This Week in Virology

By Vincent Racaniello

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Category: Medicine

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Subscribers: 1079
Reviews: 5

Rachael
 Nov 28, 2020
excellent thanks for doing a great job


 May 29, 2020

excellent
 Apr 23, 2020
great information

Reed
 Jan 15, 2020
amazing in depth podcast on the nuts and bolts of all kinds of viruses. expect in depth discussions of papers by experienced scientists with a decent sense of humour. I can follow along most details even though I have not studied virology.


 May 31, 2019

Description

This Week in Virology is a netcast about viruses - the kind that make you sick.

Episode Date
TWiV 745: Gorilla COVID with Nadine Lamberski
01:48:25

Nadine Lamberski joins TWiV to discuss an outbreak of COVID-19 among gorillas at the San Diego Zoo, and the use of a spike protein-based vaccine to immunize the animals.

Hosts: Vincent Racaniello, Alan Dove, Kathy Spindler, and Brianne Barker

Guest: Nadine Lamberski

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Weekly Picks

BrianneThe Dream Vaccine
AlanTaking vaccines to Smith Island
Kathy Daily Overviews Subscribe Tulips
VincentNextstrain

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

Apr 18, 2021
TWiV 744: COVID-19 clinical update #58 with Dr. Daniel Griffin
45:24

In COVID-19 clinical update #58, Daniel Griffin provides the latest update on the J&J vaccine pause, healthcare worker deaths, children and COVID, physical inactivity associated with higher risk, using monoclonal antibodies for prophylaxis, and shows us how to properly wear a face mask.

Hosts: Daniel Griffin and Vincent Racaniello

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Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to daniel@microbe.tv

Apr 17, 2021
TWiV 743: Shape-shifting viruses
01:54:55

The TWiVsters explain how the shape of pleomorphic virus particles – spherical or filamentous – determines the probability of virus attachment and fusion, and resistance to selective pressure such as antibodies that block cell entry.

Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Amy Rosenfeld

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Weekly Picks

Dickson A tiny particle’s wobble could upend the laws of physics
RichCOVID-19/SARS-CoV-2: Viruses, Vaccines & Variants Made Easy
Amy Vaccine Anthems
VincentDarkNet Diaries Ep. 86

Listener Picks

SteveCover Your Freakin’ Face

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

Apr 15, 2021
TWiV 742: De-fusing COVID-19
01:47:33

TWiV reviews a drug screen for inhibitors of syncytium formation, the fusing of cells caused by SARS-CoV-2, which reveals that the process is regulated by a calcium-activated ion channel and scramblase that is inhibited by the anti-parasite drug Niclosamide.

Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Brianne Barker

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Weekly Picks

BrianneCOVID-19: a disaster five years in the making
AlanThe Tyranny of Merit
Rich Racism Makes Me Question Everything. I Got the Vaccine Anyway
Kathy – The Transcontinental Burrito Tunnel
VincentTrudy Rey’s YouTube Channel

Listener Picks

Jeff Rebecca Lee Smith on Left Right and Center
RyanPerfect Strangers (clip)

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

Apr 11, 2021
TWiV 741: COVID-19 clinical update #57 with Dr. Daniel Griffin
43:19

In COVID-19 clinical update #57, Daniel Griffin covers children and MIS-C, school opening plans, transmission event with masks, fomite transmission, diagnostic test performance, AZ vaccine and blood clots, and long COVID and the effect of vaccines.

Hosts: Daniel Griffin and Vincent Racaniello

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Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to daniel@microbe.tv

Apr 10, 2021
TWiV 740: Complementation will get you everywhere
01:36:39

The Guardians of the TWiV-o-verse discuss the process of codon deoptimization for the production of experimental infectious attenuated viral vaccines, and how a respiratory syncytial virus with 619 base changes was rescued by genomes with very large internal deletions.

Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, Kathy Spindler, and Brianne Barker

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Weekly Picks

Dickson Let us now praise tiny ants
BrianneSmall-school science
Rich Smallpox ‘virus squads’ and the mandatory vaccinations upheld by the Supreme Court
KathyThe Transcontinental Burrito Tunnel
VincentGlass music by Robert Tiso

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

Apr 08, 2021
TWiV 739: COVID-19 convalescent plasma with Arturo Casadevall
01:55:12

Arturo Casadevall joins TWiV to discuss the use of convalescent plasma to treat COVID-19, including a history of the process, how plasma is prepared and tested, why it is difficult to conduct randomized clinical trials, how this treatment has fared and his hopes for the future.

Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Brianne Barker

Guest: Arturo Casadevall

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Weekly Picks

Brianne The Ocean’s Youngest Monsters Are Ready for Glamour Shots
Alan7 Billion Humans
Rich15 Fascinating Animal X-Rays From the Oregon Zoo
Vincent Respiratory pathogen trends

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

Apr 04, 2021
TWiV 738: COVID-19 clinical update #56 with Dr. Daniel Griffin
35:15

In COVID-19 clinical update #56, Daniel Griffin note increasing hospitalization in children and young adults, Pfizer vaccine efficacy results in 12-15 year olds, rapid self administered nucleic acid and antigen tests, mRNA vaccine efficacy in real world conditions, and improvement of long COVID after vaccination.

Hosts: Daniel Griffin and Vincent Racaniello

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Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to daniel@microbe.tv

Apr 03, 2021
TWiV 737: SARS-CoV-2 in NYC wastewater
01:55:15

John, Monica, and Davida join TWiV to discuss development of a method to detect SARS-CoV-2 in raw sewage from all 14 of New York City’s treatment plants, and its use to determine the presence of the genome throughout the pandemic and detection of genome mutations from variants of concern.

Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Kathy Spindler

Guest: John Dennehy, Davida Smyth, and Monica Trujillo

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Weekly Picks

Dickson250,000 Dominoes
BrianneUsing RT-PCR in COVID-19 Testing
Rich Beaded Lacewings Can Take Down Six Termites With A Single Fart
Kathy Tracking the COVID code
VincentAdministering vaccines to adults

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

Apr 01, 2021
TWiV 736: Rhapsody in T with Alessandro Sette
02:01:46

Alessandro Sette joins TWiV to discuss the role of T cells in COVID-19, the finding that amino acid changes in SARS-CoV-2 variants of concern have a negligible impact on T cell reactivity in convalescent patients and vaccinees, and whether a next generation vaccine should include more viral proteins than spike.

Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler

Guest: Alessandro Sette

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Weekly Picks

Alan – The Disinformation Dozen report
Rich No needle, but the damage was done
KathyZinn art  David Zinn
Vincent Clueless Wall Street Journal Op-Ed Endorses PACE as “Prevailing View” Among Docs

Listener Picks

Justin Finnish astrophotographer spends 12 years creating a Milky Way mosaic

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

Mar 28, 2021
TWiV 735: COVID-19 clinical update #55 with Dr. Daniel Griffin
39:37

In COVID-19 clinical update #55, Daniel Griffin reviews recommendations for keeping transmission low in school settings, optimal testing strategies for schools and businesses, impact of vaccines on asymptomatic infections, vaccine safety in PASC patients, and early use of aspirin associated with decreased mortality.

Hosts: Daniel Griffin and Vincent Racaniello

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Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to daniel@microbe.tv

Mar 26, 2021
TWiV 734: Weiss hath no furin like a virus scorned
02:10:57

Susan Weiss returns to TWiV to discuss coronavirus entry into cells and the role of spike protein cleavage by proteases, why lab escaped hypotheses for SARS-CoV-2 are unlikely, and modulation of innate immune responses during infection.

Hosts: Vincent Racaniello, Rich Condit, Alan Dove, Brianne Barker, and Amy Rosenfeld

Guest: Susan Weiss

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Weekly Picks

Brianne Tiktok of How mRNA Vaccines Work
AlanDark
RichUnmixing Color Machine (Ultra Laminar Reversible Flow) – Smarter Every Day 217
AmyMOMA Calder exhibit, reviewed in NYTimes
VincentRipple Training (free YouTube channel)

Listener Picks

Ruth 100 million year old seafloor bacteria resuscitated
IradisLinda Zall, CIA spy for science

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

Mar 21, 2021
TWiV 733: COVID-19 clinical update #54 with Dr. Daniel Griffin
34:27

In COVID-19 clinical update #54, Daniel Griffin covers effectiveness of 3 vs 6 ft physical distancing, effectiveness of masks, physical distancing, and eye shields, second vaccine dose completion, alleviation of COVID-19 symptoms after vaccination, vaccine trials in children, and IDSA approval of a mAb cocktail.

Hosts: Daniel Griffin and Vincent Racaniello

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Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to daniel@microbe.tv

Mar 20, 2021
TWiV 732: Citizen science with Forest Rohwer and Maria-Isabel Rojas
01:52:15

Forest and Maria-Isabel join TWiV to discuss their their project to engage thousands of citizens to swab inanimate surfaces in the San Diego area, then send the samples to the Rohwer Lab for nucleic acid analysis.

Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, Kathy Spindler, and Brianne Barker

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Weekly Picks

Dickson10 amazing science tricks with liquids
Brianne How Do Blind Worms See the Color Blue?
Rich Statewide Study Shows Evidence Of Significant COVID-19 Antibodies In Children
Kathy Dark side of the moon as it crosses Earth
VincentWasdkeyboards and Novelkeys

Listener Pick

Bronwen COVID Performance Index

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

Mar 18, 2021
TWiV 731: The kids aren't alright
01:54:32

On a TWiV tetramer, we review the ongoing outbreaks of Ebolavirus disease in DRC and Guinea, evidence that SARS-CoV-2 infections in children are far more prevalent than are being detected, and recent long COVID estimates from the UK.

Hosts: Vincent Racaniello, Rich Condit, Alan Dove, and Brianne Barker

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Weekly Picks

Brianne Who Would Kidnap a Space Telescope?
AlanRadio Garden
Rich Countries with more obesity have had  more covid deaths on average
VincentConcord Aerospace

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

Mar 14, 2021
TWiV 730: COVID-19 clinical update #53 with Dr. Daniel Griffin
44:35

In COVID-19 clinical update #53, Daniel Griffin reviews underreporting of infections and long term disease in children, a blood test for T cells, results of phase 3 trials for monoclonal antibodies, preliminary findings on an oral antiviral, clinical trial of ivermectin, and recommendations for upcoming gatherings.

Hosts: Daniel Griffin and Vincent Racaniello

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Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to daniel@microbe.tv

Mar 13, 2021
TWiV 729: A floret of spikes with Matt Frieman
01:57:22

Matt Frieman returns to TWiV to discuss the COVID-19 pandemic from the point of view of a coronavirologist, including his work with Novavax on their spike protein-based vaccine.

Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, Kathy Spindler, and Brianne Barker

Guest: Matt Frieman

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Weekly Picks

Dickson Covid-19 deaths per million ranked by average income
Brianne KFF COVID-19 Vaccine Monitor for Feb 2021 and KFF COVID-19 Vaccine Monitor Dashboard
Rich The Woman Who Stood Between America and a Generation of ‘Thalidomide Babies’(wiki)
KathyQuadrantid meteor (Quadrantids)
VincentHigher Superstition by Paul Gross and Norman Levitt

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

Mar 11, 2021
TWiV 728: Cover your nose and mouse
02:11:38

TWiV notes the passing of Mavis Agbandje-McKenna, and reviews data on maximizing fit for cloth and medical procedure masks, SARS-CoV-2 total and subgenomic viral load in hospitalized patients, and effect of changes in spike protein on efficacy in a mouse model of infection.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Brianne Barker

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Weekly Picks

Dickson Wild animal photos
Brianne Greater than COVID
Alan WHO report on infodemic response
Rich Reference Guide to the International Space Station
Vincent3D Molecular Designs

Listener Picks

LisbethHave the new jab
Karen Cholera exhibit at Museum of Trades and Crafts

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

Mar 07, 2021
TWiV 727: COVID-19 clinical update #52 with Dr. Daniel Griffin
35:20

In COVID-19 clinical update #52, Daniel Griffin reviews differences in attack rates between children and adults, J&J vaccine phase III data, G6PD deficiency and vaccines, NIH halts convalescent plasma trial, dexamethasone in hospitalized patients, data on tocilizumab, and long COVID in children.

Hosts: Daniel Griffin and Vincent Racaniello

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Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to daniel@microbe.tv

Mar 06, 2021
TWiV 726: Molecular animator Janet Iwasa
01:52:34

Janet Iwasa joins TWiV to recount how she became a molecular animator, including a pivot during her Ph.D. thesis research, the value of animations in science, and their latest animation of SARS-CoV-2 entry into cells.

Hosts: Vincent Racaniello, Rich Condit, Brianne Barker and Kathy Spindler

Guest: Janet Iwasa

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Weekly Picks

Brianne – How T cells see SARS-CoV2
Rich Ice bubbles in Lago Bianco, Switzerland
Kathy Music in COVID-19 control tents
Vincent Perseverance runs on processors used in 1990s iMacs

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

Mar 04, 2021
TWiV 725: Eva Harris and Janet Smith clip flavivirus wings
01:59:15

Eva Harris and Janet Smith join TWiV to discuss how an antibody against dengue virus NS1 protein blocks endothelial dysfunction and the potential of treating infections by multiple flaviviruses.

Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler

Guest: Eva Harris and Janet Smith

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Weekly Picks

AlanScience Photographer of the Year Awards
RichBar Keeper’s Friend
Kathy Perseverance secret message and other Easter eggs, 11 million Earthlings’ names, “Name the Rover” essay contest. Sign up to send your name on a future Mars mission.
VincentCOVID-19 dataset

Listener Picks

Matthew - Remembering the colleagues we lost to COVID-19
Lori - Iceberger

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

Feb 28, 2021
TWiV 724: COVID-19 clinical update #51 with Dr. Daniel Griffin
36:57

In COVID-19 clinical update #51, Daniel Griffin reviews use of two masks, effectiveness of testing in nursing homes, updates on vaccines, use of nonsteroidal anti-inflammatory drugs, little effect of vitamin D and remdesivir in clinical studies, and a long COVID research initiative from NIH.

Hosts: Daniel Griffin and Vincent Racaniello

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Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to daniel@microbe.tv

Feb 27, 2021
TWiV 723: COVID-19 palliative care with Ginger Campbell, MD
01:48:27

Ginger Campbell joins TWiV to discuss palliative care for COVID-19 patients, and how to approach the disease from a goals of care perspective.

Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Brianne Barker

Guest: Ginger Campbell, MD

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Weekly Picks

DicksonSoapbox Gallery
BrianneCell Picture Show
RichPerseverance Rover’s Descent and Touchdown on Mars (Official NASA Video)
VincentOur World in Data (see COVID-19 vaccinations)

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

Feb 25, 2021
TWiV 722: More coronaviruses in the pipeline
02:02:11

The entire TWiV team assembles to discuss resurgence of COVID-19 in Manaus, Brazil, discovery of SARS-CoV-2 related viruses in bats in Southeast Asia, and increased Ct values after administration of mRNA vaccine.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, Kathy Spindler, and Brianne Barker

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Weekly Picks

DicksonWhat is the polar vortex?
Brianne Cloning of the black-footed ferret
Alan – Explaining mRNA vaccines with Star Wars
RichBrighton Collaboration (BRAVATO); Ad26 vector template
Kathy Target public health ads to zipcodes
Vincent And Then the Gorillas Started Coughing

Listener Pick

Kim – Virus getting the shot (jpg)

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

Feb 21, 2021
TWiV 721: COVID-19 clinical update #50 with Dr. Daniel Griffin
30:21

In COVID-19 clinical update #50, Daniel Griffin discusses CDC guidance on school opening, decreased viral load after vaccination, randomized clinical trial of vitamin D treatment, a study of zinc plus vitamin C, anticoagulation therapy effect on mortality, and multi system inflammatory phase in children.

Hosts: Daniel Griffin and Vincent Racaniello

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Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to daniel@microbe.tv

Feb 20, 2021
TWiV 720: With vaccines, Offit is on it
02:00:57

Paul Offit joins TWiV to discuss all things vaccine, including how COVID-19 vaccine development was accelerated, whether the vaccines are safe and efficacious, the difference between an EUA and a licensed vaccine, sterilizing immunity, herd immunity, and much more.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Brianne Barker

Guest: Paul Offit

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Weekly Picks

DicksonLife in a Day 2020
Brianne Microcosms in Glass
AlanNEJM article on promoting vaccination, interview with lead author
Rich The Microbescope
VincentAutism’s False Prophets by Paul Offit

Listener Pick

EarlScience is Real Pins

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

Feb 14, 2021
TWiV 719: COVID-19 clinical update #49 with Dr. Daniel Griffin
27:41

In COVID-19 clinical update #49, Daniel Griffin discusses CDC guidelines on mask use, drop in test frequency in the US, resurgence of COVID-19 in Brazil, possible impact of Pfizer vaccine on viral load, EUA for bamlanivimab and etesevimab administered together, and preliminary results of Tocilizumab in hospitalized patients.

Hosts: Daniel Griffin and Vincent Racaniello

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Intro music is by Ronald Jenkees

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Feb 13, 2021
TWiV 718: Recombining vaccine schedules
01:52:10

TWiV explores single dose administration and timing of second dose of AZD1222 COVID-19 vaccine, safety and efficacy of Sputnik V, and control of coronavirus recombination by a viral proofreading exonuclease.

Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker

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Weekly Picks

BrianneDo scientists read enough fiction?
Rich Insects in flight; Insect flight|Capturing takeoff
KathyBadger seal
VincentMicrobeTV merchandise

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

Feb 11, 2021
TWiV 717: Paul and Theodora, pandemic explorers
01:57:02

Theodora and Paul return to TWiV to explain how they quickly pivoted their retrovirus laboratories towards SARS-CoV-2, their work on the antibody response to infection and its durability, and the emergence of variants with increased resistance to neutralization.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Rich Condit

Guests: Paul Bieniasz and Theodora Hatziioannou

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DicksonMars Perseverance Rover
AlanThe Outlaw Ocean
RichAnand Varma Photography
Vincent Virology Lectures 2021

Intro music is by Ronald Jenkees

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Feb 07, 2021
TWiV 716: COVID-19 clinical update #48 with Dr. Daniel Griffin
51:46

In COVID-19 clinical update #48, Daniel Griffin reviews effect of spike amino acid changes on neutralization with monoclonal antibodies, Sputnik V safety and efficacy results, increased reactogenicity after a single vaccine dose in seropositive individuals, single dose vaccination in seropositive health care workers, and results of three clinical trials on the use of anticoagulants.

Hosts: Daniel Griffin and Vincent Racaniello

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Intro music is by Ronald Jenkees

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Feb 06, 2021
TWiV 715: Fauci ouchy
01:49:59

TWiV explains why hydroxychloroquine failed in humans despite showing antiviral effects in cells, and reviews the published data on the Pfizer/BioNTech mRNA vaccine.

Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker

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Weekly Picks

BrianneHow the Body Reacts to Viruses
Rich How do wombats poop cubes?
Kathy The Verse by the Side of the Road
Vincent Janet Iwasa’s SARS-CoV-2 entry animation

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

 

Feb 04, 2021
TWiV 714: The shape of spike with Jason McLellan
02:06:48

Jason McLellan joins TWiV to reveal all we know about the SARS-CoV-2 spike protein, followed by Novavax and J&S phase 3 results and a discussion of variants of concern: neutralization by vaccine-induced antibodies, transmission, and virulence.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Amy Rosenfeld

Guest: Jason McLellan

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Dickson Pandemic Pivot and Tuba Skinny
Alan Technological challenges in vaccine rollout
Rich I was lucky to find this vaccine anywhere
VincentLady Gaga’s MIXED METER Star Spangled Banner?!

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

Jan 31, 2021
TWiV 713: COVID-19 clinical update #47 with Dr. Daniel Griffin
34:57

In COVID-19 clinical update #47, Daniel Griffin reviews phase 3 results for Novavax and J&J vaccines, transmission in K-12 settings in Wisconsin, data on Lilly and Regeneron monoclonal antibody therapy, and a study of colchicine for treatment of disease.

Hosts: Daniel Griffin and Vincent Racaniello

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Intro music is by Ronald Jenkees

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Jan 30, 2021
TWiV 712: Deutscher Virus Wahnsinn
01:38:05

Gisa, Steffi, and César join TWiV to discuss their careers, their research, and the COVID-19 pandemic in Germany.

Hosts: Vincent Racaniello, Rich Condit, and Kathy Spindler

Guests: Gisa Gerold, Stefanie Becker, and César Muñoz-Fontela

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Intro music is by Ronald Jenkees

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Jan 28, 2021
TWiV 711: The New Heal
02:00:27

The TWiVers review Biden’s national strategy for the COVID-19 responses and pandemic preparedness, and an evaluation of the BinaxNOW rapid antigen test for SARS-CoV-2 infection.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Brianne Barker

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DicksonSpelling Bee
Brianne He Made a Viral Bernie Meme Site. Now He Has to Keep it Going
Alan – America’s Cup AC75 capsize and aftermath in qualifying race
RichGame Theory’s UNCENSORED Interview With Dr. Fauci | The Truth About COVID-19 Vaccines
Vincent Top Science Podcasts

Intro music is by Ronald Jenkees

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Jan 24, 2021
TWiV 710: COVID-19 clinical update #46 with Dr. Daniel Griffin
34:36

In COVID-19 clinical update #46, Daniel Griffin discusses the BinaxNow rapid antigen test, efficacy of Bamlanivimab in nursing homes, associations of serum vitamin D concentrations with in-hospital mortality and need for invasive mechanical ventilation, trials of IL-6 receptor antagonists, effects of anticoagulants on in-hospital mortality, and symptom persistence in outpatients.

Hosts: Daniel Griffin and Vincent Racaniello

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Intro music is by Ronald Jenkees

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Jan 23, 2021
TWiV 709: COVID cherry picking
01:29:42

In this episode, President Biden elevates his science advisor to his Cabinet, a review of the current flu season, the scientific goals of the WHO-convened Global Study of the Origins of SARS-CoV-2, and answers to listener questions.

Hosts: Vincent Racaniello, Rich Condit, and Kathy Spindler

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Kathy15 YouTubers play Telestrations
VincentVince Beiser

Listener Picks

Bob, David, Janet – Sea Shanty by A Cappella Science (YouTube, TikTok, Bandcamp)

Intro music is by Ronald Jenkees

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Jan 21, 2021
TWiV 708: Alpaca llama full of nanobodies
02:01:11

The TWiVy team deconstructs CoronaVac, the inactivated SARS-CoV-2 vaccine produced by Sinovac Biotech, and production of multivalent camelid nanobodies that block infection with the virus and suppress selection of neturalization-resistant variants.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Brianne Barker

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Dickson Photos of mob attacking Capitol
Brianne Video of Neutrophil Phagocytosis
AlanFishing Through the Apocalypse
Rich A Word on Statistics by Wislawa Szymborska
Vincent Letters from an American

Listener Pick

Mike – Have the new jab

Intro music is by Ronald Jenkees

Jan 17, 2021
TWiV 707: COVID-19 clinical update #45 with Dr. Daniel Griffin
39:38

In COVID-19 clinical update #45, Daniel Griffin discusses J&J Ad26 vaccine results, reactogenicity after the second dose of mRNA vaccines, expansion of vaccine eligibility, and the finding that encephalitis after SARS-CoV-2 infection is a cytokine release syndrome.

Hosts: Daniel Griffin and Vincent Racaniello

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Intro music is by Ronald Jenkees

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Jan 16, 2021
TWiV 706: Do as Dr. Fauci says
01:36:14

TWiV answers listener questions about pandemic response, excess deaths in 25-44 year olds, vaccines, vaccines, and vaccines.

Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker

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Brianne We Know Almost Nothing About Giant Viruses
Rich The Coccolithophores Project
Kathy v-safe and  Vaccine Handbook
Vincent – Gorillas at San Diego Zoo infected with SARS-CoV-2 (pdf)

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Jan 14, 2021
TWiV 705: Rocky Mountain COVID with Emily Travanty
01:50:55

Emily Travanty from the Colorado Department of Public Health and Environment joins TWiV to discuss how her laboratory was the first in the US to detect the SARS-CoV-2 variant VOC 202012/01.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Brianne Barker

Guest: Emily Travanty

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DicksonRandal Despommier on saxophone
BrianneGiant Microbes SARS-CoV2
AlanWest of Loathing
Rich Draft landscape of COVID-19 candidate vaccines
VincentSARS-CoV-2 spillover events

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Daniel – His Vaccine Story Inspired His Father To Write A Disney Classic

Intro music is by Ronald Jenkees

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Jan 10, 2021
TWiV 704: COVID-19 clinical update #44 with Dr. Daniel Griffin
32:03

In this COVID-19 clinical update, Daniel Griffin summarizes current status of vaccination in the US, discusses a study on convalescent sera from Argentina, use of remdesivir in patients with kidney disease, and provides further considerations on the use of Ct values in patient management.

Hosts: Daniel Griffin and Vincent Racaniello

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Intro music is by Ronald Jenkees

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Jan 09, 2021
TWiV 703: Does dose matter?
02:04:55

On this episode, a discussion of why modifying the dose schedule of the mRNA vaccines in the US is not a good idea, evidence that lower Ct values on hospital admission is associated with higher mortality, and dose-dependent response to SARS-CoV-2 infection of ferrets.

Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker

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BrianneLinsey Marr on masks
KathyStriped Martian Sand Dunes and
RichHow Microwaving Grapes Makes Plasma
Vincent Musings of an anonymous, pissed off virologist

Listener Pick

LauraAuld Lang Syne follow-up

Intro music is by Ronald Jenkees

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Jan 07, 2021
TWiV 702: Year of the Pandemic
01:37:10

For this first episode of 2021, the complete TWiV team reviews compelling virology stories of 2020, and thanks the multitude of guests who have helped us to navigate the pandemic, and our many listeners who turn to us for scientific facts.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, Kathy Spindler, and Brianne Barker

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Dickson Best of 2020 by NASA and The Plague Year
Brianne Where Year Two of the Pandemic Will Take Us
Alan – Japan’s distinct form of vaccine hesitancy
Kathy Paul Offit updates on the vaccine rollout and Choral Scholars of University College Dublin (John Greene’s videoessay on the song)
Rich Do You Love Me?
Vincent Story on Katalin Kariko’s career

Listener Pick

LouiseVirus socks

Intro music is by Ronald Jenkees

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Jan 03, 2021
TWiV 701: COVID-19 clinical update #43 with Dr. Daniel Griffin
38:57

In Daniel Griffin’s final clinical report for 2020, he summarizes what we have learned about the clinical management of COVID-19 patients in the past year.

Hosts: Daniel Griffin and Vincent Racaniello

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Intro music is by Ronald Jenkees

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Jan 02, 2021
TWiV 700: 'Twas COVID and the aerosols
02:08:37

TWiV reviews additional data on the UK variant of SARS-CoV-2, the distinct variant spreading in South Africa, association of afucosylated antiviral IgG with severe COVID-19, approval of AstraZeneca vaccine in the UK, and winners of the pandemic poem contest.

Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker

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BrianneReady Player Two
Kathy Bert Hubert’s Reverse Engineering of the Pfizer/BioNTech vaccine
RichBoston Dynamics running robots
VincentFever by John Fuller

Intro music is by Ronald Jenkees

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Dec 31, 2020
TWiV 699: Arboviruses at ASTMH
01:27:11

From the 2020 online meeting of the American Society for Tropical Medicine and Hygiene, Vincent speaks with Jonathan Auguste, Carol Blair, Desiree LaBeaud, Louis Lambrechts, and Mauricio Nogueira about their careers and their research on arthropod-borne viruses.

Host: Vincent Racaniello

Guests: Jonathan Auguste, Carol Blair, Desiree LaBeaud, Louis Lambrechts, and Mauricio Nogueira

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Dec 27, 2020
TWiV 698: COVID-19 clinical update #42 with Dr. Daniel Griffin
40:09

Daniel Griffin provides his weekly clinical report on COVID-19, including his own experience with vaccination, guidelines for vaccine distribution, reasons for under-utilization of monoclonal antibody therapy, and much more.

Hosts: Daniel Griffin and Vincent Racaniello

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Intro music is by Ronald Jenkees

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Dec 26, 2020
TWiV 697: The sky is NOT falling
02:15:56

TWiV reviews the latest data on the UK variant of SARS-CoV-2, including some properties of the variant and why it is being closely studied, development of liver cancer in a participant in a adenovirus-associated virus gene therapy trial, and answers to listener questions.

Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker

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Brianne EM Rap Podcast COVID update
KathyConjunction of Jupiter and Saturn and Tony Fauci vaccinated Santa Claus
RichChicken LIttle (wiki)
Vincentvirological.org

Listener Pick

GregSomeone who wants to make a difference
UliXKCD on statistics

Intro music is by Ronald Jenkees

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Dec 24, 2020
TWiV 696: Tear down that SARS-CoV-2 manuscript
02:11:13

TWiV explains that COVID-19 is not harmless for young adults, FAA approval for Pfizer mRNA vaccine, lack of justification for the claim of reverse transcription of SARS-CoV-2 RNA and integration into the human genome, and lack of evidence for increased transmission by new variants in the UK.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Brianne Barker

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Dickson 2020 Audubon Photography Winners
Brianne COVID-19 Changed Science Forever
AlanEntangled Life by Merlin Sheldrake
Rich Lie of the Year: Coronavirus downplay and denial; John 18:38
Vincent How New York City Vaccinated 6 Million People in Less Than a Month (my article from 2009)

Intro music is by Ronald Jenkees

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Dec 20, 2020
TWiV 695: COVID-19 clinical update #41 with Dr. Daniel Griffin
41:33

Daniel Griffin provides his weekly clinical report on COVID-19, including thoughts on the first immunizations with Pfizer mRNA vaccine, the anticipated EUA for the Moderna vaccine, whether the vaccine prevents infection, not just disease, monoclonal antibody therapy, and much more.

Hosts: Daniel Griffin and Vincent Racaniello

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Intro music is by Ronald Jenkees

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Dec 18, 2020
TWiV 694: Mitigating COVID-19
01:50:33

On this episode, TWiV makes Bloomberg Business News 2020 Jealousy List, crushing of CDC revealed by insiders, seasonal influenza during the COVID-19 pandemic, FDA briefing documents from Moderna, and three-quarters attack rate of SARS-CoV-2 during an unmitigated epidemic in Brazil.

Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker

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Brianne Fears of a ‘Twindemic’ Recede as Flu Lies Low
Kathy Faculty Equity & COVID-19 UM ADVANCE
Rich ‘Sistine Chapel of the ancients’ rock art
Vincent Winners of ASM Agar Art Contest 2020

Listener Pick

Johnye2020 Year of the Vax t-shirt (and more)

Intro music is by Ronald Jenkees

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Dec 17, 2020
TWiV 693: Vax to the future
01:55:05

On this episode, FDA EUA for Pfizer mRNA vaccine, efficacy of AstraZeneca ChAdOx1 COVID-19 vaccine, and an orally administered drug that blocks SARS-CoV-2 transmission in ferrets.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Brianne Barker

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Dickson 2020 In Photos: A Year Like No Other
BrianneCooking for Geeks
AlanOn Food and Cooking
RichNASA Artemis (Wiki)
Vincent The virus, the bats, and us

Intro music is by Ronald Jenkees

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Dec 13, 2020
TWiV 692: COVID-19 clinical update #40 with Dr. Daniel Griffin
38:12

Daniel Griffin provides his weekly clinical report on COVID-19, including the anticipated EUA for the Pfizer mRNA vaccine, mitigation strategies in early care and education settings, expressive aphasia, and much more.

Hosts: Daniel Griffin and Vincent Racaniello

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Intro music is by Ronald Jenkees

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Dec 11, 2020
TWiV 691: SciArt with Laura Splan
02:11:55

SciArtist Laura Splan joins TWiV to reveal her transdisciplinary work that intersects science, technology, design and culture, then we discuss an inverse correlation between mumps virus antibodies induced by MMR vaccine and COVID-19 severity, and whether ivermectin is indicated for treatment of COVID-19.

Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker

Guest: Laura Splan

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Brianne – Patterns for Virus snowflakes
Kathy – 2020 Nobel Prize lectures (hepatitis C) (link to all and concert) Historical review by Harvey Alter
Rich New Data Confirm 2020 SO is Upper Centaur Rocket Booster from 1960’s (Wiki)
VincentThe Right Stuff

Listener Pick

Miikael Tiny tweak behind COVID-19 vaccines

Intro music is by Ronald Jenkees

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Dec 10, 2020
TWiV 690: This is your brain on SARS-CoV-2
01:59:02

TWiV reviews the difficulties in predicting species susceptibility to SARS-CoV-2 infection by only examining the ACE2 protein, and the olfactory mucosa as a portal of entry into the central nervous system in COVID-19 patients.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Rich Condit

Guest: Amy Rosenfeld

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Dickson National Geographic best animal photos of 2020
AmyAmerican Contagions: Epidemics and the law from Smallpox to COVID-19 by John Fabian Witt
AlanHamSCI citizen science organization
RichDeepMind’s AI makes gigantic leap in solving protein structures
VincentArmy Ants: Nature’s Ultimate Social Hunters by Daniel Kronauer

Intro music is by Ronald Jenkees

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Dec 06, 2020
TWiV 689: COVID-19 clinical update #39 with Dr. Daniel Griffin
37:11

Daniel Griffin provides his weekly clinical report on COVID-19, including analysis of vitamin D levels in patients, information on Moderna and Pfizer vaccines, distribution plans suggested by ACIP, and more.

Hosts: Daniel Griffin and Vincent Racaniello

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Intro music is by Ronald Jenkees

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Dec 05, 2020
TWiV 688: We put COVID-19 papers through a sieve
01:50:30

TWiV 688: We put COVID-19 papers through a sieve

December 2, 2020

On this episode, UK grants EUA for Pfizer vaccine, advice for CDC on who to immunize first, news from Das Coronavirus, SARS-CoV-2 protease regulates innate responses, and viral mRNAs are not an indication of viral replication.

Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker

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BriannePedromics
KathyGlobal map at Mars opposition
RichJaneway’s Immunobiology
VincentJanet Iwasa’s Animation Lab

Listener Pick

Cheryl – BioRender.com holiday card templates

Intro music is by Ronald Jenkees

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Dec 03, 2020
TWiV 687: Peter Hotez sticks to the vax
02:18:04

Peter Hotez joins TWiV to discuss the COVID-19 pandemic, including why it went out of control in the US, the hijacking of public health practices by anti-science extremist groups, prospects for control, and whether we will be prepared for the next one.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Brianne Barker

Guest: Peter Hotez

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Dickson The World’s First Energy-Positive Hotel to Open in Norway
Brianne The Food Lab: Better Home Cooking Through Science
Alan ACIP’s ethical principles for COVID-19 vaccine allocation
RichThe Mandolorian
VincentT. rex and the Crater of Doom by Walter Alvarez

Intro music is by Ronald Jenkees

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Nov 29, 2020
TWiV 686: COVID-19 clinical update #38 with Dr. Daniel Griffin
34:26

Daniel Griffin provides his weekly clinical report on COVID-19, including new post-exposure guidelines from CDC, clinical trials of Remdesivir and convalescent plasma, FDA EUA for baricitinib and Regeneron’s monoclonal antibody and more.

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Intro music is by Ronald Jenkees

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Nov 28, 2020
TWiV 685: Pandemicky
01:50:25

The TWiVers analyze efficacy of the AstraZeneca/Oxford adenovirus vectored vaccine, SARS-CoV-2 did not infect miners who became ill 8 years ago after cleaning bat guano from a cave in Yunnan Province, and induction of antigen-specific germinal center responses and production of neutralizing antibody by SARS-CoV-2 mRNA vaccine but not purified protein.

Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker

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Brianne Types of Scientists Coloring Book
KathySouth Pole video
RichSteve Jobs by Walter Isaacson
VincentScreenology (I interviewed Deb Sklut here)

Listener Pick

MonaAd5 vector and podcast with ImmunityBio founder

Intro music is by Ronald Jenkees

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Nov 26, 2020
TWiV 684: Persistence of SARS-CoV-2 immune memory
03:04:01

Daniel Griffin provides a clinical report on COVID-19, and Shane Crotty explains a study of antibodies, B cells and T cells in patients which suggests that immunological memory to SARS-CoV-2 might be long-lived.

Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Brianne Barker

Guests: Daniel Griffin and Shane Crotty

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Weekly Science Picks

Dickson Benoit Mandlebrot’s 96 birthday
Brianne#BlackinImmunoWeek
Rich GoISSWatch ISS Tracking; Spot The Station (NASA)
VincentMicrobes Rule

Listener Pick

Agda Sandwalk

Intro music is by Ronald Jenkees

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Nov 22, 2020
TWiV 683: Two COVID-19 mRNA vaccines
01:59:11

On this episode of TWiV, mRNA vaccines from Moderna and Pfizer show over 90% efficacy, prothrombotic auto-antibodies in serum of COVID-19 patients, and the whereabouts of SARS-CoV-2 in the human body.

Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker

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BriannePicture a Scientist
KathyColors of the Moon and Word that hasn’t changed
RichNASA YouTube channel
VincentLaura Splan science art

Listener Pick

MonaAd5 vector and podcast with ImmunityBio founder

Intro music is by Ronald Jenkees

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Nov 19, 2020
TWiV 682: Kate Rubins from the International Space Station
28:36

From Expedition 64 of International Space Station, Flight Engineer Kate Rubins joins TWiV to discuss experiments that she is working on, including cell cultures, genome sequencing, and plant growth.

Hosts: Vincent Racaniello and Rich Condit

Guest: Kate Rubins

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Intro music is by Ronald Jenkees

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Nov 17, 2020
TWiV 681: Crowley, coats, and cross-reactive antibodies
02:58:39

Daniel Griffin provides a clinical report on COVID-19, Kathleen Crowley explains the role of Environmental Health & Safety departments, update on SARS-CoV-2 transmission in farmed mink, and the presence of pre-existing antibodies to SARS-CoV-2 in unexposed individuals.

Guests: Daniel Griffin and Kathleen A. Crowley

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DicksonOSIRIS-REx | NASA
Brianne Virtual Science Museum Tours
AlanRing Fit Adventure
RichBUGSS Baltimore Underground Science Space
VincentTrilobite glassworks

Listener Pick

Gina and JoeCOVID Fan Tutte

Intro music is by Ronald Jenkees

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Nov 15, 2020
TWiV 680: Long-term COVID and ME/CFS
01:52:14

Mady, Fiona, and David join TWiV to discuss patients with long-term COVID and similarities and differences with ME/CFS.

Guests: Mady Hornig, Fiona Lowenstein, and David Tuller

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Nov 12, 2020
TWiV 679: Mink, mutation, and myocytes
02:37:24

Daniel Griffin provides a clinical report on COVID-19, Slovlakia’s plan to test all adults for SARS-CoV-2 infection, viral variants arising in Danish mink and their potential threat to humans, why it is unethical to carry out challenge trials, Nipah virus dynamics in bats and spillovers into humans, and direct cardiac damage by spike-mediated cardiomyocyte fusion.

Guests: Daniel Griffin and Amy Rosenfeld

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DicksonCNN News
AmyI voted and Grace for President
AlanThe Story of More by Hope Jahren
RichOSIRIS-REx and 101955 Bennu
VincentThe Vexed Muddler

Intro music is by Ronald Jenkees

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Nov 08, 2020
TWiV 678: Fishing for viruses with Nels Elde
01:51:12

Nels joins TWiV to reveal the discovery of a picornavirus of zebrafish by measuring immune responses in the host, genome sequence analysis of the White House COVID-19 outbreak, and a six-fold higher SARS-CoV-2 exposure rate than reported cases in German children.

Hosts: Vincent Racaniello, Rich Condit, and Kathy Spindler

Guest: Nels Elde

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Weekly Science Picks

Kathy –  Why art is important and Tagging an asteroid
RichVendee Globe
VincentPrePubMed

Intro music is by Ronald Jenkees

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Nov 05, 2020
TWiV 677: Does antibody really know what time it is?
02:41:15

Daniel Griffin provides a clinical report on COVID-19, then we discuss rapid deployment of SARS-CoV-2 testing by research laboratories in San Francisco, longitudinal observation of antibodies to SARS-CoV-2 in patients, and listener questions on vaccines, loss of smell, face masks, and more.

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Weekly Science Picks

DicksonComedy Wildlife Photography
BrianneEd Yong – Science reporting during a pandemic
AlanTree Story by Valerie Trouet
Rich Boundless Body Radio Bethany and Casey Ruff
VincentWearing is Caring

Intro music is by Ronald Jenkees

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Nov 01, 2020
TWiV 676: Tragic gene flow from Neanderthals
02:00:05

In this episode we explain how regions of the human genome associated with severe COVID-19 are identified, the finding that one of these regions was inherited from Neanderthals, and prolonged SARS-CoV-2 reproduction in an immunocompromised patient.

Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler and Brianne Barker

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Brianne Kids Meet a Virologist
Kathy –  Harvard glass marine invertebrates 3D online
Rich Chernobyl fungi
VincentArtologica

Listener Pick

JustinTotally Under Control

Intro music is by Ronald Jenkees

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Oct 29, 2020
TWiV 675: Forget what you've herd about immunity
02:54:21

Daniel Griffin provides a clinical report on COVID-19, then we discuss Bill Foege’s letter to CDC director Robert Redfield, the false promise of herd immunity for COVID-19, secret blueprints for SARS-CoV-2 vaccine trials released, and neuropilin-1 as a possible entry protein for the virus.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Brianne Barker

Guest: Daniel Griffin

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Dickson Nikon Small World Photography Competition
BrianneModeling Herd Immunity for measles
Alan Small Gods by Terry Pratchett
RichBoundless Body Radio Bethany and Casey Ruff
VincentThe Twenty-One Balloons by William Pene du Bois

Intro music is by Ronald Jenkees

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Oct 25, 2020
TWiV 674: In the company of coronaviruses with Lisa Gralinski
01:58:45

Lisa joins TWiV to discuss her research on the pathogenesis of SARS-CoV, MERS-CoV, and SARS-CoV-2, including work on vaccines and an antiviral, then we review the SARS-CoV-2 spike protein as a potential analgesic, and listener questions.

Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler and Brianne Barker

Guest: Lisa Gralinski

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Brianne The Lonely Pipette Podcast: Mentoring with Harmit Malik
Kathy –  Dr. Boyd the Chemist one and two  GREAT short videos one and two,  How to read an old school thermometer, New Marvel storyline  Wear a Mask parody of Be My Guest
Rich Clear+Vivid with Alan Alda
VincentImmune 36: Aberrant immunity in COVID-19

Listener Pick

Ryan Dr. Fauci on politicization of pandemic

Intro music is by Ronald Jenkees

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Oct 22, 2020
TWiV 673: Wake up and smell the pandemic
02:40:48

Daniel Griffin provides a clinical report on COVID-19, we debunk the Great Barrington Declaration, and discuss smell and taste changes as early indicators of the pandemic, vascular disease and thrombosis in SARS-CoV-2 infected humans and rhesus macaques, and the ability of the swine pathogen SADS-CoV to infect human respiratory tract cells.

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DicksonThe Age of Nature
Brianne Virologist, Immunologist, Science Communicator pins and Virus Earrings
Alan Sharks, Squalene, and a SARS-CoV-2 Vaccine
Rich6th Annual Science Mill Benefit
VincentThe Evolution of Infectious Disease by Paul Ewald

Intro music is by Ronald Jenkees

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Oct 18, 2020
TWiV 672: Black in Microbiology with Ari Kozik and Kishana Taylor
02:05:59

Ari and Kishana, two of the founders of Black in Microbiology, join TWiV to discuss the goals of the organization, then we review pauses of J&J and Lilly COVID-19 vaccine trials, preclinical studies of Regeneron's SARS-CoV-2 monoclonal antibody cocktail, reinfection of a patient in Nevada, and listener questions.

Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler and Brianne Barker

Guest: Ari Kozik and Kishana Taylor

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Weekly Science Picks

Brianne - A Lab of One's Own by Rita Colwell
Kathy –  Endonym map
Rich - “The Coronavirus Unveiled” by Carl Zimmer
Vincent - Principles of Virology 5th Edition

Listener Pick

Les - Coronavirus cake
Mary - Choir finds a way to sing

Intro music is by Ronald Jenkees

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Oct 15, 2020
TWiV 671: Prizes, polio, and a pandemic puzzle
02:49:43

Daniel Griffin provides a clinical report on COVID-19, then Amy joins us to discuss the 2020 Chemistry Nobel Prize for gene editing using CRISPR/Cas9, continuing circulation of poliovirus in Afghanistan, inborn errors of interferon in patients with severe COVID-19, and listener questions.

Hosts: Vincent Racaniello, Alan Dove, and Rich Condit

Guests: Daniel Griffin and Amy Rosenfeld

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Amy - Coronavirus : A book for children by Kate Wilson and Nia Roberts
Alan - Lost Prologue
Rich -RAPS COVID-19 vaccine tracker
Vincent - A Crack in Creation by Doudna and Sternberg and Sternberg on TWiM 184

Intro music is by Ronald Jenkees

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Oct 11, 2020
TWiV 670: Coronavirus vaccine preparedness with Kizzmekia Corbett
02:07:19

Kizzmekia Corbett joins TWiV to review her career and her work on respiratory syncytial virus, influenza virus, and coronaviruses and coronavirus vaccines, including her role in development and testing of a spike-encoding mRNA vaccine, and then we review the Nobel Prize for discovery of hepatitis C virus.

Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler and Brianne Barker

Guest: Kizzmekia Corbett

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Brianne - COVID-19 in Molecular Detail for Teaching
Kathy – Mars shining brightest since 2003
Rich - Lost Prologue
Vincent - Girl from Ipanema is weirder than you thought

Listener Pick

Sandra - Learn Medical Research

Intro music is by Ronald Jenkees

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Oct 08, 2020
TWiV Special: Presidential COVID-19 with Dr. Daniel Griffin
34:04

Daniel Griffin discusses President Trump's case of COVID-19, including the clinical course, the medications he received and why, and expectations for the next few weeks.

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Intro music is by Ronald Jenkees

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Oct 05, 2020
TWiV 669: All the wrong COVID-19 moves
03:00:09

Daniel Griffin provides a clinical report on COVID-19, including a discussion of the role of vitamin D in COVID-19, Michael and Christopher explain why we have made all the wrong moves during the pandemic, evidence that the D614G amino acid change improves transmission in hamsters, and listener questions.

Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Brianne Barker

Guests: Daniel Griffin, Michael B. Yaffe, and Christopher D. Barrett

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Weekly Science Picks

Dickson - Why we should all wear masks
Brianne - Milestones in Vaccines
Rich - Wallpaper/fabric designs by David Goodsell
Vincent - Das Coronavirus bullet points and a new t-shirt

Listener Pick

Justin - COVID Alert NY App | Department of Health

Intro music is by Ronald Jenkees

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Oct 04, 2020
TWiV 668: Mice, bats, and coronaviruses with Tony Schountz
01:46:21

Tony Schountz joins TWiV to explain the work of his laboratory showing that deer mice can be infected with and transmit SARS-CoV-2, and how his colony of Jamaican fruit bats is being used to understand their response to virus infections.

Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler and Brianne Barker

Guest: Tony Schountz

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Brianne - Virus Masks
Kathy – UV in the vineyards (video)
Rich - Great White Shark Attack
Vincent - Smart WiFi garage door opener

Intro music is by Ronald Jenkees

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Oct 01, 2020
TWiV 667: Building a better virus trap
02:45:17

Daniel Griffin provides a clinical report on COVID-19, review of the phase I and II trials of the Russian prime-boost vaccine, a mouse model that recapitulates age-dependent severe disease, and listener questions.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Rich Condit

Guest: Daniel Griffin

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Weekly Science Picks

Dickson - Rewilding Europe
Alan - How to Do Nothing by Jenny Odell
Rich - Gene drive engineered mosquitoes
Vincent - TWiEVO 60 with 12 guests!

Intro music is by Ronald Jenkees

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Sep 27, 2020
TWiV 666: A far-UVC light bulb went off for David Brenner
02:09:16

David Brenner joins TWiV to explain how far-UVC lights could provide protection from SARS-CoV-2 and other airborne viruses in public places, solutions to face mask fogging, transmission during airplane flights, and listener questions.

Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler and Brianne Barker

Guest: David Brenner

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Sep 24, 2020
TWiV 665: This half-week in coronavirology
02:56:03

Daniel Griffin provides a clinical report on COVID-19, superspreading potential of SARS-CoV-2 in Hong Kong, structure of virion glycoprotein of a commmon cold coronavirus reveals changes driven by prolonged circulation in humans, and listener email.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Brianne Barker

Guest: Daniel Griffin

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Intro music is by Ronald Jenkees

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Sep 20, 2020
TWiV 664: TWiV is for the dogs
02:01:49

On this mid-week edition, does it matter that SARS-CoV-2 is mutating, seasonal coronavirus immunity is short-lived, another bogus claim that the virus was produced in a laboratory (it came from Nature), and answers to listener questions.

Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler and Brianne Barker

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  • Coronavirus is mutating (Nature)
  • Seasonal CoV immunity is short (Nat Med)
  • Sorry, no link to the fake science document!
  • Letters read on TWiV 664
  • Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees

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Sep 17, 2020
TWiV 663: The joy of vax
02:36:57

Daniel Griffin provides a clinical report on COVID-19, including vaccines, Alan summarizes a vaccine webinar on the most advanced US trials, a nidovirus from snapping turtles, longevity of memory B cells in recovered patients, and listener email.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Brianne Barker

Guest: Daniel Griffin

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Intro music is by Ronald Jenkees

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Sep 13, 2020
TWiV 662: Principals of Principles, Fifth Edition
52:23

The authors of the textbook Principles of Virology gather to reveal new additions to the fifth edition, including a new author, study questions, and a chapter on therapeutic viruses.

Host: Vincent Racaniello

Guests: Jane Flint, Anna Marie Skalka, Glenn F. Rall, and Theodora Hatziioannou

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  • Purchase PoV 5e Volumes 1 + 2 (link)
  • Purchase PoV 5e Volume 1 (link)
  • Purchase PoV 5e Volume 2 (link)

Intro music is by Ronald Jenkees

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Sep 11, 2020
TWiV 661: SWAG with Ralph Baric
01:55:51

Ralph Baric returns to TWiV to provide an update on the COVID-19 resurgence in the US, monoclonal antibodies, antiviral drugs, vaccines, immunity and reinfection, reopening schools, and what will happen this fall.

Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler and Brianne Barker

Guest: Ralph Baric

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Intro music is by Ronald Jenkees

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Sep 10, 2020
TWiV 660: In case of emergency finish the trial
02:38:47

Daniel Griffin provides a clinical report on COVID-19, then we discuss decline of virus-specific bone marrow B cells within a year after influenza vaccination, the push to release SARS-CoV-2 vaccines before completion of phase 3 trials, and absence of evidence for infectious virus in aerosols.

Hosts: Vincent Racaniello, Alan Dove, Rich Condit, Kathy Spindler, and Brianne Barker

Guest: Daniel Griffin

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Intro music is by Ronald Jenkees

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Sep 06, 2020
TWiV 659: Sloppy coronavirus immunity with Christian Drosten
02:00:00

Christian Drosten returns to TWiV to provide an update on the COVID-19 situation in Germany, and general thoughts on testing, immunity, vaccines, therapeutics, epidemiology, reopening schools, and what will happen this fall.

Hosts: Vincent Racaniello, Rich Condit, and Brianne Barker

Guest: Christian Drosten

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Intro music is by Ronald Jenkees

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Sep 03, 2020
TWiV 658: Everyone needs a H.E.A.R.T.
02:21:07

Daniel Griffin provides a clinical report on COVID-19, then we discuss CDC softening testing guidelines, Moderna vaccine phase I results in older people, Abbott's $5 rapid antigen test, and reinfection with a distinct SARS-CoV-2 isolate, followed by listener email.

Hosts: Vincent Racaniello, Alan Dove, Dickson Despommier, and Rich Condit

Guest: Daniel Griffin

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Intro music is by Ronald Jenkees

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Aug 30, 2020
TWiV 657: Shane Crotty on SARS-CoV-2 immunity
02:13:23

Immunologist Shane Crotty joins TWiV to discuss the antibody and T cell responses to infection with SARS-CoV-2, followed by answers to listener questions.

Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker

Guest: Shane Crotty

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Intro music is by Ronald Jenkees

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Aug 27, 2020
TWiV 656: See, it can be done!
02:20:48

Daniel Griffin provides a clinical report on COVID-19, surgeons Lisa Smith and David Bruce detail how they have helped their Chattanooga community during the pandemic, then we discuss racial and ethnic disparities among COVID-19 cases, no more premarket review of laboratory developed tests by FDA; and emergency use authorization of convalescent plasma is on hold.

Hosts: Vincent Racaniello, Dickson DespommierRich Condit, and Brianne Barker

Guests: Daniel Griffin, Lisa A. Smith, and W. David Bruce

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Intro music is by Ronald Jenkees

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Aug 23, 2020
TWiV 655: Minority health with Robert Fullilove
02:27:23

Sociomedical scientist Robert Fullilove joins TWiV to discuss disparities in minority health; FDA announces an EUA on Yale's SalivaDirect, protection of the upper and respiratory tract of mice after intranasal inoculation with an adenovirus-vectored SARS-CoV-2 spike gene, and listener questions.

Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker

Guest: Robert Fullilove

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Intro music is by Ronald Jenkees

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Aug 20, 2020
TWiV 654: TWiVering with excitement
02:35:37

Daniel Griffin provides a clinical report on COVID-19 and the convalescent plasma trial, then we answer listener questions about the Russian vaccine, choir practice, face masks (wear them!), Mina testing, transmission, and much more.

Hosts: Vincent Racaniello, Dickson DespommierAlan Dove, Rich Condit, and Brianne Barker

Guests: Daniel Griffin and Chuck Knirsch

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Intro music is by Ronald Jenkees

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Aug 16, 2020
TWiV 653: Back to school with COVID-19
55:52

Alfonso, Ken, Mary and Janet join TWiV to explain their modeling of school reopening strategies during the SARS-CoV-2 pandemic.

Hosts: Vincent Racaniello and Rich Condit

Guests: Alfonso Landeros, Ken Lange, Mary E. Sehl, and Janet Sinsheimer

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Intro music is by Ronald Jenkees

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Aug 14, 2020
TWiV 652: The rules of contagion with Adam Kucharski
01:54:18

Epidemiologist Adam Kucharski joins TWiV to discuss SARS-CoV-2, including R0, incubation period, herd immunity, asymptomatic infection, superspreaders, children as drivers of pandemics, and how this one will end.

Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker

Guest: Adam Kucharski

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Intro music is by Ronald Jenkees

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Aug 13, 2020
TWiV 651: FDA rules with Denise Esposito
02:43:55

Daniel Griffin provides a clinical report on COVID-19, then former FDA Chief of Staff to the Commissioner Denise Esposito joins us to explain the challenges in approving vaccines, antiviral drugs, and diagnostic tests during a pandemic, followed by answers to listener questions.

Hosts: Vincent Racaniello, Dickson DespommierAlan Dove, Rich Condit, and Brianne Barker

Guests: Daniel Griffin and Denise Esposito

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Intro music is by Ronald Jenkees

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Aug 09, 2020
TWiV 650: Virology is infinite
02:02:03

In this mid-week episode of Earth's Virology Podcast, we analyze SARS-CoV-2 transmission among youths at a summer camp, adaptation to mice by passage, the importance of T cells for recovery from COVID-19, and listener questions.

Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker

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Weekly Science Picks

KathyBBC Witness History, Maurice Hilleman 9 minute audio (quotes by Paul Offit) “The fastest vaccine ever developed”And APOD Picture Rocks Sun Dagger

Intro music is by Ronald Jenkees

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Aug 06, 2020
TWiV 649: Ohio State viral
01:45:01

Vincent visits Ohio State University (March 2020) and speaks with Shan-Lu, David, Amanda, Mark, Matt, Chris, and Qiuhong about their careers and their work on retroviruses, hepatitis C virus, coronaviruses, paramyxoviruses, and environmental viruses.

Host: Vincent Racaniello

Guests: Shan-Lu Liu, David Bisaro, Amanda Panfill, Mark Peeples, Matt Sullivan, Chris Walker, Qiuhong Wang

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Intro music is by Ronald Jenkees

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Aug 04, 2020
TWiV 648: Life is for learning
02:55:23

Daniel Griffin provides a clinical report on COVID-19, followed by a review of the findings that children shed as much SARS-CoV-2 viral RNA from the respiratory tract as older patients, the lineage giving rise to SARS-CoV-2 has been circulating in bats in China for decades, and answers to listener questions.

Hosts: Vincent Racaniello, Dickson DespommierAlan Dove, Rich Condit, and Brianne Barker

Guest: Daniel Griffin and Chuck Knirsch

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Intro music is by Ronald Jenkees

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Aug 02, 2020
TWiV 647: Testing is our way out of this crisis
01:54:21

In this mid-week TWiV, children under 10 do transmit SARS-CoV-2, why hydroxychloroquine does not work for treating COVID-19, scale-up of diagnostic testing, explanation of LAMP testing, and listener questions.

Hosts: Vincent Racaniello, Rich Condit, and Kathy Spindler

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Weekly Science Picks

Kathy - Vertical Farms Fill a Tall Order by Dickson Despommier and APOD
Rich - Mars in 4K

LIstener Pick

Christiane - ZSK - Ich habe Besseres zu tun (Official Video) Drosten
Jon - The Logic of Doomsday

Intro music is by Ronald Jenkees

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Jul 30, 2020
TWiV 646: Virocentricity II with Eugene Koonin
01:55:57

From the NIH campus (recorded February 2020) Vincent and Rich meet with Eugene Koonin to discuss his theories on the evolutionary origins of viruses.

Hosts: Vincent Racaniello and Rich Condit

Guest: Eugene Koonin

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Intro music is by Ronald Jenkees

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Jul 28, 2020