This Week in Virology

By Vincent Racaniello

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Subscribers: 1383
Reviews: 6


 Aug 8, 2021

Rachael
 Nov 28, 2020
excellent thanks for doing a great job


 May 29, 2020

excellent
 Apr 23, 2020
great information

Reed
 Jan 15, 2020
amazing in depth podcast on the nuts and bolts of all kinds of viruses. expect in depth discussions of papers by experienced scientists with a decent sense of humour. I can follow along most details even though I have not studied virology.

Description

This Week in Virology is a netcast about viruses - the kind that make you sick.

Episode Date
TWiV 958: Pass the RNA and have some venison pi
01:48:33

The TWiV team reveals a variant SARS-CoV-2 that emerged in deer with deer-to-human transmission, and hybrid virus particles produced by co-infection with influenza virus and respiratory syncytial virus particles.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Kathy Spindler, and Brianne Barker

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Weekly Picks

Dickson – Jazz Project: Vocals
Best female vocalists: Ella Fitzgerald/Billie Holiday, Betty Carter
Best Male Vocalists: Mel Tormé/Joe Williams/Tony Bennett
BrianneASV Curriculum Guidelines for Virology Courses
KathyThe Snow Cruiser
Alan Rescuing bats in Ukraine
VincentWoodpeckers: The Hole Story PBS

Listener Picks

FlorenciaWorld of Viruses
MiguelFoldscope

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

Nov 27, 2022
TWiV 957: Clinical update with Dr. Daniel Griffin
43:28

In his weekly clinical update Dr. Griffin discusses human monkeypox virus infection in women and non-binary individuals during the 2022 outbreaks, changes in population immunity against infection and severe disease from SARS-CoV-2 Omicron variants in the United States, updates on COVID-19–related mortality, impact of community masking on COVID-19, effectiveness of the COVID-19 vaccines against hospitalization with Omicron sub-lineages BA.4 and BA.5 in England, cardiovascular outcomes after Tixagevimab and Cilgavimab use for pre-exposure prophylaxis against COVID-19, how Paxlovid is associated with decreased hospitalization rate among adults with COVID-19, inside the mind of an anti-paxxer, and angiotensin receptor blockers for the treatment of COVID-19.

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Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to daniel@microbe.tv

Nov 26, 2022
TWiV 956: A domesticated viral envelope with Cedric Feschotte and John Anthony Frank
01:40:57

Cedric and John join TWiV to discuss their research showing that a human protein derived from an ancient retrovirus infection can protect against infection by other retroviruses.

Hosts: Vincent Racaniello, Rich Condit, and Kathy Spindler

Guest: Cedric Feschotte and John Anthony Frank

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Weekly Picks

KathyWastewater Dashboard
Rich Artemis I MissionArtemis I launch; Artemis I Map
VincentPasta Grammar

Listener Picks

Rich Watch a virus in the moments before it attacks
JustinRespiratory syncytial virus

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

Nov 20, 2022
TWiV 955: Clinical update with Dr. Daniel Griffin
46:50

In his weekly clinical update Dr. Griffin discusses the four things to know about RSV, the burden of respiratory syncytial virus in healthy term-born infants in Europe, the diagnostic accuracy of rapid diagnostic tests for Ebola virus disease, evaluating the accuracy of self-collected swabs for the diagnosis of monkeypox, tecovirimat is effective against human monkeypox virus in vitro at nanomolar concentrations, acute and postacute sequelae associated with SARS-CoV-2 reinfection, clinical course of SARS-CoV-2 infection and recovery in lung transplant recipients, effectiveness of a third BNT162b2 mRNA COVID-19 vaccination during pregnancy, maternal antibody response and transplacental transfer following SARS-CoV-2 infection or vaccination in pregnancy, impact of community masking on COVID-19, Lifting Universal Masking in Schools – Covid-19 Incidence among Students and Staff, systematic review of the clinical effectiveness of Tixagevimab/Cilgavimab for prophylaxis of COVID-19 in immunocompromised patients, comparative effectiveness of sotrovimab and molnupiravir for prevention of severe COVID-19 outcomes in patients in the community, early adoption of anti–SARS-CoV-2 pharmacotherapies among us veterans with mild to moderate COVID-19, evaluation of viral and symptom rebound differences between Paxlovid and untreated COVID-19 participants, monoclonal antibodies for treatment of SARS-CoV-2 infection during pregnancy, twice daily oral zinc in the treatment of patients with COVID-19, cognitive deficits in long Covid-19, severe Neuro-COVID is associated with peripheral immune signatures, autoimmunity and neurodegeneration, and long-lasting symptoms after an acute COVID-19 infection and factors associated with their resolution.

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Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to daniel@microbe.tv

Nov 19, 2022
TWiV 954: Speculating sarbecovirus spillovers with Michael Letko
01:50:06

Michael Letko joins TWiV to discuss his research on understanding cell receptors required for sarbecovirus entry, including an ACE2-dependent isolate from Russian bats that is resistant to vaccine-induced antibodies.

Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit,  Kathy Spindler, and Brianne Barker

Guest: Michael Letko

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Weekly Picks

Brianne Sometimes This Octopus is So Mad it Just Wants to Throw Something or The Cosmic Bat Nebula
Kathy – APODs  JupiterLunar Eclipse Blood Moon, Ice Giant
Rich Mirror-image T7 transcription of chirally inverted ribosomal and functional RNAs (Wiki: Mirror Life)
Vincent The 2022-2023 Respiratory Virus Season Hits Early and Hard: Part 1

Listener Pick

DebbyCelebrate Bob McDonald’s 30 years as host of Quirks & Quarks

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

Nov 13, 2022
TWiV 953: Clinical update with Dr. Daniel Griffin
54:56

In his weekly clinical update Dr. Griffin discusses high demand for Amoxicillin causing shortages amid child RSV surge, epidemiologic and clinical features of children and adolescents aged <18 years with monkeypox, low risk of SARS-Cov-2 transmission by fomites, nucleocapsid antigenemia is a marker of acute SARS-CoV-2 infection, impact of community masking on COVID-19,  protection against Omicron from vaccination and previous infection in a prison system, Nirmatrelvir and the risk of post-acute sequelae of COVID-19, Bebtelovimab for high-risk outpatients with early COVID-19 in a large US health system, imprinted SARS-CoV-2 humoral immunity induces convergent Omicron RBD evolution, can SARS-CoV-2 trigger new onset of autoimmune disease in adults? A case-based review, and retrospectively modeling the effects of increased global vaccine sharing on the COVID-19 pandemic.

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Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to daniel@microbe.tv

Nov 12, 2022
TWiV 952: Jake Scott put the ID in COVID-19
01:44:30

Infectious Disease physician Jake Scott joins TWiV to provide a west coast clinical perspective on the evolution of the COVID-19 pandemic with respect to the impact of vaccines, antivirals, variants of concern and mortality.

Hosts: Vincent Racaniello, Alan Dove, Rich Condit,  and Kathy Spindler

Guest: Jake Scott

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Weekly Picks

Kathy 10 moments for Jazz at Lincoln Center Orchestra Residency (Item 7) and Alan’s pick from TWiV 931 The Kissing Bug by Daisy Hernandez
Rich Wilderness Safaris Photographic Competition 2022
AlanMassachusetts Science Education Leadership Association, and the talk I gave to them last week
Vincent Andrea Camillieri and his protagonist Inspector Montalbano

Listener Pick

Frank Economics for the Future: Beyond the Superorganism
Debby As routine vaccination rates fall, polio survivor hopes her story reverses urgent trend

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

Nov 06, 2022
TWiV 951: Clinical update with Dr. Daniel Griffin
49:45

In his weekly clinical update Dr. Griffin discusses Influenza incidence and vaccine effectiveness during the southern hemisphere influenza season in Chile, Nirsevimab for prevention of RSV infection in healthy late-preterm and term infants, severe Monkeypox in hospitalized patients, reinfections with different SARS-CoV-2 Omicron subvariants, impact of community masking on COVID-19 in Bangladesh, unadjuvanted intranasal spike vaccine elicits protective mucosal immunity against sarbecoviruses, antibody responses to Omicron BA.4/BA.5 bivalent mRNA vaccine booster shot, immunogenicity of bivalent mRNA vaccine boosters, long-term gastrointestinal sequelae following COVID-19, evaluation of an automated text message–based program to reduce use of acute health care resources after hospital discharge, and how in adults with COVID-19, melatonin was assessed for effects on inflammatory markers, clinical signs and symptoms, and mortality.

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Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to daniel@microbe.tv

Nov 05, 2022
TWiV 950: Prion diseases with Richard Knight
43:23

From the European Society for Clinical Virology 2022 Conference in Manchester UK, Vincent speaks with Richard Knight about prion diseases and the outbreak of bovine spongiform encephalitis that led to cases of variant Creutzfeldt-Jakob disease in humans.

Host: Vincent Racaniello

Guest: Richard Knight

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Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

Oct 30, 2022
TWiV 949: Clinical update with Dr. Daniel Griffin
45:09

In his weekly clinical update Dr. Griffin discusses progress toward poliomyelitis eradication in Pakistan, polio by the numbers , influenza and COVID-19 vaccination coverage among health care personnel, phase 1/2a safety and immunogenicity of an adenovirus 26 vector RSV vaccine encoding prefusion F in adults 18–50 years and RSV seropositive children 12–24 months, receipt of first and second doses of JYNNEOS vaccine for prevention of Monkeypox, distinguishing SARS-CoV-2 persistence and reinfection, Novavax NVX-COV2373 triggers potent neutralization of Omicron sub-lineages, association between regular physical activity and the protective effect of vaccination against SARS-CoV-2 in a South African case, COVID-19 outcomes in solid organ transplant recipients who received Tixagevimab-cilgavimab Prophylaxis and/or Bebtelovimab treatment, Omicron sublineage BA.2.75.2 exhibits extensive escape from neutralizing antibodies, and Tocilizumab versus Baricitinib in hospitalized patients with severe COVID-19.

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Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to daniel@microbe.tv

Oct 29, 2022
TWiV 948: Breathless with David Quammen
01:49:35

David Quammen returns to TWiV to discuss how he wrote his new book ‘Breathless’, a story about the science and the scientists behind the race to understand the pandemic coronavirus SARS-CoV-2.

Hosts: Vincent Racaniello, Rich Condit,  Kathy Spindler, and Brianne Barker

Guest: David Quammen

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Weekly Picks

David – Shepherd
Brianne – Adventure Aquarium
Kathy – DART results (Narrative, images)
Rich “Elementary” TV series
VincentStop passing the buck on intro science

Listener Pick

RichConsensus

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

Oct 23, 2022
TWiV 947: Clinical update with Dr. Daniel Griffin
33:44

In his weekly clinical update Dr. Griffin discusses the prediction of upcoming global infection burden of influenza seasons after relaxation of public health and social measures during the COVID-19 pandemic, severe COVID-19 outcomes after full vaccination of primary schedule and initial boosters, and how successful immunomodulators for treatment of COVID-19 have opened the pathway for comparative trials.

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Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to daniel@microbe.tv

Oct 22, 2022
TWiV 946: Poo versus flu
01:49:15

Angela Mingarelli joins TWiV to discuss whether the gut microbiota of bats confers tolerance to influenza virus infection in mice, and primate hemorrhagic fever-causing arteriviruses that can reproduce in human cells and might be capable of infecting humans.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit,  and Brianne Barker

Guest: Angela Mingarelli

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Weekly Picks

Dickson – Jazz pics: #5. Small group.  Art Blakey and the Jazz Messenger: Art Blakey, Drums; Lee Morgan, Trumpet; Benny Golson, Tenor saxophone; Bobby Timmons, Piano; Jymie Merrit, Bass (1958-1964). Signature album: Art Blakey And The Jazz Messengers: Blues March: Signature song: Blues March
Brianne – Why Chimps and Gorillas Form Rainforest Friendships
Rich Fly Water – FPV to New Depths
Alan – The Seven Words You Can’t Say on Television, by George Carlin, and its repercussions
Angela – Nature’s Inspiring Women in Science Award
Vincent – Mysteries of Nevada Barr and her protagonist Anna Pigeon

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

Oct 16, 2022
TWiV 945: Clinical update with Dr. Daniel Griffin
44:29

In his weekly clinical update Dr. Griffin discusses a healthcare-associated infection with Monkeypox virus, air and surface sampling for monkeypox virus in a UK hospital, misrepresentation and nonadherence regarding COVID19 public health measures, tolerability and immunogenicity of an intranasally-administered adenovirus-vectored COVID-19 vaccine, clinical, virologic, and immunologic evaluation of symptomatic rebound following Nirmatrelvir/Ritonavir treatment, early outpatient treatment with Eemdesivir in patients at high risk for severe COVID-19, Molnupiravir plus usual care versus usual care alone as early treatment for adults with COVID-19 at increased risk of adverse outcomes, and outcomes among confirmed cases and a matched comparison group in the long-COVID in Scotland.

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Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to daniel@microbe.tv

Oct 15, 2022
TWiV 944: Hacking through Borneo with Kathryn Hanley
01:53:47

Kathryn Hanley joins TWiV to discuss her career and the research in her laboratory on the molecular biology, evolution and ecology of emerging RNA viruses and their insect vectors.

Hosts: Vincent Racaniello, Rich Condit,  and Kathy Spindler

Guest: Kathryn Hanley

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Weekly Picks

Kathy – Car Talk Puzzler Archive
Rich The Molecular Biologist Who Exposed the Soviet Union”  by Sean B. Carroll
Vincent NYU Chemistry prof fired because his course was too difficult

Listener Pick

JackThe Everything Virus

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

Oct 09, 2022
TWiV 943: Clinical update with Dr. Daniel Griffin
42:34

In his weekly clinical update Dr. Griffin discusses high points of the multi-national monkeypox outbreaks, monkeypox virus genome mutations, possible occupational infection of healthcare workers with monkeypox virus, rates of monkeypox cases by vaccination status, protection of SARS-CoV-2 infection against reinfection, Paxlovid significantly reduces COVID-19 hospitalizations and deaths, and rebound in COVID19 with and without Paxlovid treatment.

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Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to daniel@microbe.tv

Oct 08, 2022
Public Health with Laurie Garrett: Wastewater Testing
01:00:47

Laurie Garrett discusses the role of wastewater testing in public health and her idea of a device that could be used by anyone to analyze water samples.

This podcast is not an episode of TWiV, but I thought it would be of interest to listeners.

Laurie Garrett and Vincent Racaniello

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Intro music is by Ronald Jenkees

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Oct 04, 2022
TWiV 942: Omicron boosters with Paul Offit
01:53:54

Paul Offit returns to TWiV for a discussion of SARS-CoV-2 bivalent boosters containing ancestral and Omicron spike mRNAs, including their composition, why they are being recommended by CDC, and who would benefit the most from them.

Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit,  Kathy Spindler, and Brianne Barker

Guest: Paul Offit

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Weekly Picks

Dickson – Jazz favorites: Small group #4: Gerry Mulligan Quartet with Chet Baker: Gerry Mulligan, Baritone saxophone; Carson Smith, Bass; Larry Bunker, Drums, Chet Baker, Trumpet. Signature album: The Best Of The Gerry Mulligan Quartet With Chet Baker: Signature song: My Funny Valentine.

Second pick: Wonder: Childhood and the Lifelong love of Science. Frank C. Keil.

Brianne – A Devious Cellular Trick Cancers Can Use to Escape Your Immune System
Kathy – Durable antimicrobial coating
RichOne Health
Vincent – The works of Dashiell Hammett

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

Oct 02, 2022
TWiV 941: Clinical update with Dr. Daniel Griffin
50:12

In his weekly clinical update Dr. Griffin discusses increased acute respiratory illnesses among children and adolescents, estimates of monkeypox incubation period, generation time, and reproduction number, rapid increase in suspected SARS-CoV-2 reinfections, interim infection prevention and control recommendations for healthcare personnel during COVID-19, SARS-CoV-2 secondary attack rates in vaccinated and unvaccinated household contacts during replacement of delta with omicron variant, breakthrough infection by SARS-CoV-2 delta and omicron variants elicited immune response comparable to mRNA booster vaccination, interval between prior SARS-CoV-2 infection and booster vaccination impacts magnitude and quality of antibody and B cell responses, further humoral immunity evasion of emerging SARS-CoV-2 BA.4 and BA.5 subvariants, short-course early outpatient Remdesivir prevents severe disease due to COVID-19 in organ transplant recipients during the Omicron BA.2 wave, effectiveness of Molnupiravir in high risk patients, and primary care and a distinct symptom pattern for long COVID.

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Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to daniel@microbe.tv

Oct 01, 2022
TWiV 940: Eddie Holmes in on viral origins
01:32:02

Eddie Holmes joins TWiV to discuss his role in the first release of the SARS-CoV-2 genome sequence, what really happened during the infamous Fauci teleconference, and evidence that the virus came from Nature and not from a lab.

Hosts: Vincent Racaniello and Dickson Despommier

Guest: Eddie Holmes

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Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

Sep 28, 2022
TWiV 939: From lizards to Lassa with Tom Monath
02:01:05

Tom Monath joins TWiV to discuss his wide-ranging career that includes medicine, field work and vaccine development while working for the US government, the US military, and multiple biotechnology companies.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Rich Condit

Guest: Tom Monath

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Weekly Picks

Dickson – Jazz – Small Group #3:  Dave Brubeck Quartet. Dave Brubeck, Piano; Joe Morello, Drums, Paul Desmond, Alto Saxophone, Eugene Wright, Bass: Signature Album: Time Out. Signature Song: Take Five.
RichWilderness Safaris (wiki)
Alan – Madhouse at the End of the Earth, by Julian Sancton
VincentRaymond Chandler and his protagonist Philip Marlowe.

Listener Picks

Philip Students bitten by bats inside college residence hall

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

Sep 25, 2022
TWiV 938: Clinical update with Dr. Daniel Griffin
53:03

In his weekly clinical update Dr. Griffin reviews the public health response to poliovirus in New York, impact of mandatory influenza vaccination, monkeypox in a young infant, health care worker exposure to monkeypox virus, monkeypox testing delays, transmission potential of monkeypox virus, TPOXX trial for monkeypox, detection of SARS-CoV-2 subgenomic mRNA, mucosal IgA against SARS-CoV-2, BNT262b2 against Omicron, awareness and use of SARS-CoV-2 antivirals, comparable outcomes for Bebtelovimab and Nirmatrelvir, and COVID-19 and Alzheimer's disease.

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Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to daniel@microbe.tv

Sep 24, 2022
TWiV 937: Pediatric hepatitis with Emma Thomson
01:00:55

From the European Society for Clinical Virology 2022 Conference in Manchester UK, Vincent speaks with Emma Thomson about the recent outbreak of pediatric hepatitis of unknown etiology and the finding that it is linked to infection by adenovirus-associated virus 2.

Hosts: Vincent Racaniello

Guest: Emma Thomson

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Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

Sep 18, 2022
TWiV 936: Clinical update with Dr. Daniel Griffin
52:06

In his weekly clinical update Dr. Griffin discusses detection of a highly divergent type 3 vaccine-derived poliovirus in a child with a severe primary immunodeficiency disorder, severe respiratory illnesses associated with rhinoviruses and/or enteroviruses including EV-D68, effects of vaccination and previous infection on Omicron infections in children, COVID-19-associated hospitalizations among vaccinated and unvaccinated adults 18 years or older in 13 US states, effectiveness of COVID-19 vaccines over time prior to Omicron emergence in Ontario, Canada, nasal IgA wanes 9 months after hospitalization with COVID-19 and is not induced by subsequent vaccination,  resistance of SARS-CoV-2 Omicron subvariant BA.4.6 to antibody neutralization, persistent circulating SARS-CoV-2 spike associated with post-acute COVID-19 sequelae, and impact of COVID-19 vaccination on the risk of developing long-covid and on existing long-covid symptoms.

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Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to daniel@microbe.tv

Sep 17, 2022
TWiV 935: Mobile DNA with Cedric Feschotte
01:23:13

Vincent travels to Cornell University to speak with Cedric about his career and his research on mobile genetic elements such as transposons and endogenous viruses and how they have shaped the evolution of nearly all organisms.

Hosts: Vincent Racaniello

Guest: Cedric Feschotte

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Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

Sep 11, 2022
TWiV 934: Clinical update with Dr. Daniel Griffin
52:27

In his weekly clinical update Dr. Griffin discusses variant influenza virus infections: recommendations for identification, treatment, and prevention for summer and fall 2022, low levels of monkeypox virus neutralizing antibodies after MVA-BN vaccination in healthy individuals, using the right tools at the right time for SARS-COV-2 infection, onset and window of SARS-COV-2 infectiousness and temporal correlation with symptom onset, transmission of SARS-COV-2: a review of viral, host, and environmental factors, antibody persistence and safety through 6 months after heterologous orally aerosolized Ad5-nCoV in individuals primed with two-dose vaccine, timely administration of tocilizumab improves outcome of hospitalized COVID-19 patients, administration of anti–SARS-COV-2 monoclonal antibodies after US Food and Drug Administration deauthorization, and clinical and genetic risk factors for acute incident venous thromboembolism in ambulatory patients with COVID-19.

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Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to daniel@microbe.tv

Sep 10, 2022
TWiV 933: Island-hopping bats
01:47:41

TWiV discusses a new henipavirus from fruit bats in Madagascar, and attenuation of SARS-CoV-2 Omicron disease in mice caused by genome mutations outside of the spike protein coding region.

Hosts: Vincent Racaniello, Dickson Despommier, Kathy Spindler, and Brianne Barker

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Weekly Picks

Dickson – Small groups: 3.  Modern Jazz Quartet. Signature song: Skating in Central Park. Signature album: Django.
BrianneTo Prevent a Martian Plague, NASA Needs to Build a Very Special Lab
Kathy – Physics Girl – Overnight in the Most Remote Camp on Earth
VincentLab leaders wrestle with paucity of postdocs

Listener Picks

GaryStan Kenton Orchestra
MiguelMicrosoft Premonition

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

Sep 04, 2022
TWiV 932: Clinical update with Dr. Daniel Griffin
49:47

In his weekly clinical update Dr. Griffin discusses vaccine effectiveness against influenza illness in children, clinical manifestations of infection with poliovirus, spike protein-independent attenuation of SARS-CoV-2 Omicron variant in laboratory mice, concordance of SARS-CoV-2 results in self-collected nasal swabs vs swabs collected by health care workers in children and adolescents, probable animal-to-human transmission of SARS-CoV-2 causing a pet shop-related outbreak, laboratory-confirmed COVID-19–associated hospitalizations among adults during BA.2 variant, SARS-CoV-2 specific T-cells and antibodies, Nirmatrelvir use and outcomes during the Omicron surge, real-world effectiveness of early Molnupiravir or Nirmatrelvir–ritonavir in hospitalized patients, and distinguishing features of long COVID.

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Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to daniel@microbe.tv

Sep 03, 2022
TWiV 931: Driven to immunodistraction
02:01:20

TWiV reviews the genetic characterization of a new strain of type 2 oral polio vaccine and its implications for eradication, and how a polymorphism in humans comprising a single amino acid change in an antibody molecule regulates vaccine elicitation of broadly neutralizing antibodies against influenza virus HA.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Kathy Spindler, and Brianne Barker

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Weekly Picks

Dickson - Small groups: 1.  Miles Davis Quintet. Signature album: Kind Of Blue. Signature song: So What.
Brianne - World Excel Championships
Kathy - Lyre bird background and video
Alan The Kissing Bug, by Daisy Hernandez
Vincent -Five top detective fiction writers. #1 Martin Beck by Maj Sjöwall and Per Wahlöö

Listener Picks

John Fevers, Feuds and Diamonds: Ebola and the Ravages of History by Paul Farmer
CarolThe Social Dilemma

Intro music is by Ronald Jenkees

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Aug 28, 2022
TWiV 930: Clinical update with Dr. Daniel Griffin
48:18

In his weekly clinical update Dr. Griffin discusses antibody response against nonpoliovirus enteroviruses, clinical presentation and virological assessment of confirmed human monkeypox virus cases in Spain, object and surface contamination with monkeypox virus, monkeypox virus infection in humans across 16 countries, clinical characteristics of ambulatory and hospitalized patients with monkeypox virus infection, compassionate use of Tecovirimat for the treatment of monkeypox infection, monitoring of Pfizer-BioNTech vaccine among children, Pfizer and BioNTech announce updated vaccine data supporting efficacy in children, direct capture of neutralized RBD enables rapid point-of-care assessment of SARS-CoV-2 neutralizing antibody titer, Pfizer and BioNTech submit application for bivalent vaccine, and Oral Nirmatrelvir and Ritonavir in non-hospitalized vaccinated patients with COVID-19.

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Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to daniel@microbe.tv

Aug 27, 2022
TWiV 929: Empathyology with Andy Slavitt
02:00:21

Andy Slavitt joins TWiV to discuss his book, Preventable and how failures in leadership, politics, and selfishness doomed the U.S. response to SARS-CoV-2.

Hosts: Vincent Racaniello, Dickson Despommier, Kathy Spindler, and Brianne Barker

Guest: Andy Slavitt

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Weekly Picks

Dickson – Best big band #5: 1. Glenn Miller’s Orchestra -1940-1944: Signature song: In The Mood. Signature album: An Album Of Outstanding Arrangements
BrianneCross-stitched Microbes
Kathy – Time trials for bottle emptying
AlanMeow Parlor
VincentVIRUS x1,000,000 (2022) by Drew Berry wehi.tv

Intro music is by Ronald Jenkees

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Aug 21, 2022
TWiV 928: Clinical update with Dr. Daniel Griffin
41:32

In his weekly clinical update Dr. Griffin discusses the public health response to a polio case in a unvaccinated NY state resident, human to dog transmission of monkeypox virus, Tecovirimat and the treatment of monkeypox, detection of asymptomatic monkeypox virus infections among male sexual health clinic attendees in Belgium, what to do if you are exposed to SARS-CoV-2 and isolation and precautions for people with COVID-19, risk of SARS-CoV-2 infection in health care workers, effectiveness of HEPA filters at removing infectious SARS-CoV-2 from the air, Pfizer reports additional data on Paxlovid, hospitalization encounters for infection after Paxlovid, a randomized trial of Metformin, Ivermectin, and Fluvoxamine, and readmissions, post-discharge mortality and sustained recovery among patients admitted to hospital with COVID-19.

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Intro music is by Ronald Jenkees

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Aug 20, 2022
TWiV 927: Merchlinsky vs monkeypox
01:50:18

Michael Merchlinsky joins TWiV to discuss the development of two smallpox antiviral drugs and two smallpox vaccines and their uses during the monkeypox outbreak.

Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Kathy Spindler

Guest: Michael Merchlinsky

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Weekly Picks

Dickson – Duke Ellington and his Orchestra. Signature song: Take The A Train; Signature album: Black, Brown, And Beige and Herding Cats: Harlem 1958
Kathy – How the US Postal Service reads terrible handwriting
Rich JWST/chorizo gag
VincentBat Conservation Trust

Listener Picks

Bill The End of Manual Transmission
JHow the Krebs cycle powers life and death – with Nick Lane

Intro music is by Ronald Jenkees

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Aug 14, 2022
TWiV 926: Clinical update with Dr. Daniel Griffin
40:38

In his weekly clinical update Dr. Griffin discusses guidance for prevention and treatment of monkeypox, post-infectious symptoms among children and adolescents, profiling post-infectious syndromes of different variants, comparison of vaccine Ankara vs intradermal routes of administration, infection in vaccinated individuals treated with or without PAXLOVID, duration of symptoms with positive rapid antigen after infection, epidemiologic characteristics of monkeypox, and sequelae of post-acute infection.

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Intro music is by Ronald Jenkees

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Aug 13, 2022
TWiV 925: First kisses and second doses
01:43:05

TWiV discusses monkeypox virus, poliovirus in NY, Marburg virus in Ghana, ancient herpes simplex virus type 1 genomes, and immunogenicity of different combinations of SARS-CoV-2 vaccines.

Hosts: Vincent Racaniello, Alan Dove, Rich Condit, Kathy Spindler, and Brianne Barker

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Weekly Picks

Brianne Everyone Loses on Jeopardy Eventually
Kathy – Climate spiral  followed by Carl Sagan
RichMost Popular Desktop Browsers 1993 – 2022
Alan – I Am Promise
VincentPolio in New York

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Aug 07, 2022
TWiV 924: TWiV clinical update with Dr. Daniel Griffin
46:24

In his weekly clinical update Dr. Griffin discusses Tecovirimat for treatment of monkeypox, the safety and acceptance of vaccination after multisystem inflammatory syndrome, variants in solid organ transplant recipients, masks for prevention of respiratory virus infections, pre-exposure prophylaxis with Evusheld, the association between Evusheld administration and infection,  if repeat administration of casirivimab and imdevimab is well-tolerated, viral and symptom rebound in untreated infection, extended Remdesivir infusion for persistent infection, Baricitinib in patients admitted with infection, and cognitive impairment 13 months after hospitalization.

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Intro music is by Ronald Jenkees

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Aug 06, 2022
TWiV 923: If a bat pees in a forest, does anyone care?
01:05:11

From The Third International Symposium on Infectious Diseases of Bats in Ft. Collins, Colorado, TWiV speaks with Vincent Munster and Raina Plowright about their careers and their research on bats, bat viruses, bat ecology and spillover events.

Hosts: Vincent Racaniello and Brianne Barker

Guests: Vincent Munster and Raina Plowright

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Intro music is by Ronald Jenkees

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Jul 31, 2022
TWiV 922: TWiV clinical update with Dr. Daniel Griffin
42:20

In his weekly clinical update Dr. Griffin discusses monkeypox infection in humans across 16 countries, pregnancy outcomes after SARS-CoV-2 infection by trimester, vaccination intent and belief, antiviral drug treatment for non-severe disease, the association of smoking with infected hospitalized patients, the association of Paxlovid on negative conversion rates among high-risk patients with COVID-19, safety and efficacy of Molnupiravir, usage of enoxaparin for primary thromboprophylaxis, statin and aspirin as therapy in infected patients, post-COVID-19 conditions among children 90 days after SARS-CoV-2 Infection, and symptoms and risk factors for long COVID in non-hospitalized adults.

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Intro music is by Ronald Jenkees

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Jul 30, 2022
TWiV 920: Science will break your heart
01:01:12

From ASV 2022 in Madison, Wisconsin, TWiV speaks with Pamela Bjorkman and Andy Mehle about their careers and their research on influenza virus, HIV-1, SARS-CoV-2, and influenza virus.

Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker

Guests: Pamela Bjorkman and Andy Mehle

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Intro music is by Ronald Jenkees

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Jul 24, 2022
TWiV 921: COVID-19 clinical update #124 with Dr. Daniel Griffin
35:13

In COVID-19 clinical update #124, Dr. Griffin discusses the results of a variant vaccine booster trial, the neutralization of variant sub-lineages by Novavax, the CDC’s recommendation of Novavax’s COVID-19 vaccine in adults, Paxlovid in patients who are immunocompromised and hospitalized, and inhaled fluticasone for outpatient treatment.

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Intro music is by Ronald Jenkees

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Jul 23, 2022
TWiV 919: Motivated by volatiles
01:41:49

TWiV reviews the FDA decision to update COVID-19 vaccine boosters in the fall, the meaning of fatigue with respect to long COVID, and a skin volatile induced by flavivirus reproduction that attracts mosquitoes to the infected host.

Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker

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Weekly Picks

BrianneRedactle
KathyKirigami paper replacing plastic bubble wrap
RichFirst Images from the James Webb Space Telescope (Gravitational lens; Einstein ring)
Vincent Spotted lanternfly

Listener Picks

Ann NASA Engineer Who Made the James Webb Space Telescope Work
Sonrisa Aloft – the pleasures and risks of flying

Intro music is by Ronald Jenkees

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Jul 17, 2022
TWiV 918: COVID-19 clinical update #123 with Dr. Daniel Griffin
40:33

In COVID-19 clinical update #123, Dr. Griffin discusses rapid diagnostic testing in response to the monkeypox outbreak, leading causes of death in the US during the COVID-19 pandemic, antibody evasion by subvariants, broadly-neutralizing antibodies against emerging variants, factors associated with severe outcomes among hospitalized immunocompromised adults, measurement of the burden of hospitalizations during the pandemic, parental vaccine hesitancy in diverse communities, evaluating saliva sampling to improve access to diagnosis in low-resource settings, oral sabizabulin for high-risk hospitalized adults, lower-risk of multisystem inflammatory syndrome in children, and neurovascular injury with complement activation and inflammation during infection.

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Intro music is by Ronald Jenkees

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Jul 16, 2022
TWiV 917: Boosters on, Paul Offit
01:43:21

Paul Offit returns to TWiV to discuss why, during the recent FDA advisory committee meeting, he voted against releasing revised COVID-19 vaccines containing an Omicron component, and the reasons why children must be vaccinated against the disease.

Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Kathy Spindler

Guest: Paul Offit

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Weekly Picks

Dickson – Woody Herman and his orchestra. 1955-1965. Signature song: The Preacher. Signature album: Woody Herman and His Orchestra (1956)
KathySolargraphic analemmas
Rich – Windy (desktop; app)
Vincent Why monkeypox is mostly hitting men who have sex with men

Listener Picks

MarkHand Wash Dance – NHK WORLD-JAPAN

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Jul 10, 2022
TWiV 916: COVID-19 clinical update #122 with Dr. Daniel Griffin
47:25

In COVID-19 clinical update #122, Dr. Griffin discusses vaccine availability and coverage among children, post-infection health impairments in children and adolescents, infection detection using salvia and nasopharyngeal samples, effectiveness of vaccines during delta dominance, durability of vaccine against severe outcomes, concern in the postvaccination era, infection rebound after Paxlovid & Molnupiravir, lack of improvement after adding ivermectin to standard care, duration of shedding of virus, how thromboprophylaxis reduces thromboembolism but increases major bleeding, multi-lineage neural and myelin dysregulation caused by infection, and the association between vaccination and post-acute infection.

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Intro music is by Ronald Jenkees

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Jul 09, 2022
TWiV 915: Mouse mouth to mouse mom
01:55:02

TWiV discusses the recent decision by an FDA advisory committee to update COVID vaccines for the fall, the monkeypox virus outbreak, and the finding that enteric viruses infect the salivary glands and are transmitted through saliva.

Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, Kathy Spindler, and Brianne Barker.

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Weekly Picks

Dickson – Jazz big bands #2: Maynard Ferguson: Signature song: Theme From Rocky: Signature album: Color Him Wild
Brianne Origami antibody and virus
Kathy Turbines resistant to high winds
RichObi-Wan Kenobi (TV Series)
Vincent The next epidemic may be here. The US isn’t ready for it.

Listener Picks

David: DALL E 2
DouglasJazz Online

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Jul 03, 2022
TWiV 914: COVID-19 clinical update #121 with Dr. Daniel Griffin
37:17

In COVID-19 clinical update #121, Dr. Griffin discusses age as a risk factor for severe disease, updated vaccine boosters for the fall, pediatric infection and antibody seroprevalence in Arkansas over the first year of the COVID-19 pandemic, all-cause maternal mortality in the United States before and during the pandemic, and the effect of 2-week interruption in methotrexate treatment and how it impacts vaccine immunity.

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Intro music is by Ronald Jenkees

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Jul 02, 2022
TWiV 913: Twinkle twinkle little SARS
01:56:54

TWiV explains the meaning of vaccine-derived poliovirus found in London sewage, risk of long COVID after infections with Delta or Omicron variants of SARS-CoV-2, and enhancers of innate immune signaling as broad-spectrum antivirals.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler.

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Weekly Picks

Dickson – Count Basie: April in Paris
Kathy – Bird aerodynamics & inertia: lay article, video, Nature
RichNASA Gateway (Thanks Ellis)
Alan Polio Eradication in Nigeria
VincentThe Tyranny of Merit by Michael J. Sandel

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Jun 26, 2022
TWiV 912: COVID-19 clinical update #120 with Dr. Daniel Griffin
45:07

In COVID-19 clinical update #120, Dr. Griffin discusses outcomes of SARS-CoV-2 reinfection, CDC recommendation for vaccines in young children, neurodevelopment outcomes in infants of mothers testing positive for COVID during pregnancy, efficacy of monoclonal antibodies and antivirals in hamsters, rebound phenomenon after PAXLOVID in high-risk persons, hospitalization for infection after PAXLOVID treatment, and risk of long COVID with different variants.

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Intro music is by Ronald Jenkees

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Jun 25, 2022
TWiV 911: Antibody can get vaccinated now
01:54:41

TWiV provides an update on hepatitis of unknown etiology in children, an experimental nanoparticle vaccine for Epstein-Barr virus, and minimal impact of bamlanivimab therapy on antiviral antibodies induced by vaccination.

Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker

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Weekly Picks

Brianne A Frog So Small, It Could Not Frog
KathyA Grand Night In: The Story of Aardman
RichArchive
VincentBandwagoning by Heran Darwin

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Jun 19, 2022
TWiV 910: COVID-19 clinical update #119 with Dr. Daniel Griffin
46:42

In COVID-19 clinical update #119, Dr. Griffin reviews tixagevimab for infection prevention, ivermectin for outpatient infection treatment, symptom rebound after PAXLOVID treatment, bamlanivimab minimally impacting immune response to vaccination, in-hospital mortality among infection patients, residual viral antigen in patients following infection, usage of Casirvimab/Imdevimab and Remdesivir in infected patients with depleted B-cells, and rheumatic symptoms following infection.

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Intro music is by Ronald Jenkees

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Jun 18, 2022
TWiV 909: Art of science
47:21

From ASM Microbe 2022 in Washington DC, Vincent and Michael speak with science artists Michele Banks and Jane Hartman about their work and their inspiration.

Hosts: Vincent Racaniello and Michael Schmidt

Guests: Michele Banks and Jane Hartman

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Intro music is by Ronald Jenkees

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Jun 16, 2022
TWiV 907: When the cats and mice are away, the viruses play
01:44:49

TWiV discusses the situation with monkeypox, risk factors for SARS-CoV-2 infections of cats and dogs, and a lineage-tracing mouse model for studying papillomavirus infections.

Hosts: Vincent Racaniello, Rich Condit, and Brianne Barker

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Weekly Picks

BrianneMicrobes Rule! at Liberty Science Center
RichArtemis I update:  Mission diagram, mission in photos, launch dates
VincentEco-sustainable 3D printed house – Tecla

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Jun 12, 2022
TWiV 908: COVID-19 clinical update #118 with Dr. Daniel Griffin
46:23

In COVID-19 clinical update #118, Dr. Griffin discusses management of hair loss after infection, FDA announcements on vaccine schedule and recommendations, Moderna announcement on bivalent booster candidate, association between vaccination and infection during pregnancy, population-level implications of Israel’s booster campaign, PAXLOVID outcomes during recent infection surge, efficacy and safety of Tixagevimab-cilgavimab, diagnostic accuracy of infection by canines, efficacy of colchicine in hospitalized patients, and factors associated with hospital readmission.  

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Intro music is by Ronald Jenkees

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Jun 11, 2022
TWiV 906: Long COVID, giant viruses, and smallish pox
01:46:11

TWiV reviews human monkeypox infections, evidence for human Mimivrus infections, and incidence of long COVID in post-vaccine SARS-CoV-2 infections.

Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Brianne Barker

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Weekly Picks

Dickson Lake Mead water level very low
Brianne Transplantation of a 3D printed ear made out of human cells
Richnderstanding Vaccine Safety and the Roles of the FDA and the CDC and The Facts About Vaccine Safety
Vincent My new favorite backpack

Listener Pick

GregAgainst the Rules

Intro music is by Ronald Jenkees

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Jun 05, 2022
TWiV 905: COVID-19 clinical update #117 with Dr. Daniel Griffin
44:24

In COVID-19 clinical update #117, Dr. Griffin discusses duration of virus shedding, association between pre-exposure to steroids and infection outcome, post-infection subtypes, rehabilitation for post-acute infection, Tixagevimab/Cilgavimab for infection prevention, antibody prophylaxis and vaccination in kidney transplant recipients, remdesivir and bebtelovimab fact sheets for providers, the updated guidelines on treatment with Famotidine, Paxlovid rebound symptom characterizations, antigen test positivity duration, viral dynamics of variants and isolation, association of inflammation in CS fluid, and transmission dynamics in Ghana.

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Intro music is by Ronald Jenkees

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Jun 04, 2022
TWiV 904: 50 years of reverse transcriptase
58:58

Vincent travels to Cold Spring Harbor Laboratory to speak with David Baltimore, John Coffin, and Harold Varmus about the discovery in 1970 of retroviral reverse transcriptase and its impact on life sciences research.

Hosts: Vincent Racaniello

Guests: David Baltimore, John Coffin, and Harold Varmus

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Intro music is by Ronald Jenkees

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May 29, 2022
TWiV 903: COVID-19 clinical update #116 with Dr. Daniel Griffin
47:47

In COVID-19 clinical update #115, Dr. Griffin discusses croup association with infection surge, rhinovirus co-circulation in children, shedding following vaccination, high vaccine efficacy in children 6 mo-5 yr, vaccine protection for hospitalized patients, convalescent plasma as post-exposure prophylaxis, real-world effectiveness of PAXLOVID, effectiveness of PAXLOVID in reducing hospitalization, infection rebound after PAXLOVID, relapse of symptomatic infection after PAXLOVID, remdesivir and bebtelovimab fact sheets for providers, guidelines on usage of anticoagulation drugs, long covid symptoms after vaccination, excess mortality in MA, infection sequelae and immunity, and post infection conditions among adults.

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Intro music is by Ronald Jenkees

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May 28, 2022
TWiV Special: Monkeypox clinical update with Dr. Daniel Griffin
26:01

In this special episode, Dr. Griffin answers questions about the recent cases of monkeypox including their origin, clinical presentation, diagnosis, treatment, and overall risk.

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  • Monkeypox multi-country outbreak risk assessment (pdf, ECDC)
  • Monkeypox update (ProMedMail)
  • Monkeypox virus genome sequences (Nextstrain)

Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to daniel@microbe.tv

May 26, 2022
TWiV 902: Autoantibodies drive severe COVID-19
02:06:39

TWiV reviews recent cases of monkeypox, presence of SARS-CoV-2 RNA but not infectious virus in feces, and the association of autoantibodies to interferons with severe COVID-19.

Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, Kathy Spindler, and Brianne Barker

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Weekly Picks

Dickson How to grow food on the moon
BrianneAPod May 16: Milky Way over French Alp Hoodoos
KathyCovid Nationwide data visualization
RichNIH All of Us Research Program
Vincent Physicians Spreading Misinformation on Social Media — Do Right and Wrong Answers Still Exist in Medicine?

Listener Pick

Lisa E.H. Danner Museum of Telephony

Intro music is by Ronald Jenkees

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May 22, 2022
TWiV 901: COVID-19 clinical update #115 with Dr. Daniel Griffin
01:00:11

In COVID-19 clinical update #115, Dr. Griffin reviews cross-variant immunity without vaccination, EUA for boosters in 5-11 year olds, B.1.1.529 attack rate, scent dogs, Omicron and pets, Paxlovid, Veklury, Fluvoxamine, antigen positivity after isolation, inflammasome activation and severe disease, and GI persistence and fecal shedding.

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Intro music is by Ronald Jenkees

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May 21, 2022
TWiV 900: Burning down the mouse
01:35:17

TWiV celebrates 900 episodes, Vincent gives the Richard R. Ernst lecture, and we discuss why inflammasome activation in infected macrophages drives severe COVID-19.

Hosts: Vincent Racaniello, Alan Dove, Rich Condit, Kathy Spindler, and Brianne Barker

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Weekly Picks

BrianneThe Milky Way’s Black Hole Comes to Light
Kathy River dolphins playing with anaconda
Rich Smallpox vaccination techniques; from knives and forks to needles and pins
AlanVacuum Tubes: a Modern Aladdin’s Lamp
VincentBooks by Pamela Jane

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May 15, 2022
TWiV 899: COVID-19 clinical update #114 with Dr. Daniel Griffin
55:56

In COVID-19 clinical update #114, Dr. Griffin discusses early treatment with ivermectin, procalcitonin not a reliable biomarker, vaccine in 6-11 year olds, FDA limits use of Janssen vaccine, does site of vaccine booster matter, sniffer dogs, monoclonals for hospitalized patients, risk assessment for public events, Paxlovid eligibility, and persistence of pediatric anosmia.

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Intro music is by Ronald Jenkees

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May 14, 2022
TWiV 898: Immunity is skin deep
01:38:23

TWiV explains why the concept of herd immunity might not apply to COVID-19, and the observation that smallpox vaccination causes an increase in skin bacteria that promote pathology and influence the immune response.

Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker

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Weekly Picks

Brianne Bacteria and Me Coloring Book
Kathy Smarter 3D printing
RichBig Ben Restoring the Worlds Most Famous Clock 2021
VincentScientific review articles as antivaccine disinformation

Listener Pick

SuellenYour Fantastic Mind Season 3 Ep 2: Long COVID and Making of a Brain Surgeon (Full Episode)

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May 08, 2022
TWiV 897: COVID-19 clinical update #113 with Dr. Daniel Griffin
47:48

In COVID-19 clinical update #113, Dr. Griffin discusses tocilizumab use in hospitalized Patients, IL-6 inhibitors and mortality, Baricitinib in hospitalized patients, post-infection neurological sequelae, comparative effectiveness of Pfizer and Moderna vaccines, phase 2/3 study of Paxlovid, infection relapse following Paxlovid, pre-hospital administration of Remdesivir, and hospitalization with different variants.

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Intro music is by Ronald Jenkees

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May 07, 2022
TWiV 896: Memory B cells, the way we were
01:41:55

TWiV explains a study of how climate change is predicted to increase cross-species viral transmission risk, and increased memory B cell potency and breadth after a SARS-CoV-2 mRNA vaccine boost.

Hosts: Vincent Racaniello, Dickson Despommier, and Amy Rosenfeld

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Weekly Picks

DicksonToots Thilelemans
Amy Largest comet ever identified
Vincent Scientific review articles as antivaccine disinformation

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May 01, 2022
TWiV 895: COVID-19 clinical update #112 with Dr. Daniel Griffin
35:37

In COVID-19 clinical update #112, Dr. Griffin reviews seroprevalence of infection-induced antibodies, Moderna filing for vaccine authorization in young children, public health impact of vaccines in US, FDA approval of first treatment for young children, phase 2 data for Sabizabulin, and post infection inflammation.

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Intro music is by Ronald Jenkees

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Apr 30, 2022
TWiV 894: Dinner with the TMPRSS family
01:39:55

TWiV explains what is known about cases of acute, severe hepatitis of unknown origin in children, and discovery of an inhibitor of TMPRSS2 protease that blocks SARS-CoV-2 infection.

Hosts: Vincent Racaniello, Alan Dove, Kathy Spindler, and Brianne Barker

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Weekly Picks

Brianne Apple AirTag
Kathy Dental art/sculpture/mobile/chandelier
AlanVintage Radio and Communications Museum of Connecticut
Vincent For the Love of Enzymes by Arthur Kornberg

Intro music is by Ronald Jenkees

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Apr 28, 2022
TWiV 893: Yellow fever virus escapes antibodies
01:28:29

Kartik, Denise, and Gorka join TWiV to discuss their finding that changes in the surface glycoprotein of South American yellow fever virus lead to reduced neutralization by antibodies induced by the vaccine, which is derived from an African isolate.

Hosts: Vincent Racaniello, Dickson Despommier, and Brianne Barker

Guests: Kartik Chandran, Denise Haslwanter, and Gorka Lasso Cabrera

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Weekly Picks

DicksonEarth Day and Earth Day History
BrianneXKCD: Family Reunion
VincentTokaido: A Journey (DVD)

Intro music is by Ronald Jenkees

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Apr 24, 2022
TWiV 892: COVID-19 clinical update #111 with Dr. Daniel Griffin
54:13

In COVID-19 clinical update #111, Dr. Griffin discusses vaccine coverage and mortality in Hong Kong, immune response to boosters in kids, hospitalization of kids, breath based diagnostic test, viral co-infections, bivalent mRNA vaccine, intramuscular Evusheld, and global long COVID.

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Intro music is by Ronald Jenkees

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Apr 23, 2022
TWiV 891: LLOV in the time of Ebola
01:24:31

Elke, Adam, and Gabor join TWiV to discuss their work on Lloviu virus, a filovirus, including recovery of infectious virus from a DNA copy of the genome and from Schreiber’s bats in Hungary.

Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker

Guests: Elke Muhlberger, Adam Hume, and Gabor Kemenesi

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Weekly Picks

BrianneAPod Stars and Globules in the Running Chicken Nebula
KathyBioRender Poster Builder
Rich The Sins of Our Fathers: An Expanse Novella (The Expanse) by James S. A. Corey
VincentBaumgartner Restoration

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JTime, Einstein, and the coolest stuff in the Universe

Intro music is by Ronald Jenkees

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Apr 21, 2022
TWiV 890: Looking into a booster crystal ball
01:55:07

This episode of TWiV is focused on COVID-19 vaccines and antibodies: who should get boosters, whether a variant matched mRNA vaccine is superior to a historical vaccine, and how the interval between vaccination and infection influences the quality of the antibody response.

Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Brianne Barker

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Weekly Picks

Dickson Webb Telescope’s coldest instrument reaches operating temperature
Brianne Video of a CTL killing a tumor cell
Rich Our Unfinished Pandemic (On the Media Podcast)
VincentLý Thị Ca

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Apr 17, 2022
TWiV 889: COVID-19 clinical update #110 with Dr. Daniel Griffin
53:16

In COVID-19 clinical update #110, Dr. Griffin covers hospital admissions during variant outbreaks, viral load in vaccinated and unvaccinated individuals, predictive capacity of symptoms in children, comparison of antigen tests, incidence of myocarditis after vaccination, steroids during replication phase, Paxlovid efficacy and safety, fluvoxamine, sabizabutin, colchicine, and prevalence of infection in Africa.

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Intro music is by Ronald Jenkees

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Apr 16, 2022
TWiV 888: Molnupiravir with Richard Plemper
01:29:57

Richard joins TWiV to discuss the SARS-CoV-2 antiviral drug Molnupiravir , including how it was discovered, its mechanism of action, whether it is a mutagen for cells, and the future of drugs for treatment of COVID-19.

Hosts: Vincent Racaniello, Alan Dove, and Brianne Barker

Guest: Richard Plemper

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BrianneBioRender Poster Builder
AlanHexbug cat toys
Vincent US Mint 2019 American Innovation Coin – PA – Polio Vaccine

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SueAmerican Visionary Art Museum
FrazerVaccine trial for killer elephant virus

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Apr 14, 2022
TWiV 887: Bonfire of the monocytes
01:48:27

TWiV explains why this season’s influenza vaccine is not protecting against mild to moderate disease caused by H3N2 virus, and that antibody-dependent entry of SARS-CoV-2 into monocytes is a major contributor to severe COVID-19.

Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Amy Rosenfeld

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Dickson Ketanji Brown Jackson confirmed to US Supreme Court
Amy Some threats just keep coming in waves
RichLady Bird Johnson Wildflower Center
VincentMartijn Doolaard

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AnnImmunological memory to SARS-CoV-2 infection and vaccines
ChrisIsoplexis

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Apr 10, 2022
TWiV 886: COVID-19 clinical update #109 with Dr. Daniel Griffin
39:29

In COVID-19 clinical update #109, Daniel Griffin discusses cardiac complications after infection or vaccination, long COVID in children, fourth vaccine dose in Israel, no need for fourth vaccine dose in EU, dexamethasone dosing, immunomodulation therapy, MIS outcomes in children, US long COVID effort launched, and herd immunity.

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Intro music is by Ronald Jenkees

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Apr 09, 2022
TWiV 885: Russian bats and Ankara vectors
01:44:06

TWiV reveals an ACE2-dependent sarbecovirus from Russian bats that is not inhibited by anti-SARS-CoV-2 antibodies, and a modified vaccinia virus Ankara vectored vaccine that protects nonhuman primates from Delta infection.

Hosts: Vincent Racaniello, Rich Condit, and Brianne Barker

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Brianne The Search for a Model Octopus That Won’t Die After Laying Its Eggs
RichVaccine Pioneers and Opponents with Paul Offit (Podcast: Connected by Controversy by Chris White)  and The Cutter Incident by Paul Offit
VincentSimply Put: Vaccines Save Lives

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Rich‘Stolen’ Charles Darwin notebooks left on library floor in pink gift bag
NevaElin Thomas, UK textile artist
VikiHistory of English Podcast

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Apr 07, 2022
TWiV 884: Cytokines and viral mimicry
02:01:51

Vincent and Amy explain how asthmatic bronchial smooth muscle increases rhinovirus replication in the bronchial epithelium, and mimicry of IL-17 by the ORF8 protein of SARS-CoV-2.

Hosts: Vincent Racaniello and Amy Rosenfeld

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Weekly Picks

AmyBen Franklin by Ken Burns
Vincent – Thoughts on a second booster: Offit and Krause/Borio

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PhilipHistory of Clemson Blue Cheese
JackPipeline and A Special Report on Polio

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Apr 03, 2022
TWiV 883: COVID-19 clinical update #108 with Dr. Daniel Griffin
45:25

In COVID-19 clinical update #107, Daniel Griffin reviews vaccine booster doses, at-home testing, transmission in ferrets, improving indoor air quality, trials of BCG, ivermectin, and fluvoxamine, vaccination during pregnancy, mRNA vaccines and Fc functions, anti-platelet and aspirin therapy and a trial of prone positioning.

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Intro music is by Ronald Jenkees

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Apr 02, 2022
TWiV 882: Elispot on about T cells and lipids
01:49:18

Vincent and Brianne review the need to better understand T cell responses to SARS-CoV-2 infection to better inform public health decisions, and how IL-1 and IL-1ra are important regulators of the inflammatory response to RNA vaccines.

Hosts: Vincent Racaniello and Brianne Barker

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Weekly Picks

Brianne Covid restrictions prevented dengue in hundreds of thousands of people in 2020
Vincent Scotch Dual Lock 250 Reclosable Fastener

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ErinJWT Preparation and Xploration Outer Space

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Mar 31, 2022
TWiV 881: 50 ways to zap your virus
01:52:13

TWiV describes the identification of a monoclonal antibody that provides broad protection against a variety of hantaviruses, and development of an oral remdesivir-like antiviral that ameliorates viral disease in mice.

Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Amy Rosenfeld

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Weekly Picks

Dickson World’s tallest wooden building
Amy Virus hunter in the Wuhan market
RichWorldPop (example)
VincentKarst Stone Paper

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Neva Can we vaccinate against EBV? and Paul Sutter reading a science paper

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Mar 27, 2022
TWiV 880: COVID-19 clinical update #107 with Dr. Daniel Griffin
47:31

In COVID-19 clinical update #107, Daniel Griffin discusses Moderna vaccine results in children, hospitalization by ethnicity, BA.2 severity in children, placentitis and thrombohematoma during pregnancy, predictive value of symptoms for diagnosis, Evusheld activity against BA.1 and BA.2, Remdesivir resistance, Ivermectin with and without strongyloidiasis, inhaled ciclesonide, home telemonitoring, pulse oximetry for remote monitoring, effectiveness of anti-platelet therapy, and deaths in Zambia.

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Intro music is by Ronald Jenkees

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Mar 26, 2022
TWiV 879: Indolent, resistant, and losing our TMPRSS
01:39:21

TWiV reviews the emergence of remdesivir-resistant SARS-CoV-2 during treatment of a persistently infected immunocompromised patient, and how altered TMPRSS2 utilization by the Omicron variant influences infectivity and fusion.

Hosts: Vincent Racaniello, Alan Dove, Rich Condit, Kathy Spindler, and Brianne Barker

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Weekly Picks

BrianneNSURP 2022
KathyVirology Jobs
Rich10 Steps from Seed to Cup (Graphic)
Alan Fathoms: The World in The Whale, by Rebecca Giggs
VincentWorldwaterday.org

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JeremyArchaeology of Light

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Mar 24, 2022
TWiV 878: Shape matters sometimes
02:04:15

TWiV revisits chronic wasting disease of cervids and the ability of the prions to infect meadow voles and raccoons, and the suggestion that stochastic assembly of influenza virus particles may play a role in phenotypic diversity.

Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Amy Rosenfeld

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Weekly Picks

DicksonJames Webb Space Telescope and Nature Conservancy Photo Contest
Amy A new strategy for staying one step ahead of the virus
RichSearching for the origin of the smallpox vaccine: Edward Jenner and his little-known horsepox hypothesis
VincentBlacktail Studio

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RichardWater Structure and Science

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Mar 20, 2022
TWiV 877: COVID-19 clinical update #106 with Dr. Daniel Griffin
28:13

In COVID-19 clinical update #106, Daniel Griffin covers failure of ivermectin to improve hospitalization, increased hospitalization of children with Omicron, seroconversion of children versus adults, effectiveness of Pfizer mRNA vaccine in children, high vaccine effectiveness in Finland against Omicron, distinct long COVID clinical phenotypes, and estimating worldwide excess mortality.

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Intro music is by Ronald Jenkees

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Mar 19, 2022
TWiV 876: Spillover market with Michael Worobey
01:36:32

Michael Worobey joins TWiV to explain evidence that SARS-CoV-2 emerged via the wildlife trade and that the Huanan market was the unambiguous epicenter of the COVID-19 pandemic.

Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker

Guest: Michael Worobey

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Weekly Picks

BrianneKartchner Caverns (info from Wikipedia here)
KathyLaminar flow and turbulent flow
RichWikipedia
VincentThe Human Lake by Carl Zimmer

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BradNASASpaceflight

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Mar 17, 2022
TWiV 875: Animal house
01:32:32

TWiV discusses the virome of game animals in China, and the finding that binding of sarbecoviruses to ACE2 is an ancestral and evolvable trait.

Hosts: Vincent Racaniello, Dickson Despommier, and Amy Rosenfeld

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Weekly Picks

Dickson Ship found at the bottom of the sea
Amy Vaccinating kids has never been easy
Vincent State data and CDC data on children and COVID-19

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Andrew – Books by Randall Munroe

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Mar 13, 2022
TWiV 874: COVID-19 clinical update #105 with Dr. Daniel Griffin
40:39

In COVID-19 clinical update #105, Daniel Griffin discusses changes in brain structure after infection, dementia in patients with pneumonia, Paxlovid in children, mask effectiveness in schools, host factors and severe disease, post-acute symptoms, and the mission of CEPI.

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Intro music is by Ronald Jenkees

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Mar 12, 2022
TWiV 873: Pig viruses and big viruses
01:56:43

TWiV reviews the six known coronaviruses that infect pigs and what can be learned about human infections, and how the giant Mimivirus DNA genome is organized into a nucleocapsid.

Hosts: Vincent Racaniello, Alan DoveRich Condit, and Brianne Barker

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Weekly Picks

Brianne The Dinosaur Age May Have Ended in Springtime
AlanThe Track of the Typhoon, and me reading it.
Rich12 Monkeys
VincentAnna Mason’s Art Channel

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Richard SARS-CoV-2 in animals: Situation report #9
Jason Counting App and CountThings from Photos

Intro music is by Ronald Jenkees

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Mar 06, 2022
TWiV 872: COVID-19 clinical update #104 with Dr. Daniel Griffin
56:03

In COVID-19 clinical update #104, Daniel Griffin reviews effectiveness of mRNA vaccines among children, number of children affected by disease, accuracy of rapid antigen tests, CDC guidance for prevention strategies, monoclonal antibody effectiveness, predicting progression to severe respiratory failure from pneumonia, risk of long COVID after two vaccine doses, and peripheral neuropathy in long COVID.

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Intro music is by Ronald Jenkees

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Mar 05, 2022
TWiV 871: If the ACE2 fits, ferret
01:42:03

TWiV discusses whether or not Omicron should be designated a new serotype of SARS-CoV-2, and the finding that amino acid changes that adapt SARS-CoV-2 to mink or ferret do not increase fitness in the human airway.

Hosts: Vincent Racaniello, Alan Dove, and Rich Condit

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Weekly Picks

Alan Which Immune Cell Are You? and Michaeleen Doucleff’s article
Rich Vaccinated: One Man’s Quest to Defeat the World’s Deadliest Diseases by Paul A. Offit
VincentEbola on Canvas

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LesOlogies podcast

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Feb 27, 2022
TWiV 870: COVID-19 clinical update #103 with Dr. Daniel Griffin
43:37

In COVID-19 clinical update #102, Daniel Griffin covers immunocompromised people, hospitalization of children, vaccine usage update, Omicron and cross-reactive neutralizing antibodies, reinfection prevents disease in hamsters, repeated infections with endemic coronaviruses, global burden of antimicrobial resistance, ivermectin not protective in hamsters, and Omicron evades therapeutic monoclonals.

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Intro music is by Ronald Jenkees

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Feb 26, 2022
TWiV 869: Epstein-Barr virus and MS, a perfect storm
01:47:45

TWiV reviews epidemiological and experimental evidence that infection with Epstein-Barr virus leads to the production of antibodies against a viral protein that cross-react with a human protein, leading to multiple sclerosis.

Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Brianne Barker

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Weekly Picks

Dickson – Rapid intensification of the emerging southwestern North American megadrought in 2020–2021
Brianne Which Immune Cell Are You?
RichNikola Tesla – 3D Anamorphosis
Vincent Paul’s Uncle Doesn’t Want to Get Vaccinated

Listener Picks

BobThe 1969 Apollo Guidance Computer
Anne Decoding the Gurus with Dan Wilson
BethFrenchGuyCooking

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Feb 20, 2022
TWiV 868: COVID-19 clinical update #102 with Dr. Daniel Griffin
46:12

In COVID-19 clinical update #102, Daniel Griffin reviews children and COVID, effectiveness of maternal vaccination, vaccines for immunocompromised, primary care physicians and vaccination rates, booster safety among adults, placentitis, azithromycin, oral Nirmatrelvir, Omicron antibody evasion, EUA for bebtelovimab, IL-1 blocking agents, thromboprophylaxis, effectiveness of vaccines against long COVID, and risks of mental health outcomes.

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Intro music is by Ronald Jenkees

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Feb 19, 2022
TWiV 867: I love the smell of vaccines in the morning
01:57:59

TWiV reviews an experimental, intranasally administered SARS-CoV-2 vaccine that utilizes adenovirus vectors to deliver three viral proteins and induces immunity to ancestral and variant isolates.

Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler

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Weekly Picks

Kathy – 477-mile-long megaflash lightning in Seattle Times (originally Washington Post) and extra info from Rich World Meteorological Org
RichNIAID Global Research (Mali)
Alan – New method for recycling electric car batteries
Vincent Q&A with A&V

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AddieVaccine Podcast
Jennie Dr. Katelyn Jetelina, aka Your Local Epidemiologist

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Feb 17, 2022
TWiV 866: EV antibodies rEVolutionize our thinking
01:39:45

Amy returns to TWiV to discuss her work on the identification of cross-reactive antibody responses among diverse enteroviruses, and the implications for our understanding of viral pathogenesis and seroprevalence studies.

Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit Brianne Barker, and Amy Rosenfeld

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Weekly Picks

Dickson European scientists set new record in production of nuclear fusion energy
Amy – Alfredo’s Magic Wand
Brianne What Happened After the Chicken-Pox Vaccine?
RichYear Three of COVID-19: Harsh Truths, Realities, and Glimmers of Hope
Vincent Economists Are Fueling the War Against Public Health

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Feb 13, 2022
TWiV 865: COVID-19 clinical update #101 with Dr. Daniel Griffin
47:58

In COVID-19 clinical update #101, Daniel Griffin discusses children and COVID, human challenge study results, effectiveness of mask use, Omicron boost in macaques, mucosal vaccine candidate, long-term cardiovascular outcomes, and global vaccine perceptions.

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Intro music is by Ronald Jenkees

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Feb 12, 2022
TWiV 864: A game of thrones
01:46:40

Monica, John, David, and Marc join TWiV to discuss their work on identifying cryptic SARS-CoV-2 lineages in New York City wastewater, and understanding whether they were shed from humans or other animals.

Hosts: Vincent Racaniello, Rich Condit, and Brianne Barker

Guests: John Dennehy, Marc Johnson, Davida Smyth, and Monica Trujillo

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  • SARS-CoV-2 in NYC wastewater (TWiV 737)
  • Cryptic SARS-CoV-2 in NYC wastewater (Nat Comm)
  • Timestamps by Jolene. Thanks!

Weekly Picks

Brianne – When scientific conferences went online, diversity and inclusion soared
RichTraffic flow measured on 30 different 4-way junctions
Vincent A Slot Machine, a Broken Test Tube by S.E. Luria

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Feb 10, 2022
TWiV 863: Does this challenge study pass the smell test?
01:41:37

TWiV reviews the results of a study in which 36 volunteers were infected with SARS-CoV-2, and what was learned about the kinetics of virus reproduction in the nose and throat, development of symptoms, and reliability of lateral flow antigen assays.

Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Brianne Barker

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Dickson Webb team begins aligning telescope
Brianne – Our Solar System in True Color Is Really Something Else
Rich When the International Space Station retires, it will plunge into the ocean to die
Vincent Gateway Program and What One Really Expensive Means to US Train Travel

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JackDr. Becky and Pasta or composer

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Feb 06, 2022
TWiV 862: COVID-19 clinical update #100 with Dr. Daniel Griffin
37:37

In COVID-19 clinical update #100, Daniel Griffin, from Accra, Ghana, reviews the challenges in evaluating Omicron severity, over 800 deaths in children, Pfizer vaccine EUA application for under 5 year olds, false positives from soft drinks, Novavax vaccine EUA application, childhood experiences and vaccine hesitancy, fourth vaccine dose in Israel, effects of antivirals and monoclonals against Omicron, and multiple factors associated with PASC.

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Intro music is by Ronald Jenkees

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Feb 05, 2022
TWiV 861: Rough draft of Omicron origins
01:54:12

Nels joins TWiV to discuss hypotheses for the origins of Omicron, including that it came from mice or arose during chronic infection of an immunocompromised patient.

Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker

Guest: Nels Elde

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Links for this episode

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Brianne Groundhogs Emerge From the Scientific Shadows
Kathy – Zig-zag Coast Guard search pattern
RichMoon Phases 2022 (Lunar Reconnaissance Orbiter)
VincentKevin Cowtan’s Book of Fourier and Live Fourier Transformation
NelsBiology versus bias

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Dusty Fighting bias in space

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Feb 04, 2022