, fatal fulminant cerebral edema in six children with SARS-CoV-2 Omicron BA.2 infection in Taiwan, certifying deaths due to COVID-19, efficacy of first dose of COVID-19 vaccine vs no vaccination on symptoms of patients with long COVID, and the effect of COVID-19 vaccination on long COVID.

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Links for this episode

• FDA authorizes over-the-counter at-home test to detect both Influenza and COVID-19 (FDA)
• Monoclonal antibody for the prevention of RSV in infants and children (JAMA)
• Epidemiologic characteristics of SARS-CoV-2 variant XBB.1.5 (CDC)
• COVID-19 vaccines vs pediatric hospitalization (Cell)
• Maternal SARS-CoV-2 vaccination and infant protection during the first six months of life (Nature)
• Immunoglobulin, glucocorticoid, or combination therapy for MIS in children (The Lancet)
• Fatal Fulminant Cerebral Edema in children with SARS-CoV-2 Omicron BA.2 infection (JPID)
• Certifying deaths due to COVID-19 (CDC)
• Efficacy of first dose of COVID-19 vaccine vs no vaccination on patients with Long COVID (BMJ)
• Effect of COVID-19 vaccination on long COVID (BMJ)
• Contribute to our ASTMH fundraiser at PWB
• Dr. Griffin's treatment guide (pdf)
• Letters read on TWiV 988
• Don't crush Paxlovid (pdf)
• Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to daniel@microbe.tv

Arturo Casadevall returns to TWiV to explain the use of convalescent plasma to treat COVID-19 patients, and the need to support virology at a time when more regulation of experiments is envisioned.

Hosts: Vincent Racaniello, Alan Dove, and Rich Condit

Guest: Arturo Casadevall

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Links for this episode

• Register for ASV 2023
• MicrobeTV Discord Server
• Early treatment of COVID-19 with convalescent plasma (NEJM)
• Neutralization of SARS-CoV-2 by convalescent plasma (Nat Comm)
• Convalescent COVID-19 plasma for immunocompromised patients (JAMA Net Open)
• Virology under the microscope (mSphere)
• Virology in peril (mSphere)
• Emil von Behring Nobel Lecture
• Letters read on TWiV 987
• Timestamps by Jolene. Thanks!

Weekly Picks

Rich - Flammarion engraving
Alan - What Remains of Edith Finch
Vincent - The CDC’s Long-Covid Deception

Listener Pick

Bill - General Relativity For Babies

Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

In his weekly clinical update Dr. Griffin discusses the efficacy and safety of two RSV vaccines in older adults, health care vaccine mandate remains as some push for an end, past SARS-CoV-2 infection protection against re-infection, a third vaccine dose equalizes the levels of effectiveness and immunogenicity of heterologous or homologous COVID-19 vaccine regimens, Sotrovimab retains activity against SARS-CoV-2 Omicron variant BQ.1.1 in a non-human primate model, effect of higher-dose Ivermectin for 6 Days vs placebo on time to sustained recovery in outpatients with COVID-19, viral burden rebound in hospitalized patients with COVID-19 receiving oral antivirals in Hong Kong, serological response to vaccination in post-acute sequelae of COVID, sex differences in cardiovascular complications and mortality in hospital patients with COVID-19, association of COVID-19 vaccination with risk for incident diabetes after COVID-19, postacute sequelae of SARS-CoV-2 in university setting, the CDC’s long-Covid deception, and podcast companies, once walking on air, feel the strain of gravity.

Become a patron of TWiV!

Links for this episode

• RSV prefusion F protein vaccine in older adults (NEJM)
• Efficacy and safety of an Ad26.RSV.preF–RSV preF protein vaccine (NEJM)
• Health care vaccine mandate remains as some push for an end (AP)
• Past SARS-CoV-2 infection protection against re-infection (The Lancet)
• A third vaccine dose equalizes the levels of effectiveness and immunogenicity of COVID-19 vaccine regimens (medRxiv)
• Sotrovimab retains activity against SARS-CoV-2 Omicron variant in primate model (bioRxiv)
• Effect of higher-dose Ivermectin for 6 days vs placebo in patients with COVID-19 (JAMA)
• Viral burden rebound in patients with COVID-19 receiving oral antivirals (The Lancet)
• Serological response to vaccination in post-acute sequelae of COVID (BMC)
• Sex differences in cardiovascular complications and mortality in patients with COVID-19 (BMI)
• Association of COVID-19 vaccination with risk for incident diabetes after COVID-19 (JAMA)
• Postacute sequelae of SARS-CoV-2 in university setting (CDC)
• The CDC’s Long-Covid deception (WSJ)
• Podcast companies, once walking on air, feel the strain of gravity (NYT)
• Contribute to our ASTMH fundraiser at PWB
• Dr. Griffin’s treatment guide (pdf)
• Letters read on TWiV 986
• Don’t crush Paxlovid (pdf)
• Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to daniel@microbe.tv

TWiV reviews an outbreak of Marburg hemorrhagic fever in Equatorial Guinea, wild poliovirus type 3 shedding from a laboratory in the Netherlands, and white-tailed deer as a reservoir for previous SARS-CoV-2 variants of concern.

Hosts: Vincent Racaniello, Dickson Despommier, and Rich Condit

Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email

Become a patron of TWiV!

Links for this episode

•Register for ASV 2023
•MicrobeTV Discord Server
•Marburg virus disease outbreak in Equatorial Guinea (WHO)
•Wild-type poliovirus type 3 from laboratory (Eurosurveillance)
•Extinct SARS-CoV-2 VOC in white-tailed deer (PNAS)
•Letters read on TWiV 985
•Timestamps by Jolene. Thanks!

Weekly Picks

Dickson – Jazz Project: Vibraphone: Lionel Hampton/Gary Burton/Cal Jader. Lionel Hampton: Signature album: The Classics Album Collection, Signature song: Flying Home. Gary Burton: Signature album: A Genuine Tong Funeral. Signature song: General Mojo’s Well Laid Plan. Cal Jader: Signature album: Latin Kick. Signature song: Soul Sauce (Wachi Wara).  Milt Jackson (a member of the Modern Jazz Quartet). Signature song: Ice Skating in Central Park.
Rich – The American Phage Group: Founders of Molecular Biology by William C. Summers
Vincent – DJ Miss Monique aka Olesia Arkusha

Listener Pick

Megan – The Day The Music Stopped: How a 1942 recording ban changed America forever and The Weather Channel presents the best of smooth Jazz

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

In his weekly clinical update Dr. Griffin discusses the political polarization of COVID-19 treatments among physicians and laypeople in the United States, seven alternatives to evidence-based medicine, Malawi’s cholera death toll crosses 1,300 in its deadliest outbreak on record, impact of coronavirus infections on pediatric patients at a tertiary pediatric hospital, maternal mRNA COVID-19 vaccination during pregnancy and delta or omicron infection or hospital admission in infants, yes masks reduce the risk of spreading infection, despite a review saying they don’t, COVID-19 and airborne transmission: science rejected, lives lost. can society do better, what were the historical reasons for the resistance to recognizing airborne transmission during the COVID-19 pandemic, a randomized trial comparing Omicron-containing boosters with the original COVID-19 vaccine mRNA-1273, SARS-CoV-2 neutralizing antibodies after bivalent vs. monovalent booster, the impacts of SARS-CoV-2 vaccine dose separation and targeting on the COVID-19 epidemic in England, intra-host evolution provides for the continuous emergence of SARS-CoV-2 variants, real-world use of Nirmatrelvir–Ritonavir in outpatients with COVID-19 during the era of Omicron variants including BA.4 and BA.5 in Colorado, viral burden rebound in hospitalized patients with COVID-19 receiving oral antivirals in Hong Kong, and guidance on the use of convalescent plasma to treat immunocompromised patients with COVID-19.

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Become a patron of TWiV!

Links for this episode

• The political polarization of COVID-19 treatments in the United States (PNAS)
• Seven alternatives to evidence-based medicine (BMJ)
• Malawi’s cholera death toll crosses 1,300 (CBC)
• Impact of coronavirus infections on pediatric patients (JHI)
• Maternal mRNA COVID-19 vaccination during pregnancy (BMJ)
• Yes, masks reduce the risk of spreading COVID (TVO)
• COVID-19 and airborne transmission (IDSA)
• What were the reasons for resistance to recognizing airborne transmission (IJIE)
• Comparing Omicron-containing boosters with COVID-19 vaccine mRNA-1273 (medRxiv)
• SARS-CoV-2 neutralizing antibodies after bivalent vs. monovalent booster (bioRxiv)
• The impact of SARS-CoV-2 vaccine dose separation and targeting (Nature)
• Intra-host evolution provides for the emergence of SARS-CoV-2 variants (ASM)
• Real-world use of nirmatrelvir–ritonavir in outpatients with COVID-19 (The Lancet)
• Viral rebound in hospitalized patients with COVID-19 receiving oral antivirals (The Lancet)
• Guidance on the use of convalescent plasma to treat immunocompromised patients with COVID-19 (CID)
• Contribute to our ASTMH fundraiser at PWB
• Dr. Griffin’s treatment guide (pdf)
• Letters read on TWiV 984
• Don’t crush Paxlovid (pdf)
• Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to daniel@microbe.tv

Scott returns to TWiV to explain the development of an experimental mRNA vaccine that encodes hemagglutinin antigens against all known influenza A virus subtypes and influenza B virus lineages, and why he is worried about avian H5N1 influenza virus.

Hosts: Vincent Racaniello, Dickson Despommier, and Brianne Barker

Guest: Scott Hensley

Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email

Become a patron of TWiV!

Links for this episode

•Research assistant position at FDA (pdf)
•Register for ASV 2023
•MicrobeTV Discord Server
•Multivalent influenza mRNA vaccine (Science)
•Influenza virus mRNA vaccines circumvent egg adaptation problems (J Virol)
•Letters read on TWiV 983
•Timestamps by Jolene. Thanks!

Weekly Picks

Dickson – Jazz Project:  Guitar. Django Reinhardt; Pat Metheny. Signature album: Still Life Talking. Signature song: Last Train Home; Joe Pass (Ella Fitzgerald’s favorite guitar accompanist). Signature album: Virtuoso. Signature song: Round Midnight.
Brianne – HHMI Virus Explorer
Vincent – Chris Luno

Listener Picks

John – White-tail deer density and SARS-CoV-2 in white-tail deer
Jessica – Classic cases revisited: Oscar the cat and predicting death

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

In his weekly clinical update Dr. Griffin discusses the consistency of COVID-19 trial preprints with published reports and impact for decision making, the negative effect of preexisting immunity on Influenza vaccine responses transcends the impact of vaccine formulation type and vaccination history, highly pathogenic avian influenza A(H5N1) virus infection in farmed minks in Spain, Peru confirms H5N1 avian flu in marine mammals, prior vaccination enhances immune responses during SARS-CoV-2 breakthrough infection with early activation of memory T cells followed by production of potent neutralizing antibodies, bacillus Calmette-Guérin vaccine for prevention of COVID-19 and other respiratory tract infections in older adults with comorbidities, incidence of chronic spontaneous urticaria following receipt of the COVID-19 vaccine booster in Switzerland, relationship between immune response to SARS-CoV2 vaccines and development of breakthrough infection in solid organ transplant recipients, early treatment with pegylated interferon lambda for COVID-19, and how long-term high-dose immunoglobulin successfully treats long COVID patients with pulmonary, neurologic, and cardiologic symptoms. 

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Links for this episode

• Consistency of COVID-19 trial preprints with published reports (BMI)
• Negative effect of preexisting immunity on Influenza vaccine (JID)
• Highly pathogenic avian influenza infection in farmed minks (Eurosurveillance)
• Peru confirms H5N1 avian flu in marine mammals (CIDRAP)
• Prior vaccination enhances immune responses during SARS-CoV-2 infection (bioRxiv)
• Bacillus Calmette-Guérin vaccine for prevention of COVID-19 and respiratory infections (CMI)
• Incidence of spontaneous Urticaria following COVID-19 vaccine booster (JAMA)
• Relationship between immune response to SARS-CoV2 vaccines and breakthrough infection in transplant recipients (CID)
• Early treatment with Pegylated Interferon Lambda for COVID-19 (NEJM)
• Long-term high-dose immunoglobulin successfully treats Long COVID patients (Frontiers)
• Contribute to our ASTMH fundraiser at PWB
• Dr. Griffin’s treatment guide (pdf)
• Letters read on TWiV 982
• Don’t crush Paxlovid (pdf)
• Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to daniel@microbe.tv

TWiV explains the recent meeting of the National Science Advisory Board for Biosecurity (NSABB) where stricter guidelines for research involving human, animal, and plant pathogens were considered, and how the consumption of viruses by small protists returns energy to food chains.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler

Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email

Become a patron of TWiV!

Links for this episode

•Research assistant position at FDA (pdf)
•Register for ASV 2023
•MicrobeTV Discord Server
•NSABB proposed oversight framework (pdf)
•Stricter US guidelines for research (Nature)
•Information on NSABB (NIH)
•Consumption of viruses by protists (PNAS)
•Letters read on TWiV 981
•Timestamps by Jolene. Thanks!

Weekly Picks

Dickson – Jazz Project: Trombone: Steve Turre/Conrad Herwig; Steve Turre; Curtis Fuller; J.J. Johnson and Kai Winding. Steve Turre: Signature album: Sanctified Shells. Signature song: Sanctified Shells. Conrad Herwig. Signature album: A Jones For Bones Tones. Signature song: Slide’s Routine; Curtis Fuller: Signature album: BLUES ette. Signature song: Bluesette. J.J. Johnson (with Kai Winding). Signature album: The Great Kai and J.J. : Signature song: Monk’s Blues.
Kathy – Measles virus ‘cooperates’ with itself to cause fatal encephalitis. Primary research article: Shirogane et al.
Rich – Firm hatches plan to bring back dodo (Colossal Biosciences – Dodo)
Alan – Mt. Washington Observatory webcam
Vincent – Ask the Experts

Listener Picks

Roberto – The Contagion of Liberty: The Politics of Smallpox in the American Revolution

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

In his weekly clinical update Dr. Griffin discusses prevalence and clinical outcomes of respiratory syncytial virus versus influenza virus in adults hospitalized with acute respiratory Illness, reconsideration of antinucleocapsid IgG antibody as a marker of SARS-CoV-2 infection postvaccination for mild COVID-19 patients, assessment of COVID-19 as the underlying cause of death among children and young people aged 0 to 19 years in the US, information for persons who are immunocompromised regarding prevention and treatment of SARS-CoV-2 Infection in the context of currently circulating Omicron sublineages, association of culturable-virus detection and household transmission of SARS-CoV-2,  effectiveness of bivalent boosters against severe Omicron infection, Covid vaccines and playing the long game, efficacy and safety of antimicrobial stewardship prospective audit and feedback in patients hospitalized with COVID-19, and severe fatigue and persistent symptoms at three months following SARS-CoV-2 Infections during the pre-Delta, Delta, and Omicron time periods.

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Links for this episode

• Prevalence and clinical outcomes of RSV vs influenza in adults (CID)
• Reconsideration of antinucleocapsid IgG antibody as a marker of SARS-CoV-2 infection (OFID)
• Assessment of COVID-19 as the underlying cause of death among children and young people (JAMA)
• Information for persons who are immunocompromised regarding prevention and treatment of SARS-CoV-2 infection (CDC)
• Association of culturable-virus detection and household transmission of SARS-CoV-2 (JID)
• Effectiveness of bivalent boosters against severe Omicron infection (NEJM)
• Covid vaccines and playing the long game (NEJM)
• Efficacy and safety of antimicrobial stewardship prospective audit and feedback in COVID-19 patients (The Lancet) 
• Severe fatigue and persistent symptoms at three months following SARS-CoV-2 Infection (CID)
• Contribute to our ASTMH fundraiser at PWB
• Dr. Griffin’s treatment guide (pdf)
• Letters read on TWiV 980
• Don’t crush Paxlovid (pdf)
• Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to daniel@microbe.tv

Paul Offit returns to TWiV to unpack the recent FDA Advisory Panel on COVID vaccines, with discussions on giving everyone the same bivalent vaccine, simplifying the immunization schedule, and how to know when the vaccine should be updated.

Hosts: Vincent Racaniello and Rich Condit

Guest: Paul Offit

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Links for this episode

• FDA briefing document (pdf)
• Effectiveness of bivalent booster against severe infection (NEJM)
• Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

TWiV gives an update on poliovirus in wastewater, and reveals a vast world of viroids that infect a wide range of host species in diverse ecosystems.

Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler

Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email

Become a patron of TWiV!

Links for this episode

•Research assistant position at FDA (pdf)
•Register for ASV 2023
•MicrobeTV Discord Server
•Nick Muzyczka passes
•CDC planning wastewater testing for polio (CDC)
•Wastewater testing for poliovirus (MMWR)
•NY state poliovirus wastewater surveillance (NYSDOH)
•CDC wastewater poliovirus surveillance in select communities (CDC)
•Vast world of viroid-like RNAs (Cell)
•Timestamps by Jolene. Thanks!

Weekly Picks

Kathy – 3B new Milky Way objects, Green comet
Rich – Virology under the Microscope—a Call for Rational Discourse
Alan – Indie story-driven games series #3: Valiant Hearts: The Great War
Vincent – Vaccines and Related Biological Products Advisory Committee Meeting January 26, 2023 – pdf

Listener Picks

Florencia – An elegant way to stop deadly Hendra virus spillovers from bats to horses … to us (Nature article)

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

In his weekly clinical update Dr. Griffin discusses co-detections of other respiratory viruses among children hospitalized with COVID-19, preprint review should form part of PhD programs and postdoc training, early and increased Influenza activity among children, COVID-19 vaccines versus pediatric hospitalization, SARS-CoV-2 variant-related abnormalities detected by prenatal MRI, protective effectiveness of previous SARS-CoV-2 infection and hybrid immunity against the Omicron variant and severe disease, protective effectiveness of previous SARS-CoV-2 infection and hybrid immunity against the omicron variant and severe disease, persistent COVID-19 Symptoms at 6 months after onset and the role of vaccination before or after SARS-COV-2 infection, effect of Dexamethasone use on viral clearance among patients with COVID-19, and the impact of vaccination on post-acute sequelae of SARS CoV-2 infection in patients with rheumatic diseases.

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Links for this episode

• Codetections of other respiratory viruses among children with COVID-19 (Pediatrics) 
• Preprint review should form part of PhD programmes and postdoc training (Nature)
• Early and increased Influenza activity among children (CDC)
• COVID-19 vaccines versus pediatric hospitalization (Cell) 
• SARS-CoV-2 variant abnormalities detected by prenatal MRI (The Lancet) 
• Protective effectiveness of previous SARS-CoV-2 infection and hybrid immunity (The Lancet) 
• Persistent COVID-19 symptoms at 6 months and role of vaccination (JAMA)
• Effects of Dexamethasone use among patients with COVID-19 (IJID)
• Impact of vaccination on sequelae of SARS CoV-2 in patients with rheumatic diseases (BMJ)
• Contribute to our MicrobeTV fundraiser at PWB
• Dr. Griffin’s treatment guide (pdf)
• Letters read on TWiV 978
• Don’t crush Paxlovid (pdf)
• Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to daniel@microbe.tv

TWiV covers a study of SARS-CoV-2 persistence at multiple sites in the human body, and the role of endogenous retroviruses in ageing and senescence.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Brianne Barker, and Angela Mingarelli

Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email

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Links for this episode

•Research assistant position at FDA (pdf)
•Register for ASV 2023
•MicrobeTV Discord Server
•Persistence of SARS-CoV-2 (Nature)
•Endogenous retroviruses and senescence (Cell)
•Timestamps by Jolene. Thanks!

Weekly Picks

Dickson – Baritone Saxophone: Gerry Mulligan. No one else comes close Signature song: Bernie’s Tune
Angela – World’s Longest Animal
Brianne – Green Comet to Pass By Earth for first time in 50,000 years
Alan – Indie games series: Golf Club Wasteland
Vincent – Bivalent Covid-19 Vaccines — A Cautionary Tale

Listener Picks

Lisa – The River and the Wall

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

In his weekly clinical update Dr. Griffin discusses China reporting almost 60,000 Covid-related deaths after abrupt shift in policy, detection of SARS-CoV-2 IgA and IgG in human milk and breastfeeding infant stool 6 months after maternal COVID-19 vaccination, effect of Fluvoxamine vs placebo on time to sustained recovery in outpatients with mild to moderate COVID-19, hyperimmune globulin for severely immunocompromised patients hospitalized with COVID-19, long COVID outcomes at one year after mild SARS-CoV-2 infection, long COVID: major findings, mechanisms and recommendations, a systematic review of trials currently investigating therapeutic modalities for post-acute COVID-19 syndrome and registered on World Health Organization international clinical trials platform, and the effect of using a structured pacing protocol on post-exertional symptom exacerbation and health status in a longitudinal cohort with the post-COVID-19 syndrome.

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Links for this episode

• China records almost 60,000 COVID-related deaths (SCMP)
• Detection of SARS-CoV-2 IgA and IgG in human milk and breastfeeding infant stool (Nature)
• Effect of Fluvoxamine vs placebo in outpatients with COVID-19 (JAMA)
• Hyperimmune Globulin for immunocompromised patients with COVID-19 (JID)
• Long COVID outcomes at one year after mild infection (BMJ) 
• Major findings, mechanisms and recommendations for Long COVID (Nature)
• Review of trials investigating therapeutic modalities for post-acute COVID-19 (CMI)
• Effect of using a structured pacing protocol (JMV)
• Contribute to our MicrobeTV fundraiser at PWB
• Dr. Griffin’s treatment guide (pdf)
• Letters read on TWiV 976
• Don’t crush Paxlovid (pdf)
• Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to daniel@microbe.tv

Daniela joins TWiV to discuss her career and her research on T cells, their role in infection with SARS-CoV-2, T cell epitopes and why a variant that evades T cell immunity is not likely to emerge.

Hosts: Vincent Racaniello, Alan Dove, and Brianne Barker

Guest: Daniela Weiskopf

Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email

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Links for this episode

•Research assistant position at FDA (pdf)
•Register for ASV 2023
•Cross reactive T cells to SARS-CoV-2 (Science)
•SARS-CoV-2 exposure history and T cell response (Cell Rep Med)
•Spike T cells cross- recognize Omicron (Nature)
•Ancestral SARS-CoV-2 T cells recognize Omicron (Nature)
•NVX-CoV2373 induces T cell responses (J Clin Inves)
•Letters read on TWiV 975
•Timestamps by Jolene. Thanks!

Weekly Picks

Brianne – Video of viral attachment (based on this article)
Alan – Starting a series of innovative indie video games. First up: The Longing.
Vincent – The Amy Papers and Calendar for live events

Listener Picks

Judy – Innate immune evasion strategies of SARS-CoV-2
Charles – Who’s Talking to Chris Wallace? Season 1, epitope 30: Dr. Anthony Fauci on HBO Max

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

In his weekly clinical update Dr. Griffin discusses poliovirus returns to New York wastewater, COVID-19 is more widespread in animals than we thought, increasing ventilation reduces SARS-CoV-2 airborne transmission in schools, the use of carbon dioxide monitoring to assess ventilation at a national infectious diseases conference, effectiveness of the bivalent mRNA vaccine in preventing severe COVID-19 outcomes, 7-month duration of SARS-CoV-2 mucosal immunoglobulin-A responses and protection, and long COVID outcomes at one year after mild SARS-CoV-2 infection.

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Links for this episode

• COVID-19 more widespread in animals than thought (Nat Geo)
• Increasing ventilation reduces airborne transmission in schools (Frontiers)
• Carbon dioxide monitoring to assess ventilation at a NID conference (CID)
• Paxlovid patient eligbiliity screening checklist (FDA)
• Effectiveness of bivalent mRNA vaccine in preventing severe COVID-19 (Lancet)
• Duration of SARS-CoV-2 mucosal immunoglobulin-A responses and protection (Lancet)
• Long COVID outcomes at one year after mild SARS-CoV-2 infection (BMJ)
• Contribute to our MicrobeTV fundraiser at PWB
• Dr. Griffin’s treatment guide (pdf)
• Letters read on TWiV 974
• Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to daniel@microbe.tv

Felicia joins TWiV to discuss her career and her research on human cytomegalovirus, which infects most of us for our entire lives yet mainly causes disease in the immunosuppressed.

Hosts: Vincent Racaniello, Alan Dove, and Brianne Barker

Guest: Felicia Goodrum

Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email

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Links for this episode

•Research assistant position at FDA (pdf)
•The loss of binary (Curr Clin Micro Rep)
•Virology in Peril (mBio)
•Letters read on TWiV 973
•Timestamps by Jolene. Thanks!

Weekly Picks

Brianne – “Leukocyte” immunology video parody
Alan – West Point Removing Confederate Monuments, and Ty Seidule’s book on that subject
Vincent – The works of Haruki Murakami – South of the Border, West of the Sun; also short stories (First Person Singular, particularly Confessions of a Shinagawa Monkey; and Men Without Women, particularly Drive My Car)

Listener Picks

Karen – On All Fours: Transient Laborers, the Threat of Movement, and the Aftermath of Disease
Kevin – James Hoffmann and Bald and Bankrupt

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

In his weekly clinical update Dr. Griffin discusses the infectiousness of SARS-CoV-2 breakthrough infections and reinfections during the Omicron wave, virological characteristics of the SARS-CoV-2 XBB variant derived from recombination of two Omicron subvariants, antibody evasion properties of rising SARS-CoV-2 BQ and XBB subvariants, comparative effectiveness of third doses of mRNA-based COVID-19 vaccines in US veterans, time to negative PCR conversion among high-risk patients with mild-to-moderate Omicron BA.1 and BA.2 COVID-19 treated by Sotrovimab or Nirmatrelvir, COVID drug Paxlovid was hailed as a game-changer, what happened?, the Fc-effector function of COVID-19 convalescent plasma contributes to SARS-CoV-2 treatment efficacy in mice, SARS-CoV-2 infection and persistence in the human body and brain at autopsy, long-term cardiovascular outcomes of COVID-19, and how heart-disease risk soars after COVID — even with a mild case.

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Links for this episode

• Infectiousness of breakthrough infections & reinfections during Omicron wave (Nature)
• Virological characteristics of the SARS-CoV-2 XBB variant (bioRxiv)
• Antibody evasion properties of BQ and XBB subvariants (Cell)
• Comparative effectiveness of third doses of mRNA vaccines in US veterans (Nature)
• Time to negative PCR conversion among high-risk patients treated by Sotrovimab or Nirmatrelvir (CMI)
• Paxlovid patient eligbiliity screening checklist (FDA)
• COVID drug Paxlovid was hailed as a game-changer. What happened? (Nature)
• Fc-effector function of COVID-19 convalescent plasma contributes to treatment efficacy (Cell)
• SARS-CoV-2 infection and persistence in the human body and brain at autopsy (Nature)
• Long-term cardiovascular outcomes of COVID-19 (Nature)
• Heart-disease risk soars after COVID (Nature)
• Contribute to our MicrobeTV fundraiser at PWB
• Dr. Griffin’s treatment guide (pdf)
• Letters read on TWiV 972
• Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to daniel@microbe.tv

In the first epitope of 2023, TWiV reviews our coverage of virology in 2022, including favorite story arcs, episodes, show titles, and much more.

Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, Kathy Spindler, and Brianne Barker

Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email

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Links for this episode

Our favorite 2022 virology stories:
•Vincent: Paul Offit on bivalent boosters (TWiV 917, 942, Special)
•Dickson: Interviews with Paul Offit and Andy Slavitt
•Rich: TWiV 948: Breathless with David Quammen
•Kathy: TWiV 915: Mouse mouth to mouse mom
•Brianne: Spillovers (TWiV 923 and 876)
•Vincent: Giant viruses (TWiV 873, 906, 968)
•Dickson: TWiV 960 – Getting Funky with Dan Wilson
•Rich: TWiV 927: Merchlinsky vs monkeypox
•Kathy: TWiV 958: Pass the RNA and have some venison pi
•Brianne: TWiV 869: Epstein-Barr virus and MS, a perfect storm
•Twiverse
•Letters read on TWiV 968
•Timestamps by Jolene. Thanks!

Weekly Picks

Dickson – Jazz Project: Tenor saxophone: John Coltrane/Dexter Gordon/Stan Getz: John Coltrane: Signature album: Giant Steps: Signature song: Blue Train; Dexter Gordon: Signature album: The Other Side Of Round Midnight. Signature song: Round Midnight; Stan Getz (with Charlie Byrd on guitar): Signature Album: Jazz Samba; Signature song: Desafinado
Brianne – A Full Circle Rainbow over Norway
Kathy – Frozen soap bubbles
Rich – It’s Turtles All the Way Down in the Fossil Record by Asher Elbein
Vincent – Vincent’s Top Ten Music

Listener Picks

Charles – Wayne Bergeron and Vince DiMartino MacArthur Park

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

In his weekly clinical update Dr. Griffin discusses modelling the adjustment of COVID-19 response and exit from dynamic zero-COVID in China, canine real-time detection of SARS-CoV-2 infections in the context of a mass screening event, two masks can be worse than one: N95 respirator failure caused by an overlying face mask, airflow patterns in double-occupancy patient rooms may contribute to roommate-to-roommate transmission of severe SARS-CoV-2, clinical validation of a novel T-Cell receptor sequencing assay for identification of recent or prior SARS-CoV-2 infection, antibody-dependent cellular cytotoxicity against SARS-CoV-2 Omicron sub-lineages is reduced in convalescent sera, regardless of the infecting variant, VV116 versus Nirmatrelvir–Ritonavir for oral treatment of Covid-19, Nirmatrelvir plus Ritonavir for early COVID-19 in a U.S. health system, Molnupiravir plus usual care versus usual care alone as early treatment for adults with COVID-19 at increased risk of adverse outcomes, higher dose corticosteroids in hospitalized COVID-19 patients with hypoxia but not requiring ventilatory support, FDA approves Roche’s Actemra (tocilizumab) for the treatment of COVID-19 in hospitalized adults, structural brain changes in post-acute COVID-19 patients with persistent olfactory dysfunction, persistent post–COVID-19 smell loss is associated with immune cell infiltration and altered gene expression in olfactory epithelium, epidemiology of long COVID in US adults, persistent symptoms and sequelae after SARS-CoV-2 infection not requiring hospitalization, and outpatient treatment of Covid-19 with metformin, ivermectin, and fluvoxamine and the development of Long Covid over 10-month follow-up.

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Links for this episode

• Modeling the adjustment of COVID-19 response and exit in China (Nature)
• Canine real-time detection of SARS-CoV-2 infections in mass screening events (BMJ)
• N95 respirator failure caused by an overlying face mask (ICHE)
• Airflow in patient rooms may contribute to transmission of severe SARS-CoV-2 (CID)
• Clinical validation of a T-Cell receptor for identification of recent or prior SARS-CoV-2 infection (CID)
• Antibody-dependent cellular cytotoxicity against SARS-CoV-2 Omicron sub-lineages (Cell)
• VV116 vs. Nirmatrelvir–Ritonavir for oral treatment of Covid-19 (NEJM)
• Nirmatrelvir plus Ritonavir for early COVID-19 in a U.S. health system (ACP)
• Molnupiravir as early treatment for adults with COVID-19 (The Lancet)
• Higher dose corticosteroids in hospitalized COVID-19 patients with hypoxia but not requiring ventilatory support (medRxiv)
• FDA approves Tocilizumab for the treatment of COVID-19 in hospitalized adults (Roche)
• Structural brain changes in post-acute COVID-19 patients with olfactory dysfunction (Annals)
• Paxlovid patient eligbiliity screening checklist (FDA)
• Persistent post–COVID-19 smell loss association (Science)
• Epidemiology of long COVID in US adults (CID)
• Persistent symptoms & sequelae after SARS-CoV-2 infection not requiring hospitalization (OFID)
• Outpatient treatment of COVID-19 with metformin, ivermectin, and fluvoxamine & the development of long COVID (medRxiv)
• Contribute to our MicrobeTV fundraiser at PWB
• Dr. Griffin’s treatment guide (pdf)
• Letters read on TWiV 970
• Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to daniel@microbe.tv

Carl Zimmer visits the Incubator to record a wide-ranging conversation about COVID-19, including origins, vaccines, public health responses, and impact on society.

Host: Vincent Racaniello

Guest: Carl Zimmer

Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email

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Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

TWiV reviews eukaryotic viruses recovered from ancient permafrost, a mistake made by scientists on Omicron origins, and close relatives of MERS-CoV from bats that bind ACE2 for entry into cells.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Brianne Barker

Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email

Become a patron of TWiV!

Links for this episode

• Support MicrobeTV with a Spike t-shirt (Vaccinated.us) with promo code MicrobeTV
• Positions with the Mosquito and Vector Control Division in Harris County Public Health (one and two)
• Ancient eukaryotic viruses from permafrost (bioRxiv)
• We made a mistake (Science)
• Bat MERS-like CoV bind ACE2 (Nature)
• Letters read on TWiV 968
• Timestamps by Jolene. Thanks!

Weekly Picks

Dickson – Alto Saxophone: Paul Desmond/Cannonball Adderley/Charlie Parker/Randal Despommier: Paul Desmond: Signature album: Paul Desmond:The Complete RCA Victor Recordings (1961-1965). Signature song: Take Five (Dave Brubeck Quartet). Cannonball Adderley: Signature album: The Cannonball Adderley Quintet: Mercy, Mercy, Mercy. Signature song: Mercy, Mercy, Mercy. Charlie Parker (Bird): played in many groups: Signature album: Dizzy Gillespie and His Allstars. Signature song: A Night In Tunisia; Randal Despommier: Signature album: A Midsummer Odyssey. Signature song: I Hope It’s Spring For You.
Brianne – How a See-Through Frog Hides its Red Blood from Predators (also covered in The Atlantic)
Rich – Mindfulness in Plain English by Ven. Henepola Gunaratana
Vincent – Unveiling skin macrophage dynamics explains both tattoo persistence and strenuous removal

Listener Picks

Rona – WKCR, FM 89.9 Columbia‘s radio station
Alan – XKCD Proxy Variable

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

Vincent travels to the NIH campus to speak with Jeffery Taubenberger about his career, the 1918 influenza pandemic, deciphering the genome sequence of the virus from tissues of disease victims and using it to rescue infectious virus.

Host: Vincent Racaniello

Guest: Jeffery Taubenberger

Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email

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Links for this episode

• Support MicrobeTV with a Spike t-shirt (Vaccinated.us) with promo code MicrobeTV
• Influenza 1918 pandemic questions answered (Sci Transl Med)
• Reconstructed 1918 influenza virus (Science)
• Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

Brazilian infectious diseases physician Esper Kallas returns to TWiV to discuss the state of viral diseases in his country, including those cause by Zika, dengue, and yellow fever viruses, MPOX, and SARS-CoV-2.

Hosts: Vincent Racaniello and Alan Dove

Guest: Esper Kallas

Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email

Become a patron of TWiV!

Links for this episode

• Support MicrobeTV with a Spike t-shirt (Vaccinated.us) with promo code MicrobeTV
• International Scientific Coordinator Position (agajewski at icsnicaragua.org for more info)
• Viral kinetics in sylvatic yellow fever (J Inf Dis)
• Safety and efficacy of Butanan-DV (Lancet Inf Dis)
• Immune responses to CoronaVac (Front Immunol)
• Timestamps by Jolene. Thanks!

Weekly Picks

Alan – A Voyage for Madmen
Vincent – Some favorite holiday cookies: pignoli cookies and pfeffernusse

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

In his weekly clinical update Dr. Griffin discusses Dr. Griffin discusses progress toward poliomyelitis eradication in Afghanistan, reduced risk for Mpox after receipt of 1 or 2 doses of JYNNEOS vaccine compared with risk among unvaccinated persons, reduced airborne transmission of SARS-CoV-2 BA.1 Omicron virus in Syrian hamsters, authorized updated (Bivalent) COVID-19 vaccines for children down to 6 months of age, low neutralization of SARS-CoV-2 Omicron BA.2.75.2, BQ.1.1, and XBB.1 by parental mRNA vaccine or a BA.5-bivalent booster, efficacy of antiviral agents against omicron subvariants BQ.1.1 and XBB, incidence of viral rebound after treatment with Nirmatrelvir-Ritonavir and Molnupiravir, and the effectiveness of coronavirus disease 2019 (COVID-19) vaccine in the prevention of post–COVID-19 conditions.

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Links for this episode

• Progress toward Poliomyelitis eradication in Afghanistan (CDC)
• Reduced risk for Mpox after receipt of 1 or 2 Doses of JYNNEOS vaccine (CDC)
• Reduced airborne transmission of BA.1 Omicron virus in Syrian hamsters (PLOS)
• Authorized bivalent vaccines for children down to 6 months of age (FDA)
• Low neutralization of BA.2.75.2, BQ.1.1, and XBB.1 by parental mRNA vaccine (Nature)
• Efficacy of antiviral agents against Omicron subvariants BQ.1.1 and XBB (NEJM)
• Viral rebound after treatment with Nirmatrelvir-Ritonavir and Molnupiravir (JAMA)
• Paxlovid patient eligbiliity screening checklist (FDA)
• Effectiveness of COVID-19 vaccines in prevention of post–infection conditions (ASHE)
• Contribute to our MicrobeTV fundraiser at PWB
• Dr. Griffin’s treatment guide (pdf)
• Letters read on TWiV 964
• Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to daniel@microbe.tv

Vincent travels to Cornell University to speak with Gary Whittaker about regulation by proteolytic processing of the fusion activity of the spike protein of SARS-CoV-2, and feline coronavirus transmission, replication and disease.

Hosts: Vincent Racaniello

Guest: Gary Whittaker

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Links for this episode

• SARS-CoV-2 spike and its furin cleavage site (Lancet Microbe)
• TMPRSS2 inhibitor blocks SARS-CoV-2 reproduction (Nature)
• Distinct spike proteins of feline coronaviruses (Viruses)
• Feline coronavirus and feline infectious peritonitis (J Zoo Wild Med)
• Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

Paul Offit returns to TWiV to discuss why the bivalent booster dosing story should be a cautionary tale of how not to move forward in this pandemic.

Hosts: Vincent Racaniello and Rich Condit

Guest: Paul Offit

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Links for this episode

• Antibody responses to bivalent booster (bioRxiv)
• Immunogenicity of bivalent vaccine (bioRxiv)
• Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

Astrophysicist Chiara Mingarelli joins TWiV to discuss her career and her work using pulse timing arrays to study the gravitational wave background, ripples in the fabric of spacetime that are caused by events such as the merging of black holes.

Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Angela Mingarelli

Guest: Chirara Mingarelli

Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email

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Links for this episode

• Support MicrobeTV with a Spike t-shirt (Vaccinated.us) with promo code MicrobeTV
• International Scientific Coordinator Position (agajewski at icsnicaragua.org for more info)
• Seeing the gravitational wave universe (Science)
• Timestamps by Jolene. Thanks!

Weekly Picks

Angela – OpenAI Playground and Nature Milestones: T cells
Chiara – The Biggest Ideas in the Universe by Sean Carroll
Kathy – Recycling PVC and here and here
Rich – Brome Bird Care Squirrel Buster Plus  (Bonus pick: 1971 Volvo 142 Commercial – With John Cameron Swayze)
Vincent – Journey to the Microcosmos

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

In his weekly clinical update Dr. Griffin discusses Mpox (formerly monkeypox) in women: epidemiological features and clinical characteristics of mpox cases in Spain, April to November 2022, triage of patients with Ebola virus disease, SARS-CoV-2 serology and self-reported infection among adults, serological markers of SARS-CoV-2 infection; anti-nucleocapsid antibody positivity may not be the ideal marker of natural infection in vaccinated individuals, sensitivity of anti-SARS-CoV-2 nucleocapsid protein antibody for breakthrough infections during the epidemic of the Omicron variants, effect of wearing glasses on risk of infection with SARS-CoV-2 in the community, and data-driven identification of post-acute SARS-CoV-2 infection subphenotypes.

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Links for this episode

• Mpox in women: Epidemiological features and clinical characteristics of cases (Eurosurveillance) 
• Triage of patients with Ebola virus disease (The Lancet) 
• SARS-CoV-2 serology and self-reported infection among adults (CDC)
• Serological markers of SARS-CoV-2 infection (JID) 
• Sensitivity of anti-SARS-CoV-2 nucleocapsid protein antibody (Journal of infection)
• Effect of wearing glasses on risk of infection with SARS-CoV-2 in the community (JAMA)
• Paxlovid patient eligbiliity screening checklist (FDA)
• Data-driven identification of post-acute SARS-CoV-2 infection subphenotypes (Nature)
• Contribute to our MicrobeTV fundraiser at PWB
• Dr. Griffin’s treatment guide (pdf)
• Letters read on TWiV 961
• Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to daniel@microbe.tv

Dan Wilson of Debunk the Funk joins TWiV to explain why he decided to take on science misinformation and how he critiques people who promulgate incorrect information.

Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Brianne Barker

Guest: Dan Wilson

Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email

Become a patron of TWiV!

Links for this episode

• Support MicrobeTV with a Spike t-shirt (Vaccinated.us) with promo code MicrobeTV
• International Scientific Coordinator Position (agajewski at icsnicaragua.org for more info)
• Debunk the Funk (YouTube)
• Letters read on TWiV 960
• Timestamps by Jolene. Thanks!

Weekly Picks

Dickson – Jazz Project:  InstrumentalTrumpet: Clifford Brown/Miles Davis/Winton Marsalis. Clifford Brown: Signature album: Study In Brown, Signature song: Sandu; Miles Davis: Signature albums: Kind Of Blue; Sketches Of Spain; Porgy And Bess; Miles. Signature song: Time After Time. Wynton Marsalis: Signature album: Standard Time. Signature song: Do You Know What It Means To Miss New Orleans
Brianne – Physicists Create a Wormhole
Rich – Dec 1 APOD: Artemis 1 Flight Day 13
Vincent – An Ancient Language, Once on the Brink, Is a British Isle’s Talk of the Town

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

In his weekly clinical update Dr. Griffin discusses effectiveness of influenza vaccination of pregnant women for prevention of maternal and early infant Influenza-associated hospitalizations in South Africa, a multivalent nucleoside-modified mRNA vaccine against all known influenza virus subtypes, single and 2-dose vaccinations with modified vaccinia Ankara-Bavarian Nordic induce durable B cell memory responses comparable to replicating smallpox vaccines, whether the risk of still and preterm birth is affected by the timing of symptomatic SARS-CoV-2 infection during pregnancy, medical masks versus N95 respirators for preventing COVID-19 among health care workers, alarming antibody evasion properties of rising SARS-CoV-2 BQ and XBB subvariants, real-world evidence of novel treatments for COVID-19 on mortality: a nationwide comparative cohort study of hospitalized patients in the 1^st, 2^nd, 3^rdand 4^th wave in the Netherlands, and effectiveness and safety of extended thromboprophylaxis in post-discharge patients with COVID-19.

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Links for this episode

• Effectiveness of Influenza vaccination in pregnant women (OFID)
• Multivalent nucleoside-modified mRNA vaccine against Influenza subtypes (Science)
• Single and 2-dose vaccinations with modified vaccinia Ankara-Bavarian Nordic (JID)
• Is the risk of still and preterm birth affected by the timing of symptomatic SARS-CoV-2 infection? (AJOG)
• Medical masks versus N95 respirators for preventing COVID-19 among health care workers (ACP)
• Bebtelovimab fact sheet for providers (FDA)
• Alarming antibody evasion properties of rising SARS-CoV-2 BQ and XBB subvariants (bioRxiV)
• Paxlovid patient eligbiliity screening checklist (FDA)
• Real-world evidence of novel treatments for COVID-19 on mortality (OFID)
• Effectiveness and safety of extended thromboprophylaxis in post-discharge patients with COVID-19 (Thrombosis Research)
• Contribute to our MicrobeTV fundraiser at PWB
• Dr. Griffin’s treatment guide (pdf)
• Letters read on TWiV 959
• Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to daniel@microbe.tv

The TWiV team reveals a variant SARS-CoV-2 that emerged in deer with deer-to-human transmission, and hybrid virus particles produced by co-infection with influenza virus and respiratory syncytial virus particles.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Kathy Spindler, and Brianne Barker

Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email

Become a patron of TWiV!

Links for this episode

• Support MicrobeTV with a Spike t-shirt (Vaccinated.us) with promo code MicrobeTV
• Testing and evaluation specialist (Harris County Public Health)
• Oveta Fuller tribute (YouTube)
• Divergent SARS-CoV-2 in deer (Nat Micro)
• Hybrid influenza virus and respiratory syncytial virus particles (Nat Micro)
• Letters read on TWiV 958
• Timestamps by Jolene. Thanks!

Weekly Picks

Dickson – Jazz Project: Vocals
Best female vocalists: Ella Fitzgerald/Billie Holiday, Betty Carter
Best Male Vocalists: Mel Tormé/Joe Williams/Tony Bennett
Brianne – ASV Curriculum Guidelines for Virology Courses
Kathy – The Snow Cruiser
Alan – Rescuing bats in Ukraine
Vincent – Woodpeckers: The Hole Story PBS

Listener Picks

Florencia – World of Viruses
Miguel – Foldscope

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

In his weekly clinical update Dr. Griffin discusses human monkeypox virus infection in women and non-binary individuals during the 2022 outbreaks, changes in population immunity against infection and severe disease from SARS-CoV-2 Omicron variants in the United States, updates on COVID-19–related mortality, impact of community masking on COVID-19, effectiveness of the COVID-19 vaccines against hospitalization with Omicron sub-lineages BA.4 and BA.5 in England, cardiovascular outcomes after Tixagevimab and Cilgavimab use for pre-exposure prophylaxis against COVID-19, how Paxlovid is associated with decreased hospitalization rate among adults with COVID-19, inside the mind of an anti-paxxer, and angiotensin receptor blockers for the treatment of COVID-19.

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Links for this episode

• Human monkeypox virus infection in women and non-binary individuals (The Lancet)
• Changes in population immunity against infection and severe disease from variants (Medrxiv)
• Updates on COVID-19 related mortality (CDC)
• Impact of community masking on COVID-19 (Science)
• Effectiveness of the COVID-19 vaccines against hospitalization (The Lancet)
• Cardiovascular outcomes after tixagevimab and cilgavimab use for pre-exposure prophylaxis (CID)
• Bebtelovimab fact sheet for providers (FDA)
• Paxlovid associated with decreased hospitalization among adults (CDC)
• Inside the mind of an Anti-Paxxer (The Atlantic)
• Paxlovid patient eligbiliity screening checklist (FDA)
• Angiotensin receptor blockers for the treatment of COVID-19 (BMJ)
• Long COVID treatment research study (Stanford)
• HHS long COVID study (pdf)
• Biden administration requests long COVID fu
• Contribute to our MicrobeTV fundraiser at PWB
• Dr. Griffin’s treatment guide (pdf)
• Letters read on TWiV 957
• Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to daniel@microbe.tv

Cedric and John join TWiV to discuss their research showing that a human protein derived from an ancient retrovirus infection can protect against infection by other retroviruses.

Hosts: Vincent Racaniello, Rich Condit, and Kathy Spindler

Guest: Cedric Feschotte and John Anthony Frank

Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email

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Links for this episode

• Support MicrobeTV with a Spike t-shirt (Vaccinated.us) with promo code MicrobeTV
• Cedric on TWiV 935
• Antiviral retroviral protein (Science)
• Stealing genes, facing consequences (Science)
• Letters read on TWiV 956
• Timestamps by Jolene. Thanks!

Weekly Picks

Kathy – Wastewater Dashboard
Rich – Artemis I Mission;  Artemis I launch; Artemis I Map
Vincent – Pasta Grammar

Listener Picks

Rich – Watch a virus in the moments before it attacks
Justin – Respiratory syncytial virus

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

In his weekly clinical update Dr. Griffin discusses the four things to know about RSV, the burden of respiratory syncytial virus in healthy term-born infants in Europe, the diagnostic accuracy of rapid diagnostic tests for Ebola virus disease, evaluating the accuracy of self-collected swabs for the diagnosis of monkeypox, tecovirimat is effective against human monkeypox virus in vitro at nanomolar concentrations, acute and postacute sequelae associated with SARS-CoV-2 reinfection, clinical course of SARS-CoV-2 infection and recovery in lung transplant recipients, effectiveness of a third BNT162b2 mRNA COVID-19 vaccination during pregnancy, maternal antibody response and transplacental transfer following SARS-CoV-2 infection or vaccination in pregnancy, impact of community masking on COVID-19, Lifting Universal Masking in Schools – Covid-19 Incidence among Students and Staff, systematic review of the clinical effectiveness of Tixagevimab/Cilgavimab for prophylaxis of COVID-19 in immunocompromised patients, comparative effectiveness of sotrovimab and molnupiravir for prevention of severe COVID-19 outcomes in patients in the community, early adoption of anti–SARS-CoV-2 pharmacotherapies among us veterans with mild to moderate COVID-19, evaluation of viral and symptom rebound differences between Paxlovid and untreated COVID-19 participants, monoclonal antibodies for treatment of SARS-CoV-2 infection during pregnancy, twice daily oral zinc in the treatment of patients with COVID-19, cognitive deficits in long Covid-19, severe Neuro-COVID is associated with peripheral immune signatures, autoimmunity and neurodegeneration, and long-lasting symptoms after an acute COVID-19 infection and factors associated with their resolution.

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Links for this episode

• Four things to know about RSV (Gates Foundation)
• The burden of RSV in healthy term-born infants in Europe (The Lancet)
• Diagnostic accuracy of rapid tests for Ebola (CMI)
• Accuracy of self-collected swabs for diagnosis of Monkeypox (CID)
• Tecovirimat is effective against human monkeypox virus in vitro (Nature)
• Acute and postacute sequelae associated with SARS-CoV-2 reinfection (NatureMedicine)
• SARS-CoV-2 infection and recovery in lung transplant recipients (Transplant Infectious Diseases)
• Effectiveness of third COVID-19 vaccination during pregnancy (Nature Communications)
• Maternal antibody response and transplacental transfer following infection or vaccination (CID)
• Impact of community masking on COVID-19 (Science)
• Lifting universal masking in schools (NEJM)
• Bebtelovimab fact sheet for providers (FDA)
• Effectiveness of Tixagevimab/Cilgavimab for prophylaxis of COVID-19 (medRxiv)
• Effectiveness of Sotrovimab and Molnupiravir for prevention of severe COVID-19 outcomes (BMJ)
• Early adoption of Anti–SARS-CoV-2 pharmacotherapies among US veterans (JAMA)
• PAXLOVID patient eligibility screening checklist (FDA)
• Viral and symptom rebound differences between Paxlovid and untreated COVID-19 participants (medRxiv)
• Monoclonal antibodies for treatment of SARS-CoV-2 during pregnancy (Annals of Internal Medicine)
• Remdesivir fact sheet for providers (Veklury) 
• Twice daily oral zinc in the treatment of patients with COVID-19 (CID) 
• Cognitive deficits in long COVID-19 (NEJM)
• Severe Neuro-COVID associated with peripheral immune signatures, autoimmunity and neurodegeneration (Nature Communications)
• Long-lasting symptoms after an acute COVID-19 Infection (JAMA)
• Contribute to our MicrobeTV fundraiser at PWB
• Dr. Griffin’s treatment guide (pdf)
• Letters read on TWiV 955
• Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to daniel@microbe.tv

Michael Letko joins TWiV to discuss his research on understanding cell receptors required for sarbecovirus entry, including an ACE2-dependent isolate from Russian bats that is resistant to vaccine-induced antibodies.

Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit,  Kathy Spindler, and Brianne Barker

Guest: Michael Letko

Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email

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Links for this episode

• Support MicrobeTV with a Spike t-shirt (Vaccinated.us) with promo code MicrobeTV
• Cell entry of SARS-CoV-2 and other sarbecoviruses (Nat Micro)
• ACE2-dependent sarbecovirus in Russian bats (PLoS Path)
• Letters read on TWiV 954
• Timestamps by Jolene. Thanks!

Weekly Picks

Brianne – Sometimes This Octopus is So Mad it Just Wants to Throw Something or The Cosmic Bat Nebula
Kathy – APODs  Jupiter,  Lunar Eclipse Blood Moon, Ice Giant
Rich – Mirror-image T7 transcription of chirally inverted ribosomal and functional RNAs (Wiki: Mirror Life)
Vincent – The 2022-2023 Respiratory Virus Season Hits Early and Hard: Part 1

Listener Pick

Debby – Celebrate Bob McDonald’s 30 years as host of Quirks & Quarks

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

In his weekly clinical update Dr. Griffin discusses high demand for Amoxicillin causing shortages amid child RSV surge, epidemiologic and clinical features of children and adolescents aged <18 years with monkeypox, low risk of SARS-Cov-2 transmission by fomites, nucleocapsid antigenemia is a marker of acute SARS-CoV-2 infection, impact of community masking on COVID-19,  protection against Omicron from vaccination and previous infection in a prison system, Nirmatrelvir and the risk of post-acute sequelae of COVID-19, Bebtelovimab for high-risk outpatients with early COVID-19 in a large US health system, imprinted SARS-CoV-2 humoral immunity induces convergent Omicron RBD evolution, can SARS-CoV-2 trigger new onset of autoimmune disease in adults? A case-based review, and retrospectively modeling the effects of increased global vaccine sharing on the COVID-19 pandemic.

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Links for this episode

• High demand for Amoxicillin causing shortages amid RSV surge (Washington Post)
• Epidemiologic and clinical features of children & adolescents with monkeypox (CDC)
• Low risk of SARS-Cov2 transmission by fomites (IDSA)
• Nucleocapsid Antigenemia Is a marker of acute SARS-CoV-2 Infection (JID)
• Impact of community masking on COVID-19 (Science)
• Remdesivir fact sheet for providers (Veklury) 
• Protection against Omicron from vaccination & previous infection in prison system (NEJM)
• Nirmatrelvir and the risk of post-acute sequelae of COVID-19 (medRxiv)
• Bebtelovimab for high-risk outpatients with COVID-19 (OFID)
• Imprinted SARS-CoV-2 immunity induces convergent Omicron evolution (bioRxiv)
• PAXLOVID patient eligibility screening checklist (FDA)
• Can SARS-CoV-2 trigger new onset of autoimmune disease in adults? (Cell)
• Bebtelovimab fact sheet for providers (FDA)
• Modeling the effects of global vaccine sharing on the COVID-19 pandemic (Nature)
• Contribute to our MicrobeTV fundraiser at PWB
• Dr. Griffin’s treatment guide (pdf)
• Letters read on TWiV 953
• Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to daniel@microbe.tv

Infectious Disease physician Jake Scott joins TWiV to provide a west coast clinical perspective on the evolution of the COVID-19 pandemic with respect to the impact of vaccines, antivirals, variants of concern and mortality.

Hosts: Vincent Racaniello, Alan Dove, Rich Condit,  and Kathy Spindler

Guest: Jake Scott

Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email

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Links for this episode

• Support MicrobeTV with a Spike t-shirt (Vaccinated.us) with promo code MicrobeTV
• Omicron variant reproduction ex vivo (Nature)
• Clinical outcomes with Omicron (Nat Med)
• Low neutralizing antibodies induced by bivalent booster (NEJM)
• Antibody responses to bivalent booster (bioRxiV)
• Spike T cell responses not enhanced by bivalent booster (Sci Immunol)
• Pandemic end will not be televised (BMJ)
• Conflation of infection and disease (Twitter)
• Timestamps by Jolene. Thanks!

Weekly Picks

Kathy – 10 moments for Jazz at Lincoln Center Orchestra Residency (Item 7) and Alan’s pick from TWiV 931 The Kissing Bug by Daisy Hernandez
Rich – Wilderness Safaris Photographic Competition 2022
Alan – Massachusetts Science Education Leadership Association, and the talk I gave to them last week
Vincent – Andrea Camillieri and his protagonist Inspector Montalbano

Listener Pick

Frank – Economics for the Future: Beyond the Superorganism
Debby – As routine vaccination rates fall, polio survivor hopes her story reverses urgent trend

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

In his weekly clinical update Dr. Griffin discusses Influenza incidence and vaccine effectiveness during the southern hemisphere influenza season in Chile, Nirsevimab for prevention of RSV infection in healthy late-preterm and term infants, severe Monkeypox in hospitalized patients, reinfections with different SARS-CoV-2 Omicron subvariants, impact of community masking on COVID-19 in Bangladesh, unadjuvanted intranasal spike vaccine elicits protective mucosal immunity against sarbecoviruses, antibody responses to Omicron BA.4/BA.5 bivalent mRNA vaccine booster shot, immunogenicity of bivalent mRNA vaccine boosters, long-term gastrointestinal sequelae following COVID-19, evaluation of an automated text message–based program to reduce use of acute health care resources after hospital discharge, and how in adults with COVID-19, melatonin was assessed for effects on inflammatory markers, clinical signs and symptoms, and mortality.

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Links for this episode

• Influenza incidence and vaccine effectiveness (CDC)
• Nirsevimab for prevention of RSV (NEJM)
• Severe Monkeypox in hospitalized patients (CDC)
• Reinfections with different SARS-CoV-2 Omicron subvariants (CDC)
• Impact of community masking on COVID-19 (Science)
• Vaccine elicits protective immunity against sarbecoviruses (Science)
• Antibody responses to bivalent mRNA vaccine booster shot (Biorxiv)
• Immunogenicity of bivalent mRNA vaccine boosters (Biorxiv)
• Long-term gastrointestinal sequelae following COVID-19 (CGH)
• Remdesivir fact sheet for providers (Veklury) 
• Bebtelovimab fact sheet for providers (FDA)
• Evaluation of an automated text message–based program (JAMA)
• Melatonin assessed for effects on inflammatory markers in COVID patients (Heliyon)
• PAXLOVID patient eligibility screening checklist (FDA)
• Contribute to our MicrobeTV fundraiser at PWB
• Dr. Griffin's treatment guide (pdf)
• Letters read on TWiV 951
• Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to daniel@microbe.tv

From the European Society for Clinical Virology 2022 Conference in Manchester UK, Vincent speaks with Richard Knight about prion diseases and the outbreak of bovine spongiform encephalitis that led to cases of variant Creutzfeldt-Jakob disease in humans.

Host: Vincent Racaniello

Guest: Richard Knight

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Links for this episode

• National CJD Research and Surveillance Unit
• Clinical diagnosis of human prion disease (Prog Mol Biol Trans Sci)
• Variant Creutzfeldt-Jakob disease (Handbook Clin Viral)
• Creutzfeldt-Jakob disease (Adv Exp Med Biol)
• Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

David Quammen returns to TWiV to discuss how he wrote his new book ‘Breathless’, a story about the science and the scientists behind the race to understand the pandemic coronavirus SARS-CoV-2.

Hosts: Vincent Racaniello, Rich Condit,  Kathy Spindler, and Brianne Barker

Guest: David Quammen

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Links for this episode

• Boston Quammens (TWiV 408)
• Breathless by David Quammen
• Spillover by David Quammen
• Song of the Dodo by David Quammen
• Timestamps by Jolene. Thanks!

Weekly Picks

David – Shepherd
Brianne – Adventure Aquarium
Kathy – DART results (Narrative, images)
Rich – “Elementary” TV series
Vincent – Stop passing the buck on intro science

Listener Pick

Rich – Consensus

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

In his weekly clinical update Dr. Griffin discusses the prediction of upcoming global infection burden of influenza seasons after relaxation of public health and social measures during the COVID-19 pandemic, severe COVID-19 outcomes after full vaccination of primary schedule and initial boosters, and how successful immunomodulators for treatment of COVID-19 have opened the pathway for comparative trials.

Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email

Become a patron of TWiV!

Links for this episode

• Support MicrobeTV with a Spike t-shirt at Vaccinated.US
• Prediction of upcoming global infection burden of Influenza (The LANCET)
• Severe COVID-19 outcomes after full vaccination (The LANCET)
• Successful immunomodulators for treatment of COVID-19 (CMI)
• Remdesivir fact sheet for providers (Veklury) 
• Bebtelovimab fact sheet for providers (FDA)
• PAXLOVID patient eligibility screening checklist (FDA)
• Dr. Griffin’s treatment guide (pdf)
• Contribute to Floating Doctors fundraiser at PWB
• Letters read on TWiV 947
• Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to daniel@microbe.tv

Angela Mingarelli joins TWiV to discuss whether the gut microbiota of bats confers tolerance to influenza virus infection in mice, and primate hemorrhagic fever-causing arteriviruses that can reproduce in human cells and might be capable of infecting humans.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit,  and Brianne Barker

Guest: Angela Mingarelli

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Links for this episode

• Research assistant position at FDA (pdf)
• Support MicrobeTV with a Spike t-shirt (Vaccinated.us)
• Bat gut microbiota and flu infection in mice (Transbound Emerg Dis)
• Primate hemorrhagic fever-causing arteriviruses (Cell)
• Timestamps by Jolene. Thanks!

Weekly Picks

Dickson – Jazz pics: #5. Small group.  Art Blakey and the Jazz Messenger: Art Blakey, Drums; Lee Morgan, Trumpet; Benny Golson, Tenor saxophone; Bobby Timmons, Piano; Jymie Merrit, Bass (1958-1964). Signature album: Art Blakey And The Jazz Messengers: Blues March: Signature song: Blues March
Brianne – Why Chimps and Gorillas Form Rainforest Friendships
Rich – Fly Water – FPV to New Depths
Alan – The Seven Words You Can’t Say on Television, by George Carlin, and its repercussions
Angela – Nature’s Inspiring Women in Science Award
Vincent – Mysteries of Nevada Barr and her protagonist Anna Pigeon

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

In his weekly clinical update Dr. Griffin discusses a healthcare-associated infection with Monkeypox virus, air and surface sampling for monkeypox virus in a UK hospital, misrepresentation and nonadherence regarding COVID19 public health measures, tolerability and immunogenicity of an intranasally-administered adenovirus-vectored COVID-19 vaccine, clinical, virologic, and immunologic evaluation of symptomatic rebound following Nirmatrelvir/Ritonavir treatment, early outpatient treatment with Eemdesivir in patients at high risk for severe COVID-19, Molnupiravir plus usual care versus usual care alone as early treatment for adults with COVID-19 at increased risk of adverse outcomes, and outcomes among confirmed cases and a matched comparison group in the long-COVID in Scotland.

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Become a patron of TWiV!

Links for this episode

• Research assistant position with Amy Rosenfeld (pdf)
• Support MicrobeTV with a Spike t-shirt at Vaccinated.US
• A healthcare-associated infection with monkeypox virus (OFID)
• Air and surface sampling for monkeypox virus (The Lancet)
• Misrepresentation & nonadherence in COVID-19 public health measures (JAMA)
• Tolerability and immunogenicity of a COVID-19 vaccine (The Lancet)
• PAXLOVID patient eligibility screening checklist (FDA)
• Evaluation of symptomatic disease rebound following PAXLOVID (CID)
• Outpatient treatment with Remdesivir in patients at high risk (OFID)
• Remdesivir fact sheet for providers (Veklury) 
• Bebtelovimab fact sheet for providers (FDA)
• Molnupiravir as early treatment for adults with COVID-19 (SSRN)
• Outcomes among confirmed cases and matched comparison group in long-COVID (Nature)
• Dr. Griffin’s treatment guide (pdf)
• Contribute to Floating Doctors fundraiser at PWB
• Letters read on TWiV 945
• Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to daniel@microbe.tv

Kathryn Hanley joins TWiV to discuss her career and the research in her laboratory on the molecular biology, evolution and ecology of emerging RNA viruses and their insect vectors.

Hosts: Vincent Racaniello, Rich Condit,  and Kathy Spindler

Guest: Kathryn Hanley

Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email

Become a patron of TWiV!

Links for this episode

• Research assistant position at FDA (pdf)
• Support MicrobeTV with a Spike t-shirt (Vaccinated.us)
• One bite is all it takes (TWiV 587)
• CREATE-NEO
• Shifts in Borneo mosquito diversity (Ecosphere)
• VSV surveillance along Rio Grande (PLoS Path)
• Virulence a trade-off between transmission and clearance (Viruses)
• West Nile virus disease indicators (Viruses)
• Identify mosquito meals by barcoding (Trop Med Inf Dis)
• SkitoSnack (Sci Rep)
• Neal Nathanson dies (Baltimore Sun)
• VRR interview with Neal Nathanson (YouTube)
• Letters read on TWiV 944
• Timestamps by Jolene. Thanks!

Weekly Picks

Kathy – Car Talk Puzzler Archive
Rich – The Molecular Biologist Who Exposed the Soviet Union”  by Sean B. Carroll
Vincent – NYU Chemistry prof fired because his course was too difficult

Listener Pick

Jack – The Everything Virus

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

In his weekly clinical update Dr. Griffin discusses high points of the multi-national monkeypox outbreaks, monkeypox virus genome mutations, possible occupational infection of healthcare workers with monkeypox virus, rates of monkeypox cases by vaccination status, protection of SARS-CoV-2 infection against reinfection, Paxlovid significantly reduces COVID-19 hospitalizations and deaths, and rebound in COVID19 with and without Paxlovid treatment.

Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email

Become a patron of TWiV!

Links for this episode

• Research assistant position with Amy Rosenfeld (pdf)
• Support MicrobeTV with a Spike t-shirt at Vaccinated.US
• Multi-National Monkeypox outbreak (CDC)
• Mutation of the Monkeypox Virus (Nature)
• Occupational infection of Healthcare workers with Monkeypox (CDC)
• Rates of Monkeypox cases by vaccination status (CDC)
• Protection of SARS-CoV-2 natural infection against reinfection (CMI)
• PAXLOVID patient eligibility screening checklist (FDA)
• Paxlovid reduces COVID19 hospitalizations & deaths (EPIC)
• Paxlovid rebound in COVID19 (NEJM)
• Remdesivir fact sheet for providers (Veklury) 
• Bebtelovimab fact sheet for providers (FDA)
• Dr. Griffin’s treatment guide (pdf)
• Contribute to Floating Doctors fundraiser at PWB
• Letters read on TWiV 943
• Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to daniel@microbe.tv

Laurie Garrett discusses the role of wastewater testing in public health and her idea of a device that could be used by anyone to analyze water samples.

This podcast is not an episode of TWiV, but I thought it would be of interest to listeners.

Laurie Garrett and Vincent Racaniello

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Links for this episode

• Support MicrobeTV with a Spike t-shirt (Vaccinated.us)
• Coliform testing of water in Florida (YouTube)
• Declining cost of genome sequencing (Illumina)
• National wastewater surveillance system (CDC)
• Advances in detection of viruses in wastewater (Med Express)
• Wastewater monitoring comes of age (Nature)
• Monitoring monkeypox virus in wastewater (Med Express)
• Poliovirus wastewater surveillance in NY (Dept of Health)
• Wastewater surveillance in NYS (Dept of Health)
• Estimating norovirus infections through wastewater (Water Res)
• Estimating antimicrobial resistant bacteria through latrine water (Antimicro Res Inf Control)

Intro music is by Ronald Jenkees

Send your questions and comments to twiv@microbe.tv

Paul Offit returns to TWiV for a discussion of SARS-CoV-2 bivalent boosters containing ancestral and Omicron spike mRNAs, including their composition, why they are being recommended by CDC, and who would benefit the most from them.

Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit,  Kathy Spindler, and Brianne Barker

Guest: Paul Offit

Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email

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Links for this episode

• Research assistant position at FDA (pdf)
• Support MicrobeTV with a Spike t-shirt (Vaccinated.us)
• CDC oversells bivalent booster (Wall St Journal)
• FDA authorizes bivalent COVID-19 booster
• Letters read on TWiV 942
• Timestamps by Jolene. Thanks!

Weekly Picks

Dickson – Jazz favorites: Small group #4: Gerry Mulligan Quartet with Chet Baker: Gerry Mulligan, Baritone saxophone; Carson Smith, Bass; Larry Bunker, Drums, Chet Baker, Trumpet. Signature album: The Best Of The Gerry Mulligan Quartet With Chet Baker: Signature song: My Funny Valentine.

Second pick: Wonder: Childhood and the Lifelong love of Science. Frank C. Keil.

Brianne – A Devious Cellular Trick Cancers Can Use to Escape Your Immune System
Kathy – Durable antimicrobial coating
Rich – One Health
Vincent – The works of Dashiell Hammett

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

In his weekly clinical update Dr. Griffin discusses increased acute respiratory illnesses among children and adolescents, estimates of monkeypox incubation period, generation time, and reproduction number, rapid increase in suspected SARS-CoV-2 reinfections, interim infection prevention and control recommendations for healthcare personnel during COVID-19, SARS-CoV-2 secondary attack rates in vaccinated and unvaccinated household contacts during replacement of delta with omicron variant, breakthrough infection by SARS-CoV-2 delta and omicron variants elicited immune response comparable to mRNA booster vaccination, interval between prior SARS-CoV-2 infection and booster vaccination impacts magnitude and quality of antibody and B cell responses, further humoral immunity evasion of emerging SARS-CoV-2 BA.4 and BA.5 subvariants, short-course early outpatient Remdesivir prevents severe disease due to COVID-19 in organ transplant recipients during the Omicron BA.2 wave, effectiveness of Molnupiravir in high risk patients, and primary care and a distinct symptom pattern for long COVID.

Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email

Become a patron of TWiV!

Links for this episode

• Research assistant position with Amy Rosenfeld (pdf)
• Support MicrobeTV with a Spike t-shirt at Vaccinated.US
• Increase in Acute Respiratory illnesses among children and adolescents (CDC)
• Estimates of Monkeypox incubation period, generation time, reproduction number (CDC)
• Rapid increase in suspected SARS-CoV-2 reinfections (CDC)
• Infection prevention and control recommendations for healthcare providers (CDC)
• SARS-CoV-2 attack rate in vaccinated and unvaccinated household contacts (CDC)
• Breakthrough Infection by variants elicited immune response comparable to vaccine (JID)
• Interval between prior SARS-CoV-2 infection and booster vaccination impacts (CELL)
• Humoral immunity evasion of BA.4 and BA.5 subvariants (The Lancet)
• Outpatient Remdesivir prevents severe disease in organ transplant recipients (Am J Transplant) 
• PAXLOVID patient eligibility screening checklist (FDA)
• Remdesivir fact sheet for providers (Veklury) 
• Bebtelovimab fact sheet for providers (FDA)
• Effectiveness of Molnupiravir in high risk patients (CID)
• Update on Long COVID for primary care (BMJ)
• Distinct symptom pattern emerges for COVID-19 long-haul (Scientific Reports)
• Dr. Griffin’s treatment guide (pdf)
• Contribute to Floating Doctors fundraiser at PWB
• Letters read on TWiV 941
• Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to daniel@microbe.tv

Eddie Holmes joins TWiV to discuss his role in the first release of the SARS-CoV-2 genome sequence, what really happened during the infamous Fauci teleconference, and evidence that the virus came from Nature and not from a lab.

Hosts: Vincent Racaniello and Dickson Despommier

Guest: Eddie Holmes

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Links for this episode

• Research assistant position at FDA (pdf)
• Support MicrobeTV with a Spike t-shirt (Vaccinated.us)
• Novel 2019 coronavirus genome (Virological)
• Proximal origins of SARS-CoV-2 (Virological and Nature versions)
• Original paper on new CoV in China that led to genome sequence release (Nature)
• Reporting on Fauci teleconference (USA Today)
• Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

Tom Monath joins TWiV to discuss his wide-ranging career that includes medicine, field work and vaccine development while working for the US government, the US military, and multiple biotechnology companies.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Rich Condit

Guest: Tom Monath

Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email

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Links for this episode

• Research assistant position at FDA (pdf)
• Support MicrobeTV with a Spike t-shirt (Vaccinated.us)
• Fever by John Fuller (Amazon)
• Crozet BioPharma
• Timestamps by Jolene. Thanks!

Weekly Picks

Dickson – Jazz – Small Group #3:  Dave Brubeck Quartet. Dave Brubeck, Piano; Joe Morello, Drums, Paul Desmond, Alto Saxophone, Eugene Wright, Bass: Signature Album: Time Out. Signature Song: Take Five.
Rich – Wilderness Safaris (wiki)
Alan – Madhouse at the End of the Earth, by Julian Sancton
Vincent – Raymond Chandler and his protagonist Philip Marlowe.

Listener Picks

Philip – Students bitten by bats inside college residence hall

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

In his weekly clinical update Dr. Griffin reviews the public health response to poliovirus in New York, impact of mandatory influenza vaccination, monkeypox in a young infant, health care worker exposure to monkeypox virus, monkeypox testing delays, transmission potential of monkeypox virus, TPOXX trial for monkeypox, detection of SARS-CoV-2 subgenomic mRNA, mucosal IgA against SARS-CoV-2, BNT262b2 against Omicron, awareness and use of SARS-CoV-2 antivirals, comparable outcomes for Bebtelovimab and Nirmatrelvir, and COVID-19 and Alzheimer's disease.

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Links for this episode

• Support MicrobeTV with a Spike t-shirt at Vaccinated.US
• Research assistant position with Amy Rosenfeld (pdf)
• Public health response to polio in New York (MMWR)
• Impact of mandatory influenza vaccination (Cambridge Core)
• Monkeypox in young infant (MMWR)
• Health care worker exposure to monkeypox virus (MMWR)
• Monkeypox testing delays (Cambridge Core)
• Monkeypox in smallpox vaccinated patient (Emerg Inf Dis)
• Transmission potential of monkeypox virus (Int J Epidemiol)
• TPOXX trial for monkeypox (ACTG)
• SARS-CoV-2 subgenomic mRNA detection (J Inf Dis)
• Quantitative SARS-CoV-2 subgenomic mRNA for Remdesivir treatment (Clin Inf Dis)
• Anti-spike mucosal IgA (NEJM)
• BNT262bs against Omicron sublineages (NEJM)
• Awareness and use of SARS-CoV-2 antivirals (Clin Inf Dis)
• Comparable outcomes for Bebtelovimab and Nirmatrelvir treatment (J Inf Dis)
• COVID-19 and Alzheimer's disease (J Alzheimer's Dis)
• Dr. Griffin's treatment guide (pdf)
• Contribute to Floating Doctors fundraiser at PWB
• Letters read on TWiV 938
• Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to daniel@microbe.tv

From the European Society for Clinical Virology 2022 Conference in Manchester UK, Vincent speaks with Emma Thomson about the recent outbreak of pediatric hepatitis of unknown etiology and the finding that it is linked to infection by adenovirus-associated virus 2.

Hosts: Vincent Racaniello

Guest: Emma Thomson

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Links for this episode

• Thomson laboratory
• Emma on TWiV 188 and TWiV 341
• AAV2-associated pediatric hepatitis (bioRxiv)
• Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

In his weekly clinical update Dr. Griffin discusses detection of a highly divergent type 3 vaccine-derived poliovirus in a child with a severe primary immunodeficiency disorder, severe respiratory illnesses associated with rhinoviruses and/or enteroviruses including EV-D68, effects of vaccination and previous infection on Omicron infections in children, COVID-19-associated hospitalizations among vaccinated and unvaccinated adults 18 years or older in 13 US states, effectiveness of COVID-19 vaccines over time prior to Omicron emergence in Ontario, Canada, nasal IgA wanes 9 months after hospitalization with COVID-19 and is not induced by subsequent vaccination,  resistance of SARS-CoV-2 Omicron subvariant BA.4.6 to antibody neutralization, persistent circulating SARS-CoV-2 spike associated with post-acute COVID-19 sequelae, and impact of COVID-19 vaccination on the risk of developing long-covid and on existing long-covid symptoms.

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Links for this episode

• Detection of poliovirus in immunosuppressed child (CDC)
• Severe respiratory illnesses associated with rhinoviruses and/or enteroviruses (CDC)
• Effects of vaccination and previous Omicron infection in children (NEJM)
• COVID-19 hospitalizations among vaccinated and unvaccinated adults (JAMA)
• Effectiveness of vaccines prior to Omicron (IDSA)
• Nasal iga wanes 9 months after COVID hospitalization (medRxiv)
• Resistance of Omicron subvariant to antibody neutralization (BioRxiv)
• PAXLOVID patient eligibility screening checklist (FDA)
• Remdesivir fact sheet for providers (Veklury) 
• Bebtelovimab fact sheet for providers (FDA)
• SARS-CoV-2 spike is associated with post-acute sequelae (IDSA)
• Impact of vaccination on the risk of developing long-COVID (The Lancet)
• Contribute to Floating Doctors fundraiser at PWB
• Dr. Griffin's treatment guide (pdf)
• Letters read on TWiV 936
• Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to daniel@microbe.tv

Vincent travels to Cornell University to speak with Cedric about his career and his research on mobile genetic elements such as transposons and endogenous viruses and how they have shaped the evolution of nearly all organisms.

Hosts: Vincent Racaniello

Guest: Cedric Feschotte

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Links for this episode

• Feschotte laboratory
• Field guide to transposable elements (Ann Rev Genetics)
• Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

In his weekly clinical update Dr. Griffin discusses variant influenza virus infections: recommendations for identification, treatment, and prevention for summer and fall 2022, low levels of monkeypox virus neutralizing antibodies after MVA-BN vaccination in healthy individuals, using the right tools at the right time for SARS-COV-2 infection, onset and window of SARS-COV-2 infectiousness and temporal correlation with symptom onset, transmission of SARS-COV-2: a review of viral, host, and environmental factors, antibody persistence and safety through 6 months after heterologous orally aerosolized Ad5-nCoV in individuals primed with two-dose vaccine, timely administration of tocilizumab improves outcome of hospitalized COVID-19 patients, administration of anti–SARS-COV-2 monoclonal antibodies after US Food and Drug Administration deauthorization, and clinical and genetic risk factors for acute incident venous thromboembolism in ambulatory patients with COVID-19.

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Links for this episode

• 2022 recommendations for Influenza infections (CDC)
• Low levels of monkeypox neutralizing antibodies after vaccination (medRxiv)
• Using the right tools during SARS-CoV-2 infection (ESMED)
• Onset and window of SARS-CoV-2 infectiousness with symptom onset (The LANCET)
• Transmission of SARS-COV-2 (ACP Journals)
• PAXLOVID patient eligibility screening checklist (FDA)
• Remdesivir fact sheet for providers (Veklury) 
• Bebtelovimab fact sheet for providers (FDA)
• Administration of anti–SARS-COV-2 monoclonal antibodies (JAMA)
• Clinical and genetic risk factors for thromboembolism (JAMA)
• Administration of tocilizumab improves outcomes (PLOS One)
• Antibody persistence and safety through 6 months (medRxiv)
• Improve risk score for thromboembolism (mdCalc)
• Contribute to Floating Doctors fundraiser at PWB
• Dr. Griffin’s treatment guide (pdf)
• Letters read on TWiV 934
• Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to daniel@microbe.tv

TWiV discusses a new henipavirus from fruit bats in Madagascar, and attenuation of SARS-CoV-2 Omicron disease in mice caused by genome mutations outside of the spike protein coding region.

Hosts: Vincent Racaniello, Dickson Despommier, Kathy Spindler, and Brianne Barker

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Links for this episode

• Research assistant position at FDA (pdf)
• Beijerinck virology prize (KNAW)
• Nipah virus vaccine (TWiV 618)
• Novel henipavirus from Madagascar (J Viral)
• Spike-independent Omicron attenuation in mice (Cell Rep)
• Letters read on TWiV 933
• Timestamps by Jolene. Thanks!

Weekly Picks

Dickson – Small groups: 3.  Modern Jazz Quartet. Signature song: Skating in Central Park. Signature album: Django.
Brianne – To Prevent a Martian Plague, NASA Needs to Build a Very Special Lab
Kathy – Physics Girl – Overnight in the Most Remote Camp on Earth
Vincent – Lab leaders wrestle with paucity of postdocs

Listener Picks

Gary – Stan Kenton Orchestra
Miguel – Microsoft Premonition

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

In his weekly clinical update Dr. Griffin discusses vaccine effectiveness against influenza illness in children, clinical manifestations of infection with poliovirus, spike protein-independent attenuation of SARS-CoV-2 Omicron variant in laboratory mice, concordance of SARS-CoV-2 results in self-collected nasal swabs vs swabs collected by health care workers in children and adolescents, probable animal-to-human transmission of SARS-CoV-2 causing a pet shop-related outbreak, laboratory-confirmed COVID-19–associated hospitalizations among adults during BA.2 variant, SARS-CoV-2 specific T-cells and antibodies, Nirmatrelvir use and outcomes during the Omicron surge, real-world effectiveness of early Molnupiravir or Nirmatrelvir–ritonavir in hospitalized patients, and distinguishing features of long COVID.

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Links for this episode

• Vaccine effectiveness against Influenza illness in children (CID)
• Clinical manifestations of infection with Polio (JAMA)
• Characteristics of deaths among fully vaccinated persons with Coronavirus (CID)
• Spike protein attenuation of Omicron Variant in lab mice (Cell Reports)
• Concordance of SARS-CoV-2 results in nasal swabs self-collected vs healthcare collected (JAMA)
• Probable animal-to-human transmission of Sars-Cov-2 (CID)
• PAXLOVID patient eligibility screening checklist (FDA)
• Remdesivir fact sheet for providers (Veklury) 
• Bebtelovimab fact sheet for providers (FDA)
• COVID-19–associated hospitalizations among adults during BA.2 variant (CDC)
• Sars-Cov-2 specific T-cells and antibodies (CID)
• Nirmatrelvir use and outcomes during the Omicron surge (NEJM)
• Effectiveness of early Molnupiravir or Nirmatrelvir–Ritonavir in hospitalized patients (The Lancet)
• Distinguishing features of long COVID (medRxiv)
• Unexplained post-acute infection syndromes (Nature Med)
• Contribute to Floating Doctors fundraiser at PWB
• Dr. Griffin’s treatment guide (pdf)
• Letters read on TWiV 932
• Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to daniel@microbe.tv

TWiV reviews the genetic characterization of a new strain of type 2 oral polio vaccine and its implications for eradication, and how a polymorphism in humans comprising a single amino acid change in an antibody molecule regulates vaccine elicitation of broadly neutralizing antibodies against influenza virus HA.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Kathy Spindler, and Brianne Barker

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Links for this episode

• Characterization of novel OPV2 from humans (MMWR)
• Engineering nOPV2 (TWiV 756)
• Genome sequence of Rockland County NY OPV2 isolate (Genbank)
• Allelic polymorphism and vaccine induction of influenza virus bnAbs (Immunity)
• Letters read on TWiV 931
• Timestamps by Jolene. Thanks!

Weekly Picks

Dickson - Small groups: 1.  Miles Davis Quintet. Signature album: Kind Of Blue. Signature song: So What.
Brianne - World Excel Championships
Kathy - Lyre bird background and video
Alan – The Kissing Bug, by Daisy Hernandez
Vincent -Five top detective fiction writers. #1 Martin Beck by Maj Sjöwall and Per Wahlöö

Listener Picks

John – Fevers, Feuds and Diamonds: Ebola and the Ravages of History by Paul Farmer
Carol – The Social Dilemma

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

In his weekly clinical update Dr. Griffin discusses antibody response against nonpoliovirus enteroviruses, clinical presentation and virological assessment of confirmed human monkeypox virus cases in Spain, object and surface contamination with monkeypox virus, monkeypox virus infection in humans across 16 countries, clinical characteristics of ambulatory and hospitalized patients with monkeypox virus infection, compassionate use of Tecovirimat for the treatment of monkeypox infection, monitoring of Pfizer-BioNTech vaccine among children, Pfizer and BioNTech announce updated vaccine data supporting efficacy in children, direct capture of neutralized RBD enables rapid point-of-care assessment of SARS-CoV-2 neutralizing antibody titer, Pfizer and BioNTech submit application for bivalent vaccine, and Oral Nirmatrelvir and Ritonavir in non-hospitalized vaccinated patients with COVID-19.

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Links for this episode

• Antibody response against nonpoliovirus enteroviruses (ASM)
• Clinical presentation of Monkeypox cases in Spain (The Lancet)
• Object and surface contamination with Monkeypox virus infection (CDC)
• Environmental persistence of Monkeypox virus (Emerg Inf Dis)
• Monkeypox virus infection across 16 countries (NEJM)
• Clinical characteristics of hospitalization patients with Monkeypox (CMI)
• Usage of Tecovirimat for treatment of Monkeypox infection (JAMA)
• PAXLOVID patient eligibility screening checklist (FDA)
• Remdesivir fact sheet for providers (Veklury) 
• Bebtelovimab fact sheet for providers (FDA)
• Monitoring of Pfizer-BioNTech vaccine among children (CDC)
• Pfizer and BioNTech announce updated vaccine data (Pfizer)
• Capture of RBD enables point of care assessment (Science Direct)
• Pfizer and BioNTech submit application for bivalent vaccine (Pfizer)
• PAXLOVID in non-hospitalized vaccinated patients 
• Contribute to Floating Doctors fundraiser at PWB
• Dr. Griffin’s treatment guide (pdf)
• Letters read on TWiV 930
• Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to daniel@microbe.tv

Andy Slavitt joins TWiV to discuss his book, Preventable and how failures in leadership, politics, and selfishness doomed the U.S. response to SARS-CoV-2.

Hosts: Vincent Racaniello, Dickson Despommier, Kathy Spindler, and Brianne Barker

Guest: Andy Slavitt

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Links for this episode

• In the Bubble podcast
• Preventable (Amazon)
• Letters read on TWiV 929
• Timestamps by Jolene. Thanks!

Weekly Picks

Dickson – Best big band #5: 1. Glenn Miller’s Orchestra -1940-1944: Signature song: In The Mood. Signature album: An Album Of Outstanding Arrangements
Brianne – Cross-stitched Microbes
Kathy – Time trials for bottle emptying
Alan – Meow Parlor
Vincent – VIRUS x1,000,000 (2022) by Drew Berry wehi.tv

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

In his weekly clinical update Dr. Griffin discusses the public health response to a polio case in a unvaccinated NY state resident, human to dog transmission of monkeypox virus, Tecovirimat and the treatment of monkeypox, detection of asymptomatic monkeypox virus infections among male sexual health clinic attendees in Belgium, what to do if you are exposed to SARS-CoV-2 and isolation and precautions for people with COVID-19, risk of SARS-CoV-2 infection in health care workers, effectiveness of HEPA filters at removing infectious SARS-CoV-2 from the air, Pfizer reports additional data on Paxlovid, hospitalization encounters for infection after Paxlovid, a randomized trial of Metformin, Ivermectin, and Fluvoxamine, and readmissions, post-discharge mortality and sustained recovery among patients admitted to hospital with COVID-19.

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Links for this episode

• Response to Polio case in an unvaccinated person in New York (CDC)
• Human to dog transmission of Monkeypox virus (The Lancet)
• Tecovirimat for the treatment of Monkeypox (NEJM)
• Detection of asymptomatic Monkeypox among Belgian men (Nature Medicine)
• Exposure to disease and precautions (CDC)
• Risk of infection in healthcare workers (JAMA)
• Effectiveness of HEPA filters (ASM)
• PAXLOVID patient eligibility screening checklist (FDA)
• Remdesivir fact sheet for providers (Veklury) 
• Bebtelovimab fact sheet for providers (FDA)
• Pfizer reports additional data on PAXLOVID (Pfizer)
• Hospitalization encounters for infection after PAXLOVID (CDC)
• Trial for Metformin, Ivermectin, and Fluvoxamine (NEJM)
• Readmission, post-discharge mortality, recovery among patients (IDSA)
• Contribute to Floating Doctors fundraiser at PWB
• Dr. Griffin’s treatment guide (pdf)
• Letters read on TWiV 928
• Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to daniel@microbe.tv

Michael Merchlinsky joins TWiV to discuss the development of two smallpox antiviral drugs and two smallpox vaccines and their uses during the monkeypox outbreak.

Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Kathy Spindler

Guest: Michael Merchlinsky

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Links for this episode

• Michael on Anything but academic (TWiM 145)
• Development of Tecoviromat (TPOXX) (Antiviral Res)
• Use of Jynneos vaccine (MMWR)
• Limitations of Tecoviromat (NEJM)
• Poliovirus in NYC wastewater (NY Times)
• Letters read on TWiV 927
• Timestamps by Jolene. Thanks!

Weekly Picks

Dickson – Duke Ellington and his Orchestra. Signature song: Take The A Train; Signature album: Black, Brown, And Beige and Herding Cats: Harlem 1958
Kathy – How the US Postal Service reads terrible handwriting
Rich – JWST/chorizo gag
Vincent – Bat Conservation Trust

Listener Picks

Bill – The End of Manual Transmission
J – How the Krebs cycle powers life and death – with Nick Lane

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

In his weekly clinical update Dr. Griffin discusses guidance for prevention and treatment of monkeypox, post-infectious symptoms among children and adolescents, profiling post-infectious syndromes of different variants, comparison of vaccine Ankara vs intradermal routes of administration, infection in vaccinated individuals treated with or without PAXLOVID, duration of symptoms with positive rapid antigen after infection, epidemiologic characteristics of monkeypox, and sequelae of post-acute infection.

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Links for this episode

• Guidance for prevention & treatment of Monkeypox (CDC)
• Post-infection symptoms among children and adolescents (CDC) 
• Profiling post-infection syndromes in different variants (medRxiv)
• Comparison  of vaccinia Ankara (MVA) vs intradermal routes of administration (NIH)
• PAXLOVID patient eligibility screening checklist (FDA)
• Remdesivir fact sheet for providers (Veklury) 
• Bebtelovimab fact sheet for providers (FDA)
• Infection in vaccinated individuals treated with or without PAXLOVID (medRxiv)
• Duration of symptoms with positive rapid antigen after infection (J Virological Methods)
• Epidemiologic characteristics of Monkeypox (CDC)
• Sequelae of post-acute infection (ScienceDirect) 
• Contribute to Floating Doctors fundraiser at PWB
• Dr. Griffin’s treatment guide (pdf)
• Letters read on TWiV 926
• Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to daniel@microbe.tv

TWiV discusses monkeypox virus, poliovirus in NY, Marburg virus in Ghana, ancient herpes simplex virus type 1 genomes, and immunogenicity of different combinations of SARS-CoV-2 vaccines.

Hosts: Vincent Racaniello, Alan Dove, Rich Condit, Kathy Spindler, and Brianne Barker

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Links for this episode

• How monkeypox virus spreads (CDC)
• Vaccination against monkeypox virus (CDC)
• Monkeypox case trends (CDC)
• Polio in New York State (NY Dept of Health)
• Poliovirus in NY wastewater (NBC New York)
• Marburg disease in Ghana (WHO)
• Ancient herpesvirus genomes (Sci Adv)
• Combinations of SARS-CoV-2 vaccines (Cell Rep Medicine)
• Timestamps by Jolene. Thanks!

Weekly Picks

Brianne – Everyone Loses on Jeopardy Eventually
Kathy – Climate spiral  followed by Carl Sagan
Rich – Most Popular Desktop Browsers 1993 – 2022
Alan – I Am Promise
Vincent – Polio in New York

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

In his weekly clinical update Dr. Griffin discusses Tecovirimat for treatment of monkeypox, the safety and acceptance of vaccination after multisystem inflammatory syndrome, variants in solid organ transplant recipients, masks for prevention of respiratory virus infections, pre-exposure prophylaxis with Evusheld, the association between Evusheld administration and infection,  if repeat administration of casirivimab and imdevimab is well-tolerated, viral and symptom rebound in untreated infection, extended Remdesivir infusion for persistent infection, Baricitinib in patients admitted with infection, and cognitive impairment 13 months after hospitalization.

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Links for this episode

• Armchair Expert with Malcolm Gladwell
• Tecovirimat for treatment of monkeypox (OFID)
• Safety and acceptance of vaccination after MIS (JPID)
• Is variant less virulent in solid organ transplant recipients (Transplant Infectious Disease)
• Masks for prevention of respiratory virus infections (Annals of Internal Medicine)
• Pre-exposure prophylaxis with Evusheld (CMI)
• Association between Evusheld administration and infection (CID)
• Repeat administration of casirivimab and imdevimab well-tolerated (ISID)
• PAXLOVID patient eligibility screening checklist (FDA)
• Remdesivir fact sheet for providers (Veklury) 
• Bebtelovimab fact sheet for providers (FDA)
• Viral and symptom rebound in untreated infection (medRxiv)
• Extended Remdesivir infusion for persistent infection (OFID)
• Baricitinib in patients admitted with infection (The Lancet)
• Cognitive Impairment 13 months after hospitalization (OFID)
• Contribute to Floating Doctors fundraiser at PWB
• Dr. Griffin’s treatment guide (pdf)
• Letters read on TWiV 924
• Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to daniel@microbe.tv

From The Third International Symposium on Infectious Diseases of Bats in Ft. Collins, Colorado, TWiV speaks with Vincent Munster and Raina Plowright about their careers and their research on bats, bat viruses, bat ecology and spillover events.

Hosts: Vincent Racaniello and Brianne Barker

Guests: Vincent Munster and Raina Plowright

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Links for this episode

• Novel Hendra virus variant in Australia (Emerg Inf Dis)
• Nipah virus detection after spillover events (Emerg Inf Dis)
• Want to prevent pandemics? Stop spillovers (Nature)
• Ecological countermeasures to prevent zoonoses (Restor Ecol)
• Land-use induced spillovers (Lancet Planet Health)
• Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

In his weekly clinical update Dr. Griffin discusses monkeypox infection in humans across 16 countries, pregnancy outcomes after SARS-CoV-2 infection by trimester, vaccination intent and belief, antiviral drug treatment for non-severe disease, the association of smoking with infected hospitalized patients, the association of Paxlovid on negative conversion rates among high-risk patients with COVID-19, safety and efficacy of Molnupiravir, usage of enoxaparin for primary thromboprophylaxis, statin and aspirin as therapy in infected patients, post-COVID-19 conditions among children 90 days after SARS-CoV-2 Infection, and symptoms and risk factors for long COVID in non-hospitalized adults.

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Links for this episode

• Monkeypox infection in humans (NEJM)
• Pregnancy outcomes after infection (PLOS ONE)
• Vaccination intent and belief (Emerging Infectious Diseases)
• Antiviral drug treatment for non-severe disease (CMAJ)
• Smoking association with infected hospitalized patients (PLOS ONE)
• Impact of Paxlovid on negative conversion rates (CID)
• PAXLOVID patient eligibility screening checklist (FDA)
• Remdesivir fact sheet for providers (Veklury) 
• Bebtelovimab fact sheet for providers (FDA)
• Safety and efficacy of Molnupiravir (Journal of Medical Virology)
• Enoxaparin for primary thromboprophylaxis (OVID)
• Statin and aspirin as therapy in infected patients (BMC)
• Post-infection conditions among children (JAMA)
• Symptoms and risk factors for long-term effects (Nature Medicine) 
• Contribute to FIMRC fundraiser at PWB
• Dr. Griffin’s treatment guide (pdf)
• Letters read on TWiV 922
• Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to daniel@microbe.tv

From ASV 2022 in Madison, Wisconsin, TWiV speaks with Pamela Bjorkman and Andy Mehle about their careers and their research on influenza virus, HIV-1, SARS-CoV-2, and influenza virus.

Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker

Guests: Pamela Bjorkman and Andy Mehle

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Links for this episode

• Bjorkman laboratory
• Mehle laboratory
• Finding the groove (Nat Immunol)
• Structure of HLA-A2 (Nat Immunol)
• Mosaic RBD nanoparticles (Science)
• Influenza virus PB2 627 (J Virol)
• ANP32B or not to be (eLife)
• Influenza virus compartmentalization (Nat Commun)
• Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

In COVID-19 clinical update #124, Dr. Griffin discusses the results of a variant vaccine booster trial, the neutralization of variant sub-lineages by Novavax, the CDC’s recommendation of Novavax’s COVID-19 vaccine in adults, Paxlovid in patients who are immunocompromised and hospitalized, and inhaled fluticasone for outpatient treatment.

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Links for this episode

• Variant vaccine boosters trial (medRxiv)
• Novavax triggers neutralization of variant sub-lineages (bioRxiv)
• CDC recommends Novavax (CDC)
• Paxlovid in patients who are immunocompromised and hospitalized (The Lancet)
• Inhaled Fluticasone for outpatient treatment (medRxiv)
• PAXLOVID patient eligibility screening checklist (FDA)
• Remdesivir fact sheet for providers (Veklury) 
• Bebtelovimab fact sheet for providers (FDA)
• Contribute to FIMRC fundraiser at PWB
• Dr. Griffin’s treatment guide (pdf)
• Letters read on TWiV 921
• Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to daniel@microbe.tv

TWiV reviews the FDA decision to update COVID-19 vaccine boosters in the fall, the meaning of fatigue with respect to long COVID, and a skin volatile induced by flavivirus reproduction that attracts mosquitoes to the infected host.

Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker

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Links for this episode

• COVID-19 vaccine booster composition (FDA)
• Settling in for the long haul (Crooked Timber)
• Flavivirus-induced skin volatile attracts mosquitoes (Cell)
• Letters read on TWiV 919
• Timestamps by Jolene. Thanks!

Weekly Picks

Brianne – Redactle
Kathy – Kirigami paper replacing plastic bubble wrap
Rich – First Images from the James Webb Space Telescope (Gravitational lens; Einstein ring)
Vincent – Spotted lanternfly

Listener Picks

Ann – NASA Engineer Who Made the James Webb Space Telescope Work
Sonrisa – Aloft – the pleasures and risks of flying

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

In COVID-19 clinical update #123, Dr. Griffin discusses rapid diagnostic testing in response to the monkeypox outbreak, leading causes of death in the US during the COVID-19 pandemic, antibody evasion by subvariants, broadly-neutralizing antibodies against emerging variants, factors associated with severe outcomes among hospitalized immunocompromised adults, measurement of the burden of hospitalizations during the pandemic, parental vaccine hesitancy in diverse communities, evaluating saliva sampling to improve access to diagnosis in low-resource settings, oral sabizabulin for high-risk hospitalized adults, lower-risk of multisystem inflammatory syndrome in children, and neurovascular injury with complement activation and inflammation during infection.

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Links for this episode

• Monkeypox outbreak rapid testing response (CDC)
• Leading causes of death during pandemic (JAMA)
• FDA recommends vaccine update (FDA)
• Antibody evasion by subvariants (Nature)
• Broadly-Neutralizing antibodies against variants (Frontiers in Immunology)
• Severe outcomes factors in immunocompromised adults (CDC)
• Measurement of the burden of hospitalizations (OFID)
• Vaccine hesitancy among parents (Academic Pediatrics) 
• PAXLOVID patient eligibility screening checklist (FDA)
• Remdesivir fact sheet for providers (Veklury) 
• Bebtelovimab fact sheet for providers (FDA)
• Saliva evaluation to improve diagnostics (ASTMH)
• Oral Sabizabulin for high-risk adults (NEJM)
• Lower risk of MIS-C in children (CID)
• Neurovascular injury during infection (Brain)
• Paul Offit on TWiV 917
• Contribute to FIMRC fundraiser at PWB
• Dr. Griffin’s treatment guide (pdf)
• Letters read on TWiV 918
• Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to daniel@microbe.tv

Paul Offit returns to TWiV to discuss why, during the recent FDA advisory committee meeting, he voted against releasing revised COVID-19 vaccines containing an Omicron component, and the reasons why children must be vaccinated against the disease.

Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Kathy Spindler

Guest: Paul Offit

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Become a patron of TWiV!

Links for this episode

• 28 June 2022 VRBPAC meeting materials (FDA)
• Don’t rush to change COVID vaccines (STAT)
• Monkeypox situation report #1 (WHO)
• Letters read on TWiV 917
• Timestamps by Jolene. Thanks!

Weekly Picks

Dickson – Woody Herman and his orchestra. 1955-1965. Signature song: The Preacher. Signature album: Woody Herman and His Orchestra (1956)
Kathy – Solargraphic analemmas
Rich – Windy (desktop; app)
Vincent – Why monkeypox is mostly hitting men who have sex with men

Listener Picks

Mark – Hand Wash Dance – NHK WORLD-JAPAN

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv