Nayan Patel, PharmD recently published his first comprehensive book, “The Glutathione Revolution: Fight Disease, Slow Aging & Increase Energy.” After 14 years of clinical research on the master antioxidant, glutathione, Dr. Patel finally shares how powerful and essential glutathione is to the body’s detox system. He speaks about the various benefits it has with slowing the aging process down, and explains how you can increase your levels naturally. Dr. Patel is a firm believer in providing the body with tools it needs to defend itself and promote a healthy lifestyle that fits the pace of the modern world. Nayan Patel, Pharm.D is globally regarded as the foremost go-to expert on absorbable forms of glutathione, and holds the only patent on transdermal glutathione.

Along with traveling the world educating practitioners on advanced biochemistry and anti-aging science, Dr. Patel also serves as adjunct faculty at the University Of Southern California School Of Pharmacy where he is also an alumnus.

9th Annual Biohacking Conference: You’ll learn from dozens of experts at an amazing event that’s designed to upgrade every area of your life. https://biohackingconference.com

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Mario Brainovic is an expert in the science of water, specifically focusing on its ability to transmit energy, frequency, and vibration. With a wealth of knowledge and extensive research under his belt, Mario has dedicated his work to understanding the profound changes that can occur in our biology when we consume water that has been treated with the right frequencies.

As the CEO of Analemma, Mario has developed a unique approach to creating positively charged water that can boost our physiology and overall health. This friendly and passionate water enthusiast is always eager to share new findings and discoveries to help others optimize their energy levels.

Find all the links and resources in the show notes.

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Biohack and advance your skincare to the next level with https://bioquantumskincare.com/ use code DAVE22 for 22% OFF

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Looking for a more balanced and fulfilling life? A life where you prioritize your own self-awareness and holistic wellness? Well, Jason Wachob has the solution to help you achieve optimal health and vitality through a mindful and prioritized approach to your well-being.

In this episode, Jason will teach you how to fortify your emotional well-being by fostering social connections and community ties. Enhance the environment through the adoption of regenerative agriculture and sustainable farming techniques. Discover happiness and significance by focusing on the crucial aspects of life. Fine-tune your diet by paying attention to your body's unique needs for optimal health.

Watch this episode on YouTube.

Find all the links and resources in the show notes.

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Genpo Roshi, the respected spiritual leader with a wealth of experience in Zen practice and personal growth, is back in this legacy upgrade episode.

In this episode, you will uncover the wisdom behind Genpo Roshi's views on Zen and meditation on your path towards enlightenment. Master the skills of non-judgmental relaxation techniques to enhance inner peace. Combine the power of deep relaxation, Big Mind process, and koan practice for a holistic meditation experience. Discover the keys to lasting happiness by embracing freedom and giving up the pursuit of external factors.

Listen in to learn how to cultivate personal growth through self-care practices, valuable introspection, and fostering healthy relationships.

Get all the links and resources in the show notes.

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What if everything you perceive is just a construction of your brain? In this episode, Anil Seth and Philip Goff explain how our perception of reality is a product of our minds and how it can be manipulated. They also delve into the implications of these findings, and take a dark turn, leaving you questioning everything you thought you knew about yourself and the world around you.

Get ready to dive into the fascinating world of perception and consciousness with our guests Philip Goff and Anil Seth. Together, they're here to unravel the mysteries of how our brains construct our conscious reality.

Tune in to explore panpsychism and its fascinating connection between consciousness and matter. Gain an understanding of how our brains craft our conscious reality through the intricate process of perception. Acknowledge the limitations of traditional views on consciousness while considering the perks of embracing panpsychism. Master the art of training perception for practical applications rather than perfect accuracy. And most importantly, discover insightful tools for probing consciousness, such as meditation and introspection.

Get all the links and resources in the show notes.

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Nancy Sheeber, a talented actress and designer who's been around the block in the entertainment industry gets deep with Dave about how to achieve the most conscious and self-sufficient death. Also, explore why despite your efforts in following strict diets, rigorous exercise routines and experimenting with various biohacking techniques, you're still struggling to achieve optimal health.

In this intervention, you will learn to appreciate the power of community in realizing optimal health. Find out about the significance of a balanced Omega 6 and Omega 3 diet for your well-being. You will also identify the benefits of addressing your ego in pursuing personal growth. You will also learn techniques to investigate cutting-edge approaches for attaining maximum wellness.

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Unravel the insights and wisdom shared by two legendary guests: Mr. Olympia Frank Zane and renowned strength expert Ben Pakulski.

Frank Zane is an American former professional bodybuilder, author, and coach who has left a lasting impact on the fitness world. With a focus on symmetry and proportion, Frank's physique earned him three Mr. Olympia titles and the nickname King of Aesthetics. Today, at 75 years old, he continues to offer personal coaching, training programs, and seminars to share his vast knowledge of bodybuilding and fitness.

Ben Pakulski, a recently retired professional bodybuilder and former Mr. Canada. Ben is on a mission to educate people globally on a holistic approach to muscle building, empowering them to change both their body and mind.

Throughout this combined episode, we explore the shared principles that underpin these two remarkable journeys. From the importance of discipline, focus, and perseverance to the significance of customized nutrition and training plans, our guests leave no stone unturned in their quest to unlock human potential.

Check out this enlightening and transformative exploration of the science of the perfect physique and the reimagining of strength training, guided by the wisdom of Frank Zane and Ben Pakulski.

Prepare to unlock your true potential and unleash the power within.

Find all the links and resources in the show notes.

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Learn how to biohack your mobility, create a movement-rich environment, and tap into the benefits of breathing, sleep, and balance. Kelly Starrett knows all the best moves. His 10 Vital Signs give you doable tests, tips, and tools so you can live your life exactly the way you want to.

That means a focus on mobility and your body’s complete range of motion. Movement like being able to sit on the floor and get back up; daily walking and squatting; increasing range of motion in your hips; and mobilizing your back and shoulders. You'll find it all in his newest book (co-authored with his wife, Juliet) “Built to Move: The 10 Essential Habits to Help You Move Freely and Live Fully.”

Physical therapist Dr. Kelly Starret is a highly respected expert in the world of functional movement and mobility. His ability to convey complex ideas in a relatable and approachable manner has made him both a pioneer and a popular figure within the fitness industry. 

In this episode, he discusses the importance of shifting away from solely traditional exercise and hour-long gym sessions. Instead, Kelly put the focus on movement quality and variety with physical practice happening over 24 hours for a more holistic approach to fitness. "Built to Move" lays a movement foundation for everyone from non-exercisers to professional athletes and everyone in between. 

“At the heart of upgrading is this idea that you are actually in charge of your own body,” he says, “And that happens in the household. No one else is coming to save you!”

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Learn how to tune into your true self and inner power by harnessing quantum energy to ward off EMFs and increase your energetic vibration. Quantum Upgrade sponsored this episode. Founder and CEO, Philipp Samor von Holtzendorff-Fehling, shares how you can reduce EMFs and increase quantum energy in your personal spaces.

He joined the show previously to bring you the science and benefits of quantum energy and energy frequencies. You’ll want to take a listen to episodes #890 and #1013 to learn more. This time, he explains how you can harness quantum energy via a remote service. Skeptical? Here’s how it all works.

Through years of research and development in tandem with its sister company, Leela Quantum, Quantum Upgrade has created a powerful source of usable quantum energy.

By using quantum entanglement, Quantum Upgrade has been shown to improve the function of heart rate variability, ATP production, and blood, among other things. Philipp mentions a recent study that found this quantum technology increased cellular activity by 20%, which has implications for athletes—a bioenergy-hacking tool!—and wound healing. 

Everyday EMF radiation creates incoherent frequencies that put stress on the human body. This creates biological disharmony and depletes you of quantum energy. The Quantum Upgrade technology “tunes” your environment to surround you with optimal level of usable quantum energy—at all times. When you join the subscription service, Quantum Upgrade “associates” you, your home, phone, business, or even your pet with this energy source.

The remote service has been tested through randomized sham-controlled double-blind studies, and Quantum Upgrade has worked with independent testing institutes and labs to test their products. 

Whether you’re new to exploring the benefits of quantum energy or already have some experience with quantum frequencies, there’s a subscription fit for you.

Watch this episode on YouTube!

Find research, links, and resources in the show notes.

SPECIAL OFFER FOR THE HUMAN UPGRADE LISTENERS: Go to https://quantumupgrade.io and use the code DAVE to get a FREE 15-day trial of the Quantum Upgrade subscription service.

Also check out Quantum Upgrade and Leela Quantum at the 9th Annual Biohacking Conference: https://biohackingconference.com

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Learn about the roots of drama addiction, how it harms the mind and body, and how to recognize signs of it in yourself and others.

If you’re on drama overload or someone close to you plows through your life dragging drama everywhere—it’s sucking the energy out of you. News, world events, and social media can cause a firestorm of drama, too. All of it causes physiological and mental chaos that weakens your resilience to life’s real stressors. In this conversation, you’re going to learn what causes someone to develop a drama addiction, some of the main symptoms of drama addiction, and ways to heal from it and keep it out of your life.

Holistic psychologist and educator Dr. Scott Lyons joins the show to talk about the pain, limiting beliefs, and trauma that show up in you and others who may have drama addiction. He focuses on what drama addiction actually is and how it can affect your mind, body, and life perspective.

Drama has become a global drug, where people are overstimulated and under-connected. Stress, too, plays a surprisingly large role in drama addiction. Other things you’ll learn about drama addiction:

• What feeds and feels good about it.
• How trauma influences it.
• How weaponized empathy poses a danger to your personal life and work life.
• How to create boundaries with a drama addict.
• How to thrive if there’s a drama addict in your environment.
• How to move from drama bonding to more authentic relationships.

Scott’s identified nearly a dozen addicted-to-drama archetypes in his new book, “Addicted to Drama: Healing Dependency on Crisis and Chaos in Yourself and Others.” You may see yourself or others in one or several of them—and that’s good—because then you can move into healing. He outlines a very action-oriented approach with 1) help questions, 2) observation & practice, 3) self-healing statements, and 4) things a therapist might suggest.

Not sure how to recognize drama in yourself or the people in your personal or work life? Start by taking Scott’s drama quiz.

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David Nurse knows exactly what’s holding you back from reaching your goals—taking action. And you’re about to be introduced to the nine action archetypes that explain your lack of follow-through. You’ll learn to identify your archetype, the way it’s affecting you, and how to use the right tools to get you moving forward.

David is an NBA Mindset Coach (and former professional basketball player himself), a Top 50 worldwide motivational speaker, and an author. He’s been teaching professional athletes and Fortune 100 executives how to develop unshakeable mindsets for the past 15 years.

“The traditional belief that hard work is the only way to succeed is flawed,” David says.

In his newest book, “Do It: The Life-Changing Power of Taking Action,” he gives you other options to explore and tells you why they work with an unconventional approach: “The heart is your armor. The brain is your sword. Together, working as one unit, this is what makes you a warrior: the brain and heart connection.” 

Today’s conversation gets into how you can defeat fear and take action by using a no-fail formula to eliminate hesitation. This requires repetition (your daily habits) plus instinct (your gut feelings) plus trust (belief in the process). You’ll also get tools that will help you unlock your personal roadblocks and achieve your goals.

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Learn how to expand your wisdom, cultivate a generous culture, invest in mentorship, and thrive in relationships as a leader.

Chip Conley, MBA, talks with Dave in Austin about the concept of wisdom, transcending age boundaries, and the importance of writing down life lessons. He firmly believes that curiosity is the elixir of life.

He also explores the paradigm shift in company culture, where focusing on “cultural add” rather than “cultural fit” can foster innovation and diversity. Drawing on his experience that propelled Airbnb’s success, Chip uncovers how Airbnb maintains its strong cultural focus through cultural values interviews and company-wide gatherings.

A big part of mid-life includes navigating and understanding different generations, especially in the workplace. Chip earned the name “Modern Elder” in a surreptitious way through his work with much younger employees. Airbnb looked to Chip’s sustained success in the hospitality space and asked him to help transform their start-up into the world’s leading hospitality brand more than a decade ago. He came on to lead Global Hospitality and Strategy.

Then 52, he was twice the age of the average Airbnb employee. This earned him the title “Airbnb's Modern Elder” who was as curious as he was wise. He’s currently the company’s Strategic Advisor for Hospitality and Leadership.

That experience influenced Chip to create the Modern Elder Academy—a new roadmap for midlife and learning opportunities—at an oceanfront campus in Baja California Sur, Mexico. 

Chip’s also a New York Times bestselling author, an in-demand public speaker (especially TEDtalks!) and is on the advisory council for the Stanford Center on Longevity.

Watch this episode on YouTube! 

Find all the links and resources in the show notes.  

SPECIAL OFFER FOR THE HUMAN UPGRADE LISTENERS: Learn more about Modern Elder Academy at https://www.modernelderacademy.com and use code DAVE20 to save 20% off in-person workshops, MEA Online, or Sabbatical Sessions. *Offer valid throughout 2023 (some minor restrictions may apply).

SPECIAL PRESENTATION: Live Fireside Chat: Dr. Mark Hyman & Chip Conley: The universe aligned to bring Dr. Mark Hyman and Chip Conley to Austin to talk with Dave on The Human Upgrade recently. If you missed Mark’s chat with Dave about how to be “Young Forever," listen here. Then, Dr. Mark and Chip connected for a Live Fireside Chat—listen here!

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Learn the Top 10 hallmarks of aging, the role of functional medicine in restoring and reversing aging, and the many practical ways you can promote your own longevity.

Mark Hyman, M.D., joins Dave in Austin to talk all things longevity. Driven by his desire for a healthier, longer life for himself and others, Dr. Mark immersed himself in the latest scientific research on aging and longevity. Through his findings, he realized that the body has an incredible built-in healing system that can be activated through understanding the emerging science of longevity. He also managed to reduce his biological age by 20 years effectively.

He consistently tackles the topic of inflammation and its impact on aging—or “Inflammaging” as he calls it. “The body only has so many ways to say ouch,” Dr. Mark says. “You have pain. You have inflammation. You have certain things that happen that create all these symptoms, but there're these common roots. So, inflammation is this common root that seems to accelerate as we get older. So, we can measure biomarkers of inflammation that are highly predictive of mortality.”

This conversation covers many components of aging, like metabolic flexibility and resilience, mTor, meat- and plant-based protein, nutrition, environmental allergies and food sensitivities, histamine, autophagy, fasting, DEXA scans, and much more!

In his newest book, "Young Forever: The Secrets to Living Your Longest, Healthiest Life,” Dr. Mark:

• shares the knowledge of how to unlock the causes of accelerated aging and treat it as a reversible disease.
• gives you practical tips for daily habits that will increase your energy and performance.
• teaches you why you age and what it really takes to live a longer, more vibrant life.

Watch this episode on YouTube! 

Get all the links and resources in the show notes. 

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Dave Asprey’s NEW Book! “Smarter Not Harder: The Biohacker’s Guide to Getting the Body and Mind You Want" https://daveasprey.com/books/ 

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Here's what you must know about the health risks and extensive symptoms of breast implant illness, as well as removal solutions. Dr. Robert Whitfield MD discusses the often-overlooked health risks associated with breast implants. Women who experience breast implant illness have symptoms like brain fog, memory loss, fatigue, joint pain, anxiety, and many more.

While there’s not a definitive cause of breast implant illness, a common theory points to an immune system response. Breast implants in the body can lead to persistent foreign body reactions, silicone toxicity, heavy metal exposure, biofilm development around the implants, and free radical/oxidative damage. Over time, these reactions weaken the immune system and cause health symptoms from minor to severe. Your autoimmune response, endocrine system, thyroid & adrenals, and gut all could be affected.

Dr. Robert Whitfield MD’s an Austin-based plastic surgeon who’s cared for hundreds of women with breast implant illness, performs breast explants, and teaches other surgeons about this illness and treatment methods. In his years of experience in breast reconstruction for cancer patients, microsurgery, and a deep understanding of the body's reactions to foreign materials, he's developed a unique insight into the world of breast implant illness.

This episode serves as a guide to what could be happening in your body, what symptoms to watch for, and breast implant removal options if you suspect you may have breast implant illness. Get more information and take a quiz at https://breastimplantillnessexpert.com and share this important episode with your spouse, a family member, a friend, or a colleague.

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Get actionable expert tips on testing, nutrition, and lifestyle changes you can do to achieve peak adrenal function. Izabella Wentz, PharmD., aka the “Thyroid Pharmacist,” takes on adrenal fatigue, its symptoms, and the importance of fixing adrenal function in addition to treating thyroid issues in her new book, “Adrenal Transformation Protocol: A 4-Week Plan to Release Stress Symptoms and Go from Surviving to Thriving.”

She went deep into the research to develop an actionable guide for you. Her new book helps you identify and mitigate the effects of adrenal dysfunction. 

• If you’re experiencing low energy, insomnia, brain fog, anxiety or burnout, your adrenals may be overworked.
• You’ll learn why adrenal, immune, and thyroid issues develop as an adaptive mechanism to protect you in times of danger.
• You’ll also learn how to manage four big stressors that influence your adrenals in a negative way.
• You’ll find out what lifestyle and mindset changes you can make that turn off danger signals and communicate safety messages to your body.

Her protocol emphasizes providing the body with more safety signals to counteract the stress response. She recommends dietary changes, anabolic-focused exercises, and supplements such as carnitine. She also explains the role of adrenal dysfunction in allergies and histamine issues, the dangers of B6 supplements, and the importance of balancing sodium and potassium intake for adrenal health. She suggests Epsom salt baths, a cold bedroom, and paying attention to factors such as H. Pylori, malabsorption, and the CBS gene mutation to address ammonia levels in the body.

If you suspect your adrenals are on the fritz, Izabella stresses the importance of a varied and holistic approach to treatment. She urges proper testing and diagnosis of adrenal dysfunction and thyroid issues to build resilience in your body.

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Feel Dangerously Good! Discover the energy, focus and performance that come from mineralized coffee designed with your biology in mind. Your cells will thank you. Go to dangercoffee.com, use code DAVE15 to save 15%

Vitamin DAKE & Minerals 101: Foundational vitamins and essential minerals that do the most good across every system in your body. Go to vitamindake.com, use code DAVE10 to save 10%

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Learn about nitric oxide’s crucial role in your body systems, how to naturally produce more of it, and how to supplement effectively and safely. 

Research scientist Nathan Bryan, Ph.D., has been involved in nitric oxide research for the past 25 years and has made many discoveries in the field. He’s an international leader in molecular medicine and nitric oxide biochemistry. You'll find out how nitric oxide works within major body functions and what you can do to increase your body's natural production of it.

Pneuma Nitric Oxide sponsored this episode.

Human performance depends on sufficient oxygen and nutrient delivery to organs, tissues, and cells so they can do their job. Nitric oxide controls oxygen and nutrient delivery. It’s now recognized “as one of the most important molecules produced in the body of humans,” Nathan says. “It's a vasodilator, so it controls the regulation of blood flow. It's what's responsible for oxygen and nutrient delivery to every organ, tissue, and cell in the body.”

That’s why it’s so important to find the right carrier to effectively deliver this complex and bioactive gas that’s gone in less than a second. Nathan was one of the first scientists to develop a technology to make a solid dose form of nitric oxide.

He shares information about Pneuma Nitric Oxide’s key products, like its lozenges, and the N1O1 skincare line. The lozenges open small blood vessels internally and the topicals open superficial blood vessels on the skin to improve blood flow and cellular turnover. He explains how to use a nitric oxide-generating serum on your skin from his N1O1 skincare line that enhances blood flow and promotes wound healing. 

Nathan presents the anti-aging, performance-enhancing, and nootropic benefits of nitric oxide along with its role in improving stem cell function, controlling telomerase activity, and improving mitochondrial function.

He identifies the different isoforms of nitric oxide for you, noting that you should choose a nitric oxide supplement that delivers the same amount of nitric oxide that the body would normally produce. He emphasizes the importance of restoring the body's ability to naturally produce nitric oxide and debunks the use of nitric oxide precursors such as L-arginine and citrulline. He also stresses using safe and effective nitric oxide products.

SPECIAL OFFER FOR THE HUMAN UPGRADE LISTENERS: Go to https://n1o1.com and use code DAVE to get 10% off and free shipping.

Watch this episode on YouTube! 

Find all the links and resources in the show notes. 

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IN THIS EPISODE OF THE HUMAN UPGRADE™... a legacy upgrade conversation with Ingrid Fetell Lee gets into the topic of joy and the influence of your surroundings on your emotions and well-being. You may be hacking your body and mind, but are you embracing joy along the way? This episode shows you how—and explains why it’s essential. You’ll also find out the difference between happiness vs. joy. Fun Fact: While you may be able to fake a smile, you can’t fake joy.

Ingrid brought joy into the popular culture conversation with her book, “Joyful: The Surprising Power of Ordinary Things to Create Extraordinary Happiness.” She’s a designer, author, TEDtalk speaker and founder of “The Aesthetics of Joy.” Her work empowers people to find more joy through the purposeful and emotion-driven design of their environments. She’s identified 10 elements of joy that resonate with nearly everyone.

1. Energy
2. Abundance
3. Freedom
4. Harmony
5. Play
6. Surprise
7. Transcendence
8. Magic
9. Celebration
10. Renewal

Ingrid explains how to recognize, feel and incorporate more joy into your everyday life.

FREE JOY RESOURCES: Downloadable guides: 50 Ways to Find Joy Every Day and Joyspotter’s Guide

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IN THIS EPISODE OF THE HUMAN UPGRADE™… former rocket scientist and former law professor Ozan Varol—an expert in creativity, innovation, and critical thinking—says that unlocking your full potential involves reimagining the status quo rather than simply resisting it. 

“The word resist for me gets in the way because often resistance becomes a different way of conformity, as in you're resisting something but you're not really offering a new path forward,” he says. “So, resistance becomes its own end in and of itself. The goal should be re-imagination.”

In this discussion about Ozan’s newest book, “AWAKEN YOUR GENIUS: Escape Conformity, Ignite Creativity, and Become Extraordinary,” you’ll learn to access the best parts of your brain and create your own path as a leader and creator by acting instead of reacting. 

While people consider those who blaze their own trail as geniuses, Ozan contends that genius is not limited to a select few. Rather, it can be discovered by anyone. 

He loaded this book with smart tips, examples, things to think about, and things to do. For example, you’ll learn why you should ignore email until noon and spend the most valuable time of your day thinking in creativity. You’ll also learn how spending more time on the “why” than the “what” moves you toward the life you really want to be living. He lays out an action roadmap for you to cultivate your own genius and be in charge of your time and creativity.

Watch this episode on YouTube!

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In this Episode of The Human Upgrade™...​ Dave talks to David Hinds of Brisbane, Australia, about gut issues and weight loss for men at mid-life. David’s already biohacking, working out, and taking supplements he thinks are the right ones—yet the weight around his mid-section persists.

This intervention looks at ways to tackle hard-to-budge love handles and extra mid-section weight with suggestions covering hormones, thyroid, sleep, SIBO, probiotics, supplements, inflammation, the pituitary gland, prolactin, and potassium. This discussion gets into libido and eyesight, too.

David’s in his early 50s and a dad to two teenagers. He started biohacking over three years ago when he discovered the Bulletproof Radio podcast (now called The Human Upgrade). He then read Dave’s books, made some life changes, saw the results, and decided 150 years on this rock would be awesome! “So, I'm one-third of the way through life, and my aim is to be in the best physical and mental state possible for all of those years,” he says.

Note: The "Interventions With Dave” recommendations are designed to help you upgrade yourself and your biology so you can perform better at everything you do. They are not, however, a substitute for advice or treatment by a trained medical professional that may be needed for specific health conditions, illness or injury.

Find a full list of the Interventions With Dave episodes here.

Listen to this episode on YouTube!

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IN THIS EPISODE OF THE HUMAN UPGRADE™… Vincent Pedre, M.D., explains how consuming too much sugar can lead to insulin resistance and diabetes by causing shifts in the microbiome that reduce insulin signaling. He also highlights how omega-6 fats found in processed foods contribute to inflammation and chronic disease by carrying lipopolysaccharide toxins through cell membranes. 

For over a decade, board-certified internist and Functional Medicine certified practitioner, Dr. Pedre, founder of Happy Gut Life, has helped people improve their well-being and quality of life by building the foundation of gut health that supports total physical and mental wellness. He believes that healing begins in the kitchen through the foods we eat. He brings together years of research and clinical experience to offer you real solutions in his newest book, “The GutSMART Protocol: Revitalize Your Health, Boost Your Energy, and Lose Weight in Just 14 Days with Your Personalized Gut-Healing Plan.”

The balance between good and bad bacteria is both important and nuanced—more microbial diversity in the gut is not always better. "The focus should be on metabolomics, not just diversity when it comes to gut bacteria,” Dr. Pedre says. 

Another focus includes gut interrelationships and the seven big systems in your body affected by leaky gut: skin, airway, brain, joints, energy, metabolism, and immune system.

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IN THIS EPISODE OF THE HUMAN UPGRADE™… An air quality expert explains the impact of your home environment on your health, mold sensitivities, and the remediation process, including DIY tips and professional interventions. You’ll also find out about The Dust Test, which identifies mold, bacteria, and biotoxins in your home so the inspector can remove all sources of contamination.

Mold is likely a problem in your home, as it is for many people, and you likely don’t know what to do about it. Every year, mold damages property and costs homeowners money. But worse than that, mold is dangerous to your health, especially if you are one of 375 million Americans who are susceptible to chronic mold sensitivity. 

With decades of field experience, Michael Rubino, president of HomeCleanse, excels at working with individuals—many of whom are who are immunocompromised—to detoxify their homes and improve indoor air quality. He has helped more than 1,000 families heal from toxic mold exposure so far, and, as he says, this is just the beginning.

Through scientific expertise and innovation, Michael developed alternative remediation protocols that eliminate common mold sources and eradicate the contamination caused by those sources.

His expert advice in this episode is a go-to resource for anyone worried about an increasingly common problem that can have life-threatening side effects. And his book The Mold Medic can definitely help you breathe easier. 

SPECIAL OFFER FOR THE HUMAN UPGRADE LISTENERS: Go to www.thedusttest.com/dave and use code DAVE to get $10 off. 

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IN THIS EPISODE OF THE HUMAN UPGRADE™… you’ll learn how Functional Medicine expert Jill Carnahan, M.D., who is board certified in Family Medicine and Integrative Holistic Medicine, survived breast cancer, Crohn’s disease, and toxic mold. Her unique healing approach looks to science for answers while also using methods that outright challenge conventional medicine. 

During the discussion, Dr. Carnahan distinguishes between visible (e.g., cancer) and invisible (e.g., mold toxicity) illnesses. “There's this new term called medical gaslighting where doctors actually say, "Oh, everything looks great," right? And you're not. You're not okay inside,” she says. 

Her new book, “Unexpected: Finding Resilience through Functional Medicine, Science, and Faith,” explores “positive transformation against all odds.” She shares her own story of confronting life-altering illnesses, fighting for her health, and overcoming sickness using both science and faith. She also shares the experiences of her patients who transformed their health and their lives.

Get ready to learn about a new path of empowerment where you can take control of your own health and well-being.

Watch this episode on YouTube!

Find all the links and resources in the show notes.

Get Your Tickets! 9th Annual Biohacking Conference: https://biohackingconference.com

Dave Asprey’s NEW Book! “Smarter Not Harder: The Biohacker’s Guide to Getting the Body and Mind You Want.” https://daveasprey.com/books/

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IN THIS EPISODE OF THE HUMAN UPGRADE™… you’ll learn why many professional athletes, especially fighters, are some of the top biohackers in the world. They hack their bodies, minds, and environments to achieve an incredibly high level of performance. Every hack they do has to be effective—and means the difference between winning and losing. 

Professional MMA (mixed martial arts) fighter Miesha Tate knows and does just that while adding being a parent and entrepreneur into the mix. Miesha is a former UFC and Strikeforce Bantamweight champion, ONE Championship vice president, and winner of Celebrity Big Brother Season 3. She always draws on her experiences, whether from home birth or competing on the world’s biggest stages as a pro athlete as proof that when the mind and body are functioning with synchronicity, you are capable of great things. 

After more than a decade of wrestling and MMA competition culminating in her UFC World Championship in 2016, she stepped out of the octagon. “I retired from the sport and it took five years to figure out who I am other than Miesha Tate, the fighter,” she says. “So not only did I go soul searching, but I also went wellness searching.”

• She found red light to help her recovery and healing, hyperbaric oxygen therapy to restore and protect her brain, and breathing techniques to keep her present and grounded. 
• She learned, too, the importance of mindfulness and attention to self—“to just be alone with your own thoughts.” 
• She says there’s reward and fulfillment in doing something every day that pushes you and makes you a little bit uncomfortable. No pain required.

She came back to professional MMA fighting after having two children and changed up nearly everything about her training. This included moving from Bantamweight to Flyweight, which meant reducing her already lean frame by another 10 pounds. She now looks at her body and mind as a comprehensive unit: the big things like hormones, nutrition, sleep and brain health; flow state during her fights; and she even takes on the more elusive soul work. 

Miesha focuses on empowering women through martial arts, with a particular emphasis on self-defense and building confidence. She’s become an advocate for women in combat sports, using her platform to promote equality and opportunities for women in the sport. She also helps others heal, recover, and discover their potential at Desert Moon Wellness, which she co-founded with two women partners.

She lists her three most important things in life as: 1) Family and friends, 2) time, and 3) goals and dreams.

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IN THIS EPISODE OF THE HUMAN UPGRADE™… Will Cole, IFMCP, DNM, DC, teaches you how your body directly affects your mood. Hint: the gut plays a role, but there are other factors too. Through treating thousands of patients, Dr. Cole developed new ideas involving both psychology and biology that you can use in your daily life.

He’s an expert in finding the underlying factors of chronic disease and challenges the labeling of “fitness” as a masculine industry and “wellness” as a feminine industry. His newest book, “Gut Feelings: Healing the Shame-Fueled Relationship Between What You Eat and How You Feel,” encourages you to be aware of the link between what you eat and how it makes you feel.

Dr. Cole explains the connection between physical and emotional health and introduces you to the term “shameflammation.” It's how stress and shame can cause gut inflammation and sabotage your health. Additionally, problems with your gut often show up as mood swings, anxiety, and food cravings. He offers a framework to better understand your gut-brain connection and solutions to help you heal. 

“Gut Feelings” gives you 50 healing recipes; dietary prescriptions founded on flexibility and awareness; and mindfulness techniques to strengthen your intuition and discover your priorities.

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IN THIS EPISODE OF THE HUMAN UPGRADE™… Daniel Amen, M.D., shares the most effective daily habits you can do to improve the way your brain works, based on his 40 years of clinical practice. 

In this discussion and in his new book, “Change Your Brain Every Day: Simple Daily Practices to Strengthen Your Mind, Memory, Moods, Focus, Energy, Habits, and Relationships,” he delivers a year’s worth of habits to you in short info bits and daily actions.

Incorporating Dr. Amen’s tiny habits and practices will help you:

·    Manage your mind to support your happiness, inner peace, and success

·    Develop lifelong strategies for dealing with whatever stresses come your way

·    Create an ongoing sense of purpose in a way that informs your daily actions

·    Learn major life lessons Dr. Amen has gleaned from studying hundreds of thousands of brain scans

A key innovator in the world of brain health, Dr. Amen shifts the paradigm of understanding what's happening in your brain. His new book is a must-have for anyone who values both their brain function and mental health. He teaches you how your gut affects your thinking, how mental health is really brain health, and how measuring brain function is tied to mitochondrial function.

A psychiatrist and clinical neuroscientist, Dr. Amen has collected the world’s largest database of brain scans for psychiatry. This totals more than 210,000 SPECT scans on patients from 155 countries. This has been key to going beyond what he learned as a psychiatrist. Actually observing “the organ” in question has been a game changer for his mission to end mental illness by creating a revolution in brain health.  

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IN THIS EPISODE OF THE HUMAN UPGRADE™…you’ll learn how much control you can actually have over your brain. There’s a new way of accessing your meat operating system that adds an important element that’s been missing from the brain training conversation. Moha Bensofia joins the show to explain a new piece of neurotech called Mendi. He shares the benefits of getting more blood to the front of your brain.

Mendi uses neurofeedback to provide visual feedback based on your brain activity. A headset measures the activity while you play a fun brain-training mobile game. The system uses fNIRS technology to measure blood flow and oxygenation in the pre-frontal cortex of the brain. The brain training game requires focus and calmness, which increases activity and control of your brain’s pathways. 

By using Mendi, you can learn to control your brain activity and reach greater heights as an entrepreneur, athlete, and professional in any field.

Mendi was developed initially for victims of war and trauma, as well as people struggling with anxiety, PTSD, and ADHD. But, as you’ll learn, everyone can benefit from this type of brain training.

SPECIAL OFFER FOR THE HUMAN UPGRADE LISTENERS: Go to https://www.mendi.io and use code DAVE to save 15%.

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Dave Asprey’s NEW Book! “Smarter Not Harder: The Biohacker’s Guide to Getting the Body and Mind You Want” is out now.https://daveasprey.com/books/

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IN THIS EPISODE OF THE HUMAN UPGRADE™… you’ll learn Luke Storey’s definition of addiction and his strategies for healing, happiness, and high performance. He’s known for his irreverent, passionate, and humorous delivery, and it shows through in this conversation.

He overcame tremendous adversity from childhood trauma, adolescent criminality, and years of chronic alcohol and drug addiction. For 25 years, he’s focused on recovery, inner work, and personal development. If you’re currently working on addiction recovery, you’ll learn a lot from his experience. And even if you don’t share any aspect of Luke’s dark background, you may have your own type of addiction that could benefit from his wisdom. 

Luke’s a great writer, meditation and metaphysics teacher and lifestyle design expert who shares with you his transformative principles of health, addiction recovery, and spirituality. This discussion dives deep into addiction, how psychedelics—properly used with the help of a professional—can aid your recovery, and what it really takes to live and thrive once you get sober. 

Watch this episode on YouTube!

SPECIAL ANNOUNCEMENT FOR THE HUMAN UPGRADE LISTENERS: Protect yourself, your home, and your family from the dangers of EMF and 5G with Luke Storey’s EMF Home Safety Masterclass. Find the class at online.lukestorey.com

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IN THIS EPISODE OF THE HUMAN UPGRADE™… Amy Shah, M.D., teaches you all you need to know about the second F word: food. That’s right, you are going to learn all about hunger from the author of the book, “I'm So Effing Hungry: Why We Crave What We Crave – and What to Do About It.” You’ll also find out why focusing on your hunger is more important and effective than going on yet another diet. 

Dr. Shah is a double board-certified medical doctor and nutrition expert with training from Cornell, Columbia, and Harvard universities. Her background includes internal medicine and allergy/immunology. During this discussion, she shares why she believes that you can diet all you want, but diets don't work—and, worse yet, they keep you addicted. They also keep you hungry and keep you unhappy. She helps you lean into your body signals and really understand what's happening. 

She developed a 5-step program for battling excessive hunger and food cravings by harnessing the power of psychobiotics and intermittent fasting. She combined scientific studies with Western and Ayurvedic approaches so you can:

1. REPLENISH your body by eating more nourishing, mood-balancing foods.
2. REWIRE your brain to undo the addiction pathways and cravings for processed foods.
3. RESET your circadian rhythm to activate hunger hormones that reduce your appetite.
4. REFRESH with a good night’s sleep, using proven good sleep habits used by the U.S. military.
5. RETRAIN your body with exercise that regulates key neurotransmitters that influence our hunger response.

You’ll want to take notes on this extremely helpful and actionable interview. You also can download the transcript in the episode show notes under "Links & Resources."

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Mute sponsored this episode.

In this "Upgrade Spotlight" Episode of The Human Upgrade™... you’re getting the latest knowledge about innovative biohacking tools and technologies that allow you to change your biology and the environment around you. 

CEO Michael Johnson joins the show from the Rhinomed headquarters near Melbourne, Australia. Rhinomed, the company behind Mute, pioneers the use of adjustable nasal devices for respiration, sleep, nasal diagnostics, and nasal drug delivery. 

You’re going to learn about a Mute nasal device that will help you get a much better night's sleep. Think of it as the first line of defense against snoring and sleep disruption. It’s a small device made of soft, adjustable polymers that sits comfortably inside your nose, increasing airflow and improving breathing.

Watch this episode on YouTube!

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Go to MUTESNORING.COM and use code DAVE10 for 10% off and free shipping in the US, Canada, and Australia

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IN THIS EPISODE OF THE HUMAN UPGRADE™... a look into the story of the human mind wonders if you’re just a machine made of meat. Guest Paul Bloom, a researcher, teacher and author, studies adult and child development in terms of how people make sense of the world. It turns out that there are all kinds of automated systems in your body that are making sense of the world for you and after they do that, they give you a picture of the world. The interesting part is that picture may be more or less accurate based on a lot of things that are part of your programming.

Paul is a professor of Psychology at the University of Toronto and professor emeritus of Psychology at Yale University. He teaches a popular “Intro to Psychology” class that he turned into his seventh book, called: “Psych: The Story of the Human Mind.”

Because he studies psychology at so many different levels, he brings new knowledge and new synthesis of ideas to the discussion of the human mind. Topics range from consciousness to ChatGPT and BDSM, from whether you have a soul or if you can attain happiness. 

Paul’s writing and lectures show how psychology can give us practical insights into important issues. He addresses the treatment of mental illnesses such as depression and anxiety and the best way to lead a fulfilling life. This episode and his new book guide you through the most important topic there is: the story of you and your mind.

Watch this episode on YouTube!

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IN THIS EPISODE OF THE HUMAN UPGRADE™... you will learn about the beliefs that kick in as normal humans age and most importantly, you will learn what you can do about those limiting beliefs. And who better to discuss this than the author of the book, "Gnar Country: Growing Old, Staying Rad," Steven Kotler. 

Steven is a friend of the show, executive director of the Flow Research Collective, a New York Times bestselling author, and an award-winning journalist. He tested his knowledge and theories on himself in a quest to learn how to park ski (an extreme type of skiing) at age 53.

Science shows that older humans are better at learning certain skills than younger people. Brain changes occur in the second half of your life that unlock levels of intelligence, wisdom, creativity, and empathy you didn’t know were possible.

In the conversation, Steven describes how his book chronicles his experience pushing his own aging body past preconceived limits. He also explains why he wrote a book about goals, grit and progression - and why he feels it's an important lesson for everyone to learn (not just those of you over 50). 

Steven also explains why he chose extreme skiing as his No. 1 anti-aging activity. “... if you really want to preserve cognitive function, you want to basically use the hippocampus in the way that evolution designed it. You want novel, challenging experiences in outdoor environments.”

Watch this episode on Youtube

Find all the links and resources in the show notes.

***

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Join us at the 9th Annual Biohacking Conference: https://biohackingconference.com

Dave Asprey’s NEW Book! “Smarter Not Harder: The Biohacker’s Guide to Getting the Body and Mind You Want” launches Feb. 28, 2023. IndieBound / Barnes & Noble / Apple Books / Amazon

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IN THIS EPISODE OF THE HUMAN UPGRADE™… the guest is one of the founders of Wired Magazine and someone who has been a continuous source of interest, news and data for decades, Jane Metcalfe. Having basically dissected nerds for her entire life, Jane now runs a fantastic newsletter and news site called NEO.LIFE where she writes about biohacking and the future. If you were to combine someone who really understands society and understands tech (and has read as much science fiction as possible) you would have Jane. 

Jane’s, focus throughout her, career has been on how technology is transforming our world. But now she is fascinated with how deeply we can see inside the body and how processing the data we collect allows us to discover new cells, understand complex biological systems, and engineer bacteria, viruses, DNA, and ultimately ourselves. 

Her new platform, NEO.LIFE is for exploring how we Homo sapiens will use these technologies and new understandings to power our own evolution. 

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Get all the links and resources in the show notes.

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Get the week’s news and fresh ideas from the neobiological frontier. https://neo.life

Join us at the 9th Annual Biohacking Conference: https://biohackingconference.com

Dave Asprey’s NEW Book! “Smarter Not Harder: The Biohacker’s Guide to Getting the Body and Mind You Want” launches Feb. 28, 2023. Pre-order yours today: IndieBound / Barnes & Noble / Apple Books / Amazon

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IN THIS EPISODE OF THE HUMAN UPGRADE™... to celebrate the imminent release of the new book, we’re doing something different than what you're used to. Dave is getting interviewed on his own podcast to give you a preview of his book, Smarter Not Harder.

In the interviewer's seat is retired Navy SEAL commander, author, expert in leadership and human performance, Rich Diviney. When Rich was a guest on the show previously (check out episode #937), he talked about mindset, optimism, resilience, and stress. This time, the script gets flipped.

This interview intends to educate and inform about the new book and install some new capabilities in your operating systems. The goal is that even if you don't read the book, you will still walk away from this interview with a brain that works better.

Smarter Not Harder: The Biohacker's Guide to Getting the Body and Mind You Want is about helping you to become the best version of yourself by embracing laziness while increasing your energy and optimizing your biology. Rich is the perfect person to dive deeply into how the big ideas in this book work and give you an even greater reason to get the mind and body you want. 

Dave packed “Smarter Not Harder” with practical, accessible information based on the latest research so you can achieve lasting health in less time. It’s biohacking fully applied. You can pick up a copy of Smarter Not Harder: The Biohacker's Guide to Getting the Body and Mind You Want at your favorite place to buy books.

Watch this episode on YouTube!

Get all the links and resources in the show notes.

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Dave Asprey’s NEW Book! “Smarter Not Harder: The Biohacker's Guide to Getting the Body and Mind You Want” launches Feb. 28, 2023. Pre-order yours today: IndieBound / Barnes & Noble / Apple Books / Amazon

9th Annual Biohacking Conference: https://biohackingconference.com

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IN THIS EPISODE OF THE HUMAN UPGRADE™... Dave talks with Cindy Fraley, who has a young daughter, works in upper-level management at a large pharmaceutical company, and is a former physical therapist who overcame RA, MRSA, Hashimoto’s and emotional stress. 

Cindy says, “Dave’s guidance, the Upgraded Collective, and biohacking have been pivotal in my journey back to the great health, sports, and outdoor activities that I previously had and love.”

In fact, in the past year, Cindy has improved her Blood work significantly using EDTA chelation suppositories, sauna, and IV therapy to deal with mold, metals, and coronary calcification. She’s done a deep dive into meditation and forgiveness and has incorporated HeartMath into her day. Cindy is also proudly managing her work stress better so it doesn’t impact her sleep or family interactions. 

During this intervention and episode, Cindy would like Dave’s help to continue working on stress reduction/management and focus on her brain and neurological fitness. 

Find all the links and resources in the show notes.

Watch this episode on YouTube.

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Shield Yourself from EMFs: https://quantumupgrade.io, use code DAVE to get a two-week free trial

Dave Asprey’s NEW Book! “Smarter Not Harder: The Biohacker's Guide to Getting the Body and Mind You Want” launches Feb. 28, 2023. Pre-order yours today: IndieBound / Barnes & Noble / Apple Books / Amazon

9th Annual Biohacking Conference: https://biohackingconference.com

Note: The “Interventions With Dave” recommendations are designed to help you upgrade yourself and your biology so you can perform better at everything you do. They are not, however, a substitute for advice or treatment by a trained medical professional that may be needed for specific health conditions, illness or injury.

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IN THIS EPISODE OF THE HUMAN UPGRADE™... Dave talks with Bryan Gardner (a self proclaimed “super-dad”) who wants to take his current hacking to the next level. Bryan has questions specifically about his brain & neurology, his fitness, and spirituality. 

Bryan is an aerospace engineer who built a small hedge fund business more than a decade ago. So he doesn’t sound like someone who would be struggling with productivity, focus and managing his energy.

This episode covers many meaningful and helpful topics, including blood flow restriction, high intensity intervals, neuromuscular electrical stimulation, neurofeedback, and a whole lot more. 

Watch this episode on YouTube!

Get all the resources and links in the show notes.

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9th Annual Biohacking Conference: https://biohackingconference.com

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Note: The “Interventions With Dave” recommendations are designed to help you upgrade yourself and your biology so you can perform better at everything you do. They are not, however, a substitute for advice or treatment by a trained medical professional that may be needed for specific health conditions, illness or injury.

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

IN THIS EPISODE OF THE HUMAN UPGRADE™... Dave talks with Mandy Pennington, a longtime Upgrade Collective member and dedicated hacker who has used biohacking techniques successfully to upgrade her body and mind.

Mandy is a sharp and curious person who wants to learn more about how to apply the topics in Smarter Not Harder to her spirituality, quantum energy, spirit guides, and leading a purpose-driven life that feels right for her soul.

An important aspect of this episode is focussed on how Mandy can refine her current spirituality practices, and increase her spiritual resilience to align with the next steps on her biohacking journey. Which is something that will likely resonate with you. 

Watch this episode on YouTube!

Note: The “Interventions With Dave” recommendations are designed to help you upgrade yourself and your biology so you can perform better at everything you do. They are not, however, a substitute for advice or treatment by a trained medical professional that may be needed for specific health conditions, illness or injury.

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Dave Asprey’s NEW Book! “Smarter Not Harder: The Biohacker's Guide to Getting the Body and Mind You Want” launches Feb. 28, 2023. Pre-order yours today: IndieBound / Barnes & Noble / Apple Books / Amazon

Knowing Labs: Test Your Own Biology: https://knowinglabs.com/dave, use code dave to save 20% off any test kit

Capture Life Force Energy: https://leelaq.com, use discount code DAVE10 to get 10% off sitewide

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

IN THIS EPISODE OF THE HUMAN UPGRADE™... I am honored and grateful to bring you a conversation that I recorded in person with Gurudev Sri Sri Ravi Shankar at the Art of Living Center in Los Angeles. 

Gurudev Sri Sri Ravi Shankar is a leader of an international movement with more than 50 million followers who do breathwork every single morning. He has worked for 40 years as a global ambassador for peace at the highest levels. 

I did his breathwork exercises every morning without fail for five years while fixing my mind, body and nervous system, and I have a huge amount of respect for his work in the world. It was a joy to chat with him in person and his childlike curiosity, enthusiasm for teaching, and deep understanding of the world are echoed in every word of this episode. 

Gurudev is a true visionary, so I am grateful that he set aside time to talk with me so I could share his wisdom with you. 

Watch this episode on YouTube!

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Dave Asprey’s NEW Book! “Smarter Not Harder: The Biohacker’s Guide to Getting the Body and Mind You Want” launches Feb. 28, 2023. Pre-order yours today: IndieBound / Barnes & Noble / Apple Books / Amazon

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IN THIS EPISODE OF THE HUMAN UPGRADE™...I do something different. Over the past 1000+ episodes, I have spent a lot of time talking and learning from my guests, but I have heard over and over that you would like to hear more from me about what I am doing, trying and thinking. Well, that can be awkward to do sitting alone in front of a microphone. 

A while ago, Danica Patrick interviewed me and it is one of my favorite podcast interviews ever. Danica did a great job of digging into why I do what I do, why I think the way I think, and best of all she allowed me to talk about parts of my life that I have never talked about anywhere else. 

So, Danica has kindly allowed me to drop that episode from her podcast, Pretty Intense, right here on the Human Upgrade.

You are going to learn a lot from the episode. We hit on a lot of pretty next-level stuff - our conversation even allowed me to dig into the concept of old souls (or reincarnation), and how that affects our current life.

Danica is a fascinating person and an excellent interviewer. You are going to enjoy this feed drop. 

Watch this episode on YouTube!

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Dave Asprey’s NEW Book! “Smarter Not Harder: The Biohacker's Guide to Getting the Body and Mind You Want” launches Feb. 28, 2023. Pre-order yours today: IndieBound / Barnes & Noble / Apple Books / Amazon

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H.V.M.N. sponsored this episode.

IN THIS “UPGRADE SPOTLIGHT” EPISODE OF THE HUMAN UPGRADE™…Metabolic biochemist Latt Mansor, Ph.D., joins the show from H.V.M.N. (Health Via Modern Nutrition), where he leads research for the company. He’s an expert in metabolism who consults with elite sport, military, clinical and research organizations. 

As a key biomarker of metabolic health, ketones are a source of fuel for your brain and body. They’re different from glucose and fat—and more efficient. Learning about the different kinds of ketones and how they work can help you both understand and harness their power. This discussion explains exogenous ketones, BDO-specific ketones BHB and ketone esters. You’ll also find out how to measure your ketones and why it’s important.

Ketones have been shown to be anti-inflammatory. Another benefit happens during exercise. The increase in your ketone levels directly increases BDNF (brain-derived nootropic factor). When you raise ketones, you have a more flexible brain.

Latt gets into the research behind H.V.M.N.’s development of drinkable ketones to improve performance. Ketone-IQ™ give you advantages like:

• Mental clarity and cognitive benefits
• Oxygen efficiency
• Sustained energy
• Performance, endurance and recovery
• Weight management and improved metabolic health

SPECIAL OFFER FOR THE HUMAN UPGRADE LISTENERS: Go to https://hvmn.com/DAVE, use code Dave to get 20% off.

Watch this episode on YouTube!

NEW IN 2023!

Dave Asprey’s NEW Book! “Smarter Not Harder: The Biohacker’s Guide to Getting the Body and Mind You Want” launches Feb. 28, 2023. Pre-order yours today: IndieBound / Barnes & Noble / Apple Books / Amazon

9th Annual Biohacking Conference: Come join like-minded people for three days of awesome biohacking, learning and connecting! June 22-24, 2023, in Orlando, Florida. https://biohackingconference.com

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

IN THIS EPISODE OF THE HUMAN UPGRADE™… Dr. Kelly Brogan shares why her views often go against conventional thinking—on topics from pharmaceuticals to sex to pole dancing to relationship compatibility. 

She's a psychiatrist who specializes in psychosomatic medicine and integrative holistic medicine. Her root-cause resolution approach to psychiatric syndromes and symptoms coupled with other support techniques helps women reclaim their divine feminine power.

I previously talked with Dr. Kelly on episode #635 about her book, "Own Your Self: The Surprising Path Beyond Depression, Anxiety, and Fatigue to Reclaiming Your Authenticity, Vitality, and Freedom.” 

This romp of a discussion tackles women’s power and what it means to claim or reclaim it. And how women themselves can be harmful critics of other women’s choices. 

Dr. Kelly went through profound personal changes over the past few years that led to changes in her business, too. Changes that rattled some people and brought out the worst kind of social media attention. She talks about how she’s stayed firmly in her choices and offers tips for you to do the same. She also gets into why the differences in feminine and masculine power matter now more than ever. It starts with your relationship with yourself.

This fun, informative interview gets a little wild and shares profound insights you can apply to your next life move.

Watch this episode on YouTube!

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Dave Asprey’s NEW Book! “Smarter Not Harder: The Biohacker's Guide to Getting the Body and Mind You Want” launches Feb. 28, 2023. IndieBound / Barnes & Noble / Apple Books / Amazon

9th Annual Biohacking Conference: https://biohackingconference.com

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IN THIS EPISODE OF THE HUMAN UPGRADE™…you’re going to learn how to work with your own biology, adapt to adversity, and get resilient AF. Doctor, educator and entrepreneur Dr. Molly Maloof joins the show in person in Austin, Texas, to talk about her debut book, “The Spark Factor: The Secret to Supercharging Energy, Becoming Resilient, and Feeling Better Than Ever.” 

For women biohackers, it’s all about energy—and hormones. 

“Cycles are exactly why the way guys biohack doesn’t always work for us [women]; we have hormonal and physiological differences, and importantly, different biological imperatives, from an evolutionary standpoint,” she says in her new book.

She last appeared on episode #706 and talked about how blood sugar powers your energy. This time, she explains why mitochondrial dysfunction is at the root of the collective human energy crisis and what you can do about it. Dr. Molly says four culprits reduce your energy capacity: inactivity, overeating and poor nutrition, too much stress and social disconnection.

"Spark Factor" outlines clear and actionable steps for women on how to make, charge, use, tune, and plug in your own batteries. New to biohacking? Start where you are. More advanced biohacker? You’ll learn tips and tweaks to get you to another level. Molly offers low-tech and tech-free guidance, too. It’s up to you where to start and how far you want to take it.

Her unique view of human performance incorporates technology and psychedelics. In this broad conversation, she covers sex and relationships, too.

Watch this episode on YouTube!

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Dave Asprey’s NEW Book! “Smarter Not Harder: The Biohacker's Guide to Getting the Body and Mind You Want” launches Feb. 28, 2023. Pre-order yours today: IndieBound / Barnes & Noble / Apple Books / Amazon

9th Annual Biohacking Conference: https://biohackingconference.com

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IN THIS EPISODE OF THE HUMAN UPGRADE™… board-certified OB/GYN and “menopause warrior” Mary Claire Haver, M.D., joins the show to give women a toolkit to manage what comes before, during and after menopause.

• She explains the science of women’s hormones, physiology and brain during the menopausal transition.
• She breaks down the studies, risks, and age timing of Hormone Replacement Therapy.
• She gives you information you can use to both help yourself and ask for help from medical professionals.
• She arms you with actions that work based on what is happening to your biology and brain chemistry during the years leading up to and after menopause.

“When I talk about the menopausal toolkit, HRT is just one small part of what I counsel patients about,” Dr. Haver says. “We talk about nutrition, we talk about exercise, we talk about stress reduction, we talk about sleep, we talk about possible other pharmaceuticals. And of course, we talk about supplementation. It's like a tackle box and everything is important.”

Although Dr. Haver’s career included taking care of women at all life stages, she didn’t expect to experience the shocks of her own menopause. So, she went looking for answers and took action along the way. She changed the entire focus of her medical practice to menopause. She also channeled the power of social media to provide menopause education and reaches more than 2 million on her TikTok channel alone.

Her new book, “The Galveston Diet: The Doctor-Developed, Patient-Proven Plan to Burn Fat and Tame Your Hormonal Symptoms," lays out three specific action areas: intermittent fasting, anti-inflammatory nutrition, and fuel refocus.

Menopause is having a moment. (As Lizzo would say, “It’s About Damn Time.”) From investor-backed start-ups in a $6B market to celebrity-led wellness brands to demands for more science—women, and women medical professionals, are changing mid-life menopause dynamics.

Watch this episode on YouTube!

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Liquid Ketones for Better Energy, Focus and Endurance. https://hvmn.com, use code DAVE to get 20% off

Dave Asprey’s NEW Book! “Smarter Not Harder: The Biohacker's Guide to Getting the Body and Mind You Want” launches Feb. 28, 2023. Pre-order yours today: IndieBound / Barnes & Noble / Apple Books / Amazon

9th Annual Biohacking Conference: https://biohackingconference.com

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IN THIS EPISODE OF THE HUMAN UPGRADE™…Susanna Soeberg, Ph.D., a Danish researcher, international scientist and expert in cold and heat therapy for health and performance, explains how you can harness the massive benefits of cold water immersion (winter swimming), sauna, breathing, and your metabolism.

When it comes to biohacking, a few things rise to the top and make a pretty big difference in your body and brain. Through her research, Susanna discovered the minimum threshold of cold and heat exposure for health benefits. We get right into that on the show. She also works with functional breathing during cold environmental conditions and cold water immersion, especially winter swimming. 

Have you been considering this biohack for awhile? Baby steps won’t get you there—prepare to go all-in with the cold. “You could take cold showers, for sure,” Susanna says, “but it's not going to activate your parasympathetic nervous system in the same way as submerging yourself into cold water.”

Earning a Ph.D. in metabolism at the University of Copenhagen set her on course to focus her expertise on ways metabolism works for and against you—and what you can do to improve your metabolic profile. She researches obesity, Type 2 diabetes and insulin management, as well as how brown and white adipose tissue (fat) function differently within the human body.

In Susanna’s new book, “Winter Swimming: The Nordic Way Towards a Healthier and Happier Life,” she describes the benefits of winter swimming and cold water immersion on your physiology, mental health, and capacity for resilience.

Watch this episode on YouTube!

SPECIAL OFFER FOR THE HUMAN UPGRADE LISTENERS: Go to https://www.soeberginstitute.com and use code DAVE for a special discount on Susanna Soeberg’s 3-week course, The Thermalist CureTM.

Opportunity: Breath, Cold, Stress & Resilience Conference, Feb. 18, 2023. Presentations by Susanna Soeberg, James Nestor and other experts. Register here.

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Leela Quantum Tech sponsored this episode.

IN THIS EPISODE OF THE HUMAN UPGRADE™…you’ll learn why energy frequencies have such a powerful influence on human physiology. Skeptics take note: science backs this up.

Philipp Samor Von Holtzendorff-Fehling introduced quantum energy on episode #809 and its benefits on body function, cellular voltage and chakra energy. He returns to the show with exciting new research that further validates the power of this energy and its frequencies on human physiology.

“Energy and frequency—that’s where the real truth is.” Philipp says. “And that's where the real life also is.”

Leela Quantum Tech creates blocs (Infinity, Quantum, Travel), frequency cards, H.E.A.L. capsules, and other products charged with quantum energy. The products have been through single- and double-blind, randomized studies and tests. This research has measured mental and physical energy, organ function, neutralization of radioactive particles, protection against pesticides and herbicides, and much more. 

Studies also explored how quantum energy affects ATP production, HRV (heart rate variability) and food allergies. You can feel and measure the effects. And dark field microscopy studies (placebo-controlled and double-blind) performed by Dr. Beverly Rubik in the U.S. and the BESA institute in Austria looked at the physical effectiveness of Leela Bloc technology.

SPECIAL OFFER FOR THE HUMAN UPGRADE LISTENERS: Go to https://leelaq.com and use code DAVE10 to get 10% off.

Watch this episode on YouTube!

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IN THIS EPISODE OF THE HUMAN UPGRADE™…Harvard psychiatrist, researcher and assistant professor Christopher Palmer, M.D., introduces a bold new premise about the root cause of mental illness based on decades of research.

Dr. Palmer integrated existing theories and research into one unifying theory—the brain energy theory of mental illness that’s rooted in your metabolism. Through his research, he initially pioneered using a medical ketogenic diet to treat psychiatric disorders. In this conversation, you’ll learn how he went even further to uncover the connection between mental health and metabolic disorders of the brain. That connection lies in mitochondrial dysfunction or dysregulation.

His new book, “Brain Energy: A Revolutionary Breakthrough in Understanding Mental Health and Improving Treatment for Anxiety, Depression, OCD, PTSD, and More,” also explains the increased risk for mental disorders in all metabolic conditions, including diabetes, heart attacks, strokes, pain disorders, obesity, Alzheimer’s disease, and epilepsy. 

“Once you see the big picture of metabolism and all of the things that influence metabolism, you actually can see novel ways to intervene,” Dr. Palmer says. “And you can also raise some red flags about some of our current treatments.” 

Watch this episode on YouTube!

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IN THIS EPISODE OF THE HUMAN UPGRADE™…you’ll meet Gloria Mark, Ph.D., who studies how digital media impacts people's lives. Her research specifically covers how attention is affected by, and has changed, with the rise of the digital age. She’s found that attention span now averages 47 seconds on a screen—and even that’s shrinking.

As a Chancellor’s Professor of Informatics at the University of California-Irvine researching human-computer interaction, Gloria examines how people handle multitasking, task-switching, interruptions, and emotions. Her new book “Attention Span: A Groundbreaking Way to Restore Balance, Happiness and Productivity” looks at human technology use from a psychological perspective.

“In the thousands of hours that I have studied people in the course of their daily work, I have heard a common sentiment,” Gloria says in her book. “People report that they are overworked and exhausted because they have to deal with too much information and too many messages.”

This conversation gets into the science of attention, the stress it’s causing, plus real solutions for how you can regain focus with your personal technologies. You’ll learn:

• How to recognize the four main types of attention;
• What consequences of constant interruption do to your stress levels and productivity;
• How to achieve focus, rhythm and balance in a day filled with attention-switching; 
• How to structure a flow state within your day; and 
• What four things you can do to gain agency in the digital world.  

Watch this episode on YouTube!

Shield Yourself from EMFs: https://quantumupgrade.io, use code DAVE to get a two-week free trial

Knowing Labs: Test Your Own Biology: https://knowinglabs.com/dave, use code dave to save 20% off any test kit

9th Annual Biohacking Conference: Come join like-minded people June 22-24 in Orlando, Florida, for three days of awesome! You’ll learn from dozens of experts at an amazing event that’s designed to upgrade every area of your life. https://biohackingconference.com

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IN THIS EPISODE OF THE HUMAN UPGRADE™… you’ll meet Robert Waldinger, M.D., who leads an extraordinary scientific study on happiness that’s still going strong after eight decades. The study set out to understand human health by what made people thrive.

Since 1938, the Harvard Study of Adult Development has tracked two groups of men and their families with the goal of discovering what really makes for a good life. Along the way, thousands of questions were asked, and hundreds of measurements were taken—from brain scans to blood work. Three strong themes emerged from the study: 

• Social connections are really good for you. Loneliness kills.
• It’s the quality of your close relationships that matters.
• Good close relationships don’t just protect your body, they protect your brain.

Dr. Waldinger combined those lifelong case studies with modern psychological research in his new book, co-authored with Marc Schulz, Ph.D., “The Good Life: Lessons from the World's Longest Scientific Study of Happiness." This discussion gives you real-life tools to hack your happiness. You’ll learn things like:

• how relationships improve your physical, mental and emotional health. (More than you know!)
• how to evaluate the effect of your relationships on your well-being. (Don’t be dragged down.)
• what social fitness is and how to practice it. (Yes, it’s a flex.)
• ways to enliven and energize your relationships. (Energy totally matters.)
• why casual and work relationships matter more than you think. (A surprisingly big contribution.)

Watch this episode on YouTube!

Don’t Miss This! Dr. Waldinger’s TEDtalk about the study is one of TED’s Top 10 episodes and viewed more than 43 million times.

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9th Annual Biohacking Conference: Come join like-minded people June 22-24 in Orlando, Florida, for three days of awesome! You’ll learn from dozens of experts at an amazing event that’s designed to upgrade every area of your life.https://biohackingconference.com

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Neurohacker Collective sponsored this episode.

IN THIS "UPGRADE SPOTLIGHT" EPISODE OF THE HUMAN UPGRADE™… you’re going to learn about the zombie cells taking up valuable space in your body and how you can clear them out with senolytics.

When these zombie cells accumulate (formally called senescent cells), they negatively impact how you age. You may experience symptoms like joint discomfort, low mental and physical energy, poor metabolic health, and diminished muscular response when you work out.

Naturopathic physician Greg Kelly joins the show from Neurohacker Collective, where he’s director of Product Development. His expertise includes nootropics, anti-aging and regenerative medicine, weight management, sleep, and the chronobiology of performance and health.

The hallmarks of aging include nine characteristics that organisms all the way up to humans share as we age, Dr. Kelly explains. One of those characteristics is senescent cells.

This discussion gets into the reasons why senescence happens, the science of senolytics, exciting new research, and new product developments that help bodies naturally eliminate senescent cells. This means a better aging process for you!

SPECIAL OFFER FOR THE HUMAN UPGRADE LISTENERS: Go to https://neurohacker.com/dave and code ASPREY to get an additional 15% off. You can trial Qualia Senolytic for up to 100 days with a full 100% money-back guarantee. 

Watch this episode on YouTube!

9th Annual Biohacking Conference: Come join like-minded people June 22-24 in Orlando, Florida, for three days of awesome! You’ll learn from dozens of experts at an amazing event that’s designed to upgrade every area of your life. https://biohackingconference.com

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IN THIS EPISODE OF THE HUMAN UPGRADE™... the new year starts off with a Legacy Upgrade conversation between Dave Asprey and Dr. Andrew Weil recorded live at True Food Kitchen in Phoenix, Arizona. 

Dr. Weil’s an internationally known pioneer and leader in integrative medicine. He’s also a Harvard-trained botanist and medical doctor recognized worldwide for his views on living a healthy lifestyle, his philosophy of healthy aging, and his critique of the future of medicine and health care. 

This broad discussion both hits the high points and goes deep into nutrition, aging, energy, lifestyle, and, of course, tea. Specifically, vibrant green matcha. (Or as Dave says, “It looks like green paint.”) There’s a lot of knowledge and humor shared, as well as hard-hitting truths: “One of the most toxic cultural messages here is that the value of life diminishes with aging,” Dr. Weil says.

His five pillars of good health touch on foundational elements that contribute to your core vitality and life force. 

• Eat right! Learn the principles of nutrition and apply them to your life
• Get regular physical activity
• Learn and practice methods to neutralize the harmful effects of stress
• Maintain emotional and intellectual connectivity as you go through life
• Attend to your spiritual well-being

More about Dr. Andrew Weil: He founded the Andrew Weil Center for Integrative Medicine at the University of Arizona. He champions the use of medicinal plants and alternative medicine, as well as the reform of medical education. He’s a clinical professor of medicine and a professor of Public Health at the University of Arizona and the author of more than a dozen books on health, wellness and optimal living. 

SPECIAL OFFER FOR THE HUMAN UPGRADE LISTENERS: Go to www.matcha.com and use code Bulletproof15 to save 15% off sitewide.

Watch this episode on YouTube!

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9th Annual Biohacking Conference: Come join like-minded people June 22-24 in Orlando, Florida, for three days of awesome! You’ll learn from dozens of experts at an amazing event that’s designed to upgrade every area of your life. https://biohackingconference.com

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IN THIS EPISODE OF THE HUMAN UPGRADE™… Humble The Poet joins the show to talk about a unique perspective on love. You’ll learn:

• what “real” love means (hint: it’s not found or earned) and how to recognize it in your life. 
• how to shift away from a mindset of earning more, achieving more, and gaining more attention so you can clear pathways for love to enter and flourish in your life
• how to ditch restrictive “resolutions” (that fail more often than they succeed) and instead set intentions that allow you more freedom to love yourself and others.

This Canadian-born rapper, spoken-word artist, poet and international bestselling author began reciting spoken word poetry in coffee shops more than a decade ago. That creative outlet turned into an adventure that crossed genres, mediums and oceans. His style stimulates audiences with ideas that challenge conventional wisdom. 

His first two books, “Unlearn” & “Things Nobody Can Teach Us” became international bestsellers. 

His newest book focuses on self love, love for others, defining love in a different way, and how to ease up on expectations that may be holding you back: “How to Be Love(d): Simple Truths for Going Easier on Yourself, Embracing Imperfection & Loving Your Way to a Better Life.” 

“I’m writing this because I’m desperate,” he says in the book. “Desperate to realize love, accept love, and learn how I keep f**king it up.”

Watch this episode on YouTube!

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IN THIS “BEST OF” EPISODE OF THE HUMAN UPGRADE™…

… Ari Whitten, Ph.D. (Cand.), CES, PES, explains how to double your energy through improved resilience, cell defense, nutrition and supplementation.  

In his newest book, “EAT FOR ENERGY: How to Beat Fatigue, Supercharge Your Mitochondria, and Unlock All-Day Energy,” Ari explains that 5.4 million adults in the U.S. have been diagnosed with chronic fatigue syndrome (the most severe case of fatigue). However, the true fatigue epidemic affects 50 to 100 times more people with many experiencing some level of being flat-out tired as hell.

This conversation gets right into the role of mitochondria in human energy. The cause of fatigue is mitochondrial dysfunction, Ari says. The biggest factors that affect your mitochondria include:

• Circadian rhythm dysregulation and poor sleep 
• Carrying too much body fat and too little muscle mass 
• Poor gut and microbiome health 
• Blood sugar dysregulation 
• Nutritional toxicities and deficiencies 
• Neurotransmitter and hormone imbalances

Ari recommends science-backed ways that you can get your mitochondria moving, dial in your nutrition and upgrade your brain, gut and hormones. 

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9th Annual Biohacking Conference: Come join like-minded people June 22-24 in Orlando, Florida, for three days of awesome! You’ll learn from dozens of experts at an amazing event that’s designed to upgrade every area of your life. https://biohackingconference.com

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IN THIS “BEST OF” EPISODE OF THE HUMAN UPGRADE™…… Steven Gundry, M.D., explains that ketones aren’t the fat-burning molecules you think they are. Ketones actually work to enhance health, weight loss, and longevity by acting as signaling molecules that stimulate your mitochondria. A cellular process known as “mitochondrial uncoupling” happens. 

He debunks common myths about keto in his newest book, “Unlocking the Keto Code: The Revolutionary New Science of Keto That Offers More Benefits Without Deprivation,” and shares eight “keys” that unlock the keto code: 

1. Intermittent fasting or time-controlled eating 
2. Polyphenols
3. Dietary fiber 
4. Fermented foods 
5. Polyamines
6. Cold temperatures
7. Hot temperatures
8. Red light therapy

Upgrading your nutrition with keto gets even simpler in this conversation that gives you real food examples of how to ignite your mitochondrial uncoupling process without a monotonous, limiting, high-fat diet.

SPECIAL OFFER FOR THE HUMAN UPGRADE LISTENERS: 

• Get 30% off products at https://gundrymd.com. Use code DAVE30 at checkout.

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IN THIS “BEST OF” EPISODE OF THE HUMAN UPGRADE™… natural vision expert Claudia Muehlenweg explains how you can take better care of your eyes and improve your vision. 

Her work is based in the Bates Method. She focuses on finding the root cause of blurry vision instead of using symptomatic treatments like glasses, contacts or surgery that actually can make eyesight worse in the long term.

For nearly 15 years, Claudia’s taught eyesight improvement for presbyopia, myopia, astigmatism, hyperopia, strabismus, convergence insufficiency, and eye diseases such as cataracts, macular degeneration and glaucoma. She also helps people restore clarity after corrective surgeries like LASIK have worn off. 

Claudia starts with root causes in your body, including nervous system regulation. She then brings in bodywork, breathwork, rest, light and movement healing methods. Listen on to get practical solutions and essential Dos and Don’ts for good eyesight.

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Biostack for High Performance: https://vatellia.com, use code DAVE2022 to save 10% or subscribe and save 15% + receive a free bottle of Kale Buster

Sleep Better on Natural Memory Foam: https://myessentia.com/daveasprey, use code DAVE to get an extra $100 off an Essentia mattress purchase on top of Essentia’s Holiday 25% off sale. Through Dec. 31, 2022, only. Learn more: Mattress Smarts 101 for High-Performance Sleep – Jack Dell’Accio – #875

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In this Episode of The Human Upgrade™… Dave talks with Rachelle Copeland about putting her energy into healing facial injuries and building new tissues—starting with the central nervous system. Rachelle experienced an accident that injured her face, teeth, nerves and jaw. She wants to heal quickly and avoid scarring and long-term damage while also managing the accompanying emotional trauma.

This intervention looks at ways to heal and recover both internally and externally, covering suggestions such as: 

• EMDR, Tapping, EFT for physical and emotional trauma (What Is EMDR and How Does It Work?, Nick Ortner: The Tapping Solution for Pain Relief – #219, Tap into Tapping: The EFT Episode – Dawson Church # 474)
• Jaw misalignment (Dr. Dwight Jennings: TMJ, Jaw Pain, & Substance P – #179)
• Vagal nerve (Stephen Porges: The Polyvagal Theory & The Vagal Nerve – #264, The Nervous System Circuitry of Safety, Sound & Gratitude – Stephen Porges #573)
• Hyperbaric therapy
• Craniosacral work
• Inflammation
• Oral and topical cayenne
• Red and infrared, LED or laser light therapy 
• Ozone therapy
• Supplements to support healing
• Enzymes

If you’re recovering from injury, take a listen to this episode for tips and resources on how to heal.

Note: The "Interventions With Dave” recommendations are designed to help you upgrade yourself and your biology so you can perform better at everything you do. They are not, however, a substitute for advice or treatment by a trained medical professional that may be needed for specific health conditions, illness or injury.

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9th Annual Biohacking Conference: Come join like-minded people June 22-24 in Orlando, Florida, for three days of awesome! You’ll learn from dozens of experts at an amazing event that’s designed to upgrade every area of your life.https://biohackingconference.com

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Viome sponsored this episode.

IN THIS EPISODE OF THE HUMAN UPGRADE™… entrepreneur and philanthropist Naveen Jain joins the show in person at the Beverly Hilton to talk about new developments in the human biome—particularly the oral microbiome. Turns out, there may be more density in your gut microbiome, but there’s more diversity in your oral microbiome.

Naveen’s company, Viome, built an AI-driven platform that analyzes the interaction between food, your body’s biomes, and your cells from at-home tests. Your results are used to develop precise ways of eating and taking supplements that prevent and can even help reverse chronic disease. They’ve so far collected 425,000 samples showing 600 trillion data points.

The newest Viome test kit takes a look at your oral health. 

Viome prepares custom supplements, probiotics and prebiotics with the exact ingredients in the exact dosages you need based on your personal test results. This customization is important because supplements are not universally healthy, more isn’t better, and consuming nutrients and biotics you don’t need can actually do more harm than good. Custom formulations work with and for your own physiology.

Viome testing also helps you see your personal health trends over time. Your tests could show different results at six months or a year. Then, your supplements would be adjusted to your changing physiology. Check out Viome’s at-home test kits:

• Oral Health Intelligence: coming soon!
• Full Body Intelligence (gut, cellular, oral health)
• Health Intelligence (gut, cellular health)
• Gut Intelligence (gut health)
• Cancer Detect (oral & throat)

SPECIAL OFFER FOR LISTENERS OF THE HUMAN UPGRADE: Go to https://viome.com/dave and use code DAVE10 to get 10% off tests and 10% off a 12-month subscription

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Pendulum sponsored this episode.

IN THIS EPISODE OF THE HUMAN UPGRADE™…molecular biologist and biochemist Colleen Cutcliffe, Ph.D., returns to the show with brand new science about your gut. She’s a regular guest because she and her team at Pendulum continue to uncover innovative ways to improve your gut health, your metabolism, your immune system, how your brain works and how long you live. 

This time, Akkermansia’s back in the spotlight, with more than 300 new studies showing connections to weight, metabolism and immunity. A unique and novel probiotic strain (species of bacteria) naturally found in your gastrointestinal tract, Akkermansia muciniphila, directly interacts with your gut lining and helps regulate the mucus lining in your gut. Now, there’s growing evidence showing Akkermansia to be a keystone bacterial strain.

This conversation dives into the latest research and what it means for you. You’ll learn how to apply this new knowledge and how to boost Akkermansia in your gut.

SPECIAL OFFER FOR LISTENERS OF THE HUMAN UPGRADE: Go to https://pendulumlife.com and use promo code DAVEVIP to get 20% off your first month of membership.                                                                                                      

Watch this episode on YouTube!

A Pre-Alcohol Probiotic to Offset a Rough Morning After: https://zbiotics.com/dave, use code DAVE to save 15% off your first order. 

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IN THIS EPISODE OF THE HUMAN UPGRADE™ … you’ll find out that kids are killing themselves more often and at younger ages. Suicide prevention expert Dr. Mark Goulston joins the show to discuss the very real and very urgent topics of youth mental health and suicide—from pre-teens to teens to young adults. These issues concern everyone, not only families, educators or professionals who connect with young people. Here’s why:

Suicide shows up in the top three causes of death in young people between the ages of 10-24, according to 2020 stats from the Centers for Disease Control and Prevention (CDC) WISQARS Leading Causes of Death Reports.

Young people are hurting. The National Alliance on Mental Illness reports that nearly 20% of high school students say they’ve had serious thoughts of suicide and 9% have made an attempt to take their lives. Dr. Mark explains that many young people struggling mentally and emotionally feel like they're a burden to everyone. And they don’t have confidence that parents can help them feel better. 

You’ll learn a lot during this conversation, such as:

• factors driving teen mental health issues and teen suicide.
• what’s going on in the teen brain from a developmental perspective that leads them to think that death is a preferable alternative to working through life situations.
• signs or red flags that a teen is struggling. 
• how parents and adults often can diminish or dismiss teens’ emotions, situations with friends or love relationships.
• what emotional intelligence skills are most useful for parents/adults to better understand teens.
• how to talk to teens—whether you’re a parent or a caring adult in a teen’s life.
• how to improve listening in a culture dominated by tech.
• how to listen to teens and help them realize and understand their emotions—without cutting them off, interrupting them, or jumping to advice and solutions.
• when to seek professional intervention.

More about Dr. Mark Goulston: He's a retired psychiatrist, former UCLA professor of psychiatry and former FBI and police hostage negotiation trainer. He recently received the “Shine the Light Media Award” from the Los Angeles County Medical Association for bringing attention to teen mental health and suicide. He’s the author or co-author of nine books: “Just Listen: Discover the Secret to Getting Through to Absolutely Anyone,” ranks in the 15 Best Communication Skills Books of All Time.

Watch this episode on YouTube!

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IN THIS EPISODE OF THE HUMAN UPGRADE™… you’ll learn about a new holistic framework for self-healing and how to heal yourself with prompts, tools and actionable tips.

Using the tenants of holistic psychology, Nicole LePera, Ph.D., created a different way to reach people and equip them with the tools necessary to heal themselves. Holistic psychology focuses on the mind, body, and soul in the service of rebalancing the body and nervous system and healing unresolved emotional wounds.  

It’s all about a daily practice of creating your own wellness by:

• seeing yourself from a new perspective,
• breaking negative patterns, 
• healing from your past, and
• creating your conscious self.

Nicole, the author of the New York Times Bestselling Book “How to Do the Work: Recognize Your Patterns, Heal from Your Past, and Create Your Self,” builds on that theme and goes even deeper with her newly published “How to Meet Your Self: The Workbook for Self-Discovery” workbook.

In this conversation, you’ll find out how to:

• objectively and compassionately observe the physical, mental, and emotional patterns that keep you stuck.
• deep dive into your ego, trauma and emotions so you can safely do the inner work that can transform your outer world.
• change ingrained beliefs and habits so you can move toward realizing your authentic self. 

Watch this episode on YouTube!

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IN THIS EPISODE OF THE HUMAN UPGRADE™… Dan Buettner joins the show to talk about the origins and food foundations of Blue Zones. He discusses how they were discovered, what makes them different, and what’s changed for people living there over the past few decades. And the big question—is it still possible to live to 100?

Dan, an explorer, National Geographic Fellow, award-winning journalist and producer, and photographer, has studied and written extensively about the five places in the world—dubbed Blue Zones—where people live the longest, healthiest, and often happiest lives. He’s partnered with epidemiologists, anthropologists, medical researchers, demographers, and statisticians to take a data-based approach to everything from genetics to census data.

Combining this intensive research with cultural immersion, Dan’s brought out aspects of Blue Zones lifestyles—like food and social connection—that form a foundation for human life quality and longevity. He’s the bestselling author of a series of Blue Zone books.

In Dan’s latest Blue Zones adventure, he took a road trip across the United States to explore food and communities. He found that pockets of Blue Zones do exist throughout the U.S. He talked to heritage cooks passing on recipes to younger generations. He uncovered the traditional roots of plant-forward cuisine in the United States and presents both traditional and revolutionary ideas in vegetarian food in his newest book, “The Blue Zones American Kitchen: 100 Recipes to Live to 100.” Stunning photography and recipes show the vitality of both food and people from five distinct areas: Indigenous, Native & Early American, African American, Latin American, Asian American and Regional and Contemporary American.

Dan also dug deep into the country’s food history and brings to light the dramatic changes in food processing, regulation, government intervention, and leadership choices that have influenced food supply. He combed through 60 oral histories, scientific reports and academic papers to reconstruct traditional American diets. In “The Blue Zones American Kitchen,” you’ll find out why the 1970s were the worst decade for America’s food environment. 

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(ZBiotics sponsored this episode.)

IN THIS EPISODE OF THE HUMAN UPGRADE™… you'll find out how to counter the sometimes rough morning after you have alcohol. The key is a new genetically engineered pre-alcohol probiotic drink. Great timing as you head into the holiday season of celebrations.

Zack Abbott, CEO & co-founder of ZBiotics, joins this 1,000th episode of the podcast to talk about new discoveries in alcohol metabolism, genetic engineering and GMOs (used in a good way!), and the power of microbes.

Ever wondered why you feel like crap the morning after drinking alcohol? The cause is a byproduct called acetaldehyde that forms in your gut when you drink alcohol. The ZBiotics Pre-Alcohol Probiotic Drink breaks down acetaldehyde while you drink so you can feel better the morning after.

Prior to starting ZBiotics, Zack, who has a Ph.D. in microbiology and immunology, worked in clinical trial design, researched HIV vaccines, and pursued novel antibiotics in both academia and industry.

He invented the ZBiotics proprietary technology using genetic engineering to develop new probiotics—ones with specific, unique abilities to improve your daily life. He’s proving through science that incredible things can be done with GMOs and genetically engineered microbes.

SPECIAL OFFER FOR THE HUMAN UPGRADE LISTENERS: Go to https://zbiotics.com/dave and use code "dave" to save 15%.

Watch this episode on YouTube! 

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Harness Cold to Improve Health & Performance: https://www.cryobuilt.com

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In this Episode of The Human Upgrade™...​

Cool Facts are quick hits of new human and world science curated into short bursts of information just for you. This fun compilation publishes one Friday a month.

• Sperm that swim together increase their chances of fertilization
• Late-night eating is worse than you thought
• Metabolic markers can be measured through your sweat
• Eye movements during REM sleep could delete unwanted memories

EPISODE SPONSOR: Humic & fulvic minerals provide critical cellular support. Go to https://www.beamminerals.com and use code DAVE20 to get 20% off. Learn more: How Minerals Combat Glyphosate’s Harm – Caroline Alan – #948.

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Timeline Nutrition sponsored this podcast.

IN THIS EPISODE OF THE HUMAN UPGRADE™… immunologist Anurag Singh, M.D., Ph.D., MBA, Chief Medical Officer at Amazentis, joins the show to talk about urolithin A’s connection between inflammation, aging and your mitochondria. 

Urolithin A activates mitophagy and renews your mitochondria.  “It takes all the cellular garbage that has been accumulating over the aging process,” Dr. Singh explains. “It revs it up, so it recharges. And so now, you're cleaning your metabolic waste products much more efficiently and they become the building blocks. This is mitochondrial biogenesis, and that means newer, healthy mitochondria coming in.”

This new conversation takes an exciting turn into immunity and your immune system’s two lines of defense: innate and adaptive. You’ll learn:

• how inflammation plus aging (AKA inflammaging) contributes to a weakened immune system and a growing incidence of cancer as you age;
• how inflammaging and cancer are connected to mitochondrial dysfunction specifically during the aging process; and
• how to approach your immune health differently with this new knowledge.

A new study recently published in Immunity looks at how immune cells fight cancer better with a focus on immune modulation, immune cell exhaustion and immune responses. “A lot of urolithin A is anti-inflammatory, but a lot of it is immune modulation," Dr. Singh says. "So, it takes a rewiring of the immune system and makes it more conducive to stopping harmful immune responses.”

Watch this episode on YouTube!

SPECIAL OFFER FOR THE HUMAN UPGRADE LISTENERS: To learn more about the benefits of urolithin A, go to https://www.timelinenutrition.com and use code UPGRADE10 to get 10% off the plan of your choice. 

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IN THIS EPISODE OF THE HUMAN UPGRADE™… Robynne Chutkan, M.D., joins the show to talk about a topic that’s foundational to biohacking—resilience. More specifically, resilience that starts in the gut. You’ll learn:

• how your microbiome continually evolves and why that matters to the state of your gut and body functions.
• how to strengthen the antiviral defenses located in your gut.
• why your body’s own ability “to resist, heal, and recover from viruses is vastly superior” to pharmaceuticals.
• what to do before taking antibiotics to protect your gut, as well as what you can do to rehab your microbiome after antibiotic use.

“Being on the winning team when battling viruses isn’t because of good luck, or coincidence, or variations in viral virulence,” Dr. Chutkan explains in her newest book, “The Anti-Viral Gut: Tackling Pathogens from the Inside Out.” "It’s due to differences in us, the hosts, and our defenses, and those differences are what determine your outcome. Put another way: it’s less about the potency of the pathogen and more about the health of the host.”

Dr. Chutkan is a Yale- and Columbia-educated integrative gastroenterologist who’s been advancing knowledge and education about gut health for decades. Nearly 20 years ago she founded the Digestive Center for Wellness to help people get to the root issue of their digestive issues and improve their gut health. 

Watch this episode on YouTube!

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Brain Training with Sound & Vibration: Change unwanted behaviors, reduce negative self-talk, and enhance motivation and performance. Go to www.braintap.com/dave to get 30% off

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Eight Sleep sponsored this podcast.

IN THIS EPISODE OF THE HUMAN UPGRADE™… you’ll learn about the intimate relationship between performance and sleep and how you can hack both with a combination of tech and lifestyle. 

Matteo Franceschetti joins the show to talk about high performance—something he experienced in athletics, business and life. He was a competitive athlete in his native Italy and a race car driver across Europe. He started two clean-tech companies on two continents. He also worked at the top tier of the international legal world

The one thing he didn’t excel at was sleep. So, he co-founded Eight Sleep nearly a decade ago to hack sleep in all the ways that fuel human potential, performance and energy.

Eight Sleep mattress and mattress pad technology redesign sleep with AI and machine learning models to track your nighttime biosignals. It’s a technology that’s catching the attention of professional athletes in sports like snowboarding, CrossFit, Formula One, and many more.

SPECIAL OFFER FOR THE HUMAN UPGRADE LISTENERS: Go to https://www.eightsleep.com/dave/ to get up to $450 off a Sleep Fit Holiday Bundle that includes the Pod 3 Cover. This is a limited-time offer. Eight Sleep currently ships within the USA, Canada, the UK, Australia and select countries in the EU.

Watch this episode on YouTube!

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BiOptimizers sponsored this podcast.

IN THIS EPISODE OF THE HUMAN UPGRADE™… you're going to get into bed with the topic of sleep. Pretty much everyone’s favorite. 

In this conversation, veteran biohacker and BiOptimers co-founder Matt Gallant returns to the show with some straight talk about how to get more and better sleep. He’s spent the big bucks—about $50K he estimates—exploring, experimenting and upgrading his own sleep. He's sharing what he now knows so you can create a sleep stack that supercharges your own energy.

You’ll learn about the most common sleep disruptors and what to do about them. You’ll also learn to recognize sleep stages and how to improve your sleep pathways.

This fun show uncovers the practical sleep devices, wearables, supplements and lifestyle hacks that will lull you to sleep. So many times, you’re tired and you know you want to go to sleep—and yet—your body and mind just don’t connect. The new Sleep Breakthrough makes that connection for you. And when cortisol runs amok and falsely perks you up with a second wind, you’ll know what to do. 

More and better sleep means you’ll be a higher-performing human. So, get some tonight!

SPECIAL OFFER FOR THE HUMAN UPGRADE LISTENERS: Go to https://sleepbreakthrough.com/dave and use code DAVE10 to get an extra 10% off. 

Watch this episode on YouTube!

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Alitura Naturals sponsored this podcast.

IN THIS EPISODE OF THE HUMAN UPGRADE™…… you’ll learn about skincare ingredients that can either nourish or harm your skin. You’ll find out about standards in skin care products, what “clean beauty” means, and what to look for on product labels.

Andy Hnilo, founder of Alitura Naturals, joins the show to talk about skin fitness from the inside out and why using skincare products with ingredients found in nature is the way to go. That means things like pearls, meteorites, clay, CoQ10, enzymes and more.

This conversation gets into ways you can get better skin by:

• choosing the right nutrient-rich specialty products you can apply topically; 
• pairing natural skin products with other biohacks, like red light;
• making nutrition and fitness upgrades; and
• exploring supplements, peptides and other wellness options.

Improving skin health also means avoiding fillers and chemicals. Toxins both in skin care products and the environment tremendously impact your skin. Acne no longer drives only teenage angst. Adult acne continues to rise, with women affected more than men. Acne affects more than 50% of women between the ages of 20 and 29 and more than 25% of women between the ages of 40 and 49. (American Academy of Dermatology 2012.) 

Andy himself struggled with acne—so he knows the toll it takes from outside appearance to inner emotional roil. So, he searched for answers: “It was the products that I was using and then also what I was ingesting,” Andy says. “What I was putting into and onto my body.”

This get-smart guide to product ingredients, environmental awareness and lifestyle tips can help you find your own skin solutions. 

SPECIAL OFFER FOR THE HUMAN UPGRADE LISTENERS: Go to https://alitura.com and use code humanupgrade to save 20% sitewide.

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Analemma sponsored this episode.

IN THIS EPISODE OF THE HUMAN UPGRADE™… you’re listening to a new Upgrade Spotlight series. Once a month, these shorter episodes feature guests who get right into useful information in a Q&A style. You’ll find out how to improve your energy and upgrade your performance. You’ll also get the latest knowledge about powerful tools and technologies that allow you to change your biology and the environment around you. 

Introducing Analemma! During this Upgrade Spotlight with Mario Brainovic, CEO of Analemma, you’re going to find out about a tool that transforms regular water into a supercharged, full-spectrum, coherent state. The kind of water you drink absolutely influences the quality of your life. You’ll learn the science behind Analemma and what it can do for your health and energy.

Why water? You think you know the basics: stay hydrated daily, avoid plastic bottles and use a filtration system at home. Well, Analemma says water goes way beyond the basics—all the way down to your cellular level. You’re 70% water in body mass, but 99% water on a molecular level. You’re basically very clever water. 

The Analemma device—similar in looks and function to a magic wand—radically changes the state of drinking water. Environmental forces cause H2O molecules in drinking water to behave chaotically. At an atomic level, water molecules crash into each other constantly. Your body’s susceptible to that influence.

“We found a way to bring order to this chaos,” Mario says. “When you swirl an Analemma through the water, what happens is that those same H2O molecules start forming a liquid crystalline structure. They start behaving harmonically. They, colloquially speaking, join hands.”

Analemma water is not exclusion zone water. It's something different. “It also is structured water, but we came to it in a very different way,” Mario says. “The key element to it is its stability.”

This conversation gets right into the science of Analemma and several studies. You’ll find out how:

• a new study is measuring the rise in ATP levels (in mitochondrial energy) when people drink this water.
• this water affects the human microbiome 
• this water reduces your biological age by one to 12 years by regenerating your cellular system, according to GlycanAge.
• you get an instant balancing effect between the left and the right brain hemisphere
• how a cooling affect happens on your brainwaves almost instantly when drinking this water
• this water restores the biodiversity of infertile soil

SPECIAL OFFER FOR THE HUMAN UPGRADE LISTENERS: Go to https://analemma-water.com and use code dave10 to save 10%.

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IN THIS EPISODE OF THE HUMAN UPGRADE™… You’ll learn about the ways using a sauna can charge your energy, help you heal physical and mental health conditions—and science that backs that up. 

Sunlighten sponsored this episode.

Connie Zack joins the show to talk about the far-reaching benefits of sauna use and what’s new in the field of infrared light. For more than 22 years, Connie and her husband, Aaron, have introduced infrared light therapy to 13 countries through Sunlighten. They’re leading innovations in infrared light therapy and infrared sauna manufacturing. 

This conversation covers a range of good things you’ll experience from using a sauna:

• how infrared light affects the body and triggers a biochemical cascade of benefits;
• how near infrared penetrates the body to interact with mitochondria;
• why the real magic of infrared combines both light and heat;
• what evidence connects infrared and detoxification—and why sweating wins;
• why you sleep better—without feeling exhausted—when you do a sauna session before bed;
• how infrared shows promising relief for those who experience depression; and 
• practical ways to incorporate sauna into your own stack for better sleep and higher performance.

Big takeaways for you:

• Sauna for Detox: Results from a blood-urine-sweat study support infrared for detoxification, and it’s more than just thermoregulation as traditional medicine often argues.
• Sauna for Depression: Chronic inflammation is associated with depression and may be a protective, inflammatory response involving thermoregulatory pathways, the immune system, serotonin system, heat shock proteins and more. Studies show that raising core body temperature can improve major symptoms of depression. 

Connie’s been on the show before, so check out Saunas Use Infrared to Power Detox, Immunity & Renewal – #823 to find out how infrared sauna helps you with immunity and recovery.

SPECIAL OFFER FOR THE HUMAN UPGRADE LISTENERS: Go to https://www.sunlighten.com/dave to save up to $600 on your sauna purchase.

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IN THIS EPISODE OF THE HUMAN UPGRADE™…Joe Polish, considered “the most connected person on the planet,” shares networking strategies that help you get what you want by giving people what they want.

Dave Asprey recently connected with Joe in person to talk about Joe’s new book so you can use nine genius principles to turn your business—and your personal relationships—around. 

If you’re not asking “what’s in it for them?” when it comes to the people in your life—clients, colleagues, family and friends—you’re missing some important opportunities. Here are a few things you’ll learn from Joe’s new book, “What's in It for Them?: 9 Genius Networking Principles to Get What You Want by Helping Others Get What They Want,” as a how-to guide:

• Deepen rapport and connect with others by identifying and reducing their suffering
• Update Dale Carnegie’s insights to win the right friends and influence the right people
• Overcome others’ intimidation tactics to find true appreciation in relationships
• Build character for better results than capabilities can ever give on their own
• Use basic marketing principles to find true love
• Protect your efforts from the “takers” of the world

Joe did the hard work to heal from trauma and overcome addiction. He then spent years developing a genuine and generous approach to networking and building rapport. This approach propelled his business and led him to develop the Genius Network, one of the world’s most impactful networking groups for high-achieving entrepreneurs.

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In this Episode of The Human Upgrade™...​

Cool Facts are quick hits of new human and world science curated into short bursts of information just for you. This fun compilation publishes one Friday a month.

• How (and why) brain cells transfer mitochondria to one another

• How a newly discovered molecule stimulates hair growth

• How a tired brain drives poor decision-making

EPISODE SPONSOR: The Eng3 NanoVi device helps repair oxidative stress damage and support the body’s natural repair mechanisms.https://eng3corp.com/DAVE/. Learn more: The Anti-Aging Science Behind the NanoVi Device – Rowena Gates & Hans Eng – #416.

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IN THIS EPISODE OF THE HUMAN UPGRADE™… you’ll learn how a yoga practice can be a vehicle for inner transformation. This conversation looks past the popularity of yoga as a fitness trend and into its deeper potential for human development. You’ll also learn how yoga can be a way for you to explore your whole being—from physicality to emotions to thinking.

“A yoga practice often can be the missing ingredient for people,” says renowned yoga master Baron Baptiste. “Often I hear, ‘I added yoga practice to my routine and regimen, and it just shifted everything for me.’ It's a very different way of working your body, mind and breath integration.”

Baron devotes his own life to the study and practices of human development. For more than 30 years, he’s facilitated education through yoga principles and teachings.

His power vinyasa yoga— The Baptiste Methodology—includes the physical (asana), meditation (dhyana) and inquiry (niyama). 

“Iyengar was one of my primary teachers,” Baron says. “One thing I borrowed from him is the rigor to a body alignment—a True North Alignment.”

Baptiste Yoga is a systematic approach made up of 53 poses, or asanas, that are linked together by connective momentum and consist of five classical pillars: Drishti (gaze), ujjayi (breath), bandhas (foundation), tapas (heat) and vinyasa (flow).

More about Baron Baptiste: Baron began to seriously study yoga at age 12. As the son of two of America's yoga pioneers, he’s got a great life story that highlights the transformative power of yoga. He trained extensively in all the major traditions before beginning to teach yoga in Los Angeles in the late 80s and creating Baptiste Power Vinyasa Yoga in the mid-90s. He’s worked with celebrities, Olympians and professional athletes. He founded the Baptiste Power Yoga Institute that reaches people around the world. Baron’s also a New York Times bestselling author of multiple books, Emmy-award film maker and public speaker.

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IN THIS EPISODE OF THE HUMAN UPGRADE™… biohacking goes in a different direction. This frank discussion looks at the dying process and how people and those close to them (family and friends) experience death. You’ll learn about the existence of angels and the power of psychic abilities—even if you may be a skeptic. The conversation also explains what a “medical intuitive” does and how a medical intuitive facilitates energetic healings.

Cool show today! And not what you might expect.

Avid biohacker Julie Ryan checks a lot of success boxes: businesswoman, serial entrepreneur, author, radio show host and podcaster. She also invents surgical devices that sell globally; some have been on the market for three decades. She’s founded nine companies in five different industries. 

She checks a lot of unconventional boxes, too. She’s a psychic and medical intuitive. This means she can sense medical conditions and illnesses in people—like a human MRI machine. Then she facilitates energetic healings and says she does a lot of work with stem cell energy.

Julie scans animals, accesses people’s past lives and senses how close to death someone is. She communicates with spirits both alive and dead. Even cooler—Julie’s psychic and medical intuitive skills are learned and she teaches those skills to others.

Julie talks about the “glorious” side of dying, a process that she says involves angels, multitudes of deceased family and friends, the spirits of deceased pets, and countless serendipitous (and miraculous) moments that are all part of a prescribed series of events. She calls this the “12 Phases of Transition™” and broadly outlines this in today’s episode.

SPECIAL OFFERS FOR THE HUMAN UPGRADE LISTENERS: Julie’s giving a digital or audio copy of her books to every listener who wants one. Go to https://askjulieryan.com/ask-julie/. Mention you heard Julie on this podcast and would like a copy.

• “Angelic Attendants: What Really Happens As We Transition From This Life Into The Next” or “Angel Messages For Kids” or “Angel Messages For Dogs” or “Angel Messages For Cats”

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Prenuvo sponsored this episode.

IN THIS EPISODE OF THE HUMAN UPGRADE™... you’ll find out about a new healthcare model that’s putting you fully in control of your health with whole-body MRI scans. 

Dr. Raj Attariwala, Prenuvo’s founding radiologist, joins the show to explain how Prenuvo gives you early insight into what’s going on under your skin. His Ph.D. in Biomedical Engineering and medical degree in Nuclear Medicine and Radiology informed how he created Prenuvo’s whole-body MRI device software. Here’s what Prenuvo’s scans can do:

• detect nine of the 10 top cancers in stage one 
• detect nearly 500 other medical conditions 
• look at degeneration of the spine and body composition
• look at the blood in the brain and the blood vessels in the center of the brain

Dave visited Prenuvo’s new Los Angeles facility right before the start of the 8th Annual Biohacking Conference in Beverly Hills to talk with Dr. Raj about Prenuvo’s innovative take on the MRI scan. With AI, Prenuvo’s bringing in quantitative reproducibility, which means you can start to see subtle changes throughout your body over time.

In this conversation, you’ll learn

• Why it’s so important to know your health baseline instead of waiting for symptoms to present and disease to progress. The reactive medical system in the U.S. focuses on disease management after it occurs. 
• What types of medical issues show up that may be overlooked or dismissed by your primary care doctor or other medical professionals. Existing annual checkups are relatively useless.
• How Prenuvo’s whole-body MRI scans can give you an “age score” for your physiology that you can track over time. This means you can make proactive, informed decisions about your own health.

SPECIAL OFFER FOR THE HUMAN UPGRADE LISTENERS: Get a $300 discount off Prenuvo’s Whole Body Scan ($2,199 instead of $2,499). You’ll get your scan images and radiologic analysis via your smartphone app or the web. Book online: https://prenuvo.com/DAVE or book via phone: 1-833-PRE-NUVO (1-833-773-6886); mention code “DAVE." This discount is valid through March 10, 2023, in all Prenuvo clinics throughout the U.S. and Canada.

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IN THIS EPISODE OF THE HUMAN UPGRADE™… menopause and the perimenopausal years leading up to it take the spotlight as a topic frequently requested by listeners. Great timing! It’s World Menopause Awareness Day Oct. 18 and World Menopause Awareness Month in October.

More than 1 million women in the United States experience menopause each year. Still, little is known, researched or taught in medical schools about the health effects of this natural biological occurrence.

Guys who love the women in their lives and younger women will get a lot of benefit out of the show, too, and come away armed with information. Note that some women go through menopause at ages earlier than 40 for various medical reasons and will want to keep listening.

“I want people to stop being afraid to say menopause,” says Dr. Suzanne Gilberg-Lenz. “I think there's a lot to be said for just saying the word out loud. If we can deweaponize the term and just be talking about it like we would any other life phase, then we can be there for each other and we can also learn from each other.”

Dr. Suzanne, an OBGYN board certified in integrative and holistic medicine, brings her expertise to the show to tackle this complex topic. Her “endless curiosity about the human experience” propelled her to uncover ways to ease women through menopause stages with effective tools. She looks at the science and also brings in holistic elements, including Ayurveda.  For more than two decades, she’s led women through life transitions. 

Her new book “Menopause Bootcamp: Optimize Your Health, Empower Your Self and Flourish as You Age” offers practical steps and solutions that can help women navigate the many menopausal changes they may experience. Some of what you’ll learn in this extensive conversation:

• Ways to de-pathologize menopause—which contributes to healing ageism.
• What’s actually going on with your hormones during the transition to menopause and beyond.
• Why hormone testing isn’t all that useful.
• Why Menopausal Hormone Therapy (MHT and what used to be called hormone replacement therapy, or HRT)—continues to be misunderstood and controversial.
• How to craft specific questions to better advocate for yourself with doctors.
• How to recognize symptoms that can range from moderate to severe to even debilitating.
• How to manage symptoms that disrupt the activities of daily living and long-term health.
• How physical changes can drive mental health issues during this time of your life.
• How to take control of your symptoms and find real solutions.

Dr. Suzanne’s “Menopause Bootcamp” touches on prejudice in medicine and how to break free from the societal bullshit surrounding menopause so you can get appropriate help and treatments.

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IN THIS EPISODE OF THE HUMAN UPGRADE™... kava expert and founder of TRU KAVA, Cameron George, joins the show to share new information about the many body/mind benefits you can get from kava.

TRU KAVA sets the industry standard for kava quality, safety and education. On episodes #731 and #859, we talked about kava’s historical origins and uses, how it can be safely consumed, and how it’s extracted and processed today.

You can use kava for both energy and sleep. It’s also a natural alternative to recreational alcohol and drug use. “It's like a calm, enhanced state of natural sobriety,” Cameron says.

If you struggle with social anxiety, kava’s roots in community and social connection can improve your relationships, too.

Today’s conversation further expands the kava discussion.

“Kava is a stress-relieving nootropic,” Cameron says. “It's a natural elixir that's prepared from the roots of a plant that grows in the South Pacific. Indigenous people have used it for thousands of years and prepared this food-grade drink kind of like coffee. On the stress-relieving side, on the nootropic side, they've prepared it and used it in almost every context imaginable, weddings, funerals, spiritual ceremonies, social gatherings. It helps to open up the opportunity for human connection, but it also helps to get people focused yet relaxed and calm and in a very safe space neurologically.”

Kava studies show promise for people who may be experiencing mental health issues. You’ll learn about kava’s potential to transform mental health care and its therapeutic applications for mental/trauma-related illnesses. Kava works on a psychological, emotional and physiologic level.

SPECIAL OFFER FOR THE HUMAN UPGRADE LISTENERS: http://www.trukava.com/, use code DAVE15 to get 15% off all products

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IN THIS EPISODE OF THE HUMAN UPGRADE™… you’ll learn how botanical remedies treat infectious and inflammatory diseases. You’ll get a fascinating look at how plants and microbes interact and how antibiotic resistance evolves. And you’ll meet a leader in the field of medical botany who travels to remote locations and communities around the globe seeking out modern medicines from plants. 

• Medicinal plants make up the primary form of medicine for 70–95 percent of people living in most developing countries. 
• At least 4 billion people are dependent on plants for medicine.

Ethnobotanist Cassandra Quave, Ph.D., is an herbarium curator and associate professor of dermatology and human health at Emory University. (She’s also a writer, speaker and podcast creator/host.) She teaches courses on medicinal plants, food, and health and her Quave Research Group leads anti-infective drug discovery research initiatives. 

Dr. Quave’s also the co-founder and CEO/CSO of PhytoTEK LLC. This drug-discovery company works to develop solutions from botanicals. In particular, they look at treatments of antibiotic-resistant infections like MRSA.

Her battle with MRSA is personal. She was born with congenital skeletal deformities and had her leg amputated at age 3. She nearly died from a staph infection that infection required more amputation. Her early life and disability experiences shaped her life’s work with medicinal plants.

She chronicles her extraordinary life, field work and scientific discovery in her book, “The Plant Hunter: A Scientist’s Quest for Nature’s Next Medicines.” 

Plants are incredibly complex, and science has barely scratched the surface, Cassandra says. “Some of our best drugs for infection, cancer and pain were originally found in plants,” she says in her book. “Even though they may be produced in a factory setting now, the original chemical blueprints came from plants.”

Cassandra studied pre-med in college with a double major in biology and anthropology. She couldn’t find a connection between the two fields until she journeyed to the Amazon where she studied with a local shaman/healer who relied on plants as medicine. She realized instead of going into the practice of medicine, her true path was the discovery of new medicines from nature.

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Othership sponsored this episode.

 IN THIS EPISODE OF THE HUMAN UPGRADE™…you’re listening to a new Upgrade Spotlight series. Once a month, these shorter episodes feature guests who get right into useful information in a Q&A style. You’ll find out how to improve your energy and upgrade your performance. You’ll also get the latest knowledge about powerful tools and technologies that allow you to change your biology and the environment around you. 

Introducing Othership! During this Upgrade Spotlight, you’ll find out how Othership’s breathwork app teaches you ways to manage your most prevalent stressors. Things like tension, anxiety, overwhelm, processing emotions, irritability, trouble sleeping, low energy, nervous system dysregulation or mental health issues. 

When you begin to regularly incorporate breathwork into your life, you notice and feel the emotional, mental and physical differences right away. Breathwork is a visceral, physiological shift that you can reach in under five minutes. It’s the perfect primer to bring you into a meditative state, with even more physical benefits. 

BONUS! You can experience this shift by following along with the live demo in this episode led by Othership co-founder, Robbie Bent. (Make sure you’re not driving!)

Robbie joins the show to talk about the power of adding a breathwork practice to your everyday routine. If you’ve tried meditation and it wasn’t your thing, or you struggle with consistent mindfulness, the Othership app gives you lots of options to find what fits.

You can access more than 500 guided breathwork sessions within three styles: up, down and explorer. Othership combines breathing techniques and guided meditations created by psychotherapists, wellness practitioners, hypnotherapists, artists and DJ’s, spiritual teachers and life coaches. The sessions are music-driven, science-backed and curated by expert facilitators. 

The Othership app helps you build and sustain a new mindfulness routine – all through the power of your breath. Whether you have time to practice for one minute, or 60, you’ll be able to shift your state in a session style that works best for you, such as:

• Deep breathing + breathwork
• Guided meditation
• Affirmations + visualizations 
• Sound healing
• Hypnosis
• Somatic release therapy
• Vocal toning
• Intention setting
• Self-massage + stretching
• Movement + dance
• Mind-body connection
• Mindful walking + working

SPECIAL OFFER FOR LISTENERS OF THE HUMAN UPGRADE: Visit https://www.othership.us/partnerships/dave-asprey and get a two-week FREE app trial.

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(BrainTap® sponsored this episode.)

IN THIS EPISODE OF THE HUMAN UPGRADE™… brain expert Patrick Porter, Ph.D., joins Dave at the 8th Annual Biohacking Conference in Beverly Hills to talk about training your brain. Dr. Porter pioneered the use of brainwave entrainment with a technology-enhanced meditation device called BrainTap.

Whether you’re a newbie, a hard-core devotee or somewhere in the middle of your biohacking journey, you already focus on body exercise and nutrition. You probably manage your stress and mental health, too. It’s all training of some sort, which is where BrainTap comes in. It’s a specific kind of training for your brain.

New discoveries in science reveal that you can form new neurons in your brain, called neurogenesis. Your brain state isn’t fixed! And then there’s neuroplasticity, a process of adaptive structural and functional changes to the brain that involves connections to your nervous system.

BrainTap’s unique technology uses light, sound and vibration to train and regulate your brain for relaxation, sleep, performance, weight loss, aging and more. To get to a higher personal frequency on the regular, you want to achieve coherence.

Since Dr. Porter specializes in the science of calming the brain, you’ll find out how you can manage your physiological and mental health in today’s super stressed-out world. You’ll also learn how impact remote work, remote learning and pandemic isolation impacted brain health and memory.

This conversation gets into some of BrainTap’s exciting research with aging populations and elite athletes. too.

SPECIAL OFFER FOR THE HUMAN UPGRADE LISTENERS: https://braintap.com/dave

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IN THIS EPISODE OF THE HUMAN UPGRADE™… you’ll learn how you can make smarter food choices to support your metabolic energy and upgrade your brain. You’ll also find out some new things about body fat. For example, did you know that it’s a complex organ that communicates throughout your entire body system? You’ll get tips on fat loss essentials and how to use them to your advantage. 

Today’s guest, Shawn Stevenson, hosts a popular podcast called The Model Health Show. He’s a nutritionist, researcher and bestselling author with education and experience in business, biology, and nutritional science.

Shawn’s been in the health and wellness space and doing clinical work as a nutritionist for nearly two decades. He’s known for his ability to keep learning and evolving his approach with deep research into the science of human health.

He’s all about improving human performance and energy with science-backed basics like food in his “Eat Smarter” book and sleep in his “Sleep Smarter“ book. 

This episode gets right into food choices you can make—and why they work—to stoke your metabolic energy. Topics like:

• How people can better understand the process of fat loss.
• How the misconstrued science of calories contributes to how much people struggle with their diets.
• What metabolic switches are, what do they do, and why it’s important for you to know how to turn them on and off.

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In this Episode of The Human Upgrade™...​

Cool Facts are quick hits of new human and world science curated into short bursts of information just for you. This fun compilation publishes one Friday a month.

• Saving your poop may save your microbiome

• Insults trigger a mini slap in the face

• Young cerebral spinal fluid supports memory in aging brains

• The distinct role your nose plays in your friendships

EPISODE SPONSOR: Get Fit in Five Minutes: Go to https://www.carolbike.com. Use code HumanUpgrade to get 2 years of free membership (a total savings of $360). CAROL Bike also offers a 100-day home trial of the CAROL Bike 2.0. Learn more: How to Hack Your Cardio Workout – Ulrich Dempfle– #978.

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BodyBio sponsored this podcast.

 IN THIS EPISODE OF THE HUMAN UPGRADE™… you’ll learn how butyrate and phospholipids keep your gut, cells and brain performing at their best. You’ll find out how your mucosal barrier defends against pathogens in your gut microbiome. You’ll also learn about discoveries in the field of cell membrane medicine. This focus determines how your body functions now and also how you age.

Jessica Kane Berman joins the show to share new information and interesting science about cellular health from the perspective of BodyBio, the company founded by her grandfather, Ed Kane, an inventor, health explorer and early biohacker. He went looking for answers to his own health issues in the 1980s and got deep into the science of fatty acid research and cell membrane medicine through blood testing.

BodyBio sticks to a very specific group of products, most notably butyrate and a phospholipid complex of phosphatidylcholine. Jess explains how true liposomal phosphatidylcholine and phospholipids get through to the cells to help rebuild that membrane. 

Here’s a few good things butyrate does in your gut:

• Helps maintain the thickness of the mucosal barrier—keeps the good in and the bad out
• Helps the expression of tight junctions and strengthens the gut wall
• Expresses MUC2: this produces mucus, which thickens your mucous lining
• Regulates T-Cells and helps lower cytokine release
• Increases microbiome diversity
• Anti-inflammatory properties help improve intestinal barrier function and mucosal immunity

Butyrate goes way beyond the gut to influence bone mass and density, asthma and allergies, histamine intolerance, body detoxification, inflammatory brain pathways, and mitochondrial function. Butyrate also can alter gene expression, protect against cancer, and regulate the body’s immune system.

SPECIAL OFFER FOR THE HUMAN UPGRADE LISTENERS: https://bodybio.com/dave, use code DAVE25 to get 25% off

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In this Episode of The Human Upgrade™...​ Dave talks about what could be causing brain fog with a podcast guest in this impromptu intervention. Keri Glassman, MS, RD, CDN, recently spoke about gut health as the expert for Omni-Biotic probiotics. During the interview, she was searching for a word and got frustrated she couldn’t grasp it quickly. This intervention looks at the potential culprits responsible for Keri’s brain fog and memory hiccups: 

• Thyroid
• Hormones, such as testosterone and DHEA
• Perimenopause
• Mast cell-mediated inflammation
• Cortisol & stress
• ADHD
• Mold toxins
• Mercury & lead

Keri is a registered dietitian, certified nutritionist, healthy cooking expert and author of four books. She also founded Nutritious Life, a lifestyle and media company and Nutritious Life Studio, an online education platform focused on nutrition, coaching, and business.

Find tips and resources on the episode webpage.

Note: The "Interventions With Dave” recommendations are designed to help you upgrade yourself and your biology so you can perform better at everything you do. They are not, however, a substitute for advice or treatment by a trained medical professional that may be needed for specific health conditions, illness or injury.

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IN THIS EPISODE OF THE HUMAN UPGRADE™…a legacy upgrade conversation with Dr. Joe Dispenza explores how you can change from the inside out through a combination of neuroscience, epigenetics, quantum physics—and even a divine source. “I teach people the science of changing their mind and what it is to truly transform,” he says.

He shows people how to rewire their brains and recondition their bodies to make lasting changes by way of science, energy and mysticism. His background and expertise include training in neuroscience, neurology, cellular biology, brain function and chemistry, memory formation, and aging and longevity.

From healing illness to evolving consciousness, Dr. Dispenza examines how to connect with the divine and bridges the mystical with science. “It's really important to have science demystify that process,” he says. Why? Because science is a contemporary language that offers you explanations, helps you understand the how and why, and assigns clear meaning. 

“Here's what I know,” Dr. Dispenza says. “We have evidence that you can make your brain work better. As you can prove also, we have evidence that you can make your heart work better. We have evidence, you can strengthen your immune system. We have evidence, you can change your gene expression in four days. We have evidence, you can lengthen your life from meditation, just by lengthening your telomeres and changing your state. We have evidence in the scientific world that people actually can transform.”

Listen on to learn about the power of inner work, elevated emotions and human connection.

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IN THIS EPISODE OF THE HUMAN UPGRADE™… you’ll learn about a “6 Phase Meditation” approach that absolutely everyone can do—and benefit from!—no exceptions. This custom-designed meditation sequence gets you into a peak state in just a few minutes. No boredom, special breathing, or clearing your mind required. You’ll find out how to make meditation work for you and how you can use intuition as one of your greatest strengths.

Episode guest Vishen Lakhiani took up meditation at age 26 as a way to cope with the stress of working for a startup in Silicon Valley. That decision changed his life so dramatically that within two years he quit to pursue meditation, other tools of personal development, and then spread awareness and education to people around the world. He’s taught his signature 6-phase meditation style to world-class athletes, professional entertainers and high-performers in all types of business. He also founded Mindvalley, an international learning platform.

Vishen’s newest book, “THE 6 PHASE MEDITATION METHOD: The Proven Technique to Supercharge Your Mind, Manifest Your Goals and Make Magic in Minutes a Day,” outlines a series of science-backed mental exercises for accomplishing your goals. It condenses the wisdom of nearly 1,000 neuroscientists, monks, yogis, and meditation experts into a hyper-efficient programming script that you can run through your mind any time of day.

Unlike traditional meditation that encourages a calm and serene environment, the 6 Phase Meditation Method can be done from anywhere—your bed, your office or even on your next flight. “It's six different practices that you layer on that put you in a hyper-optimized state,” Vishen says. 

You’ll get a lot out of this fascinating conversation that gets into realms of spirituality, psilocybin, perceptual diversity, physics, brain waves, and altered states. 

SPECIAL OFFER FOR THE HUMAN UPGRADE LISTENERS: Mindvalley.com/books/6phase

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CAROL Bike sponsored this podcast. 

IN THIS EPISODE OF THE HUMAN UPGRADE™ … you’ll learn about new research that’s pinpointing the most effective cardio workouts. You’ll find out that you can do a cardio workout in just 15 minutes a week and still increase your cardiovascular fitness. You’ll also get an introduction to the new CAROL Bike 2.0 and its upgraded great features.

Ulrich Dempfle, MBA, Chief Product Officer, CEO and co-founder of CAROL Bike, returns to the podcast with exciting new research results. CAROL’s REHIT (Reduced Exertion HIIT) workout retained all its effectiveness yet cut its time nearly in half—from 8 minutes and 40 seconds to five minutes.

CAROL Bike continues to innovate fitness and prove that more or longer sprints aren’t better. “What matters is that you sprint at your personalized maximum intensity, switching from zero to max in a fraction of a second,” Ulrich explains.  An investment of only 5 minutes, 3 times a week means you can reap powerful cardiovascular benefits, even gain strength, and get on with your other biohacks.

SPECIAL OFFER FOR THE HUMAN UPGRADE LISTENERS: Go to https://www.carolbike.com. Use code HumanUpgrade to get 2 years of free membership (a total savings of $360). CAROL Bike also offers a 100-day home trial of the CAROL Bike 2.0.

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Customized Nootropics for Your Own Neurochemistry: https://nootopia.com/dave, use code DAVE10 to get 10% off. Learn more on The Human Upgrade podcast: Hack Your Neurochemistry with Customized Nootropics – Mr. Noots & Matt Gallant – #861

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IN THIS EPISODE OF THE HUMAN UPGRADE™ … you’ll learn to define what’s really “normal” when it comes to your health. You’ll explore how today’s culture stresses the body, burdens the immune system, and undermines emotional balance. And why Western medicine often fails to treat the whole person.

This conversation covers an investigation into the causes of illness, a critique of how our society breeds disease, and offers a pathway to health and healing. One of the surprising things you’ll learn has to do with authenticity.

“The loss of authenticity is one of the major impacts of trauma,” says renowned Canadian speaker and bestselling author, Dr. Gabor Maté. “It's also a major cause of physical and mental illness.”

Dr. Maté is highly sought after for his expertise on topics like addiction, stress, trauma, and childhood development. He spent two decades in family practice and palliative care. He also worked for over a decade in Vancouver’s Downtown East Side (Canada) with patients challenged by drug addiction and mental illness.

In his newest book, “The Myth of Normal: Trauma, Illness, & Healing in a Toxic Culture,” he pushes back on the prevailing understanding of “normal” because it neglects the roles that trauma and stress—and the pressures of modern-day living—exert on our bodies and our minds at the expense of good health. 

“If you're suffering, don't accept it as normal, but ask what's going on here?” Dr. Maté says. “Let the suffering instruct you that there's something going on; that what you think is normal is actually not healthy or natural for you.”

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IN THIS EPISODE OF THE HUMAN UPGRADE™... you’ll learn that while yes, testosterone fuels energy and performance, it’s not the be-all and end-all solution for men’s health woes. A systems biology approach considers many other aspects and provides a broader perspective about what’s going on with you.

This conversation features board-certified urologist Tracy Gapin, M.D., one of the 8th Annual Biohacking Conference keynote speakers. He’ll be on the main stage in Beverly Hills in September. He joins this special preview episode to discuss new ways for men to improve their health and performance. He uses epigenetic coaching, hormones, peptide therapy, biometric monitoring, and unique nutrition and lifestyle interventions.

“Testosterone levels over the last 30 years are down by about 30 percent,” Dr. Tracy says. “Free testosterone, which is the bioavailable, active hormone testosterone is actually down over 45%. This is really important. We're not just talking about sex and muscle, we're talking about a man's life and cardiovascular health and cognitive function. The culprit can be debated, but without question, one of the biggest ones in my mind is endocrine disruptors. Toxins, chemicals in our environment that are clearly crushing men's health, clearly crushing testosterone. It's the food we eat, it's the water we drink, it's the personal care products. It's ubiquitous, it's almost everywhere and it's getting worse.”

In his book, “Male 2.0™: Cracking the Code to Limitless Health and Vitality,” he says medical school, residency training and even a two-decade career in urology and surgery specialties didn’t teach him how to get to root causes of men’s issues and solve them. He had a health crash of his own at 42. Since neither he nor his doctor had good answers, he went on a quest of discovery and change. 

He founded the Gapin Institute for High Performance Medicine and created the proprietary N1 Performance Health Program to go beyond conventional options.

This conversation goes even further into what creates epigenetic signals that affect the function and expression of your genes. You’ll learn, too, that your mindset, stress and environment—and how you do or don’t control those things—have everything to do with your energy and focus. If you’re aiming for higher performance, Dr. Tracy suggests a trifecta that makes sleep a priority, builds resilience to stress, and creates consistent behaviors with intention.

More about Dr. Tracy Gapin: He’s a member of the American Academy of Anti-Aging, the Age Management Medical Group, and the International Peptide Society. He spent almost 20 years at a urology practice in Sarasota, Fla., where he specialized in robotic surgery, minimally invasive treatment for prostate cancer, and men’s health.

SPECIAL OFFER FOR THE HUMAN UPGRADE LISTENERS:  TEXT “HEALTH” to 2 6 7 8 6 to get three bonus gifts.

***

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IN THIS EPISODE OF THE HUMAN UPGRADE™... you’ll learn about female hormones: what they are, what they do and what disrupts them. You’ll learn about the hormonal shifts that happen at different ages and life stages and get tips on how to balance hormones and make them work for you, not against you.

This conversation features Anna Cabeca, D.O., one of the 8th Annual Biohacking Conference keynote speakers. She’ll be on the main stage in Beverly Hills in September. Dr. Anna is a Doctor of Osteopathy who’s triple-board certified in gynecology and obstetrics, integrative medicine, and anti-aging and regenerative medicine. She has additional certifications in functional medicine, sexual health, and bioidentical hormone replacement therapy. 

She joins this special preview episode to talk about female hormones. It’s her particular area of expertise and one of The Human Upgrade’s all-time Top 10 podcast topics. Today’s hormone discussion includes:

• How hormone disruptors go beyond stress to mold, and product and environmental toxins
• How estrogen levels change over time
• What’s going on with progesterone, pregnenolone and DHEA, too
• What happens to hormones during perimenopause and menopause
• What’s causing brain fog
• What to know about bioidentical hormones
• How detoxing affects hormones
• How to keep your vaginal microbiome balanced
• How “food as medicine” helps balance hormones
• How hormones influence longevity
• And much more!

For the past 20 years, Dr. Anna's educated and helped women with their hormones through her private practice, books, online videos and articles. Learn more about her work with women’s hormone health:

• “MenuPause: Five Unique Eating Plans to Break Through Your Weight Loss Plateau and Improve Mood, Sleep, and Hot Flashes”
• “The Hormone Fix: Burn Fat Naturally, Boost Energy, and Stop Hot Flashes the Keto-Green™️ Way”
• “Keto-Green™️ 16”

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IN THIS EPISODE OF THE HUMAN UPGRADE™...

…you’re listening to a new Upgrade Spotlight episode with Omni-Biotic. You're going to find out how probiotics can do more than keep your gut microbiome in order—specific strains can help you manage your stress and regulate your body’s detox system. 

The beneficial bacteria in your gut support essential processes in the body, such as digestion and absorption, immune function, detoxification, and brain function. But did you know that 80% of the immune system lives in the gut and 95% of serotonin is produced in the gut? That’s a lot for the gut to do! 

Keri Glassman, MS, RD, CDN, joins the show to talk about one of her favorite topics—the gut-brain axis. Keri’s a registered dietitian, certified nutritionist, healthy cooking expert and author of four books. She also founded Nutritious Life, a lifestyle and media company and Nutritious Life Studio, an online education platform focused on nutrition, coaching, and business. 

In this conversation, you’ll learn how Omni-Biotic’s unique delivery mechanism and multi-species, multi-strain formulations work together to upgrade your gut AND your brain. 

The gut-brain access goes two ways, Keri explains. “Your brain is affecting your gut. Your gut is affecting your brain—and from everything. That's why it's so incredibly important to maintain that healthy microbiome and to have a healthy balance of good [bacteria].”

To target the gut-brain axis, Omni-Biotic developed special formulations called psychobiotics: one for detox, the other for stress. Then they put them to the test in clinical studies.

• Hetox contains eight beneficial bacterial strains. Clinical studies show improvements in liver function, cardiometabolic markers and inflammation markers related to liver health. 
• Clinical studies show that Stress Release supports digestion and the gut flora during times of stress, reduces intestinal inflammation, increases emotional balance, cognition, and mood. 

More to Know About Omni-Biotic Probiotics:

Omni-Biotic also tests its probiotics in an artificial GI simulator against other top probiotic brands in the U.S. market. It ensures that 83% of its probiotics arrive alive and active in the intestines. In comparison, the probiotic survival rate of other brands averages 7%. 

The bacterial strains in Omni-Biotic are freeze-dried to make them more shelf-stable and the powder contains specific prebiotic nutrients. These prebiotic nutrients serve as the food source for the probiotic bacteria. 

SPECIAL OFFER FOR LISTENERS OF THE HUMAN UPGRADE: Visit https://www.omnibioticlife.com and use code Dave20 to get 20% off

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IN THIS EPISODE OF THE HUMAN UPGRADE™...

… you’ll learn how to recognize your own sh*t and be a better partner in relationships. 

Want a sustainable partnership? Communicate and apologize; fight without fighting; identify codependent behavior (your own); and manage jealousy (also your own). 

This conversation gets into how you can let go of unrealistic ideals of how you think love and relationships should be and live fully in the present. You’ll also get tips on how to be emotionally responsible to people you love every day.

Guest John Kim, a licensed marriage and family therapist, as well as a life coach, cracks his life into two big pieces… split on either side of what he calls “the great divide” of his own divorce several years ago. He did the whole “get a tattoo and a Harley” thing to find his way.

He also combined what he learned in therapy school with life coaching and technology to be mobile and create online communities. He became known as an unconventional therapist, seeing clients at coffee shops, on hikes, or in a CrossFit box. He’s built a devoted following of fans who love the frank and authentic insights that he—as “The Angry Therapist”—freely shares on social media. TikTok’s his jam, with over 450K people tuning in for his “shot glass” bits of life wisdom.

In his newest book, written with his romantic partner and fellow therapist Vanessa Bennett,  John takes a different (honest, humorous, raw) approach by dissecting his own relationship dynamic to bring clarity to yours. Each part of “IT’S NOT ME, IT’S YOU: Break the Blame Cycle, Relationship Better” gives you questions to ask yourself and practices to do. It’s a book that pushes you into doing and putting your newfound knowledge to IRL use. 

Here’s a sneak peek at a few of the Love Lessons (In a Shot Glass) you’ll find in “It’s Not Me, It’s You.”

• Love is not a battlefield. Your head is. 
• If someone is unsure about you, it’s never worth the investment.
• Hold love, don’t grab it.
• Don’t stop believing (be Journey).
• Love is what teaches us how to live.

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In this Episode of The Human Upgrade™...​

… Dave tackles multiple issues with former Upgrade Collective member Nancy Pellegrino so she can better manage psoriasis, gut health and anxiety.

Nancy’s been biohacking for a few years but can’t seem to land on the right combination. She does the hacks, uses the gadgets and tech, and takes the products and supplements. Instead of feeling better, she’s feeling overwhelmed with information. She talks with Dave to sort it out, focusing on skin and gut health.

Now in her mid-50s, Nancy’s post-menopausal and does bio-identical hormone replacement therapy. She experienced—and beat!—colorectal cancer in 2017. She routinely uses her Sunlighten sauna, an ozone machine and a ChiliSleep cooling mattress pad.

Her busy life as a teacher and mom to three daughters makes it hard for her to meditate and relax. She’s looking to ease some body distress, focus on solutions and find benefit in biohacks that work for her particular symptoms.

• She hasn’t found a resolution to chronic psoriasis.
• Despite following the Bulletproof Diet, drinking Bulletproof Coffee and regularly intermittent fasting, she continues to have unexplained digestive issues. 
• She wakes up in the night with feelings of anxiety.

Note: The "Interventions With Dave” recommendations are designed to help you upgrade yourself and your biology so you can perform better at everything you do. They are not, however, a substitute for advice or treatment by a trained medical professional that may be needed for specific health conditions, illness or injury.

• Hacking Deep Sleep #957
• Hacking Mast Cells, Hormones & Mold #949
• Hacking Your Biohacks for Better Sleep, Fitness & Weight Control #939
• Hacking Weight Loss Resistance #930
• Hacking Thyroid, Autoimmunity & Aging #918
• Hacking Inflammation #915
• Hacking Your Gut Microbiome #908
• Hacking Menopausal Weight Gain #904
• Hacking Eyesight #895

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In this Episode of The Human Upgrade™...​

Cool Facts are quick hits of new human and world science curated into short bursts of information just for you. This fun compilation publishes one Friday a month.

• Gut bacteria convert vitamin A to retinoic acid

• Low-carb diets contribute to depression 

• Lifestyle affects cognitive health more than age 

• More bad news about America’s obesity epidemic 

EPISODE SPONSOR: Sleep Better on Natural Memory Foam: https://myessentia.com, use code DAVEVIP to get an exclusive discount. Learn more: Mattress Smarts 101 for High-Performance Sleep – Jack Dell’Accio – #875.

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Dave Asprey partners with Nillion as an advisor and investor.

IN THIS EPISODE OF THE HUMAN UPGRADE™...

… you’ll learn about the frontier of web3 and privacy and what happens to your private data (both on blockchains and in general). You’ll also find out how and why the future moves away from transactions (blockchain) and into computations (multi-party computation). 

Think about where you store your identity and your deepest digital secrets. The current solutions aren’t great — in web2, the Big Tech 'old guard' has been quietly storing and monetizing your data for over a decade, and in web3, blockchains aren't designed to handle private data. A new algorithm, Nillion, inspired Conrad Whelan (the Founding Engineer of Uber) to come out of early retirement and do something about this. 

This conversation looks at the data you unassumingly give away freely, and how it’s captured, held and used/computed on without your consent by large companies and other parties. Conrad believes in a future where your sensitive data and digital secrets can be fully controlled by you (and you alone) using web3 technology. This means you’d be the final gatekeeper of your data with the power to authenticate, authorize and use it as you see fit.

Conrad’s building that future as Nillion’s Founding Chief Technology Officer. His background includes electrical and computer engineering. He worked in the fields of computational electromagnetics before joining Uber as Founding Engineer. He’s developed, tested, deployed and architected software projects at all levels of the software stack as both an engineer and an engineering manager.

In 2016, he retired to focus his efforts on philanthropy and personal passion projects while keeping an eye on the tech world. The promise and potential global impact of Nillion enticed him out of retirement and into the company’s CTO role. What Conrad is building at Nillion aims to:

• render both computational encryption and centralized storage of private data obsolete;
• fundamentally change the way private data is stored and processed;
• offer alternative non-blockchain ways of using decentralized nodes;
• serve as a ‘Meta Layer’ that provides new and additional functionality to existing blockchains; and
• enable a host of new real-world applications on its native public network (the Nillion Network).

Whatever your level of tech understanding, this discussion offers critical insights about the next big move in decentralized computing and data privacy.

Find more info in the show notes on this episode's webpage: https://daveasprey.com/conrad-whelan-971/

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IN THIS EPISODE OF THE HUMAN UPGRADE™...

… you’ll learn why regenerative methods for taking care of soil and raising animals provide a solution that creates food sovereignty, improves human health, and helps reverse climate change. 

Previous episodes of this podcast featured regenerative farming and soil conservation topics. Dave Asprey keeps the conversation going because when you know what’s happening and what companies are doing about this problem, you can be informed and take action to support regeneration efforts in your own way.

Robby Sansom, co-founder and CEO of Force of Nature, joins the show to talk about the new developments igniting real change. 

His roots run deep in the natural food community, caring for soil and caring for animals. He spent much of the last decade studying regenerative agriculture at ranches all over the world. Through this education, he helped found the Austin, Texas-based regeneratively sourced meat company, Force of Nature. The company’s building brand new global supply chains of grass-fed and regeneratively managed livestock. Force of Nature works in partnership with land stewards, ranchers and farmers committed to creating a positive return on the planet. 

There’s an undeniable sense of urgency about the state of soil and its ability to provide enough food for a growing population. Over more than a hundred years of conventional farming and ranching depleted land and disrupted natural ecosystems. These harms (have and continue to) adversely affect animal and human health. Force of Nature focuses on repair and regeneration—in their own operations and by educating farmers and ranchers from homesteaders to big corporations.

In spring 2022, Force of Nature hosted a What Good Shall I Do? event about learning and leading with regenerative intent. This educational forum hosted several dozen speakers from soil scientists to leaders in the regenerative movement to individual farmers and ranchers. By providing information, resources and tools, conventional farmers and ranchers can make the switch to regenerative methods. And farmers and ranchers who already use regenerative methods can improve and have even more impact.

You can get involved, too! In this episode, Robby talks about the true cost of meat and gives tips on what to look for in your own local grocery and how you can support regenerative agriculture and ranching in a way that aligns with your own values. Every small step toward change contributes to a larger movement.

SPECIAL OFFER FOR THE HUMAN UPGRADE LISTENERS: Visit https://forceofnature.com and use code dave10 to get 10% off your first order.

DON’T MISS THIS! Force of Nature will be providing meat at select 8th Annual Biohacking Conference events coming up in September. Get your ticket.

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Uprising Food sponsored this podcast. Dave Asprey partners with Uprising Food as an advisor and investor.

IN THIS EPISODE OF THE HUMAN UPGRADE™...

… you’ll learn about bread that’s better for your body—and the important role of prebiotics and fiber in that equation. You’ll also find out about the science that supports new ways of creating bread products—what works and why it works. And you’ll get a look further into the food system and how to adopt solutions with real benefits for your energy and lifestyle.

A 5+ year biohacker, intermittent faster, and cyclical keto devotee joins the show to talk about innovations in bread as you know it. William Schumacher, co-founder and CEO of Uprising Food—aka—”The Loafer and Chief”— traded in corporate life as a former Procter and Gamble marketer to sift through the disinformation to de-villainize bread and create products that taste good and work in synergy with your body.

With all the gluten-free and alternative breads out there competing for attention, what made Uprising stand out to Dave Asprey? Simple. Uprising took action to:

• tackle the foundational things that give people disproportionate bang for their buck when they eat the products day in day out. 
• figure out what’s NOT in the product. Most products are loaded with things that are doing damage and there’s a big-time cost. 
• eliminate gluten and other inflammatory ingredients.
• choose ingredients that would produce a tasty, functional product and work in the gut to enable inside out transformation.
• partner with artisanal bakers willing to experiment with baking methods and ingredients. The star ingredient? Psyllium. In this conversation, you’ll get all the details on prebiotic fiber and the benefits of activated psyllium, a bio-active polysaccharide.

Research done at Wright State University Microbiome Labcompared Uprising Food bread with traditional bread. Early results show that Uprising’s prebiotic bread makes nice with gut microbiota.

Curious about bread again? Check out the Uprising Food “Toast Cleanse,” affectionately known as “72 hours to digestive deliverance.” This 3-day protocol includes super toast combinations and levels of bread eating designed to overhaul your microbiome. 

SPECIAL OFFER FOR THE HUMAN UPGRADE LISTENERS: www.uprisingfood.com/DAVE, use code DAVE to get $10 off the starter bundle

Excited about bread that’s better for you? Learn how you can invest in Uprising Food here. 

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IN THIS EPISODE OF THE HUMAN UPGRADE™... 

… you’ll learn about shamanism, “spiritual minimalism” and how traditional healing arts connect so profoundly to the natural world. This conversation also explores distinct themes of consciousness, the soul, and deep respect for plant medicine and Ayahuasca ceremony. 

The guest, Shaman Jorge Hachumak, is a Peruvian of Spanish descent who’s made a winding journey into shamanism as a healer. After receiving a European education, he became a practitioner of Chinese Qigong in old Lima’s (Peru) China Town. After a successful career in tai chi competition, he worked with elderly patients in hospitals in Northern Peru. 

During this time, he was taken under the wing of native shamans, witches and herbalists who spent years teaching him the ancient healings. He learned ancient Peruvian medicine arts (not from the Incas, but from the North Coast and the Northern jungle of the Amazon).

He now moves seamlessly between perspectives, having one foot firmly in the rational, scientific world and another in the spirit world.

“The ancient healing arts are deep and expansive—you never stop learning, and what you learn in a lifetime will always be a small fraction of what is available to learn,” he says in his new book, “Journeying Through the Invisible: The Craft of Healing With, and Beyond, Sacred Plants, as Told by a Peruvian Medicine Man.” “I want to offer a larger picture of the Medicine Craft and to create appreciation for other important aspects that are endangered or still not well-known.”

This larger picture includes influences from science, history, religion and the natural environment.

Shaman Hachumak looks at consciousness as two states that lead to both deep understanding of the healing arts and deep self-reflection:

• Suffering Consciousness keeps us stuck in our negative ways
• Soul Consciousness is awakened during a ceremony or spiritual moment. Your entire being awakens, and you are shown the way to live according to the dictates of your conscience and the teachings of the spirits.

He also uses his knowledge and experience to broaden people’s understanding of Ayahuasca as a powerful plant medicine. He works to protect Ayahuasca and the traditional ceremony from misuse and exploitation. 

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IN THIS EPISODE OF THE HUMAN UPGRADE™...

… you’ll find out about the relevance of shamanism in a modern world and why high performers are turning toward shamanic practices to get ahead.

The show’s guest, Manvir Singh, Ph.D., is an anthropologist at the Institute for Advanced Study in Toulouse, France. He studies universal or near-universal cultural practices, including music, shamanism, and witchcraft. For the past seven years, he’s conducted ethnographic fieldwork in Indonesia.

He recently wrote an article in WIRED magazine titled, “The Shamanification of the Tech CEO,” noting some curious parallels.

• “Silicon Valley austerity continues to grow more extreme. By 2020 intermittent fasting was no longer enough, and dopamine fasting—an abstention not just from food but from any form of stimulation, including music, eye contact, and playing Magic: The Gathering—had taken off. These self-denial fads are often touted as biohacking innovations. Yet as an anthropologist who has studied austerity in some of the most remote regions of the world, I see them as part of a larger pattern: the self-shamanification of tech CEOs.”

• “Analyzing an old dataset of 43 nonindustrial societies, I found that shamans in 81 percent of the societies observed prohibitions on food, sex, or social contact. Given that these data were collated from reports by travelers and anthropologists, they are probably an underestimate. Silicon Valley deprivation, it turns out, is less a strange, new development and more the most recent manifestation of a ubiquitous shamanic practice.”

This conversation gets into:

• shamanism in general
• the cultural significance of shamans
• how shamanic practices have made their way into modern culture
• why humans think they need shamans—or similar “magic” or “other” beings 

More about Manvir Singh, Ph.D.:  Manvir earned a Ph.D. in Human Evolutionary Biology at Harvard University and a Sc.B. with Honors in Human Biology: Evolution, Environment, & Ecosystems at Brown University. He’s received multiple awards, honors, grants and fellowships—from Fulbright Scholarship to visiting scholar and research fellow. He’s written more than a dozen peer-reviewed journal articles and more than a dozen articles for general audiences. He gives talks domestically and internationally on the topic of shamans.

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IN THIS EPISODE OF THE HUMAN UPGRADE™...

… you’ll find out how your imagined future directs your behavior right now, rather than your past. You’ll learn how to manage threats to your future self, recognize truths about your future self, and how to take steps to be your future self. You’ll also gain strategies you can start using today for creating and becoming exactly who you want to be in the present moment.

Benjamin Hardy, Ph.D., is an organizational psychologist and author of multiple books on how to improve your mindset. He joins the show to explain how you can borrow from your future and actually be that person right now. 

In his newest book, “Be Your Future Self Now: The Science of Intentional Transformation,” he says, “Research now shows that a person’s past does not drive or dictate their actions and behaviors. Rather, we are pulled forward by our future.” 

There’s no looking back, only moving ahead. Most people, out of fear, limit their view of the future to a narrow range. Take a dangerous leap to think more broadly. Take cues from your brain.

“With neuroscience, the brain is essentially considered a prediction machine,” Ben says. “So, what the brain is always doing is predicting what's going to happen, and learning is essentially just updating its sense of predictions. The brain is always anticipating the future.”

Since you’re already thinking about the future, put those thoughts to use in the here and now with 21 actions  (7 threats to, 7 truths about, and 7 steps for being your future self) designed to transform yourself. For example:

• Offset a THREAT: Urgent battles and small goals keep you stuck. To exit the rat race of day-to-day mindset requires a shift in your focus. 
• Face a TRUTH: Failing as your future self is better than succeeding as your current self. The more willing you are to invest in momentary loss and pain directed at a goal, the faster you’ll adapt to the level of your future self. 
• Take a STEP: Schedule your future self. Put the important before the urgent. Once you commit to your Future Self, you’ll be required to be courageous. Choosing freedom over security is an act of courage.

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IN THIS EPISODE OF THE HUMAN UPGRADE™...

…a legacy upgrade conversation with Byron Katie will have you digging deep into the work of fine-tuning your mindset. Her keystone practice, The Work, allows you to access the wisdom you already hold inside you. She explains it as a process to “clear the mind.”

You’ll ask yourself four questions and apply them to a specific problem you’re facing. Going through these steps gives you perspective and a new way of thinking about what’s causing you distress. Questioning diminishes the power your thoughts have over you. And THAT leads to true freedom.

Her work contains elements of therapist, a counselor or a religious leader, though she’s technically not any one of these. She’s been described as a spiritual mentor. As the bestselling author of “Loving What Is: Four Questions That Can Change Your Life," followed by "A Mind at Home with Itself: How Asking Four Questions Can Free Your Mind, Open Your Heart, and Turn Your World Around," her inspirational guidance offers people a different way to think their thoughts so they can change their mindsets and, ultimately, their lives.

Her own story of early life success that spiraled into depression, rage, addiction, and self-loathing, sets the foundation for The Work. “The thoughts like, “I’m not good enough. There's something wrong with me," which was true,” Byron explains. “It was my thinking. My thoughts were aimed out at other people. It was their fault. Then when I would say or do something, I would experience the guilt, so I had this vicious circle going of judgment, guilt, judgment, guilt. It was debilitating.”

She had to save herself.  Several weeks into treatment, she woke up one morning to a state of constant joy that has never left her and four questions clearly in her mind that would lead her out of her own darkness. 

She’s never been able to truly explain this epiphany, nor has she evangelized it. She realized that when she believed her stressful thoughts, she suffered, but that when she questioned them, she didn't suffer, and that this is true for every human being. She simply shares The Work with people who want to make profound life changes—and has continued this path for nearly 40 years.

“I have a lot of people across the globe that are saying their lives are shifting so dramatically they're unrecognizable, but I don't call it The Work for nothing,” she says. “It does take stillness. It takes silence, and it takes being courageous enough to look at the thoughts in your head without trying to change them and accept them the way they are.”

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IN THIS EPISODE OF THE HUMAN UPGRADE™...

... you’re going to find out how to cook differently using an innovative kitchen appliance, Brava, that’s got some cool features that will get you excited about making your meals at home—always a good idea!

First—what Brava is not. The Brava countertop cooking oven isn’t a microwave, isn’t a toaster oven, and isn’t a convection oven.

Instead, it’s a device that cooks with light. Six lamps deliver exact, variable, infrared light waves to your food. Brava synchronizes and controls the amount of power each lamp emits. Simultaneously, the lamps instantly reach full power and turn off just as quickly, creating three independent cooking zones inside the chamber. 

The top five benefits of this cooking method include: Searing (great for your grass-fed steaks), precision, versatility, speed and quality. Brava also cooks up to three different ingredients at the same time. You can air fry, dehydrate and cook your favorite white rice in it (Bulletproof Diet approved). It’s user- and kid-friendly, so your whole family can be part of a lifestyle that prioritizes food that nourishes your body and ups your energy.

Brava’s vice president and professional chef, Travis Rea, led the Brava Culinary Team in developing Brava's patented Pure Light Technology (physicists and mathematicians were in on it, too). He’s on the show to explain the technology behind Brava and how cooking with light will change your entire approach to food.

Travis earned a degree in Culinary Arts at the California Culinary Academy. Prior to Brava, he headed the Food Development team at Williams-Sonoma for eight years where he developed nearly 800 private label food products. His experience also includes leadership roles at Revolution Foods and NatureBox. So, he knows the many facets of creating great food.

Brava takes out the guesswork of meal planning by offering over 7,000 fully automated recipe programs. This means you can enjoy cooking more because it takes less of your time.

SPECIAL OFFER FOR LISTENERS OF THE HUMAN UPGRADE: https://www.brava.com, use code DAVE at checkout to get $200 OFF any Brava set through December 31, 2022. 

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IN THIS EPISODE OF THE HUMAN UPGRADE™...

… you’ll learn how whole body vibration works and the many ways it benefits your physiology. It’s the nexus between energy and life, says Tony Molina, a performance optimization expert.

“This biohack helps you burn more calories,” he says. “It helps you increase strength and reaction time. You can improve skin and circulation, bone density, pain relief, hormonal changes, posture and balance. It's also a lifelong health and longevity partner.” 

He’s talking about the Power Plate. He’s a high-altitude and longevity researcher and Senior Research and Development Specialist at the company.

“Whole body vibration runs off Isaac Newton's second law, so force equals mass times acceleration,” he explains. “Where acceleration is what’s being increased versus mass. And generally, we focus on the mass, whether we do any kind of strength training, we focus on holding mass or dealing with the mass or changing the mass. With whole body vibration and Power Plate, you’re focusing on the acceleration or the speed change.”

Other cool things about whole body vibration:

• You're changing the formula from conscious effort (like conventional exercise) to subconscious (harmonic vibration).
• You’re experiencing multiplanar movement that creates an unstable environment that’s proprioceptively challenging. (The nervous system doesn't know what to do, which is a good thing.)
• Your neuromuscular spindle gets stimulated without the need for the brain even to get involved. (Cognitive confidence!) 
• Your nervous system itself is ramping up safety signals so the brain understands what it needs to do without you consciously having to do anything.
• Your reflexes improve; your reaction time gets better; your ability to propriocept allows your posture to improve; and you breathe better.

Listen on to find out more about whole-body vibration training, therapy, and how it can make you live longer, whatever your fitness level or ability.

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IN THIS EPISODE OF THE HUMAN UPGRADE™...

…you’ll learn about the critical role metabolism plays in your body’s energy and performance. Important new science findings about human metabolic health shows how you can change your metabolism. To help you make these changes, this episode gives you practical tips and tools for measuring your metabolism and ways to manage it effectively.

Guest Michal Mor, Ph.D., co-founded Lumen with her twin sister, Merav Mor, Ph.D., and three long-time entrepreneur friends nearly a decade ago. As Chief of Metabolic Health & Science, Michal’s background includes degree studies in Medical Laboratory Sciences and Physiology with an emphasis on cardiac arrhythmia. 

The Lumen founders set out to close the gap of what existed in the science and something people could actually use to manage their metabolic health.

Both Michal and her twin, Merav, were multiple-year Ironman participants. Athletic performance—and how to improve it—influenced their work with metabolism. Four years of research and development plus more years of validation studies and beta test users went into developing Lumen.  

Lumen is a hand-held device that accurately measures your metabolism through the breath. It uses a CO2 sensor and flow meter to measure the CO2 concentration in your breath, indicating if your body is in carb or fat burn.

“So, this ability to shift between them, it's not only good for athletic performance it's also improving our quality of life,” Michal says. “It enables us to enjoy life to our fullest potential. It's about longevity. It's about being able to achieve our goals, not having those mood swings. This is so much more than improving athletic performance.”

Lumen has accumulated a metabolic measurement database with over 20m measurements. These insights have shown how lifestyle habits affect metabolism and the body more than previously thought possible. Listen on to learn how with just one breath in the morning, you can set your metabolism course for the day and then monitor it throughout the day.

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In this Episode of The Human Upgrade™...​

Cool Facts are quick hits of new human and world science curated into short bursts of information just for you. This fun compilation publishes one Friday a month.

• Tattoos can help monitor your blood pressure 
• Device that protects against head injuries 
• Upgrading your avocado toast
• Ways to manage the harmful aging-inflammation duo 
• Pee recycling does the soil good

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IN THIS EPISODE OF THE HUMAN UPGRADE™...

 … you’ll find out why aging and stress are the major contributors to neurodegenerative diseases in your lifetime, what you can do to stave off the effects, and how you can kickstart your brain into functioning at a way higher level.

You’ll also learn about:

• BDNF (Brain-Derived Neurotrophic Factor) and ways to increase it
• Options for how you can support your brain’s neurogenesis
• How certain mushrooms and collagen can be used to increase your cognitive function—so you can focus, concentrate and be more creative
• How customized nootropics can help you reach peak mental performance

Matt Gallant keeps coming back on the show to introduce innovative supplements that work with your brain and body. We’ve talked about nootropics, psychobiotics, magnesium, enzymes, blood sugar, gut health and more. 

As co-founder of BiOptimizers, Matt makes important connections within body systems and finds unique ways to maximum human performance. After a personal health scare with his own brain, he’s turned his professional attention to hacking and upgrading the brain in as many ways as possible.

Most people’s brains aren't at 100% due to many factors, he says, like lack of sleep, chronic high stress, an inadequate diet, and overuse of certain drugs and prescriptions.

Mr. Noots, (scientist Mark Effinger) teamed up with Matt on this quest to support brain health and improve cognitive function. After a childhood exploring everything science, chemistry and physics, he joined the US Air Force and became an endurance athlete and bodybuilder. His life, like Matt’s, took an unexpected turn and he struggled with health issues. It took creative, performance-enhancing nutrition to get himself well. He’s now Chief Product Officer for the mind-enhancing compounds and stacks of nootropics at Nootopia and works side-by-side with Matt.

Their newest product, CollaGenius, combines powerful mushroom extracts and collagen into a formula specifically to energize your brain and body. Collagen improves skin health, relieves joint issues, strengthens hair and nails, and prevents bone loss—and it also does your brain a lot of good.  

And here’s what the mushrooms do for you in the right amounts. That’s the key principle—the dose creates the effect. 

• Lion’s Mane: Boosts BDNF
• Chaga: A natural anti-inflammatory that supports immunity
• Reishi: Alleviates stress
• Cordyceps: Elevates athletic performance and maximizes brain health

Together, Matt and Mr. Noots continue pushing limits and finding ways to make your brain operate at its highest capacity. 

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IN THIS EPISODE OF THE HUMAN UPGRADE™...

…two psychiatric research pioneers open up about the benefits people experience from psychedelic treatments. From mental health conditions to crucial social connections, there’s a dose and approach that can work for you and with your own brain chemistry.

Psychiatrist and psychotherapist Dr. Phil Wolfson, creator of Ketamine Assisted Psychotherapy, leads patients through psychedelic psychotherapy sessions, guiding them through their past and present in an open, altered state of mind. His invaluable work is the result of an intense, many-decades-long clinical practice. He focuses on new pathways for healing depression, PTSD, addiction and other conditions.

“There’s really no right or wrong with psychedelics,” Dr. Wolfson says. “It’s about how do we integrate our lives and relationship in this very difficult time with people and in our beings, and what practices we bring to this whole thing. So, it’s not just about substances.” 

Psychiatrist and psychopharmacologist Dr. Julie Holland explains in her book, “Good Chemistry: The Science of Connection, From Soul to Psychedelics,” why you need connection, how you’ve lost it, and how you might find it again. She believes psychedelics can help. Taken under the direction of a trained psychiatrist, they can catalyze a connection with the self, nature, or the cosmos.

Dr. Holland’s research—with a focus on the parasympathetic nervous system—dives into how you can “turn on” and “tune in” to the brain chemistry that supports connection. At the same time, you can tamp down the fight or flight mode that derails sleep, metabolism, libido and much more. She’s leading new understanding about how your behaviors are driven by the hormones and neurotransmitters that make up good (and bad) brain chemistry, including testosterone, estrogen, dopamine, serotonin and most crucially, oxytocin. 

If you liked this special episode with Phil and Julie, you’ll learn even more from listening to their full podcasts on these topics:

• Your Guide to Psychedelic Psychotherapy – Dr. Phil Wolfson with Dave Asprey – #770
• Psychedelics Offer New Solutions for Social Isolation – Dr. Julie Holland with Dave Asprey – #757

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IN THIS EPISODE OF THE HUMAN UPGRADE™...

…Dave’s travels take him to Amsterdam where he talks with psychic psychologist Joy Martina about intuition, hypnosis and joyful learning. Here’s some of the “how-to’s” you’ll learn about in this episode:

• How to find the right hypnotist for you
• How to identify three common misperceptions about hypnosis
• How to tap into your own intuition and tune into your own wisdom
• How to recognize your body’s kinesthetic channel 
• How to learn through joyful and pleasurable experiences
• How to listen to your gut just as much as your brain
• How to use your energy for good
• How to draw from the quantum field 
• How to connect to your highest potential
• Ho to create big change in your life
• How to tune into your environment 
• How to recognize the benefit from staying stuck in old patterns and make a shift
• How to notice your triggers and react less to them
• How to move from an emotionally charged attached position to a grounded, neutral state.

After this episode, head into the podcast library for Joy’s previous conversation with Dave: Intuition is Not a Feeling – #574.

About Joy Martina: Joy Martina, psychic psychologist and a channeler of Christallin Consciousness specializes in high-level intuitive intelligence training for entrepreneurs, business owners and celebrities. She is an author, the creator of the Christallin Oracle Training, a master hypnotist and trainer of trainers.

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IN THIS EPISODE OF THE HUMAN UPGRADE™...

… Swedish journalist Johan Anderberg joins the show to talk about how he captured a rare moment in his country’s history during the worldwide COVID-19 pandemic in 2020.

His book, “The Herd: How Sweden Chose Its Own Path Through the Worst Pandemic in 100 Years,” explains this unique time. In it, he gives a fly-on-the-wall account of the herd-immunity strategy that Sweden adopted during the first year of the pandemic. 

• First, the government instituted no restrictions. 
• Then, it declined to order that people wear face masks. 
• While the rest of the world looked on with incredulity, condemnation, admiration, and even envy, Sweden stood alone in its decisions.

“We have to value the fact that different countries do different things,” Johan says.

Here’s what you’ll learn by listening:

• How the Swedish COVID-19 strategy veered far from what the rest of the world was doing.
• Why "The Swedish Experiment” has been alternately praised and held up as a cautionary tale.
• In what ways Sweden’s laissez-faire strategy with few restrictions worked.
• Differing perspectives—no judgment or right/wrong—about the actions and reactions of governments, communities and individual citizens during a medical crisis.

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In this Episode of The Human Upgrade™...​

 … Dave talks with George Hanna about how to get better deep sleep.

George says he’s been a health and fitness buff for most of his life. Now in his early 60’s, he’s adopted much of the biohacking lifestyle, including sleep hacks. Yet, deep sleep continues to elude him. He and Dave get into factors that could be messing with his circadian rhythm, like temperature, light, overtraining, heart rate variability, glucose monitoring, blood sugar and more. They also go over potential tweaks to:

• Mushrooms
• Herbs
• Amino Acids
• Testosterone
• Supplements
• Thyroid
• Statins

If you struggle with sleep or simply want to learn to fine-tune the sleep you’re getting, take a listen to this episode for tips and resources.

Listen to the other episodes in the Interventions With Dave series and don’t miss the “Links & Resources” section on the episode web page: https://daveasprey.com/intervention-george-hanna-957/

Note: The "Interventions With Dave” recommendations are designed to help you upgrade yourself and your biology so you can perform better at everything you do. They are not, however, a substitute for advice or treatment by a trained medical professional that may be needed for specific health conditions, illness or injury.

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IN THIS EPISODE OF THE HUMAN UPGRADE™...

…anesthetist and researcher, Mark Harper, M.D., Ph.D., shares how the power of cold-water practices can treat depression, anxiety, PTSD, arthritis, migraines and other health conditions you may be experiencing.

Despite all the attention cold water swimming and immersion has gotten in recent years—thank you, Wim Hof—the scientific community hasn’t taken it very seriously. That’s changing now. Dr. Harper’s research goes beyond what we already know about the benefits of cold-water therapy and lays out best practices for you.

In this episode you’ll learn: 

• How to safely establish your own customized practice of cold-water swimming
• The ideal plunge frequency 
• How to heat your body from the inside out
• Why using saunas can optimize your plunges
• The effects of putting your face in cold water vs. just your body
• Why swimming “in the wild”—lakes, rivers, seas — benefits you even more 
• How community plays a role in cold plunge practices
• And more

You’ll also learn about science and case studies found in Dr. Harper’s new book, “Chill: The Cold Water Swim Cure - A Transformative Guide to Renew Your Body and Mind.” He explains how cold water has the ability to impacts us physiologically and mentally.

As Dr. Harper shares his long-awaited evidence on cold-water’s therapeutic power to strengthen the immune system, cell regeneration, and everyday vitality, you’ll come to understand how to harness the power of cold-water swimming. 

If you are looking to up your cold-water therapy game, you’ll get a lot of value from this episode. Dr. Harper says you can start simply, one small movement into cold water at a time: “Your rest, digest, chill out, and anti-inflammatory response comes from putting your face into the water,” he says. He then goes on to other cold-water swim tips. Enjoy!

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IN THIS EPISODE OF THE HUMAN UPGRADE™...

 …two of the most adventurous people on the planet share what they’ve uncovered, faced and learned through exploration of the planet’s deepest waters. From discovering the Titanic to cave diving in places untouched by any other human, Bob Ballard and Jill Heinerth took risks, dove into fear, and came up for air with tremendous new knowledge. Combined, they’ve spent over nine decades searching the seas and documenting their findings. 

Canadian Jill Heinerth explores the underwater world as one of the greatest cave divers on the planet. She’s considered this generation’s Jacques Cousteau. She’s completed more than 7,500 dives in her career so far and dived deeper into caves than any woman in history. She became the first person to dive the ice caves of Antarctica, going further into an underwater cave system than any woman ever. She’s gone into places in the world where no one had gone before.

Considered a legend in the diving community, she’s spent more than 30 years in submerged caves around the world partnering with National Geographic, NOAA, and various educational institutions and television networks worldwide. She’s also a writer and award-winning photographer and filmmaker who takes a keen interest in the health of the Earth’s oceans.

Learn more about Jill’s lifetime of underwater cave diving in her memoir, “Into the Planet: My Life as a Cave Diver.” “We are capable of so much more than we could possibly imagine," she says.

Bob Ballard explores the vast depths of the oceans uncovering mysteries, proving theories, and revealing artifacts that tell a story about the history of humankind. An oceanographer and marine geologist, he’s led nearly 160 deep-sea expeditions and worked with the Navy on top-secret missions. His underwater career spanning more than 60 years began simply enough as a child with a love of California’s Mission Bay tide pools.

He’s gone on to discover ships thought long lost (the RMS Titanic in 1985) and provide extraordinary new understandings and discoveries in marine geology, geophysics, biology, and chemistry. He’s discovered new life-forms, traced ancient trade routes, developed robots that roam the ocean floor, and opened the underwater world to kids through telepresence. 

Bob's recent memoir chronicles his underwater journeys “Into The Deep: A Memoir from the Man Who Found Titanic.” “Just lots of crazy things have happened, and I'm still at it and I'm not going to quit,” he says.

If you liked this special episode with Jill and Bob, you’ll learn even more from listening to their full podcasts, directly below.

• Living a Life of Deep Adventure – Bob Ballard, Finder of the Titanic – #839
• A Lesson in Adventure Hacking: Step Toward Your Fear – Jill Heinerth – #663

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IN THIS EPISODE OF THE HUMAN UPGRADE™...

…a legacy upgrade conversation with Paul Chek delivers the goods on how to improve your physical, emotional and mental performance. He lays out what it takes to get into your optimal state—including a higher state of consciousness. 

For more than 30 years, he’s used a unique, integrated approach to treatment and education. Paul gets back to basics and formulates practical systems that work to help you help yourself to get well.

“I look at happiness, movement, quiet, and diet,” Paul says. “I get a holistic picture of their life because you can’t reduce a living philosophy below those four factors.”

Paul's an expert in the fields of corrective and high-performance exercise kinesiology, stress management and holistic wellness. By treating the body as a whole system and finding the root cause of a problem, he’s been successful where traditional approaches have consistently failed. 

And he goes even further into the metaphysical realm.

“The world populace due to the destruction of the environment, due to the chemicals in the environment, due to the electromagnetic pollution, due to overstimulation, due to the lack of sleep, due to the manipulation of people’s biochemistry by medical drug use, … we’re going lower and lower into our levels of consciousness, which is putting us more and more in a fight or flight state, which is making us more and more reactive.”

But you can make a difference within your own life, even going into higher levels of consciousness, Paul explains.

“Every human being has genius within it,” Paul says. “We can use the same technology and the same level of brain power that got us in trouble to reverse it.”

This legacy episode is the full version of a 2-part episode series. Now, you can listen to the entire conversation without interruption. Paul tells it like it is—no holds barred and no BS. You’re going to learn a lot and enjoy his style!

About Paul Chek:  Paul founded the CHEK Institute (Corrective Holistic Exercise Kinesiology) in 1995. He’s a certified neuromuscular therapist and clinical exercise specialist (ACE) who’s studied with experts worldwide from many disciplines. The Chek Institute offers a broad range of educational courses that include at-home study.

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IN THIS EPISODE OF THE HUMAN UPGRADE™...

…two spiritual masters continue discovering new layers of and models for human experience. This combined episode covers aspects of consciousness, conscious agents, biodynamics, emotional body energy, the Enneagram, homeopathy and much more.

Deepak Chopra, M.D., FACP, is a world-renowned pioneer in integrative medicine and personal transformation. TIME magazine described him as “one of the top 100 heroes and icons of the century.” He’s been exploring the intersection of science and spirituality for decades.

Deepak’s 90th book: “Metahuman: Unleashing Your Infinite Potential,” gets into what it means to be “beyond human.” You’ll learn how to question reality, move past limitations constructed by your mind, and enter a new state of awareness. And when you realize a “reality without limits,” you’ll be able to realize your full human potential.

Abdul Hayy Lammert Holdijk has followed a Sufi path for the past 40 years, studying religion and consciousness with a hefty dose of pragmatism. He lectures on topics such as Epigenetics, Neurobiology, the Enneagram, Shadow Work, Voice Dialogue, Love, Dream interpretation, Jekyll and Hyde, Hayy Ibn Yaqzan, and a wide range of other topics related to consciousness and personality development. 

Abdul taught at the American University in Beirut for several years, and then at the American University in Cairo for 35. His profound life story includes adventure, spirituality seeking, questioning tradition and teaching others. He also leads spiritual retreats in Lebanon, Egypt, Oman, and the surrounding region.

If you liked this special episode with Deepak and Abdul, you’ll learn even more from listening to their full podcasts, directly below.

• Going Beyond the Human Mind to Discover Your Infinite Potential – Deepak Chopra – #683
• Who Am I? Finding Spirituality by Disrupting Tradition with Abdul Hayy L. Holdijk – #710

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IN THIS EPISODE OF THE HUMAN UPGRADE™...

...you'll learn some surprising lessons sorrow and longing can teach you about creativity, connection and love. You’ll find out why longing isn’t passive—as most people think—but actually “momentum in disguise.”

Author Susan Cain combines research, the stories of others, and memoir to explain how sadness can be your superpower. “Bittersweetness is the hidden source of our moon shots, masterpieces, and love stories,” she says in her newest book, “Bittersweet: "How Sorrow And Longing Make Us Whole”.

Longing can improve your creativity and fuel a drive to express yourself. Longing coupled with pain can help you to connect to others and provide a common ground that enhances compassion and helps you feel less alone in your troubles. 

Instead of hiding or shying away from feelings like sadness and longing, Susan encourages you to embrace them as part of who you are, and part of what it means to be human. This conversation gets into:

• How bittersweet differs from melancholy
• How Acceptance Commitment Therapy helps you manage the “bitter of life” 
• How sadness is the ultimate bonding agent
• How the concept of “winners” and “losers” changed over time
• How to live and work authentically in an environment of enforced positivity
• How to embrace deep reflection and ask yourself: "What. Are. You. Longing. For?"

Special offer for The Human Upgrade listeners: Go deeper into the topics of Bittersweet and Quiet with Susan’s 30-day interactive online courses. Go to https://www.susancain.net/ and use code ASPREY15 to save 15%.  

More about Susan Cain: She’s the author of “QUIET: The Power of Introverts in a World That Can’t Stop Talking,” which spent seven years on The New York Times bestseller list and has been translated into 40 languages. Her record-smashing TED Talk, “The Power of Introverts,” has been viewed over 30 million times. She’s spoken at Microsoft, Google, the U.S. Treasury, the S.E.C., Harvard, Yale, West Point and the US Naval Academy. She’s an honors graduate of Princeton and Harvard Law School.

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In this Episode of The Human Upgrade™...​

Cool Facts are quick hits of new human and world science curated into short bursts of information just for you. This fun compilation publishes one Friday a month.

• How a gene interferes with memory linking in the brain.
• How fearful memories are seared into your brain.
• How a new device stimulates the vagus nerve to help people learn a new language.
• How global warming impacts your sleep quality.
• How and why people age, according to a new theory.

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IN THIS EPISODE OF THE HUMAN UPGRADE™...

…two food experts explain the many ways your food choices influence your body systems—and what you can do differently to improve your gut function, energy and performance. Here’s a look at how essential amino acids and the right proteins can keep inflammation at bay and keep your metabolism humming.

Teri Cochrane, CN, CCP, went down the research rabbit hole when both her son and daughter (at different ages and for different reasons) experienced severe health problems. She not only examined nutrition in-depth, but she also investigated epigenetics and nutrigenomics 

“Disruptors such as pathogens, mycotoxins, stress, amyloids and inflammatory foods work together to impair body balance,” Teri says. “We have found a direct link between amyloids, mycotoxins and these health disruptors in the acceleration of disease.”

She’s developed her own methodology that integrates a multi-level nutritional approach—including biochemistry, nutrition, genetic tendencies, herbology, supplementation and counseling. As the author of the “The Wildatarian Diet: Living as Nature Intended,” Teri lays out how the malabsorption of protein, fat, and sulfur, tamper with gene expression. 

Mareya Ibrahim believes in food flexibility while still focusing on a core system that works. She’s a holistic nutritionist, TV chef, podcast host, and award-winning entrepreneur and inventor with more than 25 years of experience in the food industry. She also founded Grow Green Industries and co-invented the patented eatCleaner line of products.

In her book, “Eat Like You Give a Fork: The Real Dish on Eating to Thrive,” she explains the nuances of clean eating, how to reset your taste buds, and all the ways essential amino acids keep your body functioning.

“Essential amino acids are what fuel us and allow us to regulate our hormones, and flex our metabolisms, and build muscle, and all of the things that we need to be functioning human beings,” Mareya says.

If you liked this special episode with Teri and Mareya, you’ll learn even more from listening to their full podcasts,:

• What You Eat is Turning Your Genes On and Off – Teri Cochrane – #646
• Just Give a Fork: Eat the Freakin’ Pasta – Mareya Ibrahim – #661

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TWO SPECIAL OFFERS FOR LISTENERS OF THE HUMAN UPGRADE!  

Visit https://paleovalley.com/humanupgrade to get your first 10-pack of meat sticks for only $4.99 + shipping.

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IN THIS EPISODE OF THE HUMAN UPGRADE™...

…you’ll learn how eating meat benefits human health, including protein specifics and the clear advantages of regenerative agriculture.

Today’s guest suffered from debilitating digestive issues and crippling anxiety for most of her life. Specialist after specialist told Autumn Smith nothing could be done to alleviate her physical and mental health distress.

As a last-ditch effort, she turned to the power of whole foods. She cleaned up her diet with Paleo-inspired eating and improved her gut in just 30 days. The changes also decreased her anxiety, increased her mental sharpness, and discovered her inner vibrancy. That experience propelled Autumn to help others capture the power of whole foods through quality food products produced by regenerative agricultural practices.

In 2013, she and her husband, Chas, along with another family member and friend, launched Paleovalley. They built a company dedicated to helping people get essential nutrients without added sugars, grains, and other harmful ingredients. With meat being the central focus of their business, they set out to learn all they could about production and regenerative farming.

In 2018, they launched Wild Pastures, a regenerative meat delivery service, and recently opened Wild Pastures Burger Company, their flagship fast casual burger restaurant in Boulder, Colorado.

This conservation gets into the problems with current methods of animal agriculture and possible solutions. You’ll find out more about the nutritional differences of animal products depending on how they’re raised. Autumn says meat labels can be tricky, too, so she breaks down the jargon and tells you what to look for and what to avoid.

Autumn advocates for meat’s many advantages and works to dispel the myths that continue to persist about meat consumption. From soil to farming to raising animals humanely, building community and managing economies, Autumn talks about how to make choices that are right for you and everything around you.

More about Autumn Smith: Autumn holds a master’s in Holistic Nutrition and currently is a doctoral candidate in Holistic Nutrition. She’s a Functional Diagnostic Nutrition Practitioner, an Eating Psychology Coach certified by the Institute for the Psychology of Eating, and received Soil Advocacy Training by Kiss The Ground. She hosts the popular Optimize Paleo podcast.

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In this Episode of The Human Upgrade™...​

… Dave talks with Lisa B. about the frustration she’s experiencing with her health conditions. She says she lives a healthy lifestyle and does the “right things” and still struggles with chronic low energy. Her kids often say, “you never feel well, mom.” She agrees but finds it difficult to explain why. 

Now in her early 50s, she’s had panic attacks and anxiety since childhood and has taken many types of anti-depressants throughout her life. She also struggles with OCD.

She’s experienced long-time hormonal imbalances, including painful periods, acne, fertility problems, and ongoing PMS “flu” that she says takes over her life during her cycles. She suffers from aggressive seasonal allergies and has a shellfish allergy. 

She’s been on Accutane, was diagnosed with Lupus in college and also diagnosed with exercise-induced urticaria and Mast Cell Activation Syndrome. She got COVID in 2021.

In this “Interventions With Dave” episode, Dave examines what’s going on with Lisa’s varied symptom. They discuss what’s working and what’s not, and what can help her gain more energy and control of her health. The conversation gets into a bunch of topics, like:

• PMS “flu” (with sore throat, hot tongue, achy, brain fog, no energy, feverish feeling with no fever present, painful periods) 
• Hormones, the Wiley Protocol and testosterone
• “Mold cough” and other symptoms of mold
• OCD and anxiety
• MTHFR gene mutation 
• Histamine, Mast Cells and Mast Cell Activation Syndrome
• Allergies
• And much more…

Find biohacking tips, tools and resources particular to this episode on the episode web page: https://daveasprey.com/interventions-with-dave-lisa-b-949/

Note: The "Interventions With Dave” recommendations are designed to help you upgrade yourself and your biology so you can perform better at everything you do. They are not, however, a substitute for advice or treatment by a trained medical professional that may be needed for specific health conditions, illness or injury.

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IN THIS EPISODE OF THE HUMAN UPGRADE™...

 …you’ll find out how plant-based humic substances have the power to stop and reverse the effects of glyphosate damage in both humans and soil.

Caroline Alan, co-founder and CEO of BEAM Minerals, explains how minerals provide your body systems with critical cellular support, how they get depleted and how you can replenish them. She goes even further to talk about glyphosate’s harmful effects on human health and soil health, particularly when it comes to minerals.

In her former corporate career of software development and business consulting, Caroline experienced problems physically, mentally and energetically. She struggled with issues like life-long gluten intolerance, whole-body inflammation, leaky gut, chronic headaches, flat-lined adrenals and low thyroid. Her chronic health issues didn’t resolve until she began taking plant-based humic and fulvic minerals.

This cellular support changed her life so dramatically, she started deep research into the science of minerals and co-founded BEAM Minerals. 

Then she kept going and began to look more closely at the current problems with farming in soils that have become unproductive due to a lack of microbial and mineral content. She investigated the effects of glyphosates on soils and in the human body and found:

• One of the root causes of unhealthy soil can be linked directly to glyphosate use in modern production farming.
• One of the root causes of mineral depletion and chronic illness in modern humans points directly to glyphosate ingestion.

The bottom Line? We all have glyphosates in our bodies. Here's what it can do: Suppress critical enzymes, create gut dysbiosis, chelate minerals from your system, reduce mitochondrial function, and cross and affect the blood–brain barrier. Studies also show more use of glyphosate can lead to an uptick in chronic and acute health conditions.

Research finds that plant-based humic and fulvic substances offset glyphosate harm. This conversation will help you recognize symptoms of mineral depletion in your own body. You’ll get practical tips about how to use 100% bioavailable, plant-based fulvic and humic mineral supplementation in easy forms like liquids and topical spray.

BONUS: For research links and other resources about glyphosate and humic/fulvic substances, visit daveasprey.com/glyphosate.

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IN THIS EPISODE OF THE HUMAN UPGRADE™...

 … you’ll get tips about how to lead a brain healthy lifestyle and how to keep perspective along your own entrepreneurial journey. 

Activism, acting and entrepreneurship are wired into Patrick Schwarzenegger’s DNA. He thoughtfully balances each passion through his work as an Alzheimer’s advocate, actor, investor and food founder. 

Patrick’s known for his trend-spotting abilities in the better-for-you food and beverage industry. He got into the fast-casual Blaze Pizza franchise when he was just a teen. That experience solidified his interest in health and wellness: “invest solely into entrepreneurs and companies that were providing Americans with the healthier alternative." He’s now an active investor and advisor to numerous brands and helps founders scale their emerging businesses to the next level.

His latest venture encourages brain health at every age and supports programs, research, and lifestyle choices designed to make your brain work better. Patrick co-founded a new brain health food brand called “MOSH” with his mom, Maria Shriver, designed specifically to up-level your brain function.

“We really want it to be a brand that was created out of a mission and out of the why, and not so much the what,” Patrick says. … “We want to be a brain health company and also educate consumers and raise money and donate that to the Women's Alzheimer's Movement. So, it's been an amazing journey.”

A journey with its share of mishaps, too: “We had so many things that went wrong and that was kind of the fun part was learning about that and finding ways to fix it. That's wanting to be an entrepreneur or that's embarking on that journey, you're going to have speed bumps. You can do as much homework as you can and want and try to perfect everything before you launch, but things come out of left field every single day.”

He’s on the show to discuss entrepreneurship, how to invest, how to build brands, how to hire the right people and what’s possible for high-functioning brains at every age.

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IN THIS EPISODE OF THE HUMAN UPGRADE™...

… you’ll learn how your cells, mitochondria, immune system, sleep patterns, inflammation, nerve growth pattern, and energy levels all benefit from mushrooms. These fungi are full of compounds and nutrients that your body will love. There’s a whole lot of science behind this now.

In this special podcast edition, you’ll hear how two mushroom experts are studying and harnessing the amazing powers of mushrooms for the deepest parts of human biology and the natural environment. 

Paul Stamets, is a speaker, author, mycologist, medical researcher and entrepreneur. He’s considered an intellectual and industry leader in habitat, medicinal use and production of fungi, and he considers himself a “mycological warrior.” He’s spent over four decades in the Pacific Northwest studying and researching the world of mushrooms. Listening to him describe, decode and illuminate the workings of the mushroom world is an enthralling experience, indeed. 

He says we’re intertwined with mushrooms at a cellular level. He believes that habitats have immune systems—just like people—and mushrooms are cellular bridges between the two. Our close evolutionary relationship to fungi can be the basis for novel pairings in the microbiome that lead to greater sustainability and immune enhancement. And from neurogenesis to our microbiome to our mitochondria, fungi are linked to us. He’s also making some amazing discoveries having to do with bears, bees, butterflies and biodefense.

Mycelium Just Might Save the Bees, And Us – Paul Stamets – #624

Learn more at fungi.com 

Julian Mitchell, —co-founder and CEO of the Australian-based company Life Cykel—and his team work with mushrooms as innovative food sources and medicinals in Australia. “Mushrooms and mushroom-based foods are going to play a huge role in the future of food,” Julian explains. “They grow quickly requiring very little resources in terms of water, power, and land. They have an amazing nutritional profile, and of course, they are 100% natural.” … “Mushrooms are almost an uncharted continent, with infinite applications not just in food but in biotechnology.”

For day-to-day use, you’ll want to go with cooked, not raw, mushrooms. For those of you who aren’t fans of eating mushrooms, there’s an option for you, too: “Having it as a tincture makes it very easy to add to a coffee, add to a tea, add to a smoothie,” Julian says. “It’s quite tasteless and at the same time micro-dosing it in small amounts straight into your mouth is a great way to have it as well and absorb it straight into your blood system.” 

Mushrooms Are Your New Anti-Aging Strategy – Life Cykel #603

Learn more at lifecykel.com

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IN THIS EPISODE OF THE HUMAN UPGRADE™...

 … you’ll learn why every breath you take makes a difference in how your entire body functions. The way you breathe affects the quality of your life and every one of your body systems. Full stop. This goes for adults and kids alike.

In this special edition, breathing experts Patrick McKeown (“THE BREATHING CURE: Develop New Habits for a Healthier, Happier, and Longer Life”) and James Nestor (“Breath: The New Science of a Lost Art”) approach the topic from diverse perspectives, but agree on a lot. Especially the benefits of nose breathing and the detriment of mouth breathing.

They explain the biochemical, biomechanics and psychological components of how you breathe. They also present exciting new research in pulmonology, psychology, biochemistry and human physiology that shows how making even slight adjustments to the way you inhale dramatically influences things like:

• sleep and snoring
• fitness and athletic performance
• brain function
• focus and concentration
• oxygen intake
• heart rate and blood pressure
• blood sugar
• internal organ function
• nervous system
• respiratory health
• asthma and allergies
• autoimmune disease
• sex
• female hormones
• pain
• stress and anxiety 

That's just the start of what you can change when you change your breathing. Big claims, yes. All true. And even bigger benefits for you.

Breathing can nurture your body, center you, and rebalance you. When you start harnessing the power of your breath, you're going to feel incredibly better than you do right now. 

Patrick McKeown, an author, educator and one of the world’s leading breathing re-education experts, has researched breathing for more than two decades. Listen to more: Shut Your Mouth! Nose Breathing Improves All Your Body Systems – Patrick McKeown – #835

James Nestor, a San Francisco-based science journalist, author, surfer, free diver, adventurer, and speaker, set out on a decade-long quest to find out where our breathing went wrong—and how to fix it. Listen to more: Breathing Essentials That Will Change Your Life – James Nestor – #751

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IN THIS EPISODE OF THE HUMAN UPGRADE™...

…you’re listening to a new Upgrade Spotlight series based on what you told me you wanted to hear on this podcast. On one Friday each month, these shorter episodes will feature guests who’ll get right into useful information in a Q&A style. 

You’ll find out how to improve your energy and upgrade your performance. You’ll also get the latest knowledge about powerful tools and technologies that allow you to change your biology and the environment around you. 

Introducing OneSkin! During this Upgrade Spotlight, you’ll learn about new products designed to target skin aging at the molecular level and promote skin and body health. You’ll also find out the science behind OneSkin’s formulas and why they are considered “daily topical supplements.” They can help you maintain functional and resilient skin as you age. 

OneSkin topical supplements are powered by a proprietary peptide: OS-01, which decreases the accumulation of aged/senescent (zombie) cells in the skin. By targeting the major driver of skin aging, OS-01 has been scientifically proven to:

• Repair cellular damage, including UV damage

• Increase epidermal thickness

• Improve barrier function

• Increase the activity of genes associated with collagen, hyaluronic acid, and elastin production

• Reverse the biological age of skin

“So this peptide has a very interesting profile because it's small enough to penetrate and it's super safe,” explains Carolina Reis Oliveira, Ph.D., scientist, CEO and co-founder of OneSkin. “There is no toxicity, no irritation. We've done all the recommended studies by FDA for personal care products, and, has this beautiful effect of reducing the accumulation of senescent cells, and also reduces the release of inflammatory markers, and increase the production of hyaluronic acid, elastin and collagen. So, in the end, there's a molecule that has all these attributes that's very important for healthy skin, overall.”

Another exciting part of this peptide work includes MolClock, the first skin-specific molecular clock, capable of reliably and accurately determining the biological age of skin. This was created by OneSkin’s team of female PhD-level longevity scientists as part of its research and development platform.

Carolina relocated from Latin America to Silicon Valley in 2016 to co-found OneSkin and lead the development of the company’s disruptive skin rejuvenation technologies. She holds a Ph.D. in Immunology, along with degrees in biochemistry, stem cell biology and tissue engineering. 

Her team of co-founders includes three other female scientists with additional expertise in skin regeneration, bioinformatics, genomics, immunology and molecular biology. Among them, they’ve invented numerous patents and have published nearly 100 peer-reviewed papers in scientific journals.

This episode explores exciting new information about improving skin health at the molecular level for the long-term. When you do that, your body will be more equipped to defend itself from environmental stressors and aggressors, especially with age. 

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IN THIS EPISODE OF THE HUMAN UPGRADE™...

…you’ll learn about emerging science that points to the effects of sugar on your gut microbiome and metabolism and the connections between sugar, your mental acuity and longevity.

Biochemist and molecular biologist Colleen Cutcliffe, Ph.D., continually searches for new ways to improve your gut health and help you live longer. As CEO and co-founder of Pendulum Therapeutics, she works to turn scientific discoveries into real products that hack and heal your microbiome and its associated body systems. At Pendulum, her team identifies and isolates new bacterial strains then combines those new strains to create unique probiotics.

“We really worked hard on ways to modulate post-postprandial glucose spikes through the microbiome,” Colleen says. The result? Pendulum’s Glucose Control lowers blood glucose spikes by 33 to 34% for people with type 2 diabetes. “What we didn't realize was how many people who don't have type 2 diabetes were going to end up benefiting from it.”

This conversation homes in on sugar management and a broad range of research that’s exploring what you can do about managing your glucose to keep up your mental acuity (less brain fog, sharper thinking) and live a longer life.

 Science has discovered that as you age:

• You have reduced ability to metabolize sugar. 
• Your microbiomes become less diverse and depleted of certain key strains that are important for sugar metabolism.
• If you improve glucose control, you see reduced neuronal inflammation and improved cognition.

In the past decade, especially, sugar dominates a lot of the conversation around diet and health. It’s been studied, substituted, moderated, restricted and demonized. With that type of focus, you lose the bigger point.  

“You can't completely cut out sugar,” Colleen says. “You do need sugar. Not all sugar is bad for you all the time. Every cell in your body, except for your colon cells, need glucose in order to survive, in order to replicate, in order to perform functions. All of the things that allow you to be a human being require some amount of sugar."

She wants you to know what’s happening to cause the change in metabolic processing as you age and what you can do about it, like:

• How to understand your blood glucose range and what fluctuations mean.
• How to track your blood glucose and what to do about peaks and dips.
• How to improve your focus, sharpness and mental endurance through diet and fitness.

“I'm a scientist, so I'm always going to say more data is better,” Colleen explains. “[Especially] when you're trying to make improvements and you're making these micro-adjustments in your life, and you want to understand what impact are they having.”

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IN THIS EPISODE OF THE HUMAN UPGRADE™...

 …you’ll learn how to connect the principles of self-coaching to biohacking. You may already be doing some things, but this topic will help you fine-tune your approach in simple, yet powerful, ways.

High performers typically know the value of coaches: experts who can train them and guide them toward goals. But what if you could become your own coach? 

Podcast guest Jason Goldsmith emphasizes the value of combining the mental and physical aspects of human performance. He knows, too, that it’s important to learn to coach yourself to achieve any kind of life success you go after. Self-coaching doesn't mean you do it all on your own, it means that you take charge of yourself, for yourself.

This episode brings these concepts together so you can be in charge of yourself and be confident and purposeful when making decisions. 

A globally recognized performance coach and founder of Goldsmith Performance, Jason’s best known for his work with golfers, from junior, to amateur to professional skill levels. He also coaches athletes from other major sports, as well as Fortune 500 executives.

He’s distilled his knowledge and partnered with David Novak, cofounder & former CEO and Chairman of Yum! Brands (owner of 45,000+ restaurants) to present sports and business coaching for high performance. They’ve created a practical guidebook for you to learn how to be your own best coach: “Take Charge Of You: How Self Coaching Can Transform Your Life and Career.”

This conversation covers strategies to develop an understanding of who you are and what drives you. “That is a crucial part of choosing your SBT (single biggest thing): it should feel big, important, impactful, even aspirational,” Jason says in his book. “There is a difference between setting a goal and choosing a destination.”

You can outline a process with that knowledge that sets you up for success. And then add in something you may not have considered: 

“Joy is a critical ingredient, and I don't think enough people have enough joy in their day-to-day life,” Jason says. “It’s really important for people to know what it is that brings them joy and what are the things that diminish their joy. So, if I was able to biohack my day, what are the things I do every single day that make me feel the best possible version of myself? But then what are the things that get in the way of that joy? And then how do I eliminate those joy blockers and have more of those joy builders?”

You’ll find out how in this episode! 

“Take Charge of You” includes do-it-yourself lessons, stories, tips, and questions to ask yourself to track your personal growth and professional development. You can follow this blueprint for self-coaching, no matter what your goals may be.

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Cool Facts are quick hits of new human and world science curated into short bursts of information just for you. This fun compilation publishes one Friday a month.

• Drugs that cut down cancer risk by 61% aren't really drugs.
• Take the right type of Vitamin D for the most benefit.
• Stressing cells in the sauna could help reverse neurological disease.
• A new discovery in brain communication and function.
• Making stem cells younger in less time.
• Active brown fat could be a marker for pre-diabetes.

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IN THIS EPISODE OF THE HUMAN UPGRADE™...

 …you’ll learn how biological age, rather than chronological age, is the primary risk factor behind diseases like cancer, heart disease, diabetes, strokes, even Alzheimer’s. Scientific discoveries show chronological aging may be written in the epigenome, those chemical tags attached to your DNA that control the way DNA operates.

We’re finding out more about both types of aging because of scientists like Morgan Levine, Ph.D., a leading voice in the field of aging and longevity science. She focuses her research on the science of biological aging, emphasizing health span over lifespan. 

“If you take the difference between someone’s biological age and chronological age, it should predict the things we care about, the actual things we're trying to prevent—so death, disease,” she says. 

She’s an assistant professor of pathology and the Director of the Laboratory for Aging in Living Systems at Yale University School of Medicine. Her team looks at using bioinformatics to quantify the aging process and test how lifestyle and pharmaceuticals alter the rate of aging. 

She’s also a founding Principal Investigator at Altos Labs, a biotech company that focuses on cellular rejuvenation programming to restore cell health and resilience.

Today, she’s going to talk about the science of aging and longevity explored in her new book, “True Age: “Cutting-Edge Research to Help Turn Back the Clock.” Three main drivers—health behaviors, recent stressors and adversity, and genetics—determine your biological aging. She shares how to measure your own biological age and why you should track your aging regularly. 

This conversation gets into topics and makes them make sense for your own aging, like:

• Epigenetics & epigenetic clocks
• DNA methylation & telomeres
• Cell lifespan 
• Ageotypes (molecular assessment of aging)
• Phenotypic age
• The “Ceiling” effect
• The “CALERIE” trial
• Nutrition & aging (plants, fasting, ketosis)
• Fitness & aging (energy & brain health)
• Rest & relaxation (sleep & biological programming)

Morgan gives great takeaways on how you can make lifestyle changes to maintain your youthfulness—both inside and out—with low-risk, data-driven biohacking. 

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IN THIS EPISODE OF THE HUMAN UPGRADE™...

…you’re going to find out why you’re missing 50% of your life to fractured attention and distraction and what it’s doing to your brain. 

Podcast guest Amishi Jha, Ph.D., a neuroscientist and professor of psychology at the University of Miami, researches how people pay attention. She co-founded the Contemplative Neuroscience for the Mindfulness Research and Practice Initiative at the University of Miami and serves as its director. For more than 25 years, she’s researched the science of attention through intensive work with the U.S. Military, first responders, medical professionals, business leaders, and elite sports teams.

She’s found that attention Is both your superpower and your kryptonite. 

As a superpower, attention allows you to time-travel in your mind (future and past), highlights what’s important, helps you problem solve, and shuts out distractions, she explains in her book, “Peak Mind: Find Your Focus, Own your Attention, Invest 12 Minutes a Day.” 

When attention is compromised, it’s your kryptonite because it impacts your cognitive function, social engagement, and emotional balance, she points out. The three main forces that degrade attention include, 1) the amount of stress you’re under (and how you’re managing it); 2) being in a crappy mood; and 3) threats real or imagined.

And when your attention gets fractured, you often default to tactics that fail to pull it back together. Amishi’s got great insights in her book that allow you to understand why this happening. When you know what’s going on, it's easier to find your focus.

It’s absolutely possible to change your brain to become more attentive, present, and productive through mindful techniques and daily focusing practices. Amishi’s research shows that mindfulness gives you a sense of control over your mind and allows you to stop negative thinking before it hijacks your brain and body.

The type of mindfulness practice you choose isn’t as important as how consistently you actually do it. The minimum effective dose equals 12 minutes a day, five days a week.

Listen on to a conversation that gives you practical tips on how to re-capture your attention, train your brain and perform at your peak.

More about Amishi Jha, Ph.D.: Amishi earned a Bachelor of Science degree in Biological Psychology then went on to earn a Ph.D. in Psychology (Cognitive Neuroscience) from the University of California–Davis. She completed post-doctoral training at the Brain Imaging and Analysis Center at Duke University in functional neuroimaging. She leads research on the neural bases of attention and the effects of mindfulness-based training programs on cognition, emotion, resilience, and performance. Her work has been featured at NATO, the World Economic Forum, and the U.S. Pentagon. 

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In this Episode of The Human Upgrade™...​

… Dave talks with Sean Plotkin about changing up his current biohacking routine to get even better results. You’ll find out how to maintain a high quality of life amid the “hustle” that can take up a lot of your everyday life.

In his mid-40s, Sean’s doing a lot to improve his energy, keep his body strong and stay ahead of aging. But, he says, the weight keeps creeping up and he’s concerned about his thyroid function. He has an intense weekly exercise routine and could use some help with nutrition before and after his fitness sessions. He also wants to tackle sleep, believing his isn’t as optimal as it could be.

He’s doing a lot of things right, including: supplementing with glutathione, using ozone, wearing a continuous glucose monitor, cooling his sleep with an Ooler Sleep System, tackling how he feels with Hapbee, managing stress and performance with NuCalm, upgrading his brain at 40 Years of Zen, and investing in a hyperbaric chamber and sauna for home use. 

In this “Interventions With Dave” episode, Dave examines what Sean’s doing, what’s working or not, and what he can do to reach his peak performance consistently. They break down:

• Nutrient availability (No. 1, energy; No. 2, protein; and No. 3, carbs)
• Blood glucose and insulin resistance
• Cortisol and stress
• Hormones
• Cognitive function
• Nutrition
• Pre-diabetes
• Fatty liver
• Inflammation
• Cold therapy
• Cholesterol
• Metabolic health
• Brain health
• And much more!

Sean’s already got great awareness, tools and data to work with. Along any journey, it takes some experimentation—and time—to find that sweet spot that makes you feel like a million bucks. 

Note: The "Interventions With Dave” recommendations are designed to help you upgrade yourself and your biology so you can perform better at everything you do. They are not, however, a substitute for advice or treatment by a trained medical professional that may be needed for specific health conditions, illness or injury.

Don't miss the previous episodes in the Interventions With Dave series:

• Hacking Weight Loss Resistance #930
• Hacking Thyroid, Autoimmunity & Aging #918
• Hacking Inflammation #915
• Hacking Your Gut Microbiome #908
• Hacking Menopausal Weight Gain #904
• Hacking Eyesight #895

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IN THIS EPISODE OF THE HUMAN UPGRADE™...

…you’ll learn about all things CBD, hemp and THC: what current research says, why quality matters, and how to get real results. Paired with particular Chinese herbs, the benefits to you increase even more.

In the last few years, CBD was a trend, then the market got saturated, and then people said: “I tried CBD and nothing happened.” That’s unfortunate, because experts like acupuncturist, herbalist and Chinese Medicine practitioner Dr. Chloe Weber know exactly what works—and how. 

There are four main ways hemp supports the mind and body, and this conversation gets into the mechanisms of them all: Anxiety and stress, GI support, immune support, and pain management/inflammatory disorders.

You’ll also find out:

• The differences between full spectrum (with 0.3% THC) vs. isolate vs. pharmaceutical cannabis.
• How your body’s endocannabinoid system works and why it’s your master regulator.
• What endocannabinoid deficiency means for your body.
• How to take CBD and how long it takes to experience its effects.
• How pairing CBD with Chinese herbs can benefit your body and brain, and power your performance.
• What to look for in high-quality hemp products.
• How to maneuver through cannabis strains and THC potencies.
• How to decide between CBD oils, capsules, topicals for your particular health needs.
• Common misconceptions about and censorship of CBD.
• What new cannabinoids are coming onto the scene, like CBG and CBN.

Chloe founded Radical Roots Herbs, a company that offers full-spectrum hemp product and also combines CBD with Chinese herbs to boost the power of both.

“By calming the nervous system and supporting our endocannabinoid system,” Chloe says, “we're actually able accept, absorb and process the Chinese herbs in a more dynamic way."

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IN THIS EPISODE OF THE HUMAN UPGRADE™...

… I will teach you everything you would ever want to know about before surgery, during surgery and after surgery, so that you come in strong, you have a better surgical experience, and you recover way faster than you're supposed to. 

Research shows that if you live in America, you’re likely to have an average of seven surgeries in your lifetime. Wouldn’t you want to know how to go in at your best so you can recover at your best? 

This was my thinking when I went under the knife last year. 

In the hours and days that followed, I blew my doctor’s mind. He had never seen a recovery like mine. 

As the Father of Biohacking, I never shy away from an opportunity to blow the lid off what we think is biologically possible. And then I share what I’ve found with the world.

In Heal with Dave, my new documentary, you’re going to learn all of the methods I used to heal without pain and recover to the fullest and beyond. I’ll teach you how.

If this sounds interesting to you and you want to know what to do to have control of your biology at a time when frankly, a lot of people take quite a while to recover and there's increased risk of all kinds of bad things like infections, systemic issues, just not healing very well and building strong tissues, go to daveaspery.com/heal. 

Watch the documentary, use the resources. It's my gift to you! 

“Heal with Dave” Documentary: https://daveasprey.com/heal/

Ali Sadrieh, DPM at Evo Foot: https://www.evofoot.com

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IN THIS EPISODE OF THE HUMAN UPGRADE™...

… you’ll learn why developing your attributes may be more important than skills when it comes to getting more out of yourself. Attributes are wired into your internal circuitry, always running in the background, says Rich Diviney. You’re born with attributes. They’re elemental and considered innate traits—not to be confused with personality traits.

Rich, a retired Navy SEAL commander, bestselling author, and leadership and human performance expert, explains how attributes determine how you absorb, process, and respond to the world around you. By knowing this, you’ll be able to assess your own attributes and put them into action with SMART steps.

In his book, “The Attributes: 25 Hidden Drivers of Optimal Performance,” Rich shows you how mindset, optimism and becoming uniquely resilient to stress can help you become a better human. His approach identifies core attributes needed for success in personal or professional tasks.

His ability to choose the right people to be in elite performance groups—like the U.S. Navy SEALs—could be considered a superpower. As the officer in charge of training for a specialized command, Rich was part of the SEAL selection process. He pared down a group of exceptional candidates to a small cadre of the most elite optimal performers. How did he do it? By looking at attributes.

It’s Rich's belief that SEALs are not born extraordinary. Instead, they’ve mastered their own mindset to get the most out of their innate abilities to make themselves extraordinary. He believes we all have the power to do this.

In “The Attributes,” you’ll find examples of attributes within five distinct categories plus a couple more that don’t fit so neatly: Grit, Mental Acuity, Drive, Leadership and Teamability. 

So, what are attributes and how are they different than skills? 

“A lot of times we get seduced by skills, and we don't think about attributes,” Rich says. “And the reason is very simple: skills are not inherent to our nature. They're very visible, which means they're very easy to assess, measure and test and you can put scores around them and stats around them. … Attributes are inherent to our nature. We're all born with levels of adaptability and situational awareness and resilience.  Attributes don't dictate our behavior or director behavior; they inform our behavior.” 

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IN THIS EPISODE OF THE HUMAN UPGRADE™...

 …you’ll learn that to be a high performer, you’ve got to have radical confidence to achieve whatever goals you set for yourself. Today’s guest, Lisa Bilyeu, explains how real confidence is an inside job, not something you gain from outside validation. 

When Lisa co-founded Quest Nutrition, she was a self-professed housewife boxing protein bars in her living room. The company grew 57,000 percent in its first three years and became a billion-dollar brand. Her learning curve was steep and fast and filled with things she didn’t know how to do—yet. 

She went on to co-found (with her husband, Tom Bilyeu) and serve as president of Impact Theory Studios. It’s a digital-first studio that produces entertaining original content focusing on themes of empowerment. That content has been viewed over half a billion times by a global audience.

Lisa oversees in-house development of projects focused on female-driven content for multiple platforms. She hosts the digital series, “Women of Impact.”

In her first book, “Radical Confidence: 10 No BS Lessons on Becoming the Hero of Your Own Life,” she shares her journey from a housewife to successful entrepreneur with relatable lessons, anecdotes, and lots of humor.

She explains how the “Purgatory of the Mundane” is even more dangerous than hitting rock bottom. She dishes tough love for those of you who are stuck in mind loops that hold you back.

From ditching the fairy tale to getting off the couch to putting on goggles when the shit hits the fan, Lisa’s got realistic tips to get you moving. An important part of that momentum is setting boundaries: material, physical, and mental and emotional. She shows you exactly how.

She also suggests a fresh perspective on a few things that can help you build “radical” confidence:

• Manage the voice in your head
• Set clear boundaries
• Learn from your mistakes
• Keep your goals top of mind
• Maintain self-awareness around your emotions and triggers

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IN THIS EPISODE OF THE HUMAN UPGRADE™...

 …you’re listening to a new Upgrade Spotlight series based on what you told me you wanted to hear on this podcast. On one Friday each month, these shorter episodes will feature guests who’ll get right into useful information in a Q&A style. 

You’ll find out how to improve your energy and upgrade your performance. You’ll also get the latest knowledge about powerful tools and technologies that allow you to change your biology and the environment around you. 

Introducing Xero Shoes! During this Upgrade Spotlight, you’ll learn how minimalist footwear reduces injury, improves foot strength and supports healthy feet. You’ll learn that getting grounded is a good thing.

Today’s guest—serial entrepreneur Steven Sashen—is a competitive sprinter. He knows the mechanics of human feet. He also knows what it feels like to move in shoes that suck. 

So, he and his wife, Lena Phoenix, founded the footwear company Xero Shoes. They ran headlong into shoe history and shoe science to intentionally create “a MOVEMENT movement” of people with happy, healthy, strong feet in addictively comfortable footwear. 

“A quarter of the bones and joints of your whole body are in your feet and ankles,” Steven says. “They're supposed to bend and move and flex just like any other joint. If you're wearing shoes that don't let them do that, that function tries unsuccessfully to move into your ankle, your knee, your hip and your back joints. Those joints aren't built for those micro motions that keep you balanced, that give you agility and mobility.”

Your feet, and by design the rest of your body, know something’s off with cushioned shoes. So does Steven.

“The value of natural movement, the importance of foot health, and all the things that relate to foot health got me going,” he says. “But what really catalyzed it was discovering that what the footwear industry has been doing for 50 years is lying to people– selling people on ideas that they know don't work, but they can't pull back. They can't tell a different story, because they've been promoting this story for so long about arch support, motion control, padding, cushioning, etc.” 

Research published by the American College of Sports Medicine in 2021, “Stepping Back to Minimal Footwear: Applications Across the Lifespan," showed that minimal footwear leads to improved musculoskeletal health across your lifetime. 

“It’s all about natural motion,” Steven explains. “Our ancestors didn't have a problem being on their feet all day, every day. It wasn't because they're different from us, it was just that they got used to using their feet correctly. We can still do that any day, anytime, any of age.”

CHECK OUT XERO SHOES and the 5,000-MILE SOLE WARRANTY! U.S.: https://xeroshoes.com and EU: https://xeroshoes.eu

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IN THIS EPISODE OF THE HUMAN UPGRADE™...

…you’ll find out why you’re tired, how to fix it and ways to increase your energy. Fatigue is a hidden epidemic, with chronic fatigue syndrome being the most severe end, but most people (in the U.S.) are experiencing some level of being flat-out tired as hell.

Guest Ari Whitten, Ph.D. (Cand.), CES, PES, says that as a culture, we have normalized fatigue. In his newest book, “EAT FOR ENERGY: How to Beat Fatigue, Supercharge Your Mitochondria, and Unlock All-Day Energy,” he explains that 5.4 million adults in the U.S. have been diagnosed with chronic fatigue syndrome (the most severe case of fatigue). However, the true fatigue epidemic affects 50 to 100 times more people.

This episode’s discussion gets right into the role of mitochondria in human energy. Ari’s research (420 citations in “Eat for Energy”!] is clear. The cause of fatigue is mitochondrial dysfunction, he says. And the biggest factors that affect your mitochondria include:

• Circadian rhythm dysregulation and poor sleep 
• Carrying too much body fat and too little muscle mass 
• Poor gut and microbiome health 
• Blood sugar dysregulation 
• Nutritional toxicities and deficiencies 
• Neurotransmitter and hormone imbalances

So what can you do to increase your energy currency? A lot, as it turns out. When you understand factors like resilience, cell defense, nutrition and supplementation, you’re on your way to better energy. In this conversation, you’ll learn:

• what’s causing the dysfunction in your mitochondria and how you can repair these critical energy cells. 
• strategies that will double your energy levels. 
• 7 top supplements (and more) that help get your mitochondria back on the energy track.

Ari has been studying and teaching natural health science for more than 25 years. He went through his own battle with chronic fatigue that inspired his obsession with energy. For the past seven years, he's focused specifically on improving human energy. His education and work in this area touches on critical aspects of human health from nutrition to physical training, to light science, to psychology, and more. 

He created The Energy Blueprint science-based lifestyle programs that target brain energy and mitochondria. He also hosts The Energy Blueprint podcast that features world-wide experts on the subject of understanding fatigue and how to get more energy. 

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IN THIS EPISODE OF THE HUMAN UPGRADE™...

… you’ll meet a holistic neurosurgeon who’s evolving spine care away from cutting. Dr. Marcella Madera’s integrative approaches to spine problems pair science with holistic healing modalities. This means way better healing for you.

Dr. Madera’s innovations in spine treatments include the “Aqua Method,” where photobiomodulated platelet rich plasma meets functional tissue mobilization and movement. You’re going to get exciting new information about this effective form of regenerative medicine and find out if this treatment may be right for you. “It's a very nuanced discussion,” says Dr. Madera. “It's very patient specific. It's very injury specific.”

“The term Aqua really gives a description of what we're trying to create in the body and that is more fluidity,” she explains. “And also, water, aqua, is pure. It’s intense at times, depending on the form. And it is soothing at times, depending on the form. And that is how our treatment goes.”

Dr. Madera’s four-part system includes: Reveal, Restore, Revitalize, Revel. You could benefit whether you have an old or new injury, or chronic pain.

During this episode, she explains how each part is interconnected and helps you heal your spine, or even knee, problems. The Aqua Method’s three-day immersive experience includes a full team of experts focused on your biology, your energy and your state of mind.

Dr. Madera, a board-certified neurosurgeon, trained extensively in conventional medicine. Her expertise in spine care includes surgical treatments, approaches, and techniques for degenerative spine disease, spine tumors, and degenerative deformity.

 She started a private practice in in Austin, Texas where she combines her technical spine care with stem cell treatments and holistic modalities like herbs, energy modalities, Chinese healing practices, autogenic training and diet modification.

SPECIAL OFFER FOR THE HUMAN UPGRADE LISTENERS: Get a $1,000 discount on the Aqua Method at Austin Integrative Spine in Austin, Texas. Call the clinic at 512-817-4600 and mention discount code DAVEASPREY.

More about Dr. Marcella Madera: She’s experienced in open surgery, minimally invasive surgery, endoscopic spine surgery, and regenerative/stem cell procedures. She’s been an assistant professor of Surgery at the University of Texas at Austin Dell Medical School. She also travelled throughout Europe and the U.S. to learn progressive endoscopic techniques and regenerative medicine practices. She completed a Spine Fellowship and faculty instructorship at Johns Hopkins School of Medicine.

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Cool Facts are quick hits of new human and world science curated into short bursts of information just for you. This fun compilation publishes one Friday a month.

• GlyNAC (glycine and N-acetylcysteine) can correct glutathione deficiency, oxidative stress, mitochondrial dysfunction and mitophagy abnormalities to help you live longer.
• Moms and dads think — and react — differently to newborn baby smells.
• Clock and Cycle factors control circadian rhythm and protect your eyes as you age. 
• Oleic acid produced in the brain helps regulate memory, learning, and mood; promotes neurogenesis; and increases cell proliferation.

EPISODE SPONSOR: The Eng3 NanoVi device helps repair oxidative stress damage and support the body’s natural repair mechanisms. https://eng3corp.com/DAVE/. Learn more: The Anti-Aging Science Behind the NanoVi Device – Rowena Gates & Hans Eng – #416.

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IN THIS EPISODE OF THE HUMAN UPGRADE™...

…you’ll learn that one of the major life upgrades you can make includes your relationships. 

Personal development expert Gary John Bishop doesn’t buy into mainstream notions of what makes a happy relationship. Not 50/50 effort, not compromise, not molding yourself into what your partner wants. It’s just you and some hard truths.

What this episode is not about;

• Blame or providing communication tips
• How to change or cope with your partner and personality types 
• Healing past trauma or understanding fear of commitment 

Instead, you’ll get the ingredients to creating a real, lasting and profound connection with another human being.

“There's some, again, cold truths that you have to face and then really have to start to take on,” he says, “but in a way that it's not always going to go your way. You're not always going to get this thing flowing the way you would want it to go, but your job is to keep bringing yourself to this phenomenon in a way that's consistent with you, who you are, what you're about. And powerfully managing all that you might do to undermine it.”

Gary, the New York Times bestselling author of the Unfu*k book series, uses an “urban philosophy” approach that’s both simple and enlightening. In his latest book, “LOVE UNFU*kED Getting Your Relationship Sh!t Together,” he puts the focus on relationships. “The quality of your relationships dictates the quality of your life,” he says in “LOVE UNFU*kED.” 

This conversation gets right to the heart of what you can do to make changes that stick in all areas of your life.

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IN THIS EPISODE OF THE HUMAN UPGRADE™...

You’ll be part of a candid conversation about choice and freedom. And, why it’s important to be able to make a living in your chosen line of work without restriction or judgment. That’s just part of being a better-performing human.

Guest Allie Rae, a wife, mother, retired nurse and Navy veteran, shares her unusual entrepreneurial journey within the adult sex entertainment industry. It may be a different topic than you expect on this show, but it’s a look at innovation opening up alternative ways of doing business outside restrictive Big Tech.

She’s CEO of a brand-new online adult platform called WetSpace. You may have heard about or know of the OnlyFans platform. WetSpace is similar, but not direct competition. 

Allie Rae saw a problem with payment systems and banking restrictions and set out to find a solution.

“At this point, this is no longer a hobby, it's a business for me,” Allie Says. “And as any business in any industry, you want to protect your business and provide stability and have long-term prosperity.”

We get into some cool topics:

• Why Allie Rae created WetSpace;
• How cryptocurrency fits into her plans;
• The influence of Big Tech; and
• How advocacy—not regulation—can guide the growth of the adult sex industry.

Today’s show looks at personal choice and freedom—both yours and other people’s. It challenges stigma, advocates for better systems of work, and supports creativity and business acumen.

it's important that we think about both sex, because that's one of those big things that nourishes us, and also think about what's going on in the world around us, that environment that controls your biology.

It matters that you’re able to choose what to do to and with your body, your energy, and your time. You get to choose to live your values—and so does everyone else. Even if you don’t agree. Being kind and respectful goes a long way in creating communities that allow you to be the highest performing human you want to be.

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

IN THIS EPISODE OF THE HUMAN UPGRADE™...

… Dave talks with Diane Closser about weight loss resistance. You’ll find out how unexpected and insidious factors–both internal and external–may be affecting your body systems. That dysregulation can cause your body to hold onto excess weight. 

Diane Closser knows a lot about chemicals. She’s a chemist by profession and works as a Certified Lubrication Specialist and Certified Reliability Leader at a Division of General Motors.

She also has a personal history of mold and heavy metal exposure, e.g., bought fixer-upper 1972 house, played with Mercury as a kid, worked as a wet bench chemist analyzing heavy metal production products, and worked in tire industry.

She’s been on a journey to wellness for several years that’s included a search for real health solutions. 

There have been some wins: In 2020, she became particularly sensitive to chemicals, perfume, and laundry detergent. She says that ozone therapy cured her of her sensitivity and reversed her autoimmunity. And some setbacks: Her health deteriorated when husband was diagnosed with a brain tumor in 2011.

She also had her house treated with Chlorine dioxide; did low-dose allergen therapy and low-dose immunotherapy; and completed chelation therapy. 

Through it all, she’s experienced a frustrating weight loss resistance. She says she’s “been on every diet and med known to man” since her teenage years. 

Now in her mid-50s, she’s looking forward to a retirement that includes sailing and bringing tap, jazz, and ballet classes to senior citizens around the country. She wants to improve her health and have the energy to make her plans a reality.

In this “Interventions With Dave” episode, Dave and Diane look at her health concerns through a new lens. They examine possible causes of her inability to shed excess weight and discuss actionable next steps. 

• Calorie counting 
• Eating too little 
• Environmental toxins
• Chemical sensitivities
• Mold 
• Ozone
• Histamine
• Mast cells
• Metal toxicity and chelation therapy
• Brain fog
• Thyroid
• Testosterone in females
• Mycotoxins
• Detox pathways
• Collagen

Note: The "Interventions With Dave” recommendations are designed to help you upgrade yourself and your biology so you can perform better at everything you do. They are not, however, a substitute for advice or treatment by a trained medical professional that may be needed for specific health conditions, illness or injury.

Listen to the Interventions With Dave series and don’t miss the “Links & Resources” section below for specific information. 

• Hacking Thyroid, Autoimmunity & Aging #918
• Hacking Inflammation #915
• Hacking Your Gut Microbiome #908
• Hacking Menopausal Weight Gain #904
• Hacking Eyesight #895

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IN THIS EPISODE OF THE HUMAN UPGRADE™...

…you’ll learn how a trainer of superheroes and superstars combines core principles of fitness, nutrition, structure and balance.

Magnus Lygdbäck, a Swedish health and wellness expert, entrepreneur, and lifestyle coach, joins the show to discuss powering your life in ways that most benefit your health and energy.

For more than 20 years, he’s trained some of the world’s most recognizable actors, musicians, athletes, artists, and high-performance business entrepreneurs.

Musicians like pop stars Katy Perry, Dua Lipa, Harry Styles and Britney Spears. Actors like Gal Gadot for Wonder Woman 1984; Alicia Vikander, for Tomb Raider; Ben Affleck, for Justice League; and many more.

He designed Alexander Skarsgård’s incredible transformation for the lead role as a Viking Berserker in the brand new movie, The Northman. 

Even with his “celebrity trainer” title (which he doesn’t love), Magnus is quick to say, “It's not who you train, it's howyou train.”

His Magnus Method training philosophy embraces the “ethos of an athlete.” This all-inclusive approach to performance includes an athlete’s intensity and structure, while also maintaining balance and energy. Time-zone travel, long days of filming, rehearsals, and the constant demands on a celebrity performer’s time means examining all aspects of fueling, rest and recovery. The same applies to the everyday lives of mere mortals.

He encourages being open to learning new things and seeking out discomfort so you can grow. “Look at three things,” Magnus recommends. “One, what do I like to do? No. 2, what does my body need? No. 3, what do I want to master or get better at? That should create your weekly programming.”

You already know, and Magnus will remind you, that there are absolutely no life shortcuts to being the superhero of your own life.

In this conversation, you’ll find out how much time to spend on your workouts (not as much as you think). “What doesn’t happen in the first hour will not happen in the second,” he says frequently. Even for superheroes.

• Learn more about Magnus Lygdbäck’s journey from hockey player to celebrity trainer.
• Find out how you can improve your own performance on Magnus’s extensive YouTube channel.
• Get Magnus’ superhero training programs, nutrition guides, coaching and a community of like-minded people with the Magnus Method app. 

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SPECIAL OFFER FOR BULLETPROOF RADIO LISTENERS: Go to https://justthrivehealth.com. You’ll find their new line, Joot, and their new Just Calm probiotic for stress management and mood support. Just Calm features the proprietary “psychobiotic” strain BL 1714™ combined with brain-nourishing B vitamins. You’ll also find other products that tackle gut health and inflammation. Use code ASPREY to get a 15% off discount.

IN THIS EPISODE OF THE HUMAN UPGRADE™...

…you’ll learn about a strain of probiotics called psychobiotics. This strain shows promising effects on stress relief, anxiety, mood, sleep and other important gut-brain axis connections.

Microbiologist Kiran Krishnan, Ph.D., explores the human microbiome and how it functions so you can have better gut health. He has an extensive research background in the fields of molecular medicine and microbiology. His particular expertise lies in gut commensal spore bacteria microbiology.

He’s been a guest on the show before to educate listeners about probiotics and the connections between your microbiome, inflammation and immune function. This time, he’s sharing exciting research about a probiotic strain that’s tackling the gut-brain axis, called Bifidobacterium longum 1714™.

Kiran says, “One really important message that I want people to really wrap their heads around and understand when we're talking about the gut-brain axis is, of course, the gut. A healthy gut is incredibly supportive to the brain. It supports the brain in a number of really important critical functions like recovery, for example, or production of serotonin and dopamine and all these important neurotransmitters, but on the other end of the spectrum, an unhealthy gut is not only not supportive, but it's arguably one of the most toxic things for the brain.”

Big topics covered in this episode include:

• Basic mechanisms by which the gut microbiome can influence neurochemicals and brain inflammation
• The gut-brain connection as it relates to stress coping and mental health
• How cortisol and interleukin 6 drive stress response and inflammation in your whole body
• Variables that can cause a breakdown or dysfunction in the psychobiome
• Therapeutic interventions, including psychobiotics that can help correct gut-brain axis dysfunction

Kiran’s great at explaining the science so you clearly understand what the studies mean and can apply new knowledge to your own biology. He also partners with Just Thrive Health on product research and development.

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IN THIS EPISODE OF THE HUMAN UPGRADE™...

…you’ll learn how nature, human health, and climate activism interconnect. Emma Loewe, environmental journalist and senior sustainability editor at mindbodygreen, joins the show to share how nature can restore all aspects of your health. You’ll find out how you can reap the benefits of specific nature landscapes, wherever you live or roam.

You’ll come away from this episode with: 

• Tips on how to combat stress, anxiety and burnout by being outdoors.
• Actions you can take to conserve the landscapes you care about.
• Mindset shifts that will change the way you think about the climate crisis.

In her new book, “Return to Nature: The New Science of How Natural Landscapes Restore Us,” she’s researched the ways eight distinct nature landscapes improve your physical, mental and spiritual health. 

• Parks & Gardens
• Oceans & Coasts
• Mountains & Highlands
• Forests & Trees
• Ice & Snow
• Deserts & Drylands
• Rivers & Streams
• Cities & Built Environments

Emma shares research-backed ways to explore nature now and protect it for the future, including SRT (stress-reduction theory). This theory says that humans are hardwired to relax while looking at environments that have extensive views, areas to retreat, and essential resources like shade and water.

“Return to Nature” also offers:

• Mindful exercises you can do in short or long chunks of time that allow you to fully experience nature when you’re in it. 
• Additional resources about the eight natural landscapes Emma writes about.
• Nearly 30 pages of research references! 

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SPECIAL OFFER FOR THE HUMAN UPGRADE LISTENERS! Go to https://get-base.com/DAVE. Use code DAVE to get 20% off your first purchase.

IN THIS EPISODE OF THE HUMAN UPGRADE™...

… you’re going to learn about the engineering it takes to build a health data app. You’ll find out how data science, mathematics and predictive analysis look at how biomarkers impact overall wellness. At Base, your own data, along with deep expertise from an advisory board of functional medicine doctors, inform the algorithms. This means you get a distinctly personalized prescription on how to manage your health concerns.

Guest Lola Priego, founder and CEO of Base, is an experienced software engineer and former medical student on a mission to help people better understand what is going on in their bodies. She possesses a unique combination of skills to do just that.

She studied medicine before transferring to engineering at the Technical University of Madrid and earned a master’s degree in Computer Science and Artificial Intelligence at the Illinois Institute of Technology. 

While struggling with her own health problems, she identified major pain points in the healthcare system like lack of access to personalized health data. She created Base to solve this issue with a data-driven approach that also provides actionable diet and lifestyle recommendations. Base gets to the root cause of health concerns through analyzing biodata like hormones, nutrition, and vitamin deficiencies to get to the core of why you feel “off.” 

Base provides testing options that usually are not available at a primary care doctor’s office (they’re often only offered by specialists). Convenience is built into the lab testing process. Base’s blood and saliva tests gets to the root of issues like stress, anxiety, fatigue, and brain fog. Here’s what Base and its accompanying app offer you so you can take control of your own biology and make meaningful life changes:

• Regular testing tells you what’s going on with your biology.
• Your own data informs recommendations on how to improve your diet, stress, energy, sleep, and sex drive.
• You can track your results over time, get help from a team of online experts, and set specific health goals.

Because it’s your own health data, there are privacy issues at play you have to know about. Lola explains that security and privacy are built-in design features at Base.

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IN THIS EPISODE OF THE HUMAN UPGRADE™...

… natural vision expert Claudia Muehlenweg shares interesting knowledge and practical solutions about how you can take better care of your eyes and improve your vision. In this longer episode, 

• You’ll discover ways you can improve your vision through natural methods that start with root causes in your body, including nervous system regulation.
• You’ll explore bodywork, breathwork, rest, light and movement healing methods.
• You’ll find out the essential Dos and Don’ts for good eyesight.
• You’ll get practical suggestions for things you can do right now to offset the effects of screen time.
• You’ll learn how you can keep your vision sharp throughout your life span.

After working to improve her own eyesight, Claudia founded Holistic Vision LLC to help others. Her work is based in the Bates Method. She focuses on finding the root cause of blurry vision instead of using symptomatic treatments like glasses, contacts or surgery that actually can make eyesight worse in the long term. 

She’s been teaching eyesight improvement since 2009. Her methods can improve presbyopia, myopia, astigmatism, hyperopia, strabismus, convergence insufficiency, and eye diseases such as cataracts, macular degeneration and glaucoma. She also helps people restore clarity after corrective surgeries like LASIK have worn off.

Her experience as a yoga teacher brings together complementary practices like myofascial release, breathwork and bodywork that greatly influence holistic vision care and natural vision healing methods.

SPECIAL OFFERS FOR THE HUMAN UPGRADE LISTENERS!

Step 1: FREE 5 Day Training “See Better in Just 5 Days” April 11-15, 2022. Click here to register.

Step 2: FREE “See Clearly Without Glasses or Surgery!” live workshops. Choose one date: April 18, 20 or 22, 2022. Click here to register.

Step 3: “Naturally Clear Vision” 10-week online holistic vision improvement program. Click here to register-waitlist only.

Just want a freebie? “10 Habits for Happy, Healthy Eyes.” Get the guide here.

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SPECIAL OFFER FOR THE HUMAN UPGRADE LISTENERS! Be Cool, Get Deeper Sleep: Check out the Dock Pro Sleep System at https://www.chilisleep.com/discount/HUMANUPGRADE20. Use code HUMANUPGRADE20 to save 20%.

IN THIS EPISODE OF THE HUMAN UPGRADE™...

…you’re listening to a new Upgrade Spotlight series based on what you told me you wanted to hear on this podcast. On one Friday each month, these shorter episodes will feature guests who’ll get right into useful information in a Q&A style. 

You’ll find out how to improve your energy and upgrade your performance. You’ll also get the latest knowledge about powerful tools and technologies that allow you to change your biology and the environment around you. 

Introducing ChiliSleep! During this Upgrade Spotlight, you’re going to learn about the physical and mental health benefits of cool sleep and how to hack your sleep with new bed technology.

You already know about the physical and psychological effects of not getting good sleep. Whether you’re dangerously sleep-deprived or can’t stop waking up in the middle of the night, struggling to get enough sleep over time can have devastating impacts on your body and mind.

Poor sleep increases a person’s risk of developing serious medical conditions, and not getting enough deep sleep increases the chance of high blood pressure; heart attack and stroke; Dementia and Alzheimer’s disease; and Type 2 Diabetes. 

Tara Youngblood founded ChiliSleep so people could get the coolest sleep ever. Water-based cooling helps your body settle into a just-right temperature that’s just right for you. 

Your core body temperature should naturally drop every night, but for lots of people for lots of reasons it doesn't. Here are a few of the good things that happen when you regulate your sleep temperature:

• Cooler temperatures cue your brain to release melatonin and help you fall asleep faster. 
• Sleeping at colder temperatures improves deep sleep and increases muscle recovery.
• Muscle repair and growth occur during deep sleep and REM sleep stages due to the natural release of growth hormones.

Tara creates technologies and apps to help you recover your sleep and your energy. She’s a trained scientist with degrees in Science and Physics who also studied traditional Chinese medicine, Ayurvedic practices, neuroscience, and psychology.

She focuses on how your physical body can get better sleep and the important essential link between sleep and mental health.

Get Dangerous with Dave's new Remineralized Coffee: https://dangercoffee.com

Join the 8th Annual Biohacking Conference: September 2022! https://biohackingconference.com

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Vascular System Protection: https://arterosil.com/DAVE/, save up to 45% a 3-pack to protect your blood vessels from vulnerable plaque.

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Business Growth With SEO: https://www.stephanspencer.com, get a FREE consultation

SPECIAL OFFER FOR THE HUMAN UPGRADE LISTENERS! Go to https://www.knowinglabs.com/DAVE. Use code DAVE to get 20% off every home test kit.

IN THIS EPISODE OF THE HUMAN UPGRADE™...

… you’re going to get a step-by-step guide to taking accurate labs at home. You’ll learn how to use home test kits effectively to get high-quality results.

At-home test kits got more popular in the past few years as people wanted to know more about their personal health data. Knowing your data gives you the power to control your own biology.

Some of the biggest value drivers of at-home labs include: Convenience, performance specificity, and being proactive rather than reactive about your symptoms.

Dolce Conde co-founded Knowing Labs to support a growing community of people who want to be proactive about their health.

Knowing Labs offers reliable laboratory testing directly to consumers in the convenience and privacy of their homes. The kinds of test kits available at Knowing Labs include panels for vitamin D, inflammation, sleep & stress, weight & energy, male and female hormones and wellness, and many more.

If you want to use home test kits to find out more about your own data and upgrade your health, here are a few essentials to know:

It’s important to choose a certified lab.

• Knowing Labs is a High Complexity CLIA Certified Laboratory in the State of Texas.
• CLIA means the Clinical Laboratory Improvement Amendments that regulate laboratory testing.
• All Knowing Labs testing is done in-house so they have total control over the quality and performance of the services.

It’s important to understand the type of at-home test kit you have and how to collect accurate samples. 

• This could be saliva, blood or urine, depending on the kit you choose. 
• For blood samples, this could mean a spot, pipette or home phlebotomist visit.
• Conde talks about some best practices and troubleshooting tips.

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

WE APPRECIATE OUR PARTNERS. CHECK THEM OUT!

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Franchise Opportunity: https://ownanupgradelabs.com, to check out the fitness center of the future

IN THIS EPISODE OF THE HUMAN UPGRADE™...

…you’ll take a deep dive into the science of healthy eating so that you can know how to leverage food for high energy and performance.

Health and science journalist Max Lugavere studies and writes about ways that food and movement fuel you. And allow you some balance and freedom in your choices.

He joins the show to round out a body of work that includes his best-selling “Genius Foods,” “The Genius Life” and now his latest to complete the trio: “GENIUS KITCHEN: Over 100 Easy and Delicious Recipes to Make Your Brain Sharp, Body Strong, and Taste Buds Happy.

“It's a kitchen and wellness guide,” Max explains. “I didn't want to just make a book of recipes. That would've been too easy. I wanted to make something that was going to stand the test of time and serve as a resource for people."

His work was inspired by his mom’s diagnosis with a rare form of dementia in her 50s. He dedicated himself to her care and also began researching how to prevent cognitive decline through nutrition. 

“Though I began to cook when my mother could no longer cook herself, I realized that culinary literacy (like health literacy) had become yet another aspect of life that we had outsourced,” Max says in “Genius Kitchen.” I became passionate about creating healthy food that is delicious and easy to make."

There’s a multi-billion dollar diet industry that makes nutrition confusing and complex. This conversation gets into the value of simple food, how to find your own food philosophy and why Max rejects diet dogma. So this is the episode for you to:

-Learn science-backed tactics to improve digestion, increase nutrient extraction and stop common digestive complaints. 

-Get practical food lists and cooking methods for easy, nutritious meals that work for your performance goals and everyday life.

-Find out how to eat like a “genius” with these topics:

• The upside & downside of plants
• Protein quality & muscle maintenance
• Organ meats
• Fantastic fats & ominous oils
• The shudder of sugar
• Essential fatty acids
• Calcium & the debate about dairy
• And more!

More about Max: 

Max gets his curious on hosting The Genius Life podcast. He appears regularly on the Dr. Oz Show, the Rachael Ray Show, and The Doctors. He’s been featured on NBC Nightly News, The Today Show, and in The New York Times and People Magazine and contributed to Medscape, Vice, Fast Company, CNN, and the Daily Beast. He’s an international speaker who’s presented at events like South by Southwest, TEDx, the New York Academy of Sciences, and the Biohacker Summit in Stockholm, Sweden.

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Cool Facts are quick hits of new human and world science curated into short bursts of information just for you. This fun compilation publishes one Friday a month.

• Strategic eating fills micronutrient gaps. 
• Use probiotics to turn down your allergies.
• Your DNA determines your coffee preferences.
• Got 3 seconds a day? Use it to strength train.
• Time your meals to control blood sugar and melatonin. 

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

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Support Immune & Digestive Health: https://justthrivehealth.com, use code ASPREY to get 15% off

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SPECIAL OFFER FOR THE HUMAN UPGRADE LISTENERS: Go to https://farmersjuice.com/pages/upgrade. Use code UPGRADE and save $10 off any box of juice.

IN THIS EPISODE OF THE HUMAN UPGRADE™...

Did you know?

• Less than 9% of people meet a daily vegetable intake that’s best for their body.
• Soil has up to 50% less nutrition than 1945
• And up to 40% of produce gets wasted on farms. 

Green juicing—done the right way—can upgrade all of those things. Junaid Kalmadi joins the show to talk about soil degradation, farming practices, and produce waste. He explains that it’s possible to do juicing safely and in ways that don’t break the planet even more.

Junaid (with Dave as an advisor) founded Farmers Juice, a keto-friendly and functional green juice line that uses a cold-pressed process. 

“You separate the pulp from the juice, and you get this end product of this incredibly high nutrient-dense jolt of vitamins, enzymes, phytochemicals that give you this tangible positive effect within your biology, within your mood, within your own like mental state to perform your best,” Junaid says.

It takes 1.5 pounds of produce (no kale!)  to make one bottle of organic Farmers Juice. The juices also contain adaptogens, antioxidants, and mushrooms to boost focus, calm, and athletic performance. 

Along with finding out what’s in the juice, you’ll learn about nutrigenomics and how food information tells your body what to do. You’ll also learn how phytonutrients act as your genetic control system and keep you healthy. 

Food and nutrients directly, immediately, and specifically interact with our genes, controlling moment-to-moment changes in your physiology and biochemistry.

For juicing 101, particularly ingredients and processing, take a listen to: Why Dave Asprey Changed His Mind About Juicing – #802.

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IN THIS EPISODE OF THE HUMAN UPGRADE™..

• You’ll learn about the science-based benefits of intermittent fasting for women, especially during midlife.
• You’ll get details about intermittent fasting advantages for women like how to gain hormonal stability and metabolic health, and how to improve your energy.
• You’ll get practical intermittent fasting how-tos, nutritional guidelines, carb cycling recommendations, food lists, and recipes to try during your feeding window.

Cynthia Thurlow joins the show to talk about how intermittent fasting can help women change their body, metabolic system and brain function. She has tips for women at all stages: from active menstrual cycles to perimenopause to menopause.

Cynthia is a Johns Hopkins-trained nurse practitioner and functional nutritionist founded and serves as CEO of Everyday Wellness Project. She holds a Master of Science degree in Nursing and Functional Nutrition certifications with advanced trainings in Endocrinology and Gastroenterology. Her career in healthcare includes nearly 20 years of emergency medicine and cardiology experience. She brings a broad perspective when working with women to improve the state of their health. 

“I really start from a foundational level talking to women about fasting,” Cynthia says. “It's really honoring our own unique physiology. It's leaning into that menstrual cycle. It's leaning into the lifestyle piece that so much of us forget to talk about with our patients, our sleep quality, stress management, anti-inflammatory nutrition, our exercise quality, our connection with nature, all of which are critically important.”

She also addresses diet dogma that frustratingly persists, even with established and emerging science about the benefits of intermittent fasting.

She tackles this outdated dogma (and a lot more!) in her new book, “Intermittent Fasting Transformation: The 45-Day Program for Women to Lose Stubborn Weight, Improve Hormonal Health, and Slow Aging.”

“[Intermittent fasting] restores our intrinsic rhythms, burns fat, regenerates our health right down to the cellular level, and stabilizes our hormones,” Cynthia says in her book. “In turn, we are less likely to develop obesity, diabetes, vascular diseases, and autoimmune disorders.”

At the end of this conversation, you’ll have the tools to decide if intermittent fasting is the right choice for the state of your own health. 

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

IN THIS EPISODE OF THE HUMAN UPGRADE™...

… Dave talks with Michael Ford about low thyroid function, autoimmunity and aging concerns.

At 70, Michael has been biohacking for over three years, takes a consistent supplement regimen, incorporates intermittent fasting, and does frequent microbiome and blood checks.

He takes only one medication for low thyroid function and is looking for alternative ways to manage it. He suspects he has an autoimmunity issue and would like to explore that more.

In the past few years, Michael has seen the health of colleagues, friends and elderly family members decline considerably. He’s concerned about aging and wants direction on how to live to be fully functional at 140 (or more!). With so much health information available to the general public–much of it contradictory, Michael asks Dave for insight and input.

In this “Interventions With Dave” episode, Dave also talks with Michael about:

• Supplements
• Testosterone
• Cortisol-causing excess weight
• Visceral fat
• Healthy fats
• Red light benefits
• Dental health
• Breathing & mouth taping
• Improving brain blood flow

They look at his health concerns through a new lens and discuss actionable next steps. Don’t miss the “Links & Resources” section below for specific information. 

Note: The "Interventions With Dave” recommendations are designed to help you upgrade yourself and your biology so you can perform better at everything you do. They are not, however, a substitute for advice or treatment by a trained medical professional that may be needed for specific health conditions, illness or injury.

Listen to the Interventions With Dave series:

• Hacking Inflammation #915
• Hacking Your Gut Microbiome #908
• Hacking Menopausal Weight Gain #904
• Hacking Eyesight #895

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Nature’s Nootropic: https://trukava.com, use code DAVE15 to get 15% off

CARBON60 for Brain & Body: https://wizardsciences.com, use code DAVE for an exclusive discount on C60 products

Trigger Autophagy: https://spermidinelife.us/dave, use code DAVE25 for 25% off your first month’s order

Special offer for The Human Upgrade listeners: Go to https://www.viome.com/daveasprey, use code DAVE to get $20 off a Health Intelligence™ Test.

IN THIS EPISODE OF THE HUMAN UPGRADE™...

Dave’s good friend, entrepreneur and philanthropist Naveen Jain, joins the show to talk about the future of human biology and wellness. What’s new right now, what’s emerging, and what’s on the horizon. He’s been a guest several times before (see the Links & Resources section below!) and there’s always something new to learn when he and Dave get together. This time, they explore testing the human biome.

Naveen’s a guy with enormous vision who builds companies and partners with others to tackle and solve the gnarliest problems affecting the health of our people and planet. 

He always encourages curiosity and big thinking: ““Curiosity is what drives the humanity forward. The day you stop being curious is the day you die.”

In this discussion, you’re going to learn ways innovation can change human biology from a micro and macro level—from your cellular health to broader planetary issues. You’ll also learn how you can test to find out what’s happening within your gut, cells and immune system. With that knowledge and personalized recommendations, you’ll have the power to change your health for the better.

Naveen founded, Viome, the worlds’ largest database of microbial gene expression. Its AI-driven personalized therapeutics platform and applications identifies predictive markers of chronic diseases. Viome does this by using a functional analysis of microbial, mitochondrial and human gene expression. “We actually see everything,” Naveen explains. “As long as an organism is alive, we see it. So whether it is a bacteria, virus, fungus, mold, it doesn't matter. We see everything.”

In particular, Viome’s Health Intelligence™ Test looks at:

• gut microbiome
• mitochondrial function
• immune cell function
• cellular health
• stress response
• biological age

The more data can inform what’s happening inside of you, the more resources you’ll have to improve your health.

More about Naveen Jain:

Naveen wrote the award-winning book, Moonshots: Creating a World of Abundance and created Mindvalley, Masterclass programs. He’s behind XPrize, a global future positive movement and is on the board of Singularity University. 

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Control Blood Glucose: https://pendulumlife.com, sign up for membership to get monthly supply delivery, use code DAVE20 to save $20 on your first shipment

IN THIS EPISODE OF THE HUMAN UPGRADE™...

 … Ellen Vora, M.D., takes a functional medicine approach to mental health that considers the whole person and addresses imbalance at the root. 

She’s a Yale and Columbia University educated holistic psychiatrist board-certified in psychiatry and integrative holistic medicine. She’s also an acupuncturist and yoga teacher.

In her new book, “The Anatomy of Anxiety: Understanding and Overcoming the Body's Fear Response,” she takes on anxiety, which hits more than 40 million people in any given year. The pandemic drove that number up even more. Even if math isn’t your strong suit, you can understand these numbers:

• An estimated one out of every nine people, or 800 million people, suffer from a mental health disorder, the most common of which is anxiety. 
• Up to 33.7 percent of Americans are affected by an anxiety disorder in their lifetime. 

Conventional medicine tends to view anxiety as a “neck up” problem of brain chemistry and psychology. Dr. Vora disagrees. She suggests that various physiologic inputs influence anxiety symptoms. 

“What we've been indoctrinated with is this idea that our mental health is genetically determined chemical imbalance,” Dr. Vora says. “There's some validity to that, although I think, for the most part, any chemical imbalance is often a downstream effect of a state of imbalance happening elsewhere in the physical body.”

In this episode, you’ll learn:

• the difference between avoidable, purposeful, false and true anxiety;
• simple strategies for tuning into “true” anxiety and using its benefits;
• how your body may be physiologically out of balance (immunity, gut health, inflammation);
• how “hanxiety” means that blood sugar is affecting your anxiety; 
• actionable lifestyle factors to bring yourself back into balance; 
• how to manage medication withdrawl; and 
• how to reframe your understanding of, and relationship with, anxiety.

Dr. Vora also confronts what she calls techxiety. This can include a boundaryless workplace, how the posture of screen use signals your body for anxiety, and, of course, social media. Research shows social media is associated with higher rates of anxiety and depression. Just 20 minutes of Facebook can impact mood.

So much of how you live your life as an adult profoundly impacts how your mental health manifests, and that's the part you can control.

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

IN THIS EPISODE OF THE HUMAN UPGRADE™...

… Dave talks with Cindy Fraley-Hunter about system-level inflammation and her fear of having an early heart attack like her father because they have such similar genes.

Cindy thought she was healthy until after the birth of her daughter at 42. She was constantly tired. Her physician told her that was just to be expected because she was a geriatric pregnancy. That unhelpful advice ignored her body functioning and lacked actionable solutions.

She then survived a case of MRSA and received Hashimoto’s and rheumatoid arthritis diagnosis. She continued to have high cholesterol and a high CAD calcium heart score. She’s scared her life will be cut short.

Feeling like conventional medicine is failing her, Cindy has turned to supplements instead of prescription drugs. She says she’s “embracing biohacking to save my life.”

In this “Interventions With Dave” episode, Dave walks Cindy through her most recent labs and other test results. They look at her health concerns through a new lens and discuss actionable next steps. Don’t miss the “Links & Resources” section of episode web page #915 for specific information.

Note: The "Interventions With Dave” recommendations are designed to help you upgrade yourself and your biology so you can perform better at everything you do. They are not, however, a substitute for advice or treatment by a trained medical professional that may be needed for specific health conditions, illness or injury.

Listen to the Interventions With Dave series:

• Hacking Your Gut Microbiome #908
• Hacking Menopausal Weight Gain #904
• Hacking Eyesight #895

Coffee & Bohacking with Dave Asprey

(coffee + minerals) - toxins = power: Discover the energy and high performance that come from Danger Coffee, designed with your biology in mind. https://dangercoffee.com

8th Annual Biohacking Conference: Come join like-minded people September 15, 16 & 17 in Beverly Hills, Calif., for three days of awesome! You’ll learn from dozens of experts at an amazing event that’s designed to upgrade every area of your life.https://biohackingconference.com

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Natural First-Aid Healing: https://3rdrockessentials.com, use code DAVE to save 20%

Non-Tobacco Nicotine Alternative: https://lucy.co, use code DAVE20 to get 20% off your first order of pouches, gums, or lozenges

Biostack for High Performance: https://vatellia.com, use code DAVE2022 to save 10% or subscribe and save 15% + receive a free bottle of Kale Buster

IN THIS EPISODE OF THE HUMAN UPGRADE™...

… you’ll get a look at synthetic biology (SYNBIO) through the lens of quantitative futurist Amy Webb in Part 2 of a special two-part episode. The Part 1 episode #913 explores the scientific perspective with microbiologist and geneticist Andrew Hessel.

Amy and Andrew recently authored, “The Genesis Machine: Our Quest to Rewrite Life in the Age of Synthetic Biology.” SYNBIO is the promising and controversial technology platform that combines biology and artificial intelligence. Amy investigates what SYNBIO means for people, commerce and the planet. 

“This is a book about science,” Amy describes, “but I did not want to write a science book. This is also a business book. It's an understanding-your-own-body book.”

She’s a futurist who works with data and does predictive modeling. Her academic background includes game theory and economics

Amy founded the Future Today Institute to help companies understand the forces that will shape their futures. She’s a professor of strategic foresight at the NYU Stern School of Business and a Visiting Fellow at Oxford University’s Säid School of Business. She writes extensively about biotechnology, artificial intelligence, technology policy, and business strategy.

“This emerging field of science—synthetic biology—promises to reveal how life is created and how it can be recreated, for many varied purposes, as explained in “The Genesis Machine:”

• to help us heal without prescription medications, 
• to grow meat without harvesting animals, and 
• to engineer our families when nature fails us.

With SYNBO developments come a slew of considerations about how to manage it responsibly.

“For the most part, in the US, the regulation is on the end product,” Amy says. “Nobody wants to regulate the process, because we don't want to hamper innovation. However, it does start to raise some gnarly questions when we're talking about alternative uses or different uses for some of these technologies, or cross-border use.”

“There's some alignment globally on what's called germline editing, which is when you edit the genome to make it heritable. So whatever that is passes on. At the moment, just about 190 countries have aligned [to agree] that they don't want that to happen. But outside of that, there's a lot of confusion.”

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Nature’s Nootropic: 

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Apple Cider Vinegar Benefits: 

https://paleovalley.com/DAVE, use code DAVE to get 15% off your first order

Franchise Opportunity:

https://ownanupgradelabs.com, to check out the fitness center of the future

IN THIS EPISODE OF THE HUMAN UPGRADE™...

… you’ll learn about the implications of synthetic biology in Part 1 of a special two-part episode.

Andrew Hessel and Amy Webb recently authored, “The Genesis Machine: Our Quest to Rewrite Life in the Age of Synthetic Biology.” This Part 1 episode gets into the scientific perspective with Andrew. Part 2 on episode #914 explores the futurist perspective with Amy.

Ask yourself, if you could edit your genes—to fix infertility, diabetes or even depression—would you do it? That’s the premise, and the promise, of synthetic biology. And a reality you’ll have to wrestle with. To make these decisions intelligently requires a deeper—and urgent—understanding of what’s happening in science.

Right now, scientists are rewriting the rules of our reality. They can use computers to gain access to the cells of any living organism and write new, potentially better, biological code. 

Andrew—a microbiologist and geneticist—works on the leading edge of genomics and bioinformatics. He’s been immersed in the world of synthetic biology for years and joins the show to explain new advancements.

As a scientist, communicator, and investor, he explores the future of biology and biotechnology. He co-founded the Center of Excellence for Engineering Biology and the Genome Project-write. The Genome Project-write is an international scientific effort that designs and builds large genomes, including the human genome. 

As we embrace that life no longer will be a game of chance, it will be the result of design, selection and choice, morechoices have to be made. Decisions like who gets to program life, create new life forms, and even bring former life back from extinction?

“The Genesis Machine" is a book about science, but it's not written for scientists, Andrew says. “It's about some amazing people and stories and we've got some fun scenarios that help you think about where some of this stuff is going. But really, this is a technology that we're all building day by day.”

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SPECIAL OFFERS FOR THE HUMAN UPGRADE LISTENERS:

• Pre-order your copy of “Unlocking the Keto Code” before March 7, 2022, and receive your choice of “The Energy Paradox,” or “The Plant Paradox,” or an early release chapter of “Unlocking the Keto Code,” and an exclusive sneak peek digital recipe guide! Go to https://drgundry.com for details. 
• Get 30% off products at https://gundrymd.com. Use code DAVE30 at checkout.

IN THIS EPISODE OF THE HUMAN UPGRADE™...

… Steven Gundry, M.D., introduces you to the biological mechanism that makes keto diets so successful: a cellular process known as “mitochondrial uncoupling.” 

He’s spent the last two decades studying the microbiome and uses diet and nutrition as a key form of treatment for people who want to improve their body health and performance. You may already know Dr. Gundry from his bestselling books like: “The Plant Paradox,” (lectins!) “The Longevity Paradox” and “The Energy Paradox.” 

This discussion gets right into new science that’s overhauling what you think you know about a keto diet. In his newest book, “Unlocking the Keto Code: The Revolutionary New Science of Keto That Offers More Benefits Without Deprivation,” Dr. Gundry debunks common myths about keto and explains:

• How ketosis actually works,
• What’s going on with ketones, and 
• What your mitochondria has to do with all of this.

You don’t have to restrict all carbs to reap the benefits of ketosis; you simply have to “unlock” mitochondrial uncoupling, Dr. Gundry explains.

He shares eight “keys” that unlock the keto code. You’ll get real food examples of how to ignite this process without the monotonous, limiting, high-fat diet.

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IN THIS EPISODE OF THE HUMAN UPGRADE™...

Entrepreneur, investor and artist Payal Kadakia brings a fresh perspective to your understanding of goals. She knows a lot about setting big goals and reaching them.

She founded ClassPass and over a decade grew it to become the leading fitness and wellness membership service valued at over $1 billion. Mindbody acquired ClassPass in October 2021. At that time, members had logged more than 100 million hours of workouts across 30,000 partner studios in over 30 countries. 

We’re going to talk today about how you can upgrade your own goal setting with “LIFEPASS: Drop Your Limits, Rise to Your Potential.” 

Using her company Class Pass as an example, Payal highlights the importance of knowing your strengths, your unique talents,  who you are, and investing in the right people and mentors to show you the way. 

Payal gives insight on how to set boundaries in service to your priorities, and how every minute of the day belongs to YOU, not anyone else. This means you don’t have to hold onto any guilt about doing what's right for you.

You’re more likely to reach your goals when you get to let go of the pressure to achieve a traditional kind of success and instead fuel your life with purpose. And when you focus on a life of creativity, you get to live the life you most want to live.

The 4-step LifePass Method combines intuition, pie-in-the-sky dreams, micro focus, and macro goals.

• Reflect: Where have you been?
• Dream: Where do you want to go?
• Focus: What are your priorities?
• Set Goals: What’s the plan?

Payal, an Operations Research and Economics graduate from MIT, been featured in most major news outlets; listed as Fast Company’s 100 Most Creative People; and named to Fortune's 40 under 40 list. 

She formerly worked as a consultant at global management consulting firm Bain & Company and was part of Warner Music Group’s Digital Strategy and Business Development Group. 

She’s also got an extraordinary artistic side. She founded The Sa Dance Company in 2008 and serves as Artistic Director.

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Cool Facts are quick hits of new human and world science curated into short bursts of information just for you. This fun compilation publishes one Friday a month.

• Breathing coordinates neuronal activity—even without smell
• Mindful breathing in virtual reality can control real pain
• Circadian cycle affects immune cells and Alzheimer’s plaques
• Brain refresh lags when processing visual stimuli
• Medical repression in the days of Ivan the Terrible

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IN THIS EPISODE OF THE HUMAN UPGRADE™...

“Americans are the unhappiest they have been since the Great Depression,” says Dr. Daniel Amen. But he’s determined to change that. 

He’s a physician and double board-certified psychiatrist who looks at happiness as a brain function. After studying more than 200,000 brain scans of people from 155 countries, Dr. Daniel Amen discovered five primary brain types and seven neuroscience secrets that influence happiness.

“I wanted to spend my time and energy and research on happiness because, ultimately... happiness is a moral obligation because of how you impact other people,” Dr. Amen says. “The big central point [is] the brain is the organ of happiness, and if your brain is not healthy, you are not likely to be happy.”

What makes you happy? The answer lies in knowing your specific brain type and how it’s being influenced by seven specific chemicals.

Happiness originates in distinct brain regions: pleasure in the orbitofrontal cortex; motivation and habit formation in the basal ganglia; and mood and cognitive flexibility in the brain stem.

You may be one or a combination of these five primary brain types: (take this brain assessment to find out yours)

Balanced: you have a very healthy brain

Spontaneous: you have low dopamine

Persistent: you’re often worried, rigid, and inflexible

Sensitive: you need other people and isolation is hard

Cautious: your GABA levels are low

Learn more about brain types and what actually boosts your happiness according to neuroscience in Dr. Amen’s book, "You, Happier: The 7 Neuroscience Secrets of Feeling Good Based on Your Brain Type.”

“Happiness comes from moving your life forward toward your life goals with meaning and purpose, based on your values, despite whatever obstacles are in your way,” Dr. Amen says. “A happy life doesn’t focus on the past with regret or look to the future with fear.”  

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SPECIAL OFFER FOR THE HUMAN UPGRADE LISTENERS: Call the phone number listed on the Docere Clinics website: (435) 604-0438. Mention you heard about stem cell treatments on the Dave Asprey podcast and get half off a consultation.

IN THIS EPISODE OF THE HUMAN UPGRADE™...

 …you’re going to find out about Dave’s recent stem cell procedure and the newest technology stem cell medicine happening at Docere Clinics in Park City, Utah.

Dr. Harry Adelson was one of the earliest adopters of the use of stem cells for the treatment of chronic musculoskeletal pain. His practice has offered 100% Regenerative Injection Therapy since 2002 and 100% stem cell therapy since 2010. He’s performed more than 6,000 stem cell procedures and invented the Full Body Stem Cell Makeover®, the most comprehensive stem cell upgrade currently available. 

His colleague, Dr. Amy B. Killen performs anti-aging and regenerative medical treatments. She’s fellowship trained in Anti-Aging and Regenerative Medicine through the American Academy of Anti-Aging Medicine. She’s also done extensive additional training in aesthetics, platelet rich plasma and stem cells, hair restoration, bio-identical hormones, nutrition, fitness and sexual health.

Drs. Adelson and Killen performed Dave’s original Full Body Stem Cell Makeover®, which used Dave's own stem cells from his fat and bone marrow, as well as extracellular vesicles. This episode gets into new developments in stem cell treatments, like the advent of VSEL (very small embryonic-like stem cells) technology. 

Stem cells therapy may be right for you if you’re interested in:

• Better skin
• Increased sexual performance
• Decreased pain
• Improved functional body movement
• Preventive aging treatment

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IN THIS EPISODE OF THE HUMAN UPGRADE™...

… Dave talks with Tim Waters about ways to improve the health of his gut microbiome. 

A former wrestler, Tim spent years cutting weight. He experienced gall stones and eventually had his gall bladder removed 20 years ago. That led to long-term use of proton pump inhibitor pharmaceutical. Now over 50, Tim wants to wean off the pharmaceutical and heal his gut. He’s made some progress on his own but has some complicating factors at play.

Here are a few things you'll learn in this “Interventions with Dave” episode:

• What causes low stomach acid
• The difference between a proton pump inhibitor and an H2 blocker
• How certain foods influence gastric reflux
• How to manipulate your gut pH (acid and heat)
• The role enzymes play in digestion
• The importance of bile
• The benefits of butyric acid
• How to get your good gut bacteria working
• How to check your methylation
• Why tracking your blood pressure regularly is a great idea

This conversation covers a lot of gut ground! Don’t miss Dave’s intervention recommendations in the “Links & Resources” section of the episode webpage: https://daveasprey.com/intervention-tim-waters-908/

Note: The "Interventions With Dave” recommendations are designed to help you upgrade yourself and your biology so you can perform better at everything you do. They are not, however, a substitute for advice or treatment by a trained medical professional that may be needed for specific health conditions, illness or injury.

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Vivobarefoot is offering 100-day free trial on their footwear. Visit https://www.vivobarefoot.com/us/daveasprey and use code ASPREY20 for adult and kids’ shoes. You’ll get 20% off your first order.

IN THIS EPISODE OF THE HUMAN UPGRADE™...

…whether you’re hiking, climbing, working or playing, your feet ground you. Except when they don’t. Shoes don’t always match up to the function of your life. You can end up with pain and misalignment throughout your body when your feet are encased in shoes that don’t support your body’s natural biomechanics.

Feet, for all their variety in shape and size, get the award for amazing. Your feet literally form the center of your body’s whole system of movement. Did you know these facts about the human foot?

• 26 bones, nearly 30 muscles and thousands of nerve endings
• 33 articulations (each with six degrees of freedom of motion) 
• Humans began running about 2 million years ago to be able to hunt

“If the foot moves normally, then the muscles start to work and so on and so on,” says Peter Francis, Ph.D. “It’s really just about allowing your foot to move as nature intended.”

Peter joins the show from the Carlow Institute of Technology in Carlow, Ireland. There, he lectures in sport and health science and researches how modern environments effect human health and performance. 

With degrees in Sport and Exercise Science and Physical Therapy, and a PhD in Exercise Science, he’s written more than two dozen peer-reviewed journal articles and led numerous research projects. He’s also worked with teams and individuals at amateur, European and Olympic level. 

He knows feet! And, he’s got a lot to share about how feet influence the way your body moves. A runner himself, Peter studies the role of foot development with and without shoes. He then figures out what that means for movement skills and injury risk.

Your feet are by their form and function incredibly sensory. When you block sensory information from your feet, you have trouble maintaining stability and balance.

You may think that your shoes help support your feet, but the opposite proves true. Shoes strip your natural movement and make your feet weak.

Your shoes, not your feet, are the problem.

In this conversation, you’ll learn what footwear works best for you and your kids and the importance of variability and fun in your movements. Start with Vivobarefoot barefoot-style shoes to reap the benefits of living life barefoot (or close to it).

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IN THIS EPISODE OF THE HUMAN UPGRADE™...

… guest Dr. David Perlmutter explains how he’s an expert in dropping acid, but not in the way you might think. A regular contributor to groundbreaking science, he’s back on the show to talk about why you should be paying attention to your uric acid levels. 

Dr. Perlmutter is a neurologist and five-time New York Times bestselling author. His books include “Brain Wash,” “Grain Brain” and  “Brain Maker.” He’s recognized internationally as a leader in the field of nutritional influences in neurological disorders. Now, he’s turning his attention to how uric acid threatens your metabolic health.

Uric acid is a waste product of metabolism, and its levels are a key health marker and indicator of chronic degenerative diseases. When uric acid levels rise, they tell your body to store fat, which messes with your metabolism and poses a danger to your health.

Alcohol, purines (breakdown product of DNA and RNA in foods) and fructose (the kind of sugar found in processed foods) are the three main sources of uric acid. Since the days of our primate ancestors, we’ve lost the ability to break down uricase, so what we choose to consume makes a big difference.

“If we can emulate those signals to our DNA and our physiology that have evolved to keep us healthy,” Dr. Perlmutter says, “we're going a long way to offsetting these incredibly powerful metabolic disruptions that are paving the way for the biggest cause of disease on our planet.”

His newest book, “Drop Acid: The Surprising New Science of Uric Acid—The Key to Losing Weight, Controlling Blood Sugar, and Achieving Extraordinary Health,” includes ways to measure, control and track your uric acid levels and key strategies to manage them. You’ll find out the top five foods that raise uric acid (hint: fructose earns the No. 1 spot). You’ll also find out the five important supplements to take to lower your uric acid levels back into a healthy range.

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